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癌变．畸变．突变 2001年第4期13卷 217-219页

作者： Ste fano Bonasi Michael Fenech 等 DepartmentofEnvironmentalEpidemiology IstitutoNazionaleperlaRicercasulCancroGenoaItaly CSIROHealthS

Molecular and Cellular Aspects of Sarcopenia, Muscle Healthy Aging and Physical Conditioning in the Elderly

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Journal of Science in Sport and Exercise 2020年第3期2卷 246-257页

作者： Ester Sara Di Filippo Danilo Bondi Tiziana Pietrangelo Giorgio fano-Illic Stefania Fulle Department of Neuroscience Imaging and Clinical SciencesUniversity“G.d’Annunzio”of Chieti-PescaraChietiItaly Interuniversity Institute of Myology(IIM) University“G.d’Annunzio”of Chieti-PescaraVia dei Vestini 3166100 ChietiItaly Libera Universitàdi Alcatraz Santa Cristina of GubbioPerugiaItaly

During aging,the skeletal muscle tissue is one of the most affected,undergoing loss of mass and function,a process defined as *** age-related muscle mass and function decline,dependent on many factors,predispose individuals to decreased mobility,reduced muscle power and increased risk of *** factors at the cellular and molecular level affect muscle aging,synergizing with each *** present,it is broadly accepted that Reactive Oxygen Species(ROS)play a primary role in the aging process,especially in those tissues like skeletal muscle,where the generation of free radicals is more pronounced as a consequence of the high consumption of ***,several studies have highlighted the involvement of muscle stem cells(satellite cells,SCs)in the progression of sarcopenia,showing a concomitant regression of activity and number of these *** a sub-cellular level,the main processes correlated with sarcopenia are the alteration of protein synthesis and mitochondrial *** to slow down or revert sarcopenia are essentially based on three approaches:use of supplements,pharmaceutical therapies and physical *** brief,it seems that appropriate physical exercise training protocols could be capable of slowing down and sometimes reversing the sarcopenic *** finding is the consequence of a beneficial action of physical exercise on mitochondria and/or on the regenerative process led by SCs with different effects on the basis of training ***,according to a recent hypothesis,early strength training should be considered as public health advice.

关键词： Sarcopenia Physical exercise Satellite cells Redox homeostasis Protein balance

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地下水经济学的重要问题

国外地质技术经济 1990年第3期6卷 102-107页

作者： fano.,E 张栩

A RESTRICTED OCCUPANCY PROBLEM AND ITS CENTRAL LIMIT THEOREM

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Chinese Science Bulletin 1982年第5期27卷 572-573页

作者：方开泰 Institute of Applied Mathematics. Academia Sinica

Johnson and Kotz (1977) presented an interesting problem (Example 3.5) which reads asfollows: 'There are n men in a room, n women enter the room, and each selects a man at random and holds one of his hands if not already held by another woman (so that no man can be selected by more than two women). Find the joint distribution of the numbers of men

关键词： hands holds woman women restricted assigned allowed neither

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发展中国家的水质管理

资源开发与市场 1988年第1期 54-56页

作者： Enzo fano 卢润生

一、前言可以预料,水质管理是今后十多年内各国水资源保护的重要问题之一。过去,特别是水资源丰富的国家往往忽略了这一问题。然而,随着城市人口、工业化程度和农业施用化肥量的增长,导致了发展中国家水质的严重恶化。今天,世界各国已... 详细信息

一、前言可以预料,水质管理是今后十多年内各国水资源保护的重要问题之一。过去,特别是水资源丰富的国家往往忽略了这一问题。然而,随着城市人口、工业化程度和农业施用化肥量的增长,导致了发展中国家水质的严重恶化。今天,世界各国已充分认识到对水质管理的重要性;然而必须弄清楚污染的方式,才能制定切实可行的政策和管理措施。本文评述了污染的性质,

关键词：不发达国家水质管理环境管理持久性污染

对密近双星中致密星发射的X射线的一般特征的解释

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天文学报 1975年第1期 19-26页

作者：方励之中国科学技术大学

本文研究了密近双星中的 X 射线源的发射机制.本文提出:在致密星（中子星或黑洞）的吸积所形成的 X 射线发射区中,电子对的产生起着重要的作用.这种模型可以定性地说明 X射线双星所具有的几个一般的观测特征,即:1.它们的 X 射线光度都在... 详细信息

本文研究了密近双星中的 X 射线源的发射机制.本文提出:在致密星（中子星或黑洞）的吸积所形成的 X 射线发射区中,电子对的产生起着重要的作用.这种模型可以定性地说明 X射线双星所具有的几个一般的观测特征,即:1.它们的 X 射线光度都在1036—1038尔格/秒范围中.2.X 射线能谱为幂形式,或热韧致形式.3.热韧致谱的温度数量级为10K.4.当光度涨落时,能谱形式无明显变化.

关键词：吸积盘恒星演化中子星恒星密近双星致密星吸积模型吸积率黑洞

Transarterial chemoembolization in combination with programmed death-1/programmed cell death-ligand 1 immunotherapy for hepatocellular

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iLIVER 2022年第4期1卷 225-234页

作者： Jingxin Yan Manjun Deng Shunyu Kong Ting Li Zhenwu Lei Lushun Zhang Yutong Zhuang Xin He Huanwei Wang Haining Fan Yingxing Guo Department of Interventional Therapies Affiliated Hospital of Qinghai UniversityXiningChina Department of Postgraduate Qinghai UniversityXiningChina Department of Hepatopancreatobiliary Surgery Affiliated Hospital of Qinghai UniversityXiningChina Qinghai Province Key Laboratory of Hydatid Disease Research XiningChina Department of Orthopedics Sichuan Provincial People's HospitalChengduChina Department of Postgraduate Chengdu Medical CollegeChengduChina Department of Pathology and Pathophysiology Chengdu Medical CollegeChengduChina Center of Sichuan for Elderly Care and Health Chengdu Medical CollegeChengduChina Department of Neurosurgery The Second School of Clinical MedicineSouthern Medical UniversityGuangzhou 510515GuangdongChina

Hepatocellular carcinoma(HCC)is one of the most common malignancies *** the development of systemic therapies,several studies are currently underway,especially those related to the use of programmed death-1/programmed cell death-ligand 1(PD-1/PD-L1)***,studies on transarterial che-moembolization(TACE)and PD-1/PD-L1 immunotherapy have demonstrated some interesting *** article reviewed the current clinical evidence on the combination of TACE and PD-1/PD-L1 ***,our review summarized that a favorable survival time could be achieved using this combination in most ***,complications such as hyperprogression should be taken seriously,and the underlying mechanisms need to be explored.

关键词： Hepatocellular carcinoma Transarterial chemoembolization Programmed death 1 Programmed cell death-ligand 1 Clinical evidence

Modelling fuel loads of understorey vegetation and forest floor components in pine stands in NW Spain

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Forest Ecosystems 2022年第6期9卷 775-789页

作者： Jose A.Vega Stefano Arellano-Perez Juan Gabriel Alvarez-Gonzalez Cristina Fernandez Enrique Jimenez Pedro Cuinas Jose María Fernandez-Alonso Daniel J.Vega-Nieva Fernando Castedo-Dorado Cecilia Alonso-Rego Teresa Fontúrbel Ana Daría Ruiz-Gonzalez Centro de Investigacion Forestal de Lourizan PO Box 12736080PontevedraSpain Unidad de Gestion Ambiental y Forestal Sostenible(UXAFORES) Departamento de Ingeniería AgroforestalEscuela Politecnica Superior de IngenieríaUniversidad de Santiago de CompostelaCampus Universitario s/n27002LugoSpain Facultad de Ciencias Forestales Universidad Juarez del Estado de DurangoRío Papaloapan y Blvd.Durango s/nCol.Valle del Sur34120DurangoMexico Departamento de Ingeniería y Ciencias Agrarias Universidad de LeonCampus de Ponferrada24401PonferradaSpain

In this study,310 destructively sampled plots were used to develop two equation systems for the three main pine species in NW Spain(***;*** and ***):one for estimating loads of understorey fuel components by size and condition(live and dead)and another one for forest floor *** systems of equations were simultaneously fitted for estimating fuel loads using overstorey,understorey and forest floor variables as *** systems of equations included both the effect of pine species and the effect of understorey compositions dominated by ferns-brambles or by woody species,due to their obvious structural and physiological *** general,the goodness-of-fit statistics indicated that the estimates were reasonably robust and accurate for all of the fuel *** best results were obtained for total understorey vegetation,total forest floor and raw humus fuel loads,with more than 76%of the observed variability explained,whereas the poorest results were obtained for coarse fuel loads of understory vegetation with a 53%of observed variability *** reduce the overall costs associated with the field inventories necessary for operational use of the models,the additive systems were fitted again using only overstorey variables as potential *** relationships for fine(<6 mm)and total understorey vegetation and total forest floor fuel loads were obtained,indicating the complexity of the forest overstorey-understorey and overstorey-forest floor ***,these models explained around 52%of the observed ***,equations estimating the total understorey vegetation and the total forest floor fuel loads based only on canopy cover were *** models explained only 26%-32%of the observed variability;however,their main advantage is that although understorey vegetation in forested landscapes is largely invisible to remote sensing,canopy cover can be estimated with moderate accuracy,allowin

关键词： Area-based approach Additive equation systems Live and dead fine fuel Pinus pinaster Pinus radiata Pinus sylvestris

姜黄素对肝纤维化大鼠CTGF及TIMP-1和NF-κB表达的影响

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中国肝脏病杂志（电子版） 2008年第1期1卷 4-9页

作者：舒建昌皮新军何雅军吕霞方力叶国荣暨南大学医学院附属广州红十字会医院广州510220

目的观察姜黄素预防肝纤维化过程中肝脏组织中结缔组织生长因子(CTGF)、金属蛋白酶组织抑制剂-1(TIMP-1)、核因子-κB(NF-κB)表达的变化,探讨姜黄素预防肝纤维化的作用机制。方法四氯化碳腹腔注射8周以建立大鼠肝纤维化模型,同时每只... 详细信息

目的观察姜黄素预防肝纤维化过程中肝脏组织中结缔组织生长因子(CTGF)、金属蛋白酶组织抑制剂-1(TIMP-1)、核因子-κB(NF-κB)表达的变化,探讨姜黄素预防肝纤维化的作用机制。方法四氯化碳腹腔注射8周以建立大鼠肝纤维化模型,同时每只大鼠按每100g体重分别给予20mg、10mg、5mg姜黄素灌胃处理,3次/周,共8周;所有大鼠随机分为6组(正常组、肝纤维化模型组、高剂量姜黄素组、中剂量姜黄素组、低剂量姜黄素组和阳性对照组。8周后处死大鼠,留取肝脏组织,免疫组织化学方法检测肝组织中CTGF、TIMP-1、NF-κB的表达水平,进行图像分析并统计各组阳性表达率差别。结果模型组大鼠肝组织中CTGF、TIMP-1、NF-κB大量表达,姜黄素可明显抑制上述因子的表达(P<0.01)。结论姜黄素预防肝纤维化作用可能与其抑制CTGF、TIMP-1、NF-κB的表达有关。

关键词：纤维化姜黄素结缔组织生长因子金属蛋白酶组织抑制剂-1 核因子-κB