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Comprehensive bibliometric analysis of pharmacotherapy for bipolar disorders:Present trends and future directions

World Journal of Psychiatry 2025年第1期15卷 153-167页

作者： Bo-Fan Chen Li Liu fang-zhen lin Hai-Min Zeng Hai-Qiang Huang Chun-fang Zhang Cong-Cong Liu Xiang Chen Jie Peng Yun-Fa Wang Zhi-lin Wang Bin Chen De-Le Liu Yun Liu zheng-zheng Li Xin-Xing Zeng The Second Affiliated Hospital Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina The Second Clinical Medical College Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Rehabilitation Medicine The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Jiangxi Provincial People’s Hospital The First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006Jiangxi ProvinceChina Department of Psychiatry Jiangxi Mental HospitalHospital of Nanchang UniversityNanchang UniversityNanchang 330029Jiangxi ProvinceChina

BACKGROUND Bipolar disorder(BD)is a severe mental illness characterized by significant mood *** drug treatment modalities are crucial for managing *** To analyze the current status and future trends of global research on BD drug treatment over the last *** The Web of Science Core Collection database spanning from 2015 to 2024 was utilized to retrieve literature related to BD drug treatment.A total of 2624 articles were *** visualization and analysis were conducted using CiteSpace,VOSviewer,Pajek,Scimago Graphica,and R-studio bibliometrix to identify RESULTS The United States,China,and the United Kingdom have made the most significant contributions to research on BD drug treatment and formed notable research collaboration *** University of Pittsburgh,Massachusetts General Hospital,and the University of Michigan have been identified as the major research institutions in this *** Journal of Affective Disorders is the most influential journal.A keyword analysis revealed research hotspots related to clinical symptoms,drug efficacy,and genetic mechanisms.A citation analysis identified the management guidelines published by Yatham et al in 2018 as the most cited *** This study provides a detailed overview of the field of BD drug treatment,highlighting key contributors,research hotspots,and future *** study findings can be employed as a reference for future research and policymaking,which may enable further development and optimization of BD pharmacotherapy.

关键词： Bipolar disorder Drug treatment Bibliometric analysis Visualization Mental disorder

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Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng lin Tianyuan fang Yuyu Zhou Chuxia Zhang Jianghui Shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

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高浓度CO_2对香蕉和大蕉后熟及果皮叶绿素降解的影响

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食品工业科技 2017年第6期38卷 313-318页

作者：宋慕波帅良唐路平方方陈振林段振华贺州学院食品科学与工程技术研究院广西贺州542899 华南农业大学园艺学院广东广州510642

以香蕉和大蕉为试材,在20%CO_2+21%O_2气调环境和20℃的后熟条件下,通过测定叶绿素含量、果实硬度、细胞膜透性、丙二醛含量、叶绿素酶和脱镁螯合酶活力来研究高浓度CO_2对香蕉和大蕉后熟和果皮叶绿素降解的影响。结果表明:20%CO_2对香... 详细信息

以香蕉和大蕉为试材,在20%CO_2+21%O_2气调环境和20℃的后熟条件下,通过测定叶绿素含量、果实硬度、细胞膜透性、丙二醛含量、叶绿素酶和脱镁螯合酶活力来研究高浓度CO_2对香蕉和大蕉后熟和果皮叶绿素降解的影响。结果表明:20%CO_2对香蕉和大蕉的后熟和叶绿素b含量均无显著影响,但对叶绿素a含量的影响不同,相比于大蕉,香蕉果皮叶绿素a的降解受到明显抑制;叶绿素酶不是香蕉和大蕉叶绿素降解的关键酶;20%CO_2明显抑制了香蕉脱镁螯合酶的活力,但大蕉脱镁螯合酶的活力反而提高,脱镁螯合酶是香蕉叶绿素降解过程中的关键酶。可见,相比于大蕉,香蕉果皮的褪绿更容易受到高浓度CO_2的贮藏环境的影响。

关键词：香蕉大蕉叶绿素叶绿素酶脱镁螯合酶

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High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen fang Huang Lijie Mao Zhimin Zhang Han lin Qixin Yan Xiangyu Lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

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C57BL/6J伪无菌与SPF小鼠高脂饮食诱导的比较研究

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现代食品科技 2016年第11期32卷 29-34页

作者：卞恒娟曾本华王丽钟青萍李文霞魏泓方祥廖振林华南农业大学食品学院广东广州510640 第三军医大学基础部实验动物学教研室重庆400038

肠道菌群与宿主肥胖密切相关,伪无菌小鼠动物模型是研究肠道菌群与肥胖及其他相关疾病关系的有利"工具"。20只8周龄C57BL/6J雄性小鼠给予抗生素混合物饮水,剔除大部分肠道微生物模拟无菌动物。随机分成两组:对照组和高脂组,分别饲喂常... 详细信息

肠道菌群与宿主肥胖密切相关,伪无菌小鼠动物模型是研究肠道菌群与肥胖及其他相关疾病关系的有利"工具"。20只8周龄C57BL/6J雄性小鼠给予抗生素混合物饮水,剔除大部分肠道微生物模拟无菌动物。随机分成两组:对照组和高脂组,分别饲喂常规纯化饲料与高脂纯化饲料8周;同时以20只SPF级小鼠作对照。常规方法测定小鼠体重、血清中血糖、血脂指标和胰岛素水平,并用软件测量脂肪细胞大小。结果表明,与高脂组SPF小鼠相比,高脂组伪无菌小鼠的体重、脂肪垫与肾周脂重量显著低于高脂组SPF小鼠;胰岛素水平和脂肪细胞大小也显著低于SPF小鼠。高脂组伪无菌小鼠出现低体重低脂肪的表型,与无菌小鼠动物模型极为相似。因此采用抗生素处理建立伪无菌小鼠动物模型可用来预示无菌小鼠试验的结果,是研究肠道菌群与某些疾病的理想动物模型。

关键词：肠道菌群肥胖抗生素伪无菌动物模型

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Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-lin Jiang Hui-Na Liu Yu-Fan Yang Zhi-Cheng Zhang Qi Dai Xiao-Yan Bao lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan Sun Xu-fang Ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

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Global Solutions of the Evolutionary Faddeev Model with Small Initial Data

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Acta Mathematica Sinica,English Series 2011年第2期27卷 309-328页

作者： zhen LEI fang Hua lin Yi ZHOU School of Mathematical Sciences LMNS and Shanghai Key Laboratory for Contemporary Applied Mathematics Fudan University Shanghai 200433 P. R. China Courant Institute of Mathematics New York University NY 10012 USA

We consider the Cauchy problem for evolutionary Faddeev model corresponding to maps from the Minkowski space R^1＋n to the unit sphere S2, which obey a system of non-linear wave equations. The nonlinearity enjoys the null structure and contains semi-linear terms, quasi-linear terms and unknowns themselves. We prove that the Cauchy problem is globally well-posed for sufficiently small initial data in Sobolev space.

关键词： Faddeev model global existence quasi-linear wave equations semi-linear wave equations

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磁性纳米材料与磁场效应加速骨损伤修复

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中国组织工程研究 2025年第4期29卷 827-838页

作者：肖放黄雷王琳华中科技大学同济医学院附属协和医院组织工程与再生医学研究中心湖北省武汉市430022 华中科技大学同济医学院附属协和医院检验科湖北省武汉市430022

背景:磁性纳米材料具有促进干细胞成骨分化和抑制破骨细胞形成等生物活性,并在磁场协同下有效促进损伤骨组织愈合,在骨损伤修复中具有广阔的应用前景。目的:综述磁性纳米材料与磁场促进骨修复的作用机制,及其在骨损伤修复领域的研究进... 详细信息

背景:磁性纳米材料具有促进干细胞成骨分化和抑制破骨细胞形成等生物活性,并在磁场协同下有效促进损伤骨组织愈合,在骨损伤修复中具有广阔的应用前景。目的:综述磁性纳米材料与磁场促进骨修复的作用机制,及其在骨损伤修复领域的研究进展。方法:在PubMed和Web of Science数据库中进行相关文献检索,检索词为“magnetic nanomaterials,magnetic field,bone repair,bone tissue engineering,stem cell,osteoblast,osteoclast”。检索文献时限为2003-2023年,将其进行筛选和分析,最终纳入98篇文献进行分析。结果与结论:①磁性纳米材料具有促成骨细胞分化、抑制破骨细胞形成和调节免疫微环境等生物效应;此外,磁性纳米材料可调节组织工程支架的机械性能和表面形貌等理化性质,并赋予其磁性,有利于调控干细胞的黏附、增殖与成骨分化。②磁场具有调控细胞内多条信号通路发挥促成骨细胞分化、抑制破骨细胞形成和刺激血管生成等生物学效应,从而加速损伤的骨组织愈合。③磁性纳米材料与磁场的联合应用,通过激活机械转导、增加细胞内磁性纳米粒子含量、增强微磁场效应等加速骨损伤修复,为骨组织工程的研究提供了新的思路。④磁场在临床骨折、骨质疏松症和骨关节炎疾病的治疗中展现出确切疗效,促进骨组织生长、减轻骨质流失和缓解疼痛,改善患者的生活质量。⑤磁性纳米材料与磁场在骨损伤修复与再生中应用潜力大,但磁性纳米材料、磁场和细胞之间的相互作用机制尚未完全阐明,而且磁场调控细胞内分子事件的关键参数,包括磁场类型、强度、频率、作用时间和作用方式等,以及特定磁场对骨细胞的精确生物效应和潜在机制仍有待明确。⑥未来需要进一步关注其对损伤组织微环境中的破骨细胞、神经、血管和免疫细胞的影响,而关于磁性材料用于人体安全性问题,有待系统性研究其分布、代谢以及急性和慢性毒性等。

关键词：磁性纳米材料磁场骨修复骨组织工程干细胞成骨细胞破骨细胞

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南海红树林底泥放线菌Streptomyces sp.H41-26的抗菌化学成分研究

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中国抗生素杂志 2017年第4期42卷 J0031-J0036页

作者：李聆莉许琳雅唐晓翠施珊珊蒲小明张英沈会芳江振友林壁润周光雄暨南大学药学院中药及天然药物研究所广东省高校中药药效物质基础与创新药物研究重点实验室广州510632 广东省农业科学院植物保护研究所广东省植物保护新技术重点实验室广州510110 暨南大学医学院微生物与免疫教研室广州510632

目的对分离自我国南海红树林底泥的链霉菌Streptomyces sp.H41-26菌株的发酵物抗菌活性成分进行分离和鉴定。方法对链霉菌Streptomyces sp.H41-26菌株的发酵菌丝体采用95%乙醇提取,醇提取物经乙酸乙酯萃取获得抗菌活性部位,通过ODS开放... 详细信息

目的对分离自我国南海红树林底泥的链霉菌Streptomyces sp.H41-26菌株的发酵物抗菌活性成分进行分离和鉴定。方法对链霉菌Streptomyces sp.H41-26菌株的发酵菌丝体采用95%乙醇提取,醇提取物经乙酸乙酯萃取获得抗菌活性部位,通过ODS开放柱层析分离和反相高效液相制备纯化。结果分离得到4个化合物,经NMR和MS等波谱学方法分别鉴定为:放线菌素D(1)、放线菌素X_2(2)、放线菌素X_β(3)和放线菌素X_a(4)。结论化合物1~4在0.1mg/mL时,对大肠埃希菌(ATCC8739)、金黄色葡萄球菌(ATCC6538P)、伤寒沙门菌(ATCC6539)、乙型副伤寒沙门菌(50094)和乙型溶血性链球菌(ATCC32204)具有明显的抗菌活性,其中化合物2在0.01mg/mL时,对除大肠埃希菌外的其他4种细菌抑制效果仍很明显。

关键词：红树林放线菌放线菌素抗菌活性

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Slow-Light Propagation in a Tapered Dielectric Periodic Waveguide over Broad Frequency Range

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Chinese Physics Letters 2011年第5期28卷 132-135页

作者： fang Yi-Jiao CHEN Zhuo WANG zhen-lin Department of Physics and National Laboratory of Solid State Microstructures Nanjing UniversityNanjing 210093

A tapered waveguide composed of a one-dimensional periodic arrangement of dielectric materialis proposed for light *** equifrequency contours(EFC)of silicon-air multilayer photonic crystals within the first bandgap region are first studied.A zero-group-velocity at the first Brillouin zone boundary along the grating vector is *** propagation constants and eigenfrequencies of the first-order guiding modes are numerically investigated for photonic crystal waveguide structures with a finite *** frequency components of the guiding modes are found to slov and stop at different thicknesses inside such a tapered waveguide *** addition,the time-evolution of a femto-second pulse propagating in the tapered waveguide is also demonstrated.

关键词： waveguide Waveguide arrangement

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