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芒针透刺天突治疗中风后吞咽障碍的理论基础及临床应用探析

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湖南中医药大学学报 2024年第4期44卷 606-611页

作者：叶宇吴凯瑞徐芳园程红亮李洪涛戴帆张宜廷凌美娟安徽中医药大学研究生院安徽合肥230038 安徽中医药大学第二附属医院脑病科安徽合肥230061 广州中医药大学研究生院广东广州510405

吞咽障碍是中风后常见并发症之一,以饮水呛咳、吞咽困难及构音障碍等为主要临床表现。目前,西医对于该病的治疗具有一定局限性,而芒针透刺天突治疗该病疗效显著,天突有“清利咽喉第一穴”之称,芒针透刺可疗“深邪远痹”。紧扣天突与中... 详细信息

吞咽障碍是中风后常见并发症之一,以饮水呛咳、吞咽困难及构音障碍等为主要临床表现。目前,西医对于该病的治疗具有一定局限性,而芒针透刺天突治疗该病疗效显著,天突有“清利咽喉第一穴”之称,芒针透刺可疗“深邪远痹”。紧扣天突与中风后吞咽障碍之病因、病机、病位的相关性,探讨芒针透刺天突治疗该病的理论基础及独特优势,以期为芒针透刺天突治疗中风后吞咽障碍的应用奠定临床基础,为针刺治疗该病提供临床新思路。

关键词：中风后吞咽障碍天突芒针透刺理论基础临床应用

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Tubulointerstitial nephritis antigen-like 1 is a novel matricellular protein that promotes gastric bacterial colonization and gastritis in the setting of Helicobacter pylori infection

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Cellular & Molecular Immunology 2023年第8期20卷 924-940页

作者： Yongsheng Teng Rui Xie Jingyu Xu Pan Wang Wanyan Chen Zhiguo Shan Zongbao Yan fangyuan Mao Ping cheng Liusheng Peng Jinyu Zhang Wenqing Tian Shiming Yang Yongliang Zhao Weisan Chen Quanming Zou Yuan Zhuang Department of Microbiology and Biochemical Pharmacy College of Pharmacy and Laboratory MedicineThird Military Medical UniversityChongqingChina The 940th Hospital of Joint Logistics Support Force of PLA LanzhouChina The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University ZunyiGuizhouChina Department of General Surgery and Center of Minimal Invasive Gastrointestinal Surgery Southwest HospitalThird Military Medical UniversityChongqingChina Department of Gastroenterology Chongqing University Cancer HospitalChongqingChina Department of Gastroenterology XinQiao HospitalThird Military Medical UniversityChongqingChina La Trobe Institute of Molecular Science La Trobe UniversityBundooraVICAustralia Department of Gastroenterology Affiliated Hospital of Southwest Medical UniversityLuzhouSichuanChina National Engineering Research Center of Immunological Products Third Military Medical UniversityChongqingChina

The interaction between the gastric epithelium and immune cells plays key roles in H. pylori-associated pathology. Here, we demonstrate a procolonization and proinflammatory role of tubulointerstitial nephritis antigen-like 1 (TINAGL1), a newly discovered matricellular protein, in H. pylori infection. Increased TINAGL1 production by gastric epithelial cells (GECs) in the infected gastric mucosa was synergistically induced by H. pylori and IL-1β via the ERK-SP1 pathway in a cagA-dependent manner. Elevated human gastric TINAGL1 correlated with H. pylori colonization and the severity of gastritis, and mouse TINAGL1 derived from non-bone marrow-derived cells promoted bacterial colonization and inflammation. Importantly, H. pylori colonization and inflammation were attenuated in Tinagl1−/− and Tinagl1ΔGEC mice and were increased in mice injected with mouse TINAGL1. Mechanistically, TINAGL1 suppressed CCL21 expression and promoted CCL2 production in GECs by directly binding to integrin α5β1 to inhibit ERK and activate the NF-κB pathway, respectively, which not only led to decreased gastric influx of moDCs via CCL21-CCR7-dependent migration and, as a direct consequence, reduced the bacterial clearance capacity of the H. pylori-specific Th1 response, thereby promoting H. pylori colonization, but also resulted in increased gastric influx of Ly6Chigh monocytes via CCL2-CCR2-dependent migration. In turn, TINAGL1 induced the production of the proinflammatory protein S100A11 by Ly6Chigh monocytes, promoting H. pylori-associated gastritis. In summary, we identified a model in which TINAGL1 collectively ensures H. pylori persistence and promotes gastritis.

关键词： Helicobacter pylori TINAGL1 Colonization Gastritis

Volatiles produced by bacteria alleviate antagonistic effects of one associated fungus on Dendroctonus valens larvae

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Science China(Life Sciences) 2017年第8期60卷 924-926页

作者： Shanshan Wang fangyuan Zhou Bo Wang Dandan Xu Qingjie Cao Min Lu Jianghua-Sun State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute of Health Sciences Anhui UniversityHefei 230039China Shandong Provincial Key Laboratory of Applied Microbiology Ecology InstituteShandong Academy of SciencesJinan 250014China Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesXishuangbanna 666303China

Dear Editor, Microbes play important roles in various symbiotic systems （Douglas, 2015; Xing et al., 2017; Zhu and Wu, 2016; Xu et al., 2016a）. In the symbiosis formed by bark beetles and microbial associates, beetles formed symbiotic relation- ships with some fungi including mutualistic and antagonistic ones （cheng et al., 2015; Lu et al., 2016; Scott et al., 2008）, and these interactions, indirectly affected by a third or even fourth participator in a community context, may change from antagonistic ones to mutualistic ones. For example.

关键词：拮抗作用挥发物 Douglas 细菌真菌幼虫共生系统共生关系

Myo-inositol content determined by myo-inositol biosynthesis and oxidation in blueberry fruit

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Myo-inositol content determined by myo-inositol biosynthesis...

切削SiCp/Al复合材料三相摩擦系数建模与模拟

2016年全国植物生物学大会

作者： fangyuan Song Hongyan Su Nan Yang Luying Zhu Jieshan cheng Lei Wang College of life sciences Ludong University College of agriculture Ludong University

Myo-inositol metabolism in plant edible organs has become the focus of many recent studies because of its benefits to human health and unique functions in plant development. In this study,MI contents in fruits were analyzed in two blueberry cultivars,cv ￠Bluecrop￠ and cv ￠Berkeley￠,along with the expression profiles of the key genes involved in MI biosynthesis and catabolism. Besides,the change patterns of the corresponding enzyme activities were analyzed. The results showed that some differences exist in the change profiles of the MI levels between the two cultivars. Furthermore,two VcMIPS genes,one VcIMP gene and one VcMIOX gene were isolated for the first time from blueberry fruits. Specifically,VcMIPS 1/2 and VcMIOX encoded the rate-limiting enzymes in MI biosynthesis and oxidation,respectively. The expression patterns of VcMIPS2,VcIMP and VcMIOX genes showed a relationship with the change profiles of MI content during fruit ripening. The results were further confirmed by the analyses of the enzyme activities. Overall,the results indicated that both MI biosynthesis and oxidation played important roles in determining MI levels in the development of blueberries. The current results will provide new information for us to understand the mechanisms regulating MI accumulation and the roles of MI in As A biosynthesis during the development of blueberries.

关键词： blueberry fruit ripening gene expression Myo-inositol

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哈尔滨工程大学学报 2019年第3期40卷 509-517页

作者：段春争孙伟傅程张方圆大连理工大学机械工程学院辽宁大连116024

为解决SiCp/Al复合材料切削力准确预测的问题,本文采用理论建模、有限元模拟和实验研究相结合的方法,研究了SiCp/Al复合材料切削过程中刀-屑接触摩擦状态。考虑基体材料与刀具接触摩擦、Si C颗粒的两体滑动摩擦和Si C颗粒的三体滚动摩擦... 详细信息

为解决SiCp/Al复合材料切削力准确预测的问题,本文采用理论建模、有限元模拟和实验研究相结合的方法,研究了SiCp/Al复合材料切削过程中刀-屑接触摩擦状态。考虑基体材料与刀具接触摩擦、Si C颗粒的两体滑动摩擦和Si C颗粒的三体滚动摩擦对SiCp/Al复合材料刀-屑接触状态的影响,提出了SiCp/Al复合材料刀-屑接触三相摩擦系数模型。建立了SiCp/Al复合材料多颗粒随机分布模型,并基于刀-屑接触三相摩擦系数模型进行了SiCp/Al复合材料切削有限元模拟以及实验研究。结果表明:采用基于刀-屑接触三相摩擦系数模型进行SiCp/Al复合材料切削过程模拟,能够较准确地预测SiCp/Al复合材料的去除过程、切屑形成、刀具与颗粒之间的相互作用以及切削力。

关键词： SiCp/Al复合材料刀-屑界面摩擦摩擦系数有限元模拟摩擦力切屑形成切削力本构关系

Mediation Effect of Attachment Avoidance Between Parental Emotional Warmth and the Preference for Infants

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Mediation Effect of Attachment Avoidance Between Parental Em...

第二十一届全国心理学学术会议

作者： Yuncheng Jia Gang cheng fangyuan Ding Bingbing Li Na Ta Dajun Zhang Faculty of Psychology Research Center for Mental Health Education Southwest University School of Educational Science Guizhou Normal University

Objective: We investigated the formation of adult attachment and its influence on the responses of parenting motivation. Method: In Study 1, 975 adults(Mage = 20.51 ± 1.74 years;547 women) completed a survey about parental emotional warmth, adult attachment, and interest in infants to determine if adult attachment mediates the relationship between parental emotional warmth and interest in infants. In Study 2, 270 adults(Mage = 21.58 ± 1.96 years;142 women) assessed the preference for infants’ faces including pleasure, cuteness, and willingness to care to examine how adult attachment affects this preference. Results: Results illustrated that(1) parental emotional warmth had a major impact on attachment avoidance,(2) attachment avoidance influenced interest in infants and the preference for infants’ faces, and(3) attachment avoidance mediated the relationship between parental emotional warmth and the preference for infants including interest in infants and preference for infants’ faces. Conclusions: Adults with decreased attachment avoidance who perceived emotional warmth from their parents during childhood displayed elevated parenting motivation. These findings have implications for adults with insecure attachment during the parent-child relationship and can provide the basis for conducting the corresponding brain mechanism research.

关键词： adult attachment mediation parental emotional warmth parenting motivation the preference for infants

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习近平新时代意识形态话语权思想解读

云南行政学院学报 2019年第4期21卷 80-85页

作者：李芳园程早霞哈尔滨工程大学马克思主义学院黑龙江哈尔滨150000 浙江大学马克思主义学院浙江杭州310000

意识形态话语权作为习近平治国理政思想的重要内容,自党的十八大以来,在习近平系列讲话中被反复强调。习近平主要针对战略定位、根本任务、基本方略、建构路径上提出了系统深刻的新观点、新论断、新思想、新理念:用“三个事关”明确主... 详细信息

意识形态话语权作为习近平治国理政思想的重要内容,自党的十八大以来,在习近平系列讲话中被反复强调。习近平主要针对战略定位、根本任务、基本方略、建构路径上提出了系统深刻的新观点、新论断、新思想、新理念:用“三个事关”明确主流意识形态话语权极端重要的战略意义;用“两个巩固”强调主流意识形态话语的指导地位;用“坚守与坚定”构成意识形态话语权的纲领方针;用“三个创新”指明意识形态话语权的建设指向。要求我们立足新时代中国特色社会主义的建设与发展情势,牢牢掌握主流意识形态的领导权与话语权。

关键词：习近平新时代话语权意识形态话语权

相异模型下Stacking集成结构的异常用电用户识别方法

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电网技术 2021年第12期45卷 4828-4836页

作者：程超鹏彭显刚曾勇斌许方园广东工业大学自动化学院广东省广州市510006

针对电力用户异常用电行为造成电网非技术性损失(non-technical-loss,NTL),影响企业收益及供电质量等问题,文中提出一种相异模型下Stacking集成结构的异常用电用户识别方法。该方法综合分析用户用电侧历史数据特性,建立并提取用户用电特... 详细信息

针对电力用户异常用电行为造成电网非技术性损失(non-technical-loss,NTL),影响企业收益及供电质量等问题,文中提出一种相异模型下Stacking集成结构的异常用电用户识别方法。该方法综合分析用户用电侧历史数据特性,建立并提取用户用电特征;采用支持向量机(support vector machine,SVM)、随机森林(random forests,RF)、梯度决策树(gradient boosting decision tree,GBDT)及深度森林(deep forest)4种相异模型做为Stacking结构的基分类模型,对用电特征进行Stacking转换;并选取XGBoost(extreme gradient boosting)算法作为Stacking结构的元分类模型,对转换后的用电特征集进行分类,判断用户用电是否异常。通过实例分析,验证本文所提模型相比于单个模型有更高效的分类性能,为供电企业用电监察工作及经济效益管理提供参考。

关键词：异常用电支持向量机随机森林 XGBoost 深度森林 Stacking集成

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结合灰度信息的压敏漆图像配准

光电工程 2019年第2期46卷 46-55页

作者：梁诚蒲方圆梁磊高志升西华大学计算机与软件工程学院四川成都610039 中国空气动力研究与发展中心四川绵阳621000

压敏漆技术是一种经济性高、速度快的风洞测压前沿技术。在风洞试验中,由于强风影响,模型会发生畸变,造成有风图像和无风图像难以配准,从而严重影响测压精度。针对这一问题,本文创新性的将二维非刚性ICP算法用于此问题,采用点云方式使... 详细信息

压敏漆技术是一种经济性高、速度快的风洞测压前沿技术。在风洞试验中,由于强风影响,模型会发生畸变,造成有风图像和无风图像难以配准,从而严重影响测压精度。针对这一问题,本文创新性的将二维非刚性ICP算法用于此问题,采用点云方式使得图像细节区域有效配准,同时也有利于后续三维重建工作。然而由于二维非刚性ICP算法仅考虑二维坐标位置关系,忽略压敏漆图像像素灰度具有的相关性,使得配准精度不高。直接利用三维非刚性ICP算法又会发生误配准,所以为了进一步提高配准精度,本文提出了一种基于像素关联搜索策略的非刚性ICP算法,算法设计了综合考虑2D坐标与像素灰度值的双目标搜索策略,实现了精确的局部匹配点搜索与双目标优化。在多组压敏漆图像上将本文算法与五种配准算法进行了对比实验分析。实验结果表明,本文所提出的算法具有最好的配准精度。相比次优算法,RMSE提升超过15%,NMI提升在5%左右。

关键词：压敏漆图像图像畸变非刚性ICP 归一化互信息图像配准