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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang fangyuan cheng Zhaoli Han Bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

Porous Single-Crystalline Monolith to Enhance Catalytic Activity and Stability

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Research 2022年第4期2022卷 347-358页

作者： Xiaoyan Yu fangyuan cheng Xiuyun Duan Kui Xie Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002China University of Chinese Academy of Sciences Bejing 100049China Fujian Science Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou350108 FujianChina Key Laboratory of Design e Assembly of Functional Nanostructures Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002China

Engineering the catalytic activity and stability of materials would require the identification of the structural features that can tailor active sites at *** single crystals combine the ordered lattice structures and disordered interconnected pores,and they would therefore provide the advantages of precise structure features to identify and engineer the active sites at ***,we fabricate porous single-crystalline vanadium nitride(VN)at centimeter scale and further dope Fe(Fe0.1V0.9N)and Co(Co0.1V0.9N)in lattice to engineer the active sites at *** demonstrate that the active surface is composed of unsaturated coordination of V-N,Fe-N,and Co-N structures which lead to the generation of high-density active sites at the porous single-crystalline monolith *** interconnected pores aid the pore-enhanced fluxion to facilitate species diffusion in the porous *** the nonoxidative dehydrogenation of ethane to ethylene,we demonstrate the outstanding performance with ethane conversion of 36%and ethylene selectivity of 99%at 660°*** stability as a result of their single-crystalline structure,the monoliths achieve the outstanding performance without degradation being observed even after 200 hours of a continuous operation in a monolithic *** work not only demonstrates the effective structural engineering to simultaneously enhance the stability and overall performance for practically useful catalytic materials but also provide a new route for the element doping of porous single crystals at large scale for the potential application in other fields.

关键词： surface crystalline stability

Intelligent checking model of Chinese radiotelephony read-backs in civil aviation air traffic control

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Chinese Journal of Aeronautics 2018年第12期31卷 2280-2289页

作者： Guimin JIA fangyuan cheng Jinfeng YANG Dan LI Tianjin Key Lab for Advanced Signal Processing Civil Aviation University of China

Federal Aviation Administration(FAA) and NASA technical reports indicate that the misunderstanding in radiotelephony communications is a primary causal factor associated with operation errors, and a sizable proportion of operation errors lead to read-back errors. We introduce deep learning method to solve this problem and propose a new semantic checking model based on Long Short-Time Memory network(LSTM) for intelligent read-back error checking. A meanpooling layer is added to the traditional LSTM, so as to utilize the information obtained by all the hidden activation vectors, and also to improve the robustness of the semantic vector extracted by LSTM. A MultiLayer Perceptron(MLP) layer, which can maintain the information of different regions in the concatenated vectors obtained by the mean-pooling layer, is applied instead of traditional similarity function in the new model to express the semantic similarity of the read-back pairs quantitatively. The K-Nearest Neighbor(KNN) classifier is used to verify whether the read-back pairs are consistent in semantics according to the output of MLP layer. Extensive experiments are conducted and the results show that the proposed model is more effective and more robust than the traditional checking model to verify the semantic consistency of read-backs automatically.

关键词： Air traffic control Chinese radiotelephony read-backs LSTM Mean pooling MLP Semantic checking

经右下腹切口取标本并行预防性造口在腹腔镜下直肠癌低位前切除术中的应用

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实用医学杂志 2024年第19期40卷 2720-2725页

作者：李星王有财徐勇超唐礼恭程方圆郑州大学附属肿瘤医院河南省肿瘤医院普外科河南郑州450008

目的探讨经右下腹切口取标本并行预防性造口在腹腔镜下直肠癌低位前切除术中应用的安全性、临床效果及对术后还纳手术的影响。方法回顾性分析2020年1月至2023年12月间我院普外科收治的腹腔镜下直肠癌低位前切除术并行回肠末段造口的127... 详细信息

目的探讨经右下腹切口取标本并行预防性造口在腹腔镜下直肠癌低位前切除术中应用的安全性、临床效果及对术后还纳手术的影响。方法回顾性分析2020年1月至2023年12月间我院普外科收治的腹腔镜下直肠癌低位前切除术并行回肠末段造口的127例患者临床资料。根据术中是否经右下腹切口取标本并行造口将患者分为两组:观察组60例经右下腹切口取标本并行预防性造口术,对照组67例经下腹正中切口取标本并另行造口术,比较两组患者的临床相关数据及造口还纳手术相关临床资料。结果(1)两组患者的相关基线资料比较差异无统计学意义(P>0.05),具有可比性。(2)观察组在手术时间、术后2 d内疼痛评分、术后排气时间方面比较均优于对照组,差异有统计学意义(P0.05)。(3)在术后相关并发症及造口相关并发症方面,组间比较差异无统计学意义(P>0.05)。(4)观察组在造口还纳术后疼痛评分及术后排气时间方面均优于对照组,差异有统计学意义(P0.05)。结论需行预防性造口的腹腔镜下直肠癌低位前切除术患者,经右下腹切口取标本并行预防性回肠造口可提高患者腹壁切口美观、缩短手术时间、减轻患者痛苦且不增加术后并发症及还纳手术难度,安全可行,值得临床推广。

关键词：直肠肿瘤腹腔镜手术辅助切口回肠造口

Evaluating Parameterizations for Turbulent Fluxes over the Landfast Sea-Ice Surface in Prydz Bay, Antarctica

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Advances in Atmospheric Sciences 2023年第10期40卷 1816-1832页

作者： fangyuan cheng Qinghua YANG Changwei LIU Bo HAN Shijie PENG Guanghua HAO School of Atmospheric Sciences Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519080China National Marine Environmental Forecasting Center Beijing 100081China

It is crucial to appropriately determine turbulent fluxes in numerical *** data collected in East Antarctica from 8 April to 26 November 2016,this study evaluates parameterization schemes for turbulent fluxes over the landfast seaice surface in five numerical *** Community Noah Land Surface Model with Multi-Parameterizations Options(Noah_mp)best replicates the turbulent momentum flux,while the Beijing Climate System Model(BCC_CSM)produces the optimum sensible and latent heat *** particular,two critical issues of parameterization schemes,stability functions and roughness lengths,are *** tests indicate that roughness lengths play a decisive role in model *** on the observed turbulent fluxes,roughness lengths over the landfast sea-ice surface are *** results,which can provide a basis for setting up model parameters,reveal that the dynamic roughness length(z0m)increases with the increase of frictional velocity(u*)when u*≤0.4 m s^(−1) and fluctuates around 10^(−3 )m when u*>0.4 m s^(−1);thermal roughness length(z0t)is linearly related to the temperature gradient between air and sea-ice surface(ΔT)with a relation of lg(z0t)=−0.29ΔT−3.86;and the mean water vapor roughness length(z0q)in the specific humidity gradient(Δq)range ofΔq≤−0.6 g kg^(−1) is 10^(−6) m,3.5 times smaller than that in the range ofΔq˃−0.6 g kg^(−1).

关键词： turbulent fluxes Antarctica landfast sea-ice surface parameterization evaluating numerical models

炎琥宁注射液对轮状病毒感染性腹泻患儿IL-6、CRP及心肌酶水平的影响

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临床医学工程 2024年第7期31卷 851-852页

作者：段红云程方圆柳蕊郑州市金水区总医院儿科河南郑州450040 河南省胸科医院呼吸科河南郑州450003

目的探讨炎琥宁注射液对轮状病毒(RV)感染性腹泻患儿白介素6(IL-6)、C反应蛋白(CRP)及心肌酶水平的影响。方法将2020年11月至2022年11月我院收治的96例RV感染性腹泻患儿随机分为两组各48例。对照组采用利巴韦林注射液治疗,观察组在对照... 详细信息

目的探讨炎琥宁注射液对轮状病毒(RV)感染性腹泻患儿白介素6(IL-6)、C反应蛋白(CRP)及心肌酶水平的影响。方法将2020年11月至2022年11月我院收治的96例RV感染性腹泻患儿随机分为两组各48例。对照组采用利巴韦林注射液治疗,观察组在对照组基础上采用炎琥宁注射液治疗,两组均治疗5d。比较两组的血清炎性因子、心肌酶乳酸脱氢酶(LDH)、磷酸肌酸激酶(CK)和磷酸肌酸激酶同工酶(CK-MB)水平及不良反应。结果观察组治疗总有效率高于对照组(P<0.05)。治疗后,观察组IL-6、CRP、LDH、CK、CK-MB水平低于对照组(P<0.05)。两组均未见明显不良反应。结论炎琥宁注射液能够有效控制RV感染性腹泻患儿的炎性因子水平,改善心肌酶指标,且安全可靠。

关键词：轮状病毒感染性腹泻炎琥宁注射液炎性因子心肌酶

基于HMAC算法的网络通信安全数据传输系统设计

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电子设计工程 2024年第6期32卷 175-179页

作者：艾雪瑞许放张涛程方圆曹瑾北京中电飞华通信有限公司北京100000

目前的网络通信安全数据传输系统稳定性较差,导致通信质量下降。为了解决上述问题,设计基于HMAC算法的网络通信安全数据传输系统。通过加密模块、解密模块实现网络通信数据加密和解密处理,采用HMAC算法对身份认证模块字段的含义进行延伸... 详细信息

目前的网络通信安全数据传输系统稳定性较差,导致通信质量下降。为了解决上述问题,设计基于HMAC算法的网络通信安全数据传输系统。通过加密模块、解密模块实现网络通信数据加密和解密处理,采用HMAC算法对身份认证模块字段的含义进行延伸,利用逻辑发生器减少外来伪造信息的攻击。获取Logistic映射和Chebyshev映射的迭代初值和控制参数,将其作为HMAC算法的序列值,保证消息的传播安全性和不可逆转性,以此实现网络通信安全数据传输。实验结果表明,基于HMAC算法的网络通信安全数据传输系统的传输稳定性高达99%,通信质量较好。

关键词： HMAC算法网络通信通信安全安全数据数据传输传输系统

Cytochrome P450s in algae:Bioactive natural product biosynthesis and light-driven bioproduction

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Acta Pharmaceutica Sinica B 2022年第6期12卷 2832-2844页

作者： Shanmin Zheng Jiawei Guo fangyuan cheng Zhengquan Gao Lei Du Chunxiao Meng Shengying Li Xingwang Zhang School of Life Sciences Shandong University of TechnologyZibo 255000China State Key Laboratory of Microbial Technology Shandong UniversityQingdao 266237China School of Pharmacy Binzhou Medical UniversityYantai 264003China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China

Algae are a large group of photo synthetic organisms responsible for approximately half of the earth’s total *** addition to their fundamental ecological roles as oxygen producers and as the food base for almost all aquatic life,algae are also a rich source of bioactive natural products,including several clinical *** P450 enzymes(P450s) are a superfamily of biocatalysts that are extensively involved in natural product biosynthesis by mediating various types of *** the post-genome era,a growing number of P450 genes have been discovered from algae,indicating their important roles in algal ***,the functional studies of algal P450s remain *** from the recent technical advances in algae cultivation and genetic manipulation,the researches on P450s in algal natural product biosynthesis have been approaching to a new ***,some photoauto trophic algae have been developed into "photo-bioreactors" for heterologous P450s to produce high-value added pharmaceuticals and chemicals in a carbon-neutral or carbon-negative ***,we comprehensively review these advances of P450 studies in algae from 2000 to 2021.

关键词： Natural product biosynthesis Algal pharmaceuticals Cytochrome P450 enzymes Algae Light-driven bioproduction

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基于移动终端双模定位的多场景入侵报警方法

电子设计工程 2024年第9期32卷 6-10页

作者：许放欧清海张晖艾雪瑞程方圆北京中电飞华通信有限公司北京100070

针对现有入侵检测算法精度偏低且漏检情况较为严重的问题,文中提出了一种基于移动终端双模定位的入侵检测算法。该算法构建了包括监测模块、移动终端模块、无线传输模块、中心数据处理模块及自动报警模块等组成的硬件系统。同时在双模... 详细信息

针对现有入侵检测算法精度偏低且漏检情况较为严重的问题,文中提出了一种基于移动终端双模定位的入侵检测算法。该算法构建了包括监测模块、移动终端模块、无线传输模块、中心数据处理模块及自动报警模块等组成的硬件系统。同时在双模定位技术的基础上,采用最速下降法(SDA)和遗传算法(GA)辅助下的粒子滤波法(GPF)对双模入侵定位数据加以校准,从而设计了基于移动终端双模定位的入侵检测算法。在不同场景下进行的实验测试结果验证了所提算法的可靠性,对比同类入侵报警方法,其误检率低至3.8%,漏检率则平均下降了约70%,而且其他性能指标也优于同类文献。

关键词：双模定位入侵检测算法卷积神经网络融合算法