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ABCA1基因多态性R219K与帕金森症和阿尔兹海默症发病率的相关性研究

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现代生物医学进展 2020年第9期20卷 1733-1736,1744页

作者：亚拉盖梁琨锡林塔娜陶娜拉刘燕内蒙古自治区人民医院老年医学中心内蒙古呼和浩特010020 内蒙古锡林郭勒盟蒙医医院心身医学科内蒙古锡林浩特026000 内蒙古农业大学遗传育种实验室内蒙古呼和浩特010010 内蒙古自治区人民医院内分泌科内蒙古呼和浩特010020

目的:探讨与研究三磷酸腺苷结合盒转运体A1(Adenosine triphosphate(ATP)-binding cassette transporter A1)基因多态性R219K与帕金森症(Parkinson disease,PD)和阿尔兹海默症(Alzheimer disease,AD)发病率的相关性。方法:选择2016年2月到2019年8月在本院门诊与住院的帕金森症患者42例作为PD组,同期选择本院门诊与住院的阿尔兹海默症患者42例作为AD组,同期选择本院门诊健康体检者84例作为对照组。调查入选者的一般资料,检测三组血液样本的ABCA1基因多态性R219K情况并进行相关性分析。结果:AD组低密度脂蛋白(low-density lipoprotein,LDL-C)、总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)与尿酸(Uric acid,UA)均低于对照组,而高密度脂蛋白(high-density lipoprotein,HDL-C)、同型半胱氨酸(homocysteine,Hcy)值高于对照组(P0.05),三组空腹血糖(Fasting blood glucose,FBG)值对比差异无统计学意义(P>0.05)。PD组与AD组的ABCA1 R219K GA基因型、A等位基因频率都显著高于对照组(P0.05)。在168例入选者中,直线相关分析显示ABCA1 R219K GA基因型与A等位基因与帕金森症或阿尔兹海默症发生有显著相关性(P<0.05)。结论:ABCA1基因多态性R219K在帕金森症和阿尔兹海默症患者中比较常见,ABCA1 R219K GA基因型与A等位基因可诱发帕金森症和阿尔兹海默症的发生。

关键词：三磷酸腺苷结合盒转运体A1 基因多态性帕金森症阿尔兹海默症

地屈孕酮片联合绒毛膜促性素治疗原因不明复发性流产及对T淋巴细胞和炎症因子影响

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中国计划生育学杂志 2020年第1期28卷 32-35页

作者：塔拉张琰王晓彩由艳艳辽宁省丹东市妇女儿童医院 118000 辽宁省沈阳市妇婴医院

目的:探析地屈孕酮片联合绒毛膜促性素治疗原因不明复发性流产(URSA)疗效及对患者T淋巴细胞因子和炎症因子影响。方法:收集本院2017年6月—2018年11月收治的URSA患者100例,简单法随机分组,观察组50例采取地屈孕酮片联合绒毛膜促性素治疗... 详细信息

目的:探析地屈孕酮片联合绒毛膜促性素治疗原因不明复发性流产(URSA)疗效及对患者T淋巴细胞因子和炎症因子影响。方法:收集本院2017年6月—2018年11月收治的URSA患者100例,简单法随机分组,观察组50例采取地屈孕酮片联合绒毛膜促性素治疗,对照组50例采取黄体酮联合绒毛膜促性素治疗。对比两组妊娠8、12周血清白介素(IL)-4、IL-6、IL-10、IL-17、γ干扰素(INF-γ)、肿瘤坏死因子(TNF)-α,高敏C-反应蛋白(hs-CRP),CD4+调节性T细胞Treg(Treg/CD4+)、CD4+T辅助细胞Th17(Th17/CD4+)、辅助性T细胞17/调节性T细胞(Th17/Treg)。统计妊娠结局。结果:与妊娠8周比较,两组妊娠12周时IL-4、IL-10、Treg/CD4+均升高,IL-6、IL-17、INF-γ、TNF-α、hs-CRP、Th17/CD4+、Th17/Treg均降低(P<0.05),且观察组变化幅度高于对照组(均P<0.05)。观察组流产率(17.0%)低于对照组(40.9%),足月分娩率(63.8%)高于对照组(31.8%)(P<0.05)。结论:地屈孕酮片联合绒毛膜促性素治疗URSA效果良好,可调节患者T淋巴细胞因子及炎症因子水平,促进“母—胎”免疫平衡,降低流产风险,提高保胎成功率。

关键词：复发性流产地屈孕酮绒毛膜促性激素 T淋巴细胞因子炎症因子

Prevalence of Salmonella in Fresh Produce Tomatoes Sold in Open Market in Ouagadougou, Burkina Faso

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Food and Nutrition Sciences 2023年第12期14卷 1259-1268页

作者： Hanseni Bognini Assèta Kagambèga WP Bertrand Tiendrebeogo Abdallah Sawadogo Nicolas Barro Théodore Knight-Jones Michel Dione laboratoire de Biologie Moléculaire D’épidémiologie et de Surveillance des Bactéries et Virus Transmissibles par les Aliments (LaBESTA)/Ecole Doctorale Sciences et Technologies (EDST)/Université Joseph KI-ZERBO Ouagadougou Burkina Faso Ecole Normale Supérieure Ministère des Enseignement Supérieur de la Recherche Scientifique et de L’innovation Ouagadougou Burkina Faso Animal and Human Health Program International Livestock Research Institute Rue 18 Cité Mamelles BP Ouakam Dakar Senegal

Tomato is a widely consumed vegetable in Burkina Faso and throughout the world. However, when handled improperly, it can serve as a vector of pathogen transmission to human if ingested raw or through cross-contamination with cooked food. This study aimed to determine the prevalence of Salmonella spp from tomatoes sold in the markets of Ouagadougou, Burkina Faso and characteristics of vending conditions. One hundred and ninety-eight (198) different tomato samples were randomly purchased from one hundred and thirteen (113) different vendors in the markets of Ouagadougou. The samples were examined and classified into three categories according to their texture and the level of deterioration. The prevalence of Salmonella spp identification was determined using standard microbiological methods. A survey was conducted using a questionnaire on transport and vending conditions for tomatoes. In total, Salmonella prevalence was 19.19% in all tomato’s samples analyzed and was 18.18% for intact category, 22.73% in D2 category and 16.67% in category D4. The survey revealed poor transport and sales conditions for the majority of tomato sellers. The present study revealed the presence of Salmonella in tomatoes samples. These results highlight the risk associated with the consumption of tomatoes if hygienic practices are not respected during tomatoes handling and preparation. The results of the study also show the need to wash tomatoes systematically after purchase with a disinfectant, especially tomatoes sold in open markets in developing countries.

关键词： Salmonella Tomatoes Hygiene Food Security

Management of Severe Acute Malnutrition in a Senegalese Paediatric Hospital

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Open Journal of Pediatrics 2021年第2期11卷 198-207页

作者： Ndiogou Seck Idrissa Basse Djibril Boiro Younoussa Keïta lamine Thiam Aliou Abdoulaye Ndongo Ndéye rama Diagne-Gueye Service de péDiatrie Centre Hospitalier Régional de Saint-Louis Saint-Louis Sénégal Hô pital pour Enfants de Diamniadio Bargny Sénégal Service de péDiatrie Centre Hospitalier Abass Ndao Dakar Sénégal Service de péDiatrie Hô pital Aristide Ledantec Dakar Sénégal Service de PéDiatrie H&ocirc pital de la Paix Boucoutte Ziguinchor Sénégal

Malnutrition is a global health problem. It is very common in developing countries where it contributes to an increase in morbidity and mortality, especially among children under five years of age. The main objective of this study was to describe the management of severe acute malnutrition (SAM) in children six months to five years of age hospitalized at Diamniadio Children’s Hospital (DCH). This was an epidemiological, retrospective, descriptive and cross-sectional study of children aged six to 59 months hospitalized at DCH for SAM. The study took place over a 12-month period (from January 1, 2018 to December 31, 2018). During the study period, 67 children were admitted for SAM, representing a hospital prevalence of 8.4%. The majority (88%) children were less than 24 months old. Reasons for consultations were dominated by diarrhea (57.5%) vomiting (38.8%). Complications related to SAM were mainly: anaemia (74.6%), infections (85%) and severe acute dehydration (40.3%). Factors associated with SAM were young age (infants under 24 months of age), poverty, the first four children of a sibling, poor behaviour of food diversification. The average length of hospitalization was 12 days. The nutritional recovery rate was 73.1% and lethality was 3%. Conclusion: The prevention of malnutrition must involve the fight against poverty, an optimal and well-diversified diet, monitoring the nutritional status of children up to five years of age.

关键词： Severe Acute Malnutrition Children Complications Risk Factors Lethality

Impact of multivitamin and mineral supplements on mortality and nutritional status of hospitalized severely malnourished HIV/AIDS infected children

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Open Journal of Epidemiology 2013年第4期3卷 213-219页

作者： Léon G. Blaise Savadogo Philippe Donnen Fla Kouéta Eléonore Kafando Philippe Hennart Michèle Dramaix CR2-Epidemiology-Biostatistics-Clinical Research School of Public Health Université Libre de Bruxelles Bruxelles Belgique Department of Epidemiology and Public Health Child and Mother Health Nutrition and Survival Unit Institut Supérieur des Sci- ences de la Santé Bobo Dioulasso Burkina Faso Pediatric Hospital and University Ouagadougou Burkina Faso

Micronutrient deficiencies, in HIV/AIDS infected children, are common and associated with disease progression and increased mortality. There is no evidence to support specific recommendation for in-patient treatment of severely malnourished HIV/AID infected children. We analyzed the impact of daily oral multivitamin and mineral supplementation on nutritional status and on mortality rate, of severely malnourished HIV/AIDS infected infants, hospitalized in a feeding therapeutic center. Children were randomized at admission in one of the two treatment groups: WHO standard group or additional dose group. The trial has been approved by the national health research ethics committee. Case fatality rate was high in each group. There was no difference in mortality rate between WHO standard group (mortality rate = 16.9%) and “additional dose” group (mortality rate = 17.6%). Kaplan Meir survival curves did not differ between the two groups, (p Log rank = 0.87). During the inpatient follow-up, the median weight gain (g/kg/d) was low in groups and did not differ between WHO standard group (8.88g/kg/d Min = 4.70, Max = 17.23) and “additional dose” group (10.50g/kg/d, Min = 3.29 Max = 17.81) (Wilcoxon test p-value = 0.10). From admission to discharge, anthropometric Z-scores means evolution did not differ between the two groups: WHZ (p = 0.74), WAZ (p = 0.79) and MUAC (p = 0.73). In this randomized trial among severely malnourished HIV/AIDS infected children, we found no evidence that the provision of daily additional micro-nutrient dose during inpatient treatment, compared to WHO standard, improves nutritional status or reduces case fatality rate. Rigorous malnutrition inpatient treatments, including effective HIV/AIDS management, improve nutritional status of severely mal-nourished HIV infected children.

关键词： Multivitamin Mortality Nutritional Status Malnourished HIV Children

Impact of HIV/AIDS on mortality and nutritional recovery among hospitalized severely malnourished children before starting antiretroviral treatment

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Open Journal of Pediatrics 2013年第4期3卷 340-345页

作者： Léon G. Blaise Savadogo Philippe Donnen Fla Kouéta Eléonore Kafando Philippe Hennart Michèle Dramaix CR2-Epidemiology-Biostatistics-Clinical Research School of Public Health Université Libre de Bruxelles (ULB) Brussels Belgium Department of Epidemiology and Public Health Child and Mother Health Nutrition and Survival Unit Institut Supérieur des Sciences de la Santé (IN.S.SA) Bobo Dioulasso University Bobo-Dioulasso Burkina Faso Ouagadougou Pediatric Hospital and University of Ouagadougou Ouagadougou Burkina Faso

In low income countries, severe acute malnutrition remains a major problem for HIV-infected children and an important risk factor for mortality. This study aims to analyze HIV impact on mortality rate and nutritional recovery among severely malnourished HIV/AIDS uninfected and infected children. This was a retrospective cohort study conducted from data of 521 hospitalized severely malnourished children. We used Pearson’s Chi square test to compare proportions;and Student’s independent t-test to compare means;general linear model to analyze repeated measurements. We used mortality relative risk with confidence interval (CI 95%), Kaplan-Meir survival curves and Cox proportional hazard models to analyze the HIV impact on mortality rate. Case fatality rate differed significantly from SAM HIV uninfected (10.7%) and HIV infected children (39.7%), p tality relative risk was 3.71, 95% IC [2.51 - 5.47] for HIV infected children. Kaplan-Meir survival curves differed significantly between the two groups, (p Log rank tality relative risk of HIV infected children was 4.27, CI: 2.55 - 7.15, p tality relative risk was 3.71 times higher for HIV infected children. Multiples infections and metabolic complications have synergism on death occurrence in sever acute malnutrition;when associated to HIV infection, case fatality rate increases many times. Weight gain and anthropometrics index evolution were very slow for SAM HIV infected children, and specific diet may be needed for more nutritional recovery. Effective interventions, updated and adapting to local country context, to improve survival of severely malnourished HIV/AIDS infected children in HIV and SAM prevalent se

关键词： Mortality Severely Malnourished HIV/AIDS Children

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通用I/O口实现串行异步通讯方法研究

水利水文自动化 2004年第1期 30-33页

作者：徐群塔拉甫别刘汉刚河海大学电气工程学院江苏南京210098 山东引黄济青工程管理局山东济南250013

提出了一种利用通用I/O口实现串行异步通讯的方法,该方法接口简单,程序实现方便,特别适合各种单片机应用系统。

关键词：串行异步通讯 RS一485接口单片机数据通讯数据采集

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LNG罐车运输安全的应力分析与评定

广东化工 2018年第7期45卷 215-217,221页

作者：塔拉提别克.艾尔肯孟永彪董龙新疆大学化学与化工学院新疆乌鲁木齐830046

LNG在人们的生产生活中应用越来越广泛,LNG的起源地输送方式主要有两种:管道输送和罐车运输。中短距离的LNG运输以罐车为主,伴随着运输增多,LNG运输罐车对不同道路的适应性,极端工况的适应性成为行业的共性问题。本论文主要分析在运输... 详细信息

LNG在人们的生产生活中应用越来越广泛,LNG的起源地输送方式主要有两种:管道输送和罐车运输。中短距离的LNG运输以罐车为主,伴随着运输增多,LNG运输罐车对不同道路的适应性,极端工况的适应性成为行业的共性问题。本论文主要分析在运输过程中承受几种不稳定的运输载荷时(紧急制动,急转弯,遇到凹坑和凸起路面时四种情况下),可能引起LNG运输罐车的失效事故。利用ANSYS Workbench有限元分析罐体的应力分布与结构强度,采用等效压力法进行应力分析,对应力集中位置进行应力分类并强度评定,推导出满足运输安全高可靠性的运输条件和操作要求。

关键词： LNG运输罐车有限元分析强度评定

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槲皮素体外对肠道单菌株生长增殖影响

营养学报 2020年第6期42卷 607-612页

作者：石塔拉赵慧娟宓伟衣卫杰练武尹淑英郭长江滨州医学院营养与食品卫生学教研室烟台264003 军事科学院军事医学研究院环境医学与作业医学研究所天津300050

目的探讨槲皮素益生元及抑菌作用,为开发利用槲皮素提供理论依据。方法采用活菌计数法和比浊法测定并分析不同浓度槲皮素对肠道10种常见菌株生长增殖的影响,用气相色谱仪测定培养上清中短链脂肪酸的含量,用MTT法分析槲皮素对Caco-2细胞... 详细信息

目的探讨槲皮素益生元及抑菌作用,为开发利用槲皮素提供理论依据。方法采用活菌计数法和比浊法测定并分析不同浓度槲皮素对肠道10种常见菌株生长增殖的影响,用气相色谱仪测定培养上清中短链脂肪酸的含量,用MTT法分析槲皮素对Caco-2细胞活性的影响。结果在模拟胃肠道环境中不同浓度槲皮素可促进嗜酸乳酸杆菌CGMCC1.1878和鼠李糖乳酸杆菌CGMCC1.3724的生长(P<0.05),可显著提高这两种菌株丙酸和丁酸生成量(P<0.05),并且可显著(P<0.05)抑制粪肠球菌ATCC29212、大肠杆菌CMCC21531、鼠伤寒沙门氏菌CMCC50015、金黄色葡萄球菌CMCC26003四种致病菌的生长增殖。两种乳酸杆菌菌体槲皮素干预组与其无处理组比较Caco-2细胞的活性显著增强(P<0.05)。结论槲皮素可选择性的影响肠道菌株的生长增殖,有很好的益生元及抑菌作用。

关键词：槲皮素肠道单菌株短链脂肪酸 Caco-2细胞