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Chinese Chemical Letters 2024年第6期35卷 531-535页

作者： Jia-li Xie Tian-Jin Xie Yu-Jie Luo Kai Mao Cheng-Zhi Huang yuan-fang li Shu-Jun Zhen Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University) Ministry of EducationCollege of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China Key Laboratory of Luminescent and Real-Time Analytical Chemistry(Southwest University) Chongqing Science and Technology BureauCollege of Pharmaceutical SciencesSouthwest UniversityChongqing 400715China

Fluorescence Anisotropy(FA)is an effective biochemical detection method based on molecular *** oxide(GO)has been extensively used as an FA ***,the enhancement of FA by GO alone is limited and the strong scattering of GO will easily make the measurement of FA *** order to address these problems,an octopus-like DNA nanostructure(ODN)was designed and coupled with GO to enhance the FA together in this *** mimicking the multi-clawed structure of the octopus,the ODN can be adsorbed on GO tightly,which not only could improve the sensitivity because of the double FA enhancement abilities of GO and ODN,but also could improve the specificity due to the decrease of the nonspecific interaction in complex ***,ODN could maintain a certain distance between the fluorophore and GO to reduce the fluorescence quenching efficiency of GO,which could improve the *** method has been applied for the detection of hepatitis B virus DNA(HBV-DNA)in a range of 1-50 nmol/L and the limit of detection(LOD)was 330 pmol/*** addition,the proposed method has been successfully utilized to detect HBV-DNA in human serum,indicating that this method has a great practical application prospect.

关键词： Fluorescence anisotropy Graphene oxide(GO) Octopus-like DNA nanostructure HBV-DNA

The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2023

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Cancer Communications 2024年第1期44卷 127-172页

作者： Feng-Hua Wang Xiao-Tian Zhang Lei Tang Qi Wu Mu-Yan Cai yuan-fang li Xiu-Juan Qu Hong Qiu Yu-Jing Zhang Jie-Er Ying Jun Zhang ling-Yu Sun Rong-Bo lin Chang Wang Hao liu Miao-Zhen Qiu Wen-Long Guan Sheng-Xiang Rao Jia-Fu Ji Yan Xin Wei-Qi Sheng Hui-Mian Xu Zhi-Wei Zhou Ai-Ping Zhou Jing Jin Xiang-lin yuan Feng Bi Tian-Shu liu Han liang Yan-Qiao Zhang Guo-Xin li Jun liang Bao-Rui liu lin Shen Jin li Rui-Hua Xu Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer HospitalBeijingP.R.China Department of Radiology Peking University Cancer HospitalBeijingP.R.China Department of Endoscopy Center Peking University Cancer HospitalBeijingP.R.China Department of Pathology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology The First Hospital of China Medical UniversityShenyangLiaoningP.R.China Department of Medical Oncology Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Radiotherapy Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Department of Medical Oncology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China Department of Surgical Oncology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Medical Oncology Fujian Cancer HospitalFuzhouFujianP.R.China Tumor Center The First Hospital of Jilin UniversityChangchunJilinP.R.China Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Department of Radiology Zhongshan HospitalFudan UniversityShanghaiP.R.China Department of

The 2023 update of the Chinese Society of Clinical Oncology(CSCO)Clini-cal Guidelines for Gastric Cancer focuses on standardizing cancer diagnosis and treatment in China,reflecting the latest advancements in evidence-based medicine,healthcare resource availability,and precision *** updates address the differences in epidemiological characteristics,clinicopatho-logical features,tumor biology,treatment patterns,and drug selections between Eastern and Western gastric cancer *** revisions include a structured template for imaging diagnosis reports,updated standards for molecular marker testing in pathological diagnosis,and an elevated recommendation for neoadju-vant chemotherapy in stage III gastric *** advanced metastatic gastric cancer,the guidelines introduce new recommendations for immunotherapy,anti-angiogenic therapy and targeted drugs,along with updated management strategies for human epidermal growth factor receptor 2(HER2)-positive and deficient DNA mismatch repair(dMMR)/microsatellite instability-high(MSI-H)***,the guidelines offer detailed screening recommendations for hereditary gastric cancer and an appendix listing drug treatment regimens for various stages of gastric *** 2023 CSCO Clinical Guidelines for Gastric Cancer updates are based on both Chinese and international clinical research and expert consensus to enhance their applicability and relevance in clinical practice,particularly in the heterogeneous healthcare landscape of China,while maintaining a commitment to scientific rigor,impartiality,and timely revisions.

关键词： Chinese Society of Clinical Oncology(CSCO) gastric cancer diagnosis surgery neoadjuvant adjuvant radiotherapy chemotherapy targeted therapy immunotherapy

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拉萨市医疗设施地域分布及优化研究

医院管理论坛 2024年第1期41卷 31-36页

作者：许鹏方丽媛中国移动通信集团陕西有限公司汉中分公司陕西科技大学经济与管理学院

目的后疫情时代,优化医疗设施空间布局,将有限的医疗资源进行合理分配以提升医疗服务质量与效率是实现医疗机构高质量发展的必由之路。方法通过收集拉萨市医疗设施分布信息,使用地理信息空间分析技术,对拉萨市医疗设施的地域分布特征... 详细信息

目的后疫情时代,优化医疗设施空间布局,将有限的医疗资源进行合理分配以提升医疗服务质量与效率是实现医疗机构高质量发展的必由之路。方法通过收集拉萨市医疗设施分布信息,使用地理信息空间分析技术,对拉萨市医疗设施的地域分布特征及其影响因素进行研究。结果拉萨市医疗设施空间聚集度较高,主要集中在人口密集的城关区,郊县医疗机构服务范围大,布局较为薄弱。在整体上应加强拉萨市西南方向区县医疗设施配置,向东方向加强区县医疗资源能力储备。结论拉萨市医疗设施布局主要受人口和经济、交通、政策等因素的影响,需通过综合优化手段,从整体和局部角度提升全市区域医疗保障能力,促进拉萨市医疗服务的均衡与公平。

关键词：医疗机构医疗服务资源地域分布拉萨市

Selectively colorimetric detection of cysteine with triangular silver nanoprisms

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Chinese Chemical Letters 2009年第5期20卷 611-614页

作者： Tong Wu yuan fang li Cheng Zhi Huang College of Pharmaceutical Sciences MOE Key Laboratory on Luminescence and Real-Time Analysis Southwest University Chongqing 400715 PR China College of Chemistry and Chemical Engineering MOE Key Laboratory on Luminescence and Real-Time Analysis Southwest University Chongqing 400715 PR China

Triangular silver nanoprisms were prepared and applied to make colorimetric detection of cysteine based on our findings that cysteine could lead to the blue shift of the dipole plasmon resonance absorption, but other 19 kinds of natural amino acids could not. Cysteine with a concentration 160 nmol/L can result in a color change that can be discerned with naked eyes.

关键词： Triangular silver nanoprisms Cysteine Colorimetric detection

One-step synthesis of Cu(Ⅱ) metal–organic gel as recyclable material for rapid, efficient and size selective cationic dyes adsorption

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Journal of Environmental Sciences 2019年第12期31卷 203-212页

作者： Qing Wu li He Zhong Wei Jiang Yang li Ting Ting Zhao Yu Han li Cheng Zhi Huang yuan fang li Key Laboratory of Luminescent and Real-Time Analytical Chemistry(Southwest University) Ministry of EducationSchool of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China College of Pharmaceutical Science Soiithiuest UniuersityChongqing 400715China College of Science Beihua UniversityJilin 132013China

Efficient removal of non-biodegradable and hazardous dyes from wastewater remains a hot research ***,a rationally designed a Cu(Ⅱ)-based metal–organic gel(Cu-MOG)with a nanoporous 3 D network structure prepared via a simple one-step mixing method was successfully employed for the removal of cationic *** Cu-MOG exhibited high efficiency,with an adsorption capacity of up to 650.32 mg/g,and rapid adsorption efficiency,with the ability to adsorb 80%of Neutral Red within 1 *** high adsorption efficiency was attributed to its large specific surface area,which enabled it to massively bind cationic dyes through electrostatic interaction,and a nanoporous structure that promoted intra-pore ***,the Cu-MOG displayed size-selective adsorption,based on adsorption studies concerning dyes of different sizes as calculated by density functional ***,the adsorption performance of the Cu-MOG still maintained removal efficiency of 100%after three regeneration *** results suggested that the Cu-MOG could be expected to be a promising and competitive candidate to conveniently process wastewater.

关键词： Cu(Ⅱ)-based metal–organic gel Electrostatic interaction Intraporous diffusion Dyes removal Size selective

Determination of Chlorine in Human Urine by Detecting Backscattering Signals with a New Optical Assembly

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Chinese Chemical Letters 2006年第5期17卷 679-682页

作者： Ke Jun TAN yuan fang li Cheng Zhi HUANG Xue lian liU College of Chemistry and Chemical Engineering Southwest University Chongqing 400715

Detection of backscattering signals （BSS） generally suffers from the interference of reflected light, and it is hard to apply these signals for analytical purpose. Herein we provided an optical assembly, which effectively eliminated the interference of reflected light so that the scattering signals of analyte could be measured distinctly. With this assembly, chlorine in human urine could be detected with the limit of detection （LOD） of 2.0 ng/mL by measuring the enhanced BSS signals produced between the interactions of chlorine with silver nitrate.

关键词： Chlorine urine backscattering signals.

Successful treatment of an enormous rectal mucosa-associated lymphoid tissue lymphoma by endoscopic full-thickness resection:A case report

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World Journal of Gastroenterology 2022年第10期28卷 1078-1084页

作者： fang-yuan li Xiao-Long Zhang Qi-De Zhang Yao-Hui Wang Digestive Endoscopy Center Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of TCMNanjing 210046Jiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of TCMNanjing 210046Jiangsu ProvinceChina

BACKGROUND Colorectal mucosa-associated lymphoid tissue lymphoma(MALToma),a rare kind of nongastric MALToma,lacks consensus on its endoscopic features and standard *** to previous studies on the clinical characteristics and outcomes of colorectal MALToma,endoscopic resection remains a good therapeutic *** SUMMARY A 71-year-old woman suffered intermittent hematochezia for 1 mo,accompanied with abdominal pains but without weight loss,fever,chills or *** showed a massive hemispheric mass with rough and hyperemic mucosa in the lower ***-band imaging magnifying endoscopy detected some branching abnormal blood vessels and disappearance of glandular structure,which was similar with the tree-like appearance sign in gastric *** ultrasonography revealed the lesion to be hypoechoic,boundary-defined,and echo uniform inside,originating from the muscularis *** enhanced computed tomography(CT)demonstrated a soft tissue mass with defined *** enlarged superficial lymph nodes were detected by B-mode ultrasound.C13-urea breath test and serum Helicobacter pylori antibody were both *** patient underwent endoscopic full-thickness *** pathological analysis indicated colorectal *** patient remained asymptomatic after discharge,and follow-up positron emission tomography–CT and colonoscopy showed no residual lesion,remnants or lymph node *** This case provides new information on the specific endoscopic features of colorectal MALToma and an alternative treatment for patients.

关键词： Mucosa-associated lymphoid tissue lymphoma Endoscopic full-thickness resection Endoscopic minimally invasive surgery Endoscopy Case report

Normal carcinoembryonic antigen indicates benefit from perioperative chemotherapy to gastric carcinoma patients

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World Journal of Gastroenterology 2012年第29期18卷 3910-3916页

作者： Shi Chen Ying-Bo Chen yuan-fang li Xing-Yu Feng Zhi-Wei Zhou Xiu-Hong yuan Chao-Nan Qian State Key Laboratory of Oncology in South China Sun Yat-sen Univer- sity Cancer Center Guangzhou 510060 Guangdong Province China

AIM:To evaluate pretreatment serum carcinoembryonic antigen(CEA) as a predictor of survival for patients with locally advanced gastric cancer receiving perioperative ***:We retrospectively studied a cohort of 228 gastric cancer patients who underwent D2 gastrectomy combined with chemotherapy at the Sun Yat-sen University Cancer Center between January 2005 and December *** them,168 patients received 6-12 cycles of oxaliplatin-based adjuvant(post-operative) chemotherapy,while 60 received perioperative chemotherapy(2 cycles of FOLFOX6 or XELOX before surgery and 4-10 cycles after surgery).Serum CEA was measured using an enzyme *** followup lasted until December ***:In the group that had elevated serum CEA,the difference in survival time between patients receiving perioperative chemotherapy and those receiving adjuvant chemotherapy had no statistical significance(P > 0.05).However,in the group that had normal serum CEA,patients receiving perioperative chemotherapy had a longer survival *** multivariate analysis,T staging and lymph node metastatic rate were independent prognostic factors for the *** chemotherapy improved the overall survival of patients who had a normal pretreatment CEA level(P = 0.070).CONCLUSION:Normal pretreatment serum CEA is a predictor of survival for patients receiving perioperative chemotherapy.

关键词： Carcinoembryonic antigen Perioperative chemotherapy Prognosis Gastric adenocarcinoma Survival

A Dietary Source of High Level of Fluoroquinolone Tolerance in mcr-Carrying Gram-Negative Bacteria

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Research 2024年第3期2023卷 105-121页

作者： Tianqi Xu Dan fang Fulei li Zhiqiang Wang yuan liu Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses College of Veterinary MedicineYangzhou UniversityYangzhou 225009China. Joint International Research Laboratory of Agriculture and Agri-Product Safety the Ministry of Education of ChinaYangzhou UniversityYangzhou 225009China. Institute of Comparative Medicine Yangzhou UniversityYangzhou 225009China.

The emergence of antibiotic tolerance,characterized by the prolonged survival of bacteria following antibiotic exposure,in natural bacterial populations,especially in pathogens carrying antibiotic resistance genes,has been an increasing threat to public ***,the major causes contributing to the formation of antibiotic tolerance and underlying molecular mechanisms are yet poorly ***,we show that potassium sorbate(PS),a widely used food additive,triggers a high level of fluoroquinolone tolerance in bacteria carrying mobile colistin resistance gene *** studies demonstrate that PS treatment results in the accumulation of intracellular fumarate,which activates bacterial two-component system and decreases the expression level of outer membrane protein OmpF,thereby reducing the uptake of *** addition,the supplementation of PS inhibits aerobic respiration,reduces reactive oxygen species production and alleviates DNA damage caused by bactericidal ***,we demonstrate that succinate,an intermediate product of the tricarboxylic acid cycle,overcomes PS-mediated ciprofloxacin *** multiple animal models,ciprofloxacin treatment displays failure outcomes in PS preadministrated animals,including comparable survival and bacterial loads with the vehicle *** together,our works offer novel mechanistic insights into the development of antibiotic tolerance and uncover potential risks associated with PS use.

关键词： overcome thereby additive

Plasmonic locator with sub-diffraction-limited resolution for continuously accurate positioning

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Aggregate

Aggregate 2022年第2期3卷 154-161页

作者： Peng Fei Gao Hong Yan Zou Ming Xuan Gao yuan fang li Cheng Zhi Huang Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University) Ministry of EducationCollege of Pharmaceutical SciencesSouthwest UniversityChongqing 400715China College of Chemistry and Chemical Engineering Southwest UniversityChongqing 400715China

Both the accurate distance measurement and positioning information at the nanoscale are important for the analysis of micro/nano *** ruler has been an indispensable optical tool to detect the chemical and biological dynamic processes via distance-dependent plasmon coupling in the nearly aggregated *** it cannot disclose the detailed and accurate information of positions and dynamic movements of its two plasmonic components owing to the inherent diffraction ***,a plasmonic locator is presented which consists of a heterotypic pair of red/blue plasmonic components with significant wavelength difference(∼150 nm).Attributed to the detuned energy(∼0.64 eV)of the two components,the plasmonic locator has the ability of sub-diffraction-limited resolution(center to center,30 nm)and accurate positioning under conventional dark-field microscopy,making the relative dynamic information of nearby red/blue components be recorded accurately at video *** an important complement to the current aggregate science and technology of plasmonics,this newly developed plasmonic locator presents a facile means to realize super-resolution imaging,accurate positioning,and continuous tracing in chemical and biological interactions at the single-molecule level.

关键词： accurate positioning dark-field microscopy image reconstruction plasmonic locator sub-diffractionlimited resolution