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Sperm quality metrics were improved by a biomimetic microfluidic selection platform compared to swim-up methods

Microsystems & Nanoengineering 2023年第2期9卷 261-274页

作者： Steven A.Vasilescu Lin Ding farin yazdan parast Reza Nosrati Majid Ebrahimi Warkiani NeoGenix Biosciences pty Itd SydneyNSW 2126Australia. School of Biomedical Engineering University of Technology SydneySydneyNSW 2007Australia Department of Mechanical&Aerospace Engineering Monash UniversityClaytonVIC 3800Australia institute for Biomedical Materials&Devices(IBMD) Faculty of ScienceUniversity of Technology SydneySydneyNSW.2007Australia

Sperm selection is an essential component of all assisted reproductive treatments(ARTs)and is by far the most neglected step in the ART workflow in regard to technological *** sperm selection methodologies typically produce a higher total number of sperm with variable motilities,morphologies,and levels of DNA ***-standard techniques,including density gradient centrifugation(DGC)and swim-up(SU),have been shown to induce DNA fragmentation through introducing reactive oxygen species(ROS)during ***,we demonstrate a 3D printed,biologically inspired microfluidic sperm selection device(MSSP)that utilizes multiple methods to simulate a sperms journey toward *** are first selected based on their motility and boundary-following behavior and then on their expression of apoptotic markers,yielding over 68%more motile sperm than that of previously reported methods with a lower incidence of DNA fragmentation and *** from the MsSP also demonstrated higher motile sperm recovery after cryopreservation than that of sU or neat *** were conducted side-by-side against conventional SU methods using human semen(n=33)and showed over an 85%improvement in DNA integrity with an average 90%reduction in sperm *** results that the platform is easy-to-use for sperm selection and mimics the biological function of the female reproductive tract during conception.

关键词： utilize yielding neglected

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