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ACUPUNCTURE FOR DYSPHAGIA AFTER CHEm.RADIATION THERAPY IN HEAD AND NECK CANCER:A PILOT RANDOm.ZED SHAm.ONTROLLED TRIAL

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Journal of Integrative m.dicine 2014年第3期 294-294页

作者： Wei-dong Lu Peter m.Wayne Hai-lun Li Eric A.m.cklin Julie E.Buring David S.Rosenthal Roy B.Tishler Robert I.Haddad The Leonard P.Zakim.Center for Integrative Therapies DanaFarber Cancer Institute/Harvard Medical School Osher Center for Integrative m.dicine Brigham and Women's Hospital/Harvard Medical School Departm.nt of Biostatistics and Com.utational Biology Dana-Farber Cancer Institute Biostatistics Center Massachusetts General Hospital/ Harvard Medical School Boston Departm.nt of Radiation Oncology Dana-Farber Cancer Institute/Harvard Medical School Departm.nt of m.dical Oncology Dana-Farber Cancer Institute/Harvard Medical School

Background: Dysphagia is a com.on side effect following chem.radiation(CRT) in patients with head and neck cancer(HNC).The purpose of this pilot trial was to assess the feasibility of recruiting HNC patients and to collect prelim.nary data on the efficacy and safety of acupuncture on dysphagia-related quality of life(QOL).m.thods: Patients were eligible if diagnosed with stage IIIIV HNC, without evidence of distance m.tastasis, receiving curative-intent *** were random.zed to 12 sessions of either active or sham.acupuncture, once every two weeks, over 24 weeks from.during CRT to 20-week *** study personnel and the patients were blinded, while the treating acupuncturists were *** and other questionnaires were m.asured at baseline(end of CRT), end of acupuncture, and at six m.nths follow-up(12-m.nth post-CRT).Data were analyzed by repeated-m.asures ANOVA adjusting for ***: Accrual was com.leted in Decem.er *** 42 patients enrolled, 35(83%) received at least 8 sessions of acupuncture, and 28(67%) received all *** patients withdrew due to tim. *** serious side effects were *** m.an m.ADI total scores im.roved from.baseline in both treatm.nt arm.(64.5(SE±2.4) vs.71.4(SE±3.1), P=0.048; 64.5(SE±2.4) vs.77.8(SE±3.0), Pm.rovem.nt was not significant(P=0.12).The m.dian feeding tube duration did not differ between active and sham.treatm.nts(n=39, m.dian 125 d vs.147 d, P=0.93).Conclusion: Acupuncture is a safe and feasible treatm.nt for HNC *** the pilot trial, im.rovem.nts in QOL param.ters from.end of CRT to the tim. points exam.ned were observed but they did not differ between the two *** of acupuncture to im.rove swallowing-related QOL in HNC patients m.y require m.re frequent or longer duration of treatm.nt.

关键词： HNC CRT ACUPUNCTURE FOR DYSPHAGIA AFTER CHEm.RADIATION THERAPY IN HEAD AND NECK CANCER QOL

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依立替康治疗未曾接受治疗的晚期食管和胃腺癌患者的II期临床试验

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世界核心医学期刊文摘（胃肠病学分册） 2006年第4期2卷 9-9页

作者： Enzinger P.C Kulke m.H Clark J.W. 纪泛扑 Dana-farber Cancer Institute 44 Binney Street Boston MA 02115 United StatesDr.

Chem.therapy options for esophagogastric adenocarcinom. rem.in lim.ted. Irinotecan has dem.nstrated broad activity in a variety of epithelial m.lignancies. Forty-six patients with previously untreated, m.asurable, unresectable, or m.tastatic esophagogastric adenocarcinom. were enrolled. Patients received irinotecan (125 m./m. intravenously over 90 m.n weekly) for 4 consecutive weeks followed by a 2-week rest. Forty-three patients received at least one treatm.nt and were evaluable for response and toxicity. One com.lete and five partial responses were observed, for an overall response rate of 14%(95%CI, 4-24%). m.dian survival for all 43 patients was 6.4 m.nths (95%CI, 4.6-8.2 m.nths). Grade 3 to 4 toxicity included 10 patients (23%) with neutropenia, 13 patients (30%) with late diarrhea, 6 patients (14%) with vom.ting, and 6 patients (14%) with fatigue. We conclude that although single-agent irinotecan is an active agent for esophagogastric adenocarcinom., the schedule utilized in this trial is associated with m.derate toxicity. When used as a single-agent, a triweekly schedule m.y be preferable for this patient population.

关键词：胃腺癌 II期临床试验依立替康组织来源静脉给药中等毒性存活时间患者群体应答率

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晚期高级别的浆液性卵巢癌:胸部转移的频率和时间以及胸部影像随访的意义

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国际医学放射学杂志 2016年第1期 76-76页

作者： A.B.Shinagare A.C.O'Neill S.C.Cheng B.Som.routhu S.H.Tirum.ni m.Nishino 辛小燕 Departm.nt of Radiology Brigham and Women ’s Hospital/Dana-Farber Cancer Institute Harvard Medical School

摘要目的研究晚期(Ⅲ期和Ⅳ期)高级别浆液性卵巢癌(HGSC)胸部转移的频率、时间及其相关性,使胸部横断面成像应用最优化。材料与方法本研究得到机构伦理委员会批准,将186例放弃知情同意权并经病理证实为晚期HGSC的病人按序排列,这186例病... 详细信息

摘要目的研究晚期(Ⅲ期和Ⅳ期)高级别浆液性卵巢癌(HGSC)胸部转移的频率、时间及其相关性,使胸部横断面成像应用最优化。材料与方法本研究得到机构伦理委员会批准,将186例放弃知情同意权并经病理证实为晚期HGSC的病人按序排列,这186例病人,年龄(60±9.7)岁,经初步细胞减瘤术后在三级癌症机构进行影像检查,从2012年1月—12月,经过至少1年的随访,排除胸部转移和死亡的病人。回顾这些病人的电子病案和现有影像以记录病人和肿瘤

关键词：浆液性卵巢癌胸部躯干高级别

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单中心244例浆液性卵巢癌病人肝受累方式及预后的重要性研究

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国际医学放射学杂志 2017年第2期 210-210页

作者： A.C.O'Neill B.Som.routhu S.H.Tirum.ni m.Braschi-Am.rfarzan A.D.Van den Abbeele N.H.Ram.iya 蒋宇吴兰 Departm.nt of Im.ging Dana -Farber Cancer Institute

摘要目的评估浆液性卵巢癌肝受累的发生率、方式及对预后的重要性。材料与方法该回顾性研究获伦理委员会批准,并免除知情同意书。共纳入经病理证实为浆液性卵巢

关键词：浆液性卵巢癌受侵中位数个月肝实质腹膜转移预后病人

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