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microRNAs and JAK/STAT3 signaling:A new promising therapeutic axis in blood cancers

Genes & Diseases 2022年第4期9卷 849-867页

作者： mehdi Sajjadi-Dokht Talar Ahmad merza mohamad Heshu Sulaiman Rahman marwah Suliman maashi Svetlana Danshina Navid Shomali Saeed Solali faroogh m.rofi Elham Zeinalzadeh morteza Akbari Ali Adili Ramin Aslaminabad majid Farshdousti Hagh mostafa Jarahian Immunology Research Center Tabriz University of Medical SciencesTabriz ***Iran Department of Pharmacology College of PharmacyHawler Medical UniversityErbil 44001Iraq Department of Physiology College of MedicineUniversity of SulaymaniyahSulaymaniyah 46001Iraq Department of medical Laboratory Sciences Komar University of Science and TechnologySulaymaniyah 46002Iraq Department of Propaedeutics of Dental Diseases I.M.Sechenov First Moscow State Medical UniversityMoscow 119991Russia Department of Immunology Faculty of MedicineTabriz University of Medical SciencesTabriz ***Iran Department of Oncology Tabriz University of Medical SciencesTabriz ***Iran German Cancer Research Center(DKFZ) Toxicology and Chemotherapy Unit(G401)Heidelberg 69120Germany Stem Cells and Regenerative medicine Unit at King Fahad medical Research Centre Jeddah 21589Saudi Arabia

Blood disorders include a wide spectrum of blood-associated malignancies resulting from inherited or acquired *** ineffectiveness of existing therapies against blood disorders arises from different reasons,one of which is drug resistance,so different types of leukemia may show different responses to *** occurs for a variety of genetic and acquired reasons,leading to uncontrolled proliferation in one or more cell *** the genetic defects,oncogene signal transducer and activator of transcription(STAT)family transcription factor,especially STAT3,play an essential role in hematological disorders onset and progress upon mutations,dysfunction,or ***,microRNAs,as biological molecules,has been shown to play a dual role in either tumorigenesis and tumor suppression in various ***,a strong association between STAT3 and miRNA has been *** example,miRNAs can regulate STAT3 via targeting its upstream mediators such as IL6,IL9,and JAKs or directly binding to the STAT3 *** the other hand,STAT3 can regulate *** this review study,we aimed to determine the role of either microRNAs and STAT3 along with their effect on one another's activity and function in hematological malignancies.

关键词： Interleukin JAKs Leukemia miRNAs STAT3

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