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Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain

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Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： Xiaoyu Zhang Yuqi Liu fangxia Xu Chengcheng zhou Kaimei Lu Bin fang Lijuan Wang Lina Huang Zifeng Xu Department of Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Embryo Original Diseases ShanghaiChina

Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this *** this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic *** results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer *** addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 ***,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ***,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 *** findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons

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基于USB接口的低速率声码器设计研究

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四川大学学报（自然科学版） 2003年第1期40卷 59-62页

作者：刘嘉勇方勇周安民四川大学电子信息学院成都610064

以专用语音信号处理器CT8020为核心,应用单片机控制技术及通信接口电路,介绍了一种基于USB接口的低速率声码器的设计与实现方法.在给出系统硬件总体结构的基础上,重点讨论了声码器和上位机软件设计中的若干问题.

关键词： USB接口低速率声码器语音压缩总线列举通用串行总线语音信号处理器系统设计

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二丙酸倍氯米松纳米微囊治疗豚鼠哮喘模型的实验研究

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天津医药 2002年第9期30卷 518-521页

作者：林芳孙铭周立波肖琅天津市第三中心医院呼吸内科 300170 天津市第三中心医院肝胆研究所

目的 :研究二丙酸倍氯米松 (BDP)纳米缓释微囊对豚鼠哮喘的治疗作用 ,以研制哮喘长期吸入治疗的糖皮质激素新剂型。方法 :以聚乳酸聚羟基乙酸共聚物 (PLGA )为基质材料 ,采用超声乳化法制备BDP纳米缓释微囊 ,经扫描电镜观察微囊形态 ... 详细信息

目的 :研究二丙酸倍氯米松 (BDP)纳米缓释微囊对豚鼠哮喘的治疗作用 ,以研制哮喘长期吸入治疗的糖皮质激素新剂型。方法 :以聚乳酸聚羟基乙酸共聚物 (PLGA )为基质材料 ,采用超声乳化法制备BDP纳米缓释微囊 ,经扫描电镜观察微囊形态 ,激光散射实验测定其粒径分布 ,并进行体内过敏实验及药效学研究。结果 :BDP PLGA纳米微囊为表面光滑的球形囊 ,粒径分布呈均值为126 4nm的正态分布 ;BDP PLGA纳米缓释微囊对豚鼠无过敏反应 ,能明显控制哮喘发作且呈剂量依赖性 ;纳米微囊治疗组血中白细胞总数和肺泡灌洗液中细胞总数及嗜酸性粒细胞明显低于模型组 (P<0 01) ,且嗜酸性粒细胞减少呈剂量依赖性 (P<0 05)。结论 :BDP PLGA纳米缓释微囊显著抑制气道内炎性细胞浸润并有良好的缓释性。

关键词：二丙酸倍氯米松哮喘迟效制剂纳米缓释微囊药效学

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Early light induced protein（ELIP） gene from Medicago falcata confers resistance to abiotic stresses

Early light induced protein（ELIP） gene from Medicago falca...

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中国草学会青年学术研讨会

作者： ZHUO,Chunliu,CAI Jiongliang,fang Junyang,zhou ming,GUO Zhenfei (Biotechnology Laboratory for Turfgrass and Forages,Department of Plant Science,College of Life Sciences,South China Agricultural University,Guangzhou 510642:China.)

＜正＞Early-light induced protein（ELIP）is proposed to play a key role in the protection of photosynthetic apparatus from high light *** this work,the role of ELIP in resistance to abiotic stress of plants was investigated.A full length cDNA of MfELIP was cloned from ***,a cold-resistant germplasm of forage *** showed a rapidly induced expression following exposure to cold treatment,and the induced transcripts existed in green *** was also induced in expression in response to dehydration,salt and abscisic acid（ABA）*** with inhibitor of ABA biosynthesis reversed the induction by ABA,cold or dehydration,indicating that ABA was involved in the cold-or dehydration-induced expression of MfELIP. Transgenic tobaccos overexpressing MfELIP were generated and analyzed for resistance to abiotic *** data indicated that the transgenic tobaccos exhibited a significantly increased resistance to abiotic stresses, including high light,freezing,chilling,drought and *** is suggested that MfELIP confers resistance to abiotic stresses.

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Electrode/Electrolyte Optimization-Induced Double-Layered Architecture for High-Performance Aqueous Zinc-(Dual) Halogen Batteries

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NANO-MICRO LETTERS 2025年第1期17卷 1-17页

作者： zhou, Chengwang Ding, Zhezheng Ying, Shengzhe Jiang, Hao Wang, Yan fang, Timing Zhang, You Sun, Bing Tang, Xiao Liu, Xiaomin Qingdao Univ Sch Text & Clothing Sch Chem & Chem Engn Qingdao 266071 Shandong Peoples R China Univ Technol Sydney Fac Sci Ctr Clean Energy Technol Sch Math & Phys Sci Ultimo NSW 2007 Australia Henan Normal Univ Sch Chem & Chem Engn Xinxiang 453007 Henan Peoples R China

A double-layered protective film based on zinc-based coordination compound and ZnF2-rich solid electrolyte interphase layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic *** double-layered architecture can effectively modulate Zn2+ flux and suppress the zinc dendrite growth, thus facilitating the uniform zinc *** as-developed zinc-(dual) halogen batteries based on double-layered protective film can present high areal capacity and satisfactory cycling stability. Aqueous zinc-halogen batteries are promising candidates for large-scale energy storage due to their abundant resources, intrinsic safety, and high theoretical capacity. Nevertheless, the uncontrollable zinc dendrite growth and spontaneous shuttle effect of active species have prohibited their practical implementation. Herein, a double-layered protective film based on zinc-ethylenediamine tetramethylene phosphonic acid (ZEA) artificial film and ZnF2-rich solid electrolyte interphase (SEI) layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic optimization. The ZEA-based artificial film shows strong affinity for the ZnF2-rich SEI layer, therefore effectively suppressing the SEI breakage and facilitating the construction of double-layered protective film on the zinc metal anode. Such double-layered architecture not only modulates Zn2+ flux and suppresses the zinc dendrite growth, but also blocks the direct contact between the metal anode and electrolyte, thus mitigating the corrosion from the active species. When employing optimized metal anodes and electrolytes, the as-developed zinc-(dual) halogen batteries present high areal capacity and satisfactory cycling stability. This work provides a new avenue for developing aqueous zinc-(dual) halogen batteries.

关键词： Zn metal anodes Double-layered protective film Electrode/electrolyte optimization Aqueous zinc-(dual) halogen batteries

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浅析拟人化无人驾驶交互界面对信任度的影响

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艺术与设计（理论版） 2016年第12期 125-126页

作者：牛东方邓明周淼东北大学沈阳110819

无人驾驶技术近些年发展迅速,但信任始终是对于大众接受和依赖无人驾驶汽车的关键。许多研究已经证明信息透明化能够提升无人驾驶的信任度,而拟人化可以对自动化系统的信任度产生影响。我们期望拟人化同样在无人驾驶领域可以提升用户对... 详细信息

无人驾驶技术近些年发展迅速,但信任始终是对于大众接受和依赖无人驾驶汽车的关键。许多研究已经证明信息透明化能够提升无人驾驶的信任度,而拟人化可以对自动化系统的信任度产生影响。我们期望拟人化同样在无人驾驶领域可以提升用户对无人驾驶汽车的信任度。

关键词：无人驾驶拟人化交互界面信任度

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Inter-Skeleton Conductive Routes Tuning Multifunctional Conductive Foam for Electromagnetic Interference Shielding, Sensing and Thermal Management

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NANO-MICRO LETTERS 2025年第1期17卷 1-18页

作者： Li, Xufeng Chen, Chunyan Li, Zhenyang Yi, Peng Zou, Haihan Deng, Gao fang, ming He, Junzhe Sun, Xin Yu, Ronghai Shui, Jianglan Pan, Caofeng Liu, Xiaofang Beihang Univ Sch Mat Sci & Engn Beijing 100191 Peoples R China Beihang Univ Inst Atom Mfg Beijing 100191 Peoples R China Tianmushan Lab Xixi Octagon City Hangzhou 310023 Peoples R China Beijing Inst Environm Features Sci & Technol Electromagnet Scattering Lab Beijing 100854 Peoples R China

Unique inter-skeleton conductive films are constructed in polymer *** resistance change of the foam can reach four orders of magnitude under *** foam exhibits strain-adaptive electromagnetic interference shielding performance, anti-interference pressure sensor with high sensitivity over a wide pressure range and compression-regulated Joule heating function. Conductive polymer foam (CPF) with excellent compressibility and variable resistance has promising applications in electromagnetic interference (EMI) shielding and other integrated functions for wearable electronics. However, its insufficient change amplitude of resistance with compressive strain generally leads to a degradation of shielding performance during deformation. Here, an innovative loading strategy of conductive materials on polymer foam is proposed to significantly increase the contact probability and contact area of conductive components under compression. Unique inter-skeleton conductive films are constructed by loading alginate-decorated magnetic liquid metal on the polymethacrylate films hanged between the foam skeleton (denoted as AMLM-PM foam). Traditional point contact between conductive skeletons under compression is upgraded to planar contact between conductive films. Therefore, the resistance change of AMLM-PM reaches four orders of magnitude under compression. Moreover, the inter-skeleton conductive films can improve the mechanical strength of foam, prevent the leakage of liquid metal and increase the scattering area of EM wave. AMLM-PM foam has strain-adaptive EMI shielding performance and shows compression-enhanced shielding effectiveness, solving the problem of traditional CPFs upon compression. The upgrade of resistance response also enables foam to achieve sensitive pressure sensing over a wide pressure range and compression-regulated Joule heating function.

关键词： Inter-skeleton conductive films Conductive polymer foam Liquid metal Electromagnetic interference shielding

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上海中医书局探微

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世界中西医结合杂志 2018年第2期13卷 149-152,248页

作者：杨东方周明鉴北京中医药大学国学院北京100029 中央民族大学附属中学北京100081

1929年创办的上海中医书局是民国期间创办最早,也是最大的中医类书业机构。在钱季寅、秦伯未等人的主持下,抗战前的中医书局资本充足,在中医典籍的流通发行方面贡献极大,出版的《影印古本医学丛书》等书籍学术价值很高。后由于战火的影... 详细信息

1929年创办的上海中医书局是民国期间创办最早,也是最大的中医类书业机构。在钱季寅、秦伯未等人的主持下,抗战前的中医书局资本充足,在中医典籍的流通发行方面贡献极大,出版的《影印古本医学丛书》等书籍学术价值很高。后由于战火的影响,中医书局的发展步入低潮。中华人民共和国成立后,中医书局与千顷堂书局等一起组成上海卫生出版社,后又被并入上海科学技术出版社。中医书局的存在时间并不长,但发行出版中医典籍颇多,对其进行研究既可管窥民国中医发展的复杂环境,又能管窥民国中医典籍出版的整体概貌。

关键词：中医书局中医史秦伯未

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影响聚合物改性多孔混凝土性能的因素研究

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武汉理工大学学报 2009年第4期31卷 84-86页

作者：徐方周明凯李北星沈卫国张涛方东武汉理工大学硅酸盐材料工程教育部重点实验室武汉430070

研究了成型方式、养护方式、集料级配等因素对聚合物改性多孔水泥混凝土(PMPC)性能的影响。研究结果表明:成型方式方面,宜采用振动台振动成型,试件上方配重5 kg,振动时间为30 s;养护方式方面,采用7 d薄膜保湿养护,之后自然养护为宜;采... 详细信息

研究了成型方式、养护方式、集料级配等因素对聚合物改性多孔水泥混凝土(PMPC)性能的影响。研究结果表明:成型方式方面,宜采用振动台振动成型,试件上方配重5 kg,振动时间为30 s;养护方式方面,采用7 d薄膜保湿养护,之后自然养护为宜;采用碎石(4.75—9.5 mm)与机制砂作为混凝土集料,当w(碎石(4.75—9.5 mm))∶w(机制砂)=9∶1时,PMPC具有较好的强度及透水性能。

关键词：聚合物聚合物改性多孔水泥混凝土成型方式养护方式集料级配

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血液透析滤过对尿毒症患者中性粒细胞吞噬功能的影响

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临床肾脏病杂志 2017年第4期17卷 211-215页

作者：王丽芳王明军周红卫广西医科大学第一附属医院肾内科南宁530021

目的探讨血液透析滤过对尿毒症患者中性粒细胞吞噬功能及酸碱、电解质的影响。方法选择尿毒症患者29例作为治疗组,接受高通量血液透析滤过(hign flux hemadiafileration,HFHDF)治疗。治疗组患者在维持性血液透析期间均接受1次HFHDF治疗... 详细信息

目的探讨血液透析滤过对尿毒症患者中性粒细胞吞噬功能及酸碱、电解质的影响。方法选择尿毒症患者29例作为治疗组,接受高通量血液透析滤过(hign flux hemadiafileration,HFHDF)治疗。治疗组患者在维持性血液透析期间均接受1次HFHDF治疗,透析滤过过程中平均置换液流量为125~150 ml/min,置换液总量为30~40 L,透析超滤量为2.0~4.0 L,血流量为250~300 ml/min,透析液流量为500 ml/min,治疗时间4 h。所有接受透析治疗的患者其血管通路构建采用内瘘或颈内长期留置法留置导管,透析液为碳酸氢盐透析液,采用低分子肝素或普通肝素抗凝。观察治疗前后中性粒细胞吞噬率、吞噬指数、血尿素氮(BUN)、血肌酐(SCr)、白蛋白(albumin,Alb)、超敏C反应蛋白(highsensitivity C-reactive protein,hs-CRP)、β2-微球蛋白(β2-microglobulin,β2-MG)、电解质及二氧化碳结合力(carbon dioxide combining power,CO_2CP)。另选择体检健康的志愿者25例作为健康组,测定中性粒细胞吞噬率、吞噬指数。将尿毒症患者及健康组的血标本与白色葡萄球菌孵育30 min后,油镜下观察中性粒细胞吞噬白色葡萄球菌的情况,并计算中性粒细胞吞噬率、吞噬指数。其余项目送至我院检验科检测。结果尿毒症患者HFHDF治疗前中性粒细胞吞噬率、吞噬指数均低于健康组(P0.05)。尿毒症患者HFHDF治疗后中性粒细胞吞噬率、吞噬指数及CO_2CP、补体C3均高于治疗前(均P0.05)。结论尿毒症患者中性粒细胞吞噬功能低于健康人水平。HFHDF治疗能有效清除小分子和中分子物质,并纠正酸碱、电解质紊乱,提高尿毒症患者中性粒细胞的吞噬功能。

关键词：血液透析滤过尿毒症中性粒细胞吞噬功能尿毒症毒素

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