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CD36 promotes tubular ferroptosis by regulating the ubiquitination of FSP1 in acute kidney injury

Genes & Diseases 2024年第1期11卷 449-463页

作者： Yixin Ma Lili Huang Zheng Zhang Pengfei Yang Qingsong Chen Xujia Zeng fangyan tan Chunxia Wang Xiongzhong Ruan Xiaohui Liao Department of Nephrology The Second Affiliated HospitalChongqing Medical UniversityChongqing 400010China Department of Cell Biology and Genetics Chongqing Medical UniversityChongqing 400016China Centre for Nephrology Royal Free and University College Medical SchoolUniversity College LondonRoyal Free CampusRowland Hill StreetLondon NW32PFUnited Kingdom Centre for Lipid Research Key Laboratory of Molecular Biology on Infectious DiseasesMinistry of EducationChongqing Medical UniversityChongqing 400016China Kuanren Laboratory of Translational Lipidology Centre for Lipid ResearchSecond Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

Reactive oxidative species(ROos)production-driven ferroptosis plays a role in acute kidney injury(Akl).However,its exact molecular mechanism is poorly *** receptor CD36 has important roles in oxidizing lipids,lipid accumulation,metabolic syndrome,and insulin resistance in chronic kidney disease,but its roles remain unexplored in *** present study investigated the role and mechanism of CD36 in regulating proximal tubular cell ferroptosis and *** expression of CD36 was found to be significantly up-regulated in AKI renal tissues and correlated with renal function,which might serve as an independent biomarker for AKl ***,in adult mice subjected to AKl,deletion of CD36(CD36-/-)induced tubular cell Ros accumulation,ferroptosis activation,and renal ***,combining LC-MS/MS,co-IP,and ubiquitination analyses revealed that CD36 could specifically bind to ferroptosis suppressor protein 1(FSP1)and regulate its ubiquitination at sites K16 and K24,leading to FSP1 degradation and progression of ferroptosis in *** present results emphasize a novel mechanism of CD36 in cisplatin-induced *** discovery of the special CD36 roles in promoting ferroptosis and AKI development by regulating the ubiquitination of FSP1 in proximal tubular cells may be potential therapeutic targets for ***,CD36 may play a key role in the progression of ***,targeting CD36 may provide a promising treatment option for AKI.

关键词： Acute kidney injury CD36 Ferroptosis FSP1 Ubiquitin-dependent degradation

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Parameter calibration of discrete element model for alfalfa seeds based on EDEM simulation experiments

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 33-38页

作者： Xinjiu Zhang Hongti Wang fangyan Wang Zhengguo Lian College of Mechanical and Electrical Engineering Qingdao Agricultural UniversityQingdao 266109ShandongChina

In order to establish an accurate discrete element model of alfalfa seeds,real physical experiments were combined with simulation experiments,and the contact parameters of alfalfa seeds were calibrated using the repose angle of alfalfa seeds as the response *** intrinsic parameters(thousand grain weight,triaxial size,density)and contact parameters(static friction coefficient,rolling friction coefficient)of alfalfa seeds were obtained through physical experiments,and a spherical particle model was *** the Plackett Burman experiment,the static friction coefficient between alfalfa seeds,the rolling friction coefficient between alfalfa seeds,and the static friction coefficient between alfalfa seeds and ABS plastic were determined to have a significant impact on the *** steepest climb test is used to narrow down the selection range of the optimal parameters,and the box Behnken test is used to obtain the quadratic regression equation of the repose *** optimal parameter combination was obtained with the objective of minimizing the repose angle error:the static friction coefficient between alfalfa seeds and alfalfa seeds was 0.418,the rolling friction coefficient between alfalfa seeds and alfalfa seeds was 0.086,and the static friction coefficient between alfalfa seeds and ABS plastic was *** repose angle and mass flow rate experiments show that the model is effective and reliable.

关键词： alfalfa seeds discrete element parameter calibration EDEM

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Polar solvent induced in-situ self-assembly and oxygen vacancies on Bi_(2)MoO_(6)for enhanced photocatalytic degradation of tetracycline

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Nano Research 2024年第6期17卷 4951-4960页

作者： fangyan Liu Dongyue Su Weizhen Liu Baiquan Liu Chuan Liu Hong Wang Mengye Wang State Key Laboratory of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Material and TechnologySchool of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510275China School of Materials Sun Yat-Sen UniversityShenzhen 518107China School of Environment and Energy Guangdong Provincial Key Laboratory of Solid Wastes Pollution Control and RecyclingSouth China University of TechnologyGuangzhou 510006China

It has been proved to be an effective route to efficiently ameliorate photocatalytic performance of catalysts via designing three-dimensional(3D)hierarchical nanostructures and constructing oxygen vacancies(VOs).However,controlling the self-assembly of organization into 3D hierarchical nanostructures while introducing VOs in photocatalysts remains a ***,we reported an ethylene glycol(EG)mediated approach to craft 3D hydrangea-structure Bi_(2)MoO_(6)with VOs for efficient photocatalytic degradation of *** manipulating the EG concentration during the fabrication process,the influence of EG concentration on the Bi_(2)MoO_(6)structure was systematically *** could promote the self-assembly of Bi_(2)MoO_(6)nanosheets to form a 3D hierarchical *** with 2D nanoplates,3D hierarchical architecture enhanced the surface area and the amount of active sites of Bi_(2)MoO_(6).In addition,the reduction effect of EG on metallic oxide enabled the generation of VOs in Bi_(2)MoO_(6).The VOs adjusted the electronic structure of Bi_(2)MoO_(6),which not only enhanced the light harvesting,but also facilitated the simultaneous utilization of photo-induced electrons and holes to form reactive oxygen species(·O2−and·OH)for the efficient tetracycline decomposition.3D Bi_(2)MoO_(6)hydrangea with VOs achieved a 79.4%removal efficiency of tetracycline after 75 *** work provides a simple yet robust EG-mediated strategy,which not only promotes the self-assembly of nano-catalysts into 3D hierarchical architectures,but also crafts tunable VOs for highly efficient photocatalysis.

关键词： three-dimensional(3D)hierarchical nanostructures tunable oxygen vacancies ethylene glycol(EG)-mediated strategy bismuth molybdate photocatalytic degradation tetracycline

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Ultrasound-responsive spherical nucleic acid against c-Myc/PD-L1 to enhance anti-tumoral macrophages in triple-negative breast cancer progression

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Science China(Life Sciences) 2024年第4期67卷 698-710页

作者： Runtian Wang Gaigai Li fangyan Gao Feng Xu Xintong Li Jian Zhang Jinbo Li Xiaoxiang Guan Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China State Key Laboratory of Analytical Chemistry for Life Sciences Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringChemistry and Biomedicine Innovation Center(ChemBIC)Nanjing UniversityNanjing 210023China Department of Medical Oncology Fudan University Shanghai Cancer CenterDepartment of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjing 211166China

Triple-negative breast cancer(TNBC)is the most challenging breast cancer subtype because of its aggressive behavior and limited therapeutic targets.c-Myc is hyperactivated in the majority of TNBC tissues,however,it has been considered an“undruggable”target due to its disordered ***,we developed an ultrasound-responsive spherical nucleic acid(SNA)against c-Myc and PD-L1 in *** is a self-assembled and carrier-free system composed of a hydrophilic small-interfering RNA(si RNA)shell and a hydrophobic core made of a peptide nucleic acid(PNA)-based antisense oligonucleotide(ASO)and a *** accomplished significant enrichment in the tumor by enhanced permeability and retention(EPR)effect,the controllable release of effective elements by ultrasound activation,and the combination of targeted therapy,immunotherapy and *** study demonstrated significant anti-tumoral effects in vitro and in *** cytometry showed an invigorated tumor microenvironment(TME)characterized by a significant alteration in the composition of tumor-associated macrophages(TAM)and decreased proportion of PD-1-positive(PD-1+)T effector cells after appropriate treatment of the ultrasound-responsive SNA(USNA).Further experiments verified that tumor-conditioned macrophages residing in the TME were transformed into the anti-tumoral *** finding offers a novel therapeutic strategy against the“undruggable”c-Myc,develops a new targeted therapy for c-Myc/PD-L1 and provides a treatment option for the TNBC.

关键词： triple-negative breast cancer c-Myc spherical nucleic acid self-assembly

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A bHLH transcription factor,CsSPT,regulates high-temperature resistance in cucumber

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Horticultural Plant Journal 2024年第2期10卷 503-514页

作者： Yonggui Liang Chenyu Yang fangyan Ming Bingwei Yu Zhihua Cheng Yixi Wang Zhengkun Qiu Xiaolan Zhang Bihao Cao Shuangshuang Yan Key Laboratory of Biology and Genetic Improvement of Horticultural Crops(South China) Ministry of Agriculture and Rural AffairsGuangdong Vegetable Engineering and Technology Research CenterCollege of HorticultureSouth China Agricultural UniversityGuangzhouGuangdong 510642China State Key Laboratories of Agrobiotechnology Beijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable CropsMOE Joint Laboratory for International Cooperation in Crop Molecular BreedingChina Agricultural UniversityBeijing 100193China

High-temperature stress threatens the growth and yield of crops. Basic helix-loop-helix(bHLH) transcription factors(TFs) have been shown to play important roles in regulating high-temperature resistance in plants. However, the bHLH TFs responsible for high-temperature tolerance in cucumbers have not been identified. We used transcriptome profiling to screen the high temperature-responsive candidate bHLH TFs in cucumber. Here, we found that the expression of 75 CsbHLH genes was altered under high-temperature stress. The expression of the CsSPT gene was induced by high temperatures in TT(Thermotolerant) cucumber plants. However, the Csspt mutant plants obtained by the CRISPR-Cas9 system showed severe thermosensitive symptoms, including wilted leaves with brown margins and reduced root density and cell *** Csspt mutant plants also exhibited elevated H_(2)O_(2) levels and down-regulated photosystem-related genes under normal ***, there were high relative electrolytic leakage(REC), malondialdehyde(MDA), glutathione(GSH), and superoxide radical(O_(2)^(·-)) levels in the Csspt mutant plants, with decreased Proline content after the high-temperature treatment. Transcriptome analysis showed that the photosystem and chloroplast activities in Csspt mutant plants were extremely disrupted by the high-temperature stress compared with wildtype(WT) plants. Moreover, the plant hormone signal transduction, as well as MAPK and calcium signaling pathways were activated in Csspt mutant plants under high-temperature stress. The HSF and HSP family genes shared the same upregulated expression patterns in Csspt and WT plants under high-temperature conditions. However, most bHLH, NAC, and bZIP family genes were significantly down-regulated by heat in Csspt mutant plants. Thus, these results demonstrated that CsSPT regulated the high-temperature response by recruiting photosynthesis components, signaling pathway molecules, and transcription factors. Our results pro

关键词： Cucumber bHLH CsSPT Photosynthesis High temperature

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Precise nano-system-based drug delivery and synergistic therapy against androgen receptor-positive triple-negative breast cancer

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2685-2697页

作者： fangyan Gao Yueyao Wu Runtian Wang Yuhui Yao Yiqiu Liu Lingling Fan Jingtong Xu Jian Zhang Xin Han Xiaoxiang Guan Department of Oncology the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization School of Medicine&Holistic Integrative MedicineNanjing University of Chinese MedicineNanjing 210023China Department of Oncology the Second Hospital of NanjingNanjing University of Chinese MedicineNanjing 210023China Department of Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjing 211166China

Targeting androgen receptor(AR)has shown great therapeutic potential in triple-negative breast cancer(TNBC),yet its efficacy remains ***,we aimed to identify promising targeted agents that synergize with enzalutamide,a second-generation AR inhibitor,in *** using a strategy for screening drug combinations based on the Sensitivity Index(SI),we found that MK-8776,a selective checkpoint kinase1(CHK1)inhibitor,showed favorable synergism with enzalutamide in AR-positive *** combination of enzalutamide and MK-8776 was found to exert more significant anti-tumor effects in TNBC than the single application of enzalutamide or MK-8776,***,a nanoparticle-based on hyaluronic acid(HA)-modified hollow-manganese dioxide(HMnO_(2)),named HMnE&M@H,was established to encapsulate and deliver enzalutamide and *** HA-modified nanosystem managed targeted activation via pH/glutathione ***&M@H repressed tumor growth more obviously than the simple addition of enzalutamide and MK-8776 without a ***,our study elucidated the synergy of enzalutamide and MK-8776 in TNBC and developed a novel tumor-targeted nano drug delivery system HMnE&M@H,providing a potential therapeutic approach for the treatment of TNBC.

关键词： Triple-negative breast cancer Androgen receptor Checkpoint kinase 1 Enzalutamide MK-8776 Synergy HMnO_(2) Nanodrug delivery system

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老年护理机器人的关怀能力及其边界

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医学与哲学 2024年第6期45卷 31-36页

作者：苗芳艳东南大学人文学院江苏南京211189

护理机器人在医疗保健领域发挥着正向价值,缓解了老龄人口增加和护理人员数量短缺的冲突,为社会隔离状态下的老年人提供高质量的护理,也引发了机器人可能取代人类护理员的担忧。关怀作为护理的基本伦理价值,基于特朗托的“活动”关怀、... 详细信息

护理机器人在医疗保健领域发挥着正向价值,缓解了老龄人口增加和护理人员数量短缺的冲突,为社会隔离状态下的老年人提供高质量的护理,也引发了机器人可能取代人类护理员的担忧。关怀作为护理的基本伦理价值,基于特朗托的“活动”关怀、赫尔德的“价值”关怀和范莱尔的“真实”关怀能力理论,论证了当前护理机器人无法拥有人类意义上的关怀能力。护理机器人是老年人生命历程中的重要伙伴,未来其发展有三方面的边界:其一,划分人机护理的范围;其二,嵌入关怀的伦理价值;其三,发展人性化的护理。

关键词：护理机器人老年人关怀护理关怀伦理学

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Investigation on the wear of spur gears generated by modified cutter

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Friction 2021年第2期9卷 288-300页

作者： fangyan ZHENG Jun ZHANG Ligang YAO Rulong tan School of Automotive Engineering Wuhan University of TechnologyWuhan 430070China School of Mechanical Engineering and Automation Fuzhou UniversityFuzhou 350116China School of Mechanical Engineering Chongqing University of TechnologyChongqing 400000China

Tooth surface wear damage is one of the main causes of gearing system *** wear leads to tooth profile loss and an increase in transmission errors,as the worn gear surfaces are no longer ***,the enhancement of gear durability against wear is important for gear *** works show that cutter modification can aid in reducing the tool wear in gear processing,while the wear performance of the gears produced by modified cutters is still ***,this study focuses on the wear performance of the gear generated by modified *** results show that the wear resistance can be enhanced through proper cutter modification.

关键词： gear wear cutter modification gear modification

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薄壁高筋筒件的径向包络成形装备运动学分析

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锻压技术 2024年第1期49卷 165-172页

作者：金奇伟郑方焱武汉理工大学汽车工程学院现代汽车零部件技术湖北省重点实验室湖北武汉430070

对径向包络成形装备的位置反解、奇异位形和工作空间等运动学进行分析。通过闭环矢量法建立六连杆三自由度并联机构的运动学模型,利用雅可比矩阵求解奇异位形,通过位置约束条件求解工作空间。揭示六连杆三自由度并联机构的运动学特性;... 详细信息

对径向包络成形装备的位置反解、奇异位形和工作空间等运动学进行分析。通过闭环矢量法建立六连杆三自由度并联机构的运动学模型,利用雅可比矩阵求解奇异位形,通过位置约束条件求解工作空间。揭示六连杆三自由度并联机构的运动学特性;建立驱动滑块位置和包络辊位姿之间的映射关系,得到驱动滑块的位移、速度和加速度表达式;得到并联机构的两种奇异位形;分析机构工作空间的影响因素和限制条件,求解了并联机构的工作空间。通过径向包络成形装备的运动学分析,表明了当前构型和运动参数的可行性,在运动平台转角γ最小时,并联机构可获得最大的移动工作空间。上述研究为径向包络成形装备运动控制提供了理论依据。

关键词：径向包络成形装备工作空间奇异位形并联机构驱动滑块转角

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舒适护理干预对血液透析联合血液灌流尿毒症患者心理状态的影响

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中国医药指南 2024年第22期22卷 173-175页

作者：许芳燕谭丽廖翠婷贵港市中医医院血液净化科贵港537100

目的本研究旨在深入探究舒适护理干预对接受血液透析联合血液灌流治疗的尿毒症患者心理状态所产生的影响。方法选取2021年2月至2023年8月于贵港市中医医院接受血液透析联合血液灌流治疗的尿毒症患者120例作为研究对象。依据随机数字表... 详细信息

目的本研究旨在深入探究舒适护理干预对接受血液透析联合血液灌流治疗的尿毒症患者心理状态所产生的影响。方法选取2021年2月至2023年8月于贵港市中医医院接受血液透析联合血液灌流治疗的尿毒症患者120例作为研究对象。依据随机数字表法将所有患者划分为对照组(60例)和观察组(60例)两组。其中,对照组采用传统常规护理模式;而观察组则在接受常规护理的基础上,额外实施舒适护理干预措施。运用焦虑自评量表(SAS)和抑郁焦虑自评量表(SDS)进行心理状态评分,并比较两组患者的心理状态、生活质量、护理满意度以及并发症发生率。结果干预后,观察组SAS、SDS评分均优于对照组,生活质量评分高于对照组(P<0.05),护理满意度高于对照组(P<0.001),并发症发生率低于对照组(P=0.022)。结论应用血液透析联合血液灌流治疗尿毒症的同时辅以舒适护理干预能够显著改善患者心理状态,提高患者生活质量和护理效果,减少并发症发生。

关键词：尿毒症舒适护理血液透析血液灌流心理状态

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