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Nanoporous titanium implant surface promotes osteogenesis by suppressing osteoclastogenesis via integrin β1/FAKpY397/MAPK pathway

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Bioactive Materials 2022年第2期7卷 109-123页

作者： Yide He Zhe Li Xin Ding Boya Xu Jinjin Wang Yi Li Fanghao Chen fanhui meng Wen Song Yumei Zhang State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Key Laboratory of Oral Diseases Department of ProsthodonticsSchool of StomatologyThe Fourth Military Medical UniversityXi’anChina Huaian Stomatological Hospital NanjingChina State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Key Laboratory of Oral Diseases Department of PeriodontologySchool of StomatologyThe Fourth Military Medical UniversityXi’anChina State Key Laboratory of Military Stomatology Department of Dental MaterialsSchool of StomatologyThe Fourth Military Medical UniversityXi’anShaanxiChina

Macrophages and osteoclasts are both derived from monocyte/macrophage lineage,which plays as the osteoclastic part of bone metabolism.Although they are regulated by bone implant surface nanoarchitecture and involved in osseointegration,the beneath mechanism has not been simultaneously analyzed in a given surface model and their communication with osteoblasts is also blurring.Here,the effect of implant surface topography on monocyte/macrophage lineage osteoclastogenesis and the subsequent effect on osteogenesis are systematically investigated.The nanoporous surface is fabricated on titanium implant by etching and anodizing to get the nanotubes structure.The early bone formation around implant is significantly accelerated by the nanoporous surface in vivo.Meanwhile,the macrophage recruitment and osteoclast formation are increased and decreased respectively.Mechanistically,the integrin mediated FAK phosphorylation and its downstream MAPK pathway(p-p38)are significantly downregulated by the nanoporous surface,which account for the inhibition of osteoclastogenesis.In addition,the nanoporous surface can alleviate the inhibition of osteoclasts on osteogenesis by changing the secretion of clastokines,and accelerate bone regeneration by macrophage cytokine profiles.In conclusion,these data indicate that physical topography of implant surface is a critical factor modulating monocyte/macrophage lineage commitment,which provides theoretical guidance and mechanism basis for promoting osseointegration by coupling the osteogenesis and osteoclastogenesis.

关键词： Nanoporous implant Osteogenesis Osteoclastogenesis FAK phosphorylation MAPK

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CO hydrogenation combined with water-gas-shift reaction for synthetic natural gas production:a thermodynamic and experimental study

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International Journal of Coal Science & Technology 2018年第4期5卷 439-451页

作者： fanhui meng Xin Li Xiaoyang Lv Zhong Li Key Laboratory of Coal Science and Technology of Ministry of Education and Shanxi Province Institute of Coal Chemical EngineeringTaiyuan University of TechnologyNo.79 West Yingze StreetTaiyuan 030024ShanxiChina

The hydrogenation of CO to synthetic natural gas (SNG) needs a high molar ratio of H2/CO (usually large than 3.0 in industry), which consumes a large abundant of hydrogen. The reverse dry reforming reaction (RDR, 2H2 + 2CO←→CH4 + CO2), combining CO methanation with water-gas-shift reaction, can significantly decrease the H2/CO molar ratio to 1 for SNG production. A detailed thermodynamic analysis of RDR reaction was carried out based on the Gibbs free energy minimization method. The effect of temperature, pressure. H2/CO ratio and the addition of H2O, CH4, CO2, O2 and C2H4 into the feed gas on CO conversion, CH4 and CO2 selectivity, as well as CH4 and carbon yield, are discussed. Experimental results obtained on homemade impregnated Ni/Al2O3 catalyst are compared with the calculations. The results demonstrate that low temperature (200-500 °C), high pressure (1-5 MPa) and high H2/CO ratio (at least 1) promote CO conversion and CH4 selectivity and decrease carbon yield. Steam and CO2 in the feed gas decrease the CH4 selectivity and carb on yield, and enhance the CO2 con tent. Extra CH4 elevates the CH4 content in the products, but leads to more carbon formation at high temperatures. O2 significantly decreases the CH4 selectivity and C2H4 results in the generation of carbon.

关键词： Synthetic natural gas Reverse dry reforming of methane Gibbs free energy minimization Experimental study CO conversion

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Influence of Na^(+) on the synthesis of silicalite-1 catalysts for use in the vapor phase Beckmann rearrangement of cyclohexanone oxime

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Frontiers of Chemical Science and Engineering 2011年第4期5卷 401-408页

作者： Rumin YANG fanhui meng Xiao WANG Yaquan WANG Key Laboratory for Green Chemical Technology School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China

Silicalite-1 was hydrothermally synthesized in the presence of different concentrations of Na+using tetrapropylammonium hydroxide(TPAOH)as a template.The synthesis was followed by a base treatment.The silicalite-1samples were characterized using X-ray diffrac-tion,scanning electron microscopy,N2 adsorption,X-ray photoelectron spectroscopy,Fourier transform infrared spectroscopy and NH3 temperature-programmed deso-rption.The samples were used as catalysts for the vapor phase Beckmann rearrangement of cyclohexanone oxime.During the synthesis,the sodium ions were incorporated onto the silicalite-1 crystals,but were then removed by the base treatment.All the catalysts exhibited nearly complete conversion of cyclohexanone oxime toε-caprolactam with selectivities grater than 95%.Addition of less than 2.5 mol-%Na^(+)(relative to TPAOH)did not inﬂuence the catalytic properties.However,for Na+concentrations≥5 mol-%,the particle sizes of silicalite-1 increased and the catalytic activities decreased,which can be attributed to carbon deposition.The results in this work are of great importance for the polymer industry.

关键词： silicalite-1 cyclohexanone oxime vapor phase Beckmann rearrangement ε-caprolactam

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富含高岭石结构的煤矸石活化及合成NaY分子筛

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石油学报（石油加工） 2024年第2期40卷 317-326页

作者：姚隆帆孟凡会戴露霏汪洋洋李忠太原理工大学省部共建煤基能源清洁高效利用国家重点实验室化学工程与技术学院山西太原030024

以煤矸石为原料,在无模板剂和无添加剂的条件下,采用“高温焙烧-碱熔-碱溶-晶化”过程水热合成NaY分子筛。采用XRF、TG、XRD、SEM、N_(2)吸附-脱附曲线、NH3-TPD等手段对高温热处理的煤矸石及合成的NaY分子筛进行表征。结果表明:煤矸石... 详细信息

以煤矸石为原料,在无模板剂和无添加剂的条件下,采用“高温焙烧-碱熔-碱溶-晶化”过程水热合成NaY分子筛。采用XRF、TG、XRD、SEM、N_(2)吸附-脱附曲线、NH3-TPD等手段对高温热处理的煤矸石及合成的NaY分子筛进行表征。结果表明:煤矸石中的高岭石相在600~800℃生成无定型偏高岭石相,随着碳酸钠与煤矸石质量比的增加或碱熔温度的升高,硅铝酸钠的晶相含量先增多后减少;加入质量分数0.1%~2.0%的NaY分子筛晶种提高了产物分子筛样品的相对结晶度和比表面积;增加NaOH浓度导致NaY分子筛硅/铝比下降;提高投料硅/铝摩尔比(n(SiO_(2))/n(Al_(2)O_(3))=6~30)使得NaY分子筛硅/铝比和相对结晶度先增大后减小。当晶种加入质量分数0.5%、投料n(SiO_(2))/n(Al_(2)O_(3))为20且NaOH浓度为3 mol/L时,合成的NaY分子筛n(SiO_(2))/n(Al_(2)O_(3))达到4.3、相对结晶度为87.4%、比表面积达到584 m^(2)/g、孔径主要分布在3.4 nm、颗粒粒径为100 nm左右。

关键词：煤矸石活化 NaY分子筛高岭石结构晶种硅/铝比相对结晶度

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Alpha particle detection with a planar CdZnTe detector and relative simulations

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Radiation Detection Technology and Methods 2021年第4期5卷 609-617页

作者： Yu Xiang Xiaopan Jiang Chao Wang fanhui meng Yiding Han Xianchao Huang Long Wei Beijing Engineering Research Center of Radiographic Techniques and Equipment Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Jinan Laboratory of Applied Nuclear Science Jinan 250131China

Purpose The performance of CZT inγ-ray and X-ray detection is growing rapidly in these years.However,there are only a few reports on its utilization inαparticle detection.Therefore,to study the properties of CZT for detection ofαparticle,a detection system has been manufactured,and a series of simulations have been done.Methods A 22×22×0.7mm^(3) planar CZT detector is deployed to detect theαparticles from a radiation source containing Am-241 and Pu-239,while COMSOL MultiPhysics and GEANT4 are employed in the simulation of charge collection and interaction betweenαparticles and CZT.Results An energy resolution of 1.47%FWHM at 5.486MeV and 1.32%at 5.157MeV has been achieved.A simulated spectrum has been created,and it is analogous to the one from experiment.Conclusion The experiment results show the potential of CZT inαdetection.The simulations are confirmed effective and will guide a better design of the detecting system.

关键词： αparticle CZT detector Simulation Energy resolution Mobility-lifetime product Charge collection Interaction

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Conserved and differentiated functions of CIK receptor kinases in modulating stem cell signaling in Arabidopsis

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Molecular Plant 2021年第7期14卷 1119-1134页

作者： Yafen Zhu Chong Hu Yanwei Cui Li Zeng Sunjingnan Li Mingsong Zhu fanhui meng Shuting Huang Li Long Jing Yi Jia Li Xiaoping Gou Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations School of Life SciencesLanzhou UniversityLanzhou 730000China

The shoot apical meristem(SAM)and root apical meristem(RAM)act as pools of stem cells that give rise to aboveground and underground tissues and organs in higher plants,respectively.The CLAVATA3(CLV3)-WUSCHEL(WUS)negative-feedback loop acts as a core pathway controlling SAM homeostasis,while CLV3/EMBRYO SURROUNDING REGION(ESR)40(CLE40)and WUSCHEL-RELATED HOMEOBOX5(WOX5),homologs of CLV3 and WUS,direct columella stem cell fate.Moreover,CLV3 INSENSITIVE KINASES(CIKs)have been shown to be essential for maintaining SAM homeostasis,whereas whether they regulate the distal root meristem remains to be elucidated.Here,we report that CIKs are indispensable for transducing the CLE40 signal to maintain homeostasis of the distal root meristem.We found that the cik mutant roots displayed disrupted quiescent center and delayed columella stem cell(CSC)differentiation.Biochemical assays demonstrated that CIKs interact with ARABIDOPSIS CRINKLY4(ACR4)in a ligand-independent manner and can be phosphorylated by ACR4 in vitro.In addition,the phosphorylation of CIKs can be rapidly induced by CLE40,which partially depends on ACR4.Although CIKs act as conserved and redundant regulators in the SAM and RAM,our results demonstrated that they exhibit differentiated functions in these meristems.

关键词： ACR4 CIKs CLE40 stem cells distal root meristem phosphorylation

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Reducibility for a Class of Two-Dimensional almost Periodic System with Small Perturbation

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Advances in Pure Mathematics 2021年第12期11卷 950-962页

作者： fanhui meng Wenhua Qiu School of Mathematics and Statistics Zaozhuang University Zaozhuang China

This paper focuses on the reducibility of two-dimensional almost periodic system with small perturbation. We use the KAM iterative method to get the reducibility by an almost periodic transformation. The system has be... 详细信息

关键词： Almost Periodic System KAM Iterative Method Reducibility

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基于Kano模型的鲜活农产品冷链物流服务质量分析

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兰州工业学院学报 2024年第3期31卷 107-111页

作者：蒋旋孟凡会滁州学院经济与管理学院安徽滁州239000

中国鲜活农产品消费不断升级,冷链物流服务需求呈现爆发式增长,但冷链物流服务仍存在着客户满意度低、体验感差等问题,为此对鲜活农产品冷链物流服务质量进行研究,运用SEVRQUAL模型和LSQ模型构建鲜活农产品冷链物流服务质量评价指标体系... 详细信息

中国鲜活农产品消费不断升级,冷链物流服务需求呈现爆发式增长,但冷链物流服务仍存在着客户满意度低、体验感差等问题,为此对鲜活农产品冷链物流服务质量进行研究,运用SEVRQUAL模型和LSQ模型构建鲜活农产品冷链物流服务质量评价指标体系,通过实证研究,基于Kano模型和Better-Worse系数分布图,分析鲜活农产品冷链物流服务质量要素类型,获取影响鲜活农产品冷链物流服务质量的关键因素,并提出针对性建议,对全面推进乡村振兴有重要意义。

关键词：冷链物流服务质量鲜活农产品 Kano模型

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青岛沿海地区雷暴过程闪电始发位置的微物理参量特征分析

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海洋科学 2024年第2期48卷 58-68页

作者：张源源孙豪王鹏孟繁辉刘钊栾在茂青岛市气象局.青岛市气象灾害防御工程技术研究中心山东青岛266003 中国气象局气象探测中心北京100081 潍坊市气象局山东潍坊261000

本文通过低频磁脉冲闪电探测系统和双偏振雷达联合观测结果,针对2019—2020年青岛沿海地区发生的5次雷电灾害天气,研究了雷暴的闪电始发位置与微物理参数之间的关系,结果如下:(1)闪电主要始发于组合反射率大于45 dBz的强回波区,地闪的... 详细信息

本文通过低频磁脉冲闪电探测系统和双偏振雷达联合观测结果,针对2019—2020年青岛沿海地区发生的5次雷电灾害天气,研究了雷暴的闪电始发位置与微物理参数之间的关系,结果如下:(1)闪电主要始发于组合反射率大于45 dBz的强回波区,地闪的接闪位置距离主雷暴云系可达10~30 km左右。闪电始发区域组合反射率的中位数为55 dBz,液态水含量的中位数为37 kg/m^(2)。(2)闪电始发位置的双偏振雷达水平反射率主要集中于35~45 dBz,差分反射率主要集中在1.5~2.5 dB,相关系数集中于0.97~0.99。大部分雷电始发于0℃等温线和–10℃等温线之间,位于液态水、湿霰和干霰混合相态粒子区。部分雷电过程发生于湿霰区的中上部,这种情况一般差分反射率值很大。(3)在–10~0℃等温层之间存在相关系数大值区且相态粒子为湿霰粒子,说明为过冷水区。过冷水区中极易产生大直径的霰粒,在强上升气流的作用下,大直径霰粒与冰晶碰撞从而极易发生闪电过程。

关键词：三维闪电定位双偏振雷达微物理特征相态识别

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高比能锂离子电池温升现象研究

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电源技术 2024年第6期48卷 1088-1094页

作者：孙浩伟曹宏涛张方忠侯宾孟繁慧海装沈阳局驻沈阳地区第四军事代表室辽宁沈阳110066 中电科蓝天科技股份有限公司天津300384

研究了高比能三元软包锂离子电池(LIBs)体系工作过程中的温升现象,通过电化学阻抗(EIS)、增量容量分析(ICA)、工作过程温度变化曲线,研究了NCM622-SiO/C锂离子电池倍率充放电及温度放电测试中的温升现象,解释了不同测试过程中温升规律... 详细信息

研究了高比能三元软包锂离子电池(LIBs)体系工作过程中的温升现象,通过电化学阻抗(EIS)、增量容量分析(ICA)、工作过程温度变化曲线,研究了NCM622-SiO/C锂离子电池倍率充放电及温度放电测试中的温升现象,解释了不同测试过程中温升规律差异的原因,并对温升机理进行了分析。结果表明,充放电电流的增加和温度的降低会造成锂离子电池充放电容量的降低,并加剧充放电过程中电化学极化现象;同时,电池的电解液含量减少使其RS、RSEI和RCT逐渐增大,验证了电解液含量的减少将会加剧电池的物理极化和电化学极化现象。这对锂离子电池的设计、制造、应用及温升机理分析具有重要的借鉴意义。

关键词：锂离子电池三元正极材料温升电解液含量机理分析

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