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仰卧位胸部X线片图像质量:计算机X线摄影和低剂量线样裂隙数字X线摄影的个体间对比

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国际医学放射学杂志 2009年第6期 594-594页

作者： Z.Szucs-farkas P.Vock 余丽芳 Department of Diagnostic Interventional and Paediatric RadiologyInselspitalBerne University Hospital and University of BerneFreiburgstrasse 4Berne3010Switzerland

该回顾性研究的目的是比较个体间计算机X线摄影(CR)与低剂量线性裂隙数字X线摄影(LSDR)在仰卧位胸片的图像质量。共90例病人(女28例,男62例,平均年龄55.1岁)在(2.8±3.0)d时间间隔内进行CR和LSDR的检查。2位专业人员按照改良的欧洲胸部... 详细信息

该回顾性研究的目的是比较个体间计算机X线摄影(CR)与低剂量线性裂隙数字X线摄影(LSDR)在仰卧位胸片的图像质量。共90例病人(女28例,男62例,平均年龄55.1岁)在(2.8±3.0)d时间间隔内进行CR和LSDR的检查。2位专业人员按照改良的欧洲胸部X线片

关键词：图像质量胸部躯干低剂量摄影美术仰卧位计算机

A Synonymous Polymorphism of APCDD1 Affects translation Efficacy and is Associated with Androgenic Alopecia

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Journal of Life Sciences 2014年第2期8卷 106-114页

作者： Nikoletta Nagy Katalin farkas Agnes Kinyo Barbara Fazekas Kornelia Szabo Edit Kollar Balazs Sztano Angela Meszes Dora Beke Lajos Kemeny Laszlo Royo Marta Szell Department of Medical Genetics University of Szeged Szeged 6720 Hungary Department of Dermatology andAllergology University ofSzeged Szeged 6720 Hungary Dermatological Research Group Hungarian Academy of Sciences Szeged 6720 Hungary Department of Rhino-Laryngology and Head-Neck Surgery University ofSzeged Szeged 6720 Hungary

the APCDD1 (adenomatosis polyposis coli down-regulated 1) gene is an inhibitor of the Wnt signaling pathway, and a rare mutation of this gene has been associated with hereditary hypotrichosis simplex. In this study, the authors aimed to investigate whether common APCDD1 gene polymorphisms contribute to the development of androgenic alopecia. Patients (n = 210) with androgenic alopecia and 98 controls were investigated. SNPs (Single nucleotide polymorphisms) in the coding region of the gene were sequenced. A significant difference in genotype distribution was found for the c.1781C/t, p. L476L SNP (rs3185480) of the APCDD1 gene. this SNP is located in exon 5 and is associated with a 3.5- and a 2.8-fold increase in risk for the development of androgenic alopecia for homozygote (CI 0.933-13.125; nominal regression P = 0.063) and heterozygote (CI 1.086-7.217; nominal regression P = 0.033) carriers, respectively. these data suggest that the rs3185480 polymorphism contributes to the development of androgenic alopecia. Protein expression experiments revealed that the polymorphism is associated with reduced APCDD1 protein abundance. this reduction is likely due to altered codon usage for leucine from a preferred codon (CtC) to a rare codon (Ctt), which might influence translation efficiency and, thus, APCDD1 protein level.

关键词：基因多态性翻译效率脱发素性 Wnt信号通路单核苷酸多态性密码子使用 SNPs

肥胖病人腹部Ct影像质量及低对比度检测能力的评估:一种新型集成电路与常规分立电路探测器在不同管电压条件下的比较

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国际医学放射学杂志 2015年第3期 289-289页

作者： A.Euler t.Heye M.Kekelidze G.Bongartz Z.Szucs-farkas C.Sommer 柯勤兵 Clinic of Radiology and Nuclear Medicine University of Basel HospitalPetersgraben 4 4031Basel Switzerland

目的在低管电压条件下对肥胖病人行腹部Ct检查,采用集成电路(IC)探测器与常规探测器技术,比较两种技术的影像质量及低对比度检测能力。方法将一个含45个

关键词：肥胖病人探测器低对比度影像质量常规腹部躯干 Ct

基于衰减的管电压自动选择与迭代重建联合应用:肝脏体模研究

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国际医学放射学杂志 2014年第3期 296-296页

作者： D.B.Husarik S.t.Schindera F.Morsbac N.Chuck B.Seifert Z.Szucs-farkas 许玉峰 Institute for Diagnostic and Interventional Radiology University Hospital ZurichRaemistrasse 1008091 ZurichSwitzerland

摘要目的确定基于衰减的自动管电压选择联合迭代重建(IR)技术对于优化Ct影像显示肝脏低密度病变的价值。方法含有低密度病变的肝脏体模分别使用与不使用基

关键词：管电压病变体模迭代重建肝脏

Utility of serum tNF-a,infliximab trough level,and antibody titers in inflammatory bowel disease

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World Journal of Gastroenterology 2014年第17期20卷 5031-5035页

作者： va Pallagi-Kunstár Klaudia farkas Zoltán Szepes Ferenc Nagy Mónika Szucs Róbert Kui Rolland Gyulai Anita Bálint tibor Wittmann tamás Molnár First Department of Medicine University of SzegedH6720 SzegedHungary Department of Medical Physics and Informatics University of SzegedH6720 SzegedHungary Department of Dermatology and Allergology University of SzegedH6720 SzegedHungary

AIM:to assess tumor necrosis factor-a(tNF-a),infliximab(IFX)concentrations,and antibodies against IFX molecules in patients with inflammatory bowel disease(IBD)who develop loss of response,side effects,or allergic reaction during anti tNF-a ***:Blood samples of 36 patients with response loss,side effects,or hypersensitivity to IFX therapy(Group?Ⅰ)and 31 patients in complete clinical remission(GroupⅡ)selected as a control group were collected to measure trough serum tNF-a level,IFX,and anti-IFX antibody(AtI)*** examined the correlation between loss of response,the development of side effects or hypersensitivity,and serum tNF-a,IFX trough levels,and AtI ***:the serum tNF-a level was shown to be correlated with the presence of AtI;AtI positivity was significantly correlated with low trough levels of *** were detected in 25%of IBD patients with loss of response,side effects,or hypersensitivity,however no association was revealed between these patients and antibody positivity or lower serum IFX *** use of IFX correlated with the development of AtI,although concomitant immunosuppression did not have any impact on ***:On the basis of the present study,we suggest that the simultaneous measurement of serum tNF-a level,serum anti tNF-a concentration,and antibodies against anti tNF-a may further help to optimize the therapy in critical situations.

关键词： tumor necrosis factor-a Infliximab Antibody Inflam

采用心脏MR(CMR)成像进行心外病变检查

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国际医学放射学杂志 2012年第4期 405-405页

作者： R.Wyttenbach N. Médioni P. Santini P. Vock Z. Szucs-farkas 王鹤 Department of Radiology Ospedale San Giovanni Bellinzona (EOC)CH -6500 Bellinzona Switzerland

摘要目的确定进行临床心脏MR(CMR)检查的病人心外表现(ECF)的出现率及其重要性,并验证关于CMR初始读片时仅关注心脏会低估心外病变的假设。方法401例连续病人接受1.5t CMR检查,平均年龄53岁。主要检查指征为缺血性心脏病(183例)和心肌病... 详细信息

摘要目的确定进行临床心脏MR(CMR)检查的病人心外表现(ECF)的出现率及其重要性,并验证关于CMR初始读片时仅关注心脏会低估心外病变的假设。方法401例连续病人接受1.5t CMR检查,平均年龄53岁。主要检查指征为缺血性心脏病(183例)和心肌病(164例)。由同一名放射科医生在首次临

关键词： MRI 意外发现心外异常心脏成像胸部

计算机临床决策支持系统对急诊Ct肺动脉成像使用率和阳性检出率的影响

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国际医学放射学杂志 2012年第2期 178-178页

作者： A.S.Raja I.K.Ip L.M.Prevedello A.D.Sodickson C.farkas R.D.Zane 康振 Center for Evidence Based Imaging and Departments of Radiology Emergency MedicineBrigham and Women's Hospital75 Francis StNeville House 312-EBostonMA 02115

目的为了确定在急诊室循证临床决策支持(CDS)系统对Ct肺动脉成像在急性肺栓塞(PE)诊断中使用率和阳性诊断率的影响。材料与方法本HIPAA依从性研究得到机构审查委员会的批准,实施时间为2003年10月1日—

关键词：肺动脉成像 CDS 阳性检出率急诊 Ct

曝光量:自动化解剖学特异性Ct射线曝光量选取的质量保证和辐射监测

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国际医学放射学杂志 2012年第5期 483-483页

作者： A.Sodickson G.I.Warden C.E.farkas I.Ikuta L.M.Prevedello K.P.Andriole 龙柳 Department of Radiology and Center for Evidence-Based Imaging Brigham and Women's HospitalHarvard Medical School75 Francis StBostonMA02115

摘要目的开发和验证一种信息工具库,使得能从光学字符识别的现有数字图像档案中获取解剖学特异性Ct的射线曝光量(容积Ct剂量指数和剂量长度积)Ct剂量报告的屏幕截图(剂量屏幕)结合数字成像和通信医学属性。材料与方法这一机构审查委员... 详细信息

摘要目的开发和验证一种信息工具库,使得能从光学字符识别的现有数字图像档案中获取解剖学特异性Ct的射线曝光量(容积Ct剂量指数和剂量长度积)Ct剂量报告的屏幕截图(剂量屏幕)结合数字成像和通信医学属性。材料与方法这一机构审查委员会批准的遵循HIPAA的研究在一个大型城市保健医疗提供的服务网络中完成。数据来自2000—2010年之间随机抽样的Ct样本;这些样本的图像包含在企业图像档案中,其中包括从一个成熟的学术性三级中心医院及其附属网站获得的图像,涵盖有肿瘤中心、社区医院、门诊影像中心,以及其他设施所引入的图像。

关键词：曝光量数字图像档案解剖学特异性解剖部位剂量用药量 Ct