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Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： wei Zhang Yubao Lu Ruoqi Shen Yingjie wu Chenrui Liu Xingxing fang Liangming Zhang Bin Liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

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A New Statistic for Variable Selection in Questionnaire Analysis

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Journal of Systems Science and Systems Engineering 2001年第3期13卷 315-322页

作者： ZHANG Jun-hua, fang wei-wu Institute of Applied Mathematics, Academy of Mathematics and System Sciences, Chinese Academy of Sciences, Beijing 100080, China Institute of Applied Mathematics Academy of Mathematics and System Sciences Chinese Academy of Sciences Beijing 100080 China

In this paper, a new statistic is proposed for variable selection which is one of the important problems in analysis of questionnaire data. Contrasting to other methods, the approach introduced here can be used not on... 详细信息

关键词： questionnaire variable selection information divergence statistic

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基于全蛋白质组的微生物系统发育树构建

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大连理工大学学报 2005年第6期45卷 925-930页

作者：张文唐焕文方伟武蔡旭张伟伟大连理工大学计算生物学和生物信息学研究所辽宁大连116024 中国科学院应用数学研究所北京100080

新近出现的信息离散性度量方法(简称FDOD方法)已在多个领域获得成功的应用,是一种非比对距离方法.随着越来越多的微生物全基因组测序任务的完成,人们开始在整个基因组水平上探讨物种的系统发育关系.因此,将FDOD方法应用于微生物系统发... 详细信息

新近出现的信息离散性度量方法(简称FDOD方法)已在多个领域获得成功的应用,是一种非比对距离方法.随着越来越多的微生物全基因组测序任务的完成,人们开始在整个基因组水平上探讨物种的系统发育关系.因此,将FDOD方法应用于微生物系统发育分析是一项很有意义的工作.因为氨基酸序列比DNA序列更为保守,能为物种的进化分析提供更为有用的信息.对收集到的163个原核生物和5个真核生物,从完全蛋白质组出发去分析推断其系统的发育关系,所得的系统发育树包括145个细菌、18个古细菌和5个真核细菌,这与三界进化理论符合,大部分低层分支与权威的《伯杰氏系统细菌学手册》相同.并且对高层分支关系提出了一些新建议.

关键词：微生物原核生物古细菌系统发育信息离散性度量

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Epidemiological survey of cystic echinococcosis in southwest China:From the Qinghai-Tibet plateau to the area of Yunnan

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World Journal of Hepatology 2024年第2期16卷 229-240页

作者： Jin-Rong Zi Dan Xiao Jia Peng fang-wei wu Jian-Xiong Li Xin-Liu Yan Zheng-Qing Wang Xuan Cai Qian Xu Ben-Fu Li Ya-Ming Yang Yunnan Provincial Center of Malaria Research Yunnan Institute of Parasitic DiseasesPuer 665000Yunnan ProvinceChina Yunnan Institute of Parasitic Diseases Yunnan Institute of Parasitic DiseasesPuer 665000Yunnan ProvinceChina Tibet Center for Disease Control and Prevention Tibet Center for Disease Control and PreventionLhasa 85000Tibet Autonomous RegionChina Yunnan Provincial Center of Malaria Research Yunnan Institute of Parasitic DiseasesPuer 655000Yunnan ProvinceChina

BACKGROUND Echinococcosis is prevalent in 9 provinces in Western and Northern *** epidemiological survey of echinococcosis in 2012 and 2016 showed cases of echinococcosis in Yunnan *** To understand the spatial distribution and epidemiological characteristics of echinococcosis in Yunnan for the prevention and control of echinococcosis and to reduce the risk of infection in Yunnan *** Based on the China Information System for Disease Control and Prevention(CISDCP),echinococcosis cases reported from 36 hospitals and 34 Centers for Disease Control were investigated and epidemiologically analyzed from 2021 to *** exclusion criteria included suspected cases,same case only counted once and cases not from Yunnan.A total of 705 cases were investigated,of which 397 cases were suitable for statistical *** these 397 cases,epidemiological investigation was tracked in 187 *** data were inputted using double entry in the Excel database,with error correction by double-entry *** data on echinococcosis cases in Yunnan Province were analyzed by ArcGIS 10.1 software to generate a density map of echinococcosis *** statistical analyses were conducted using SPSS 17.0,including the chi-square test,linear regression test and logistic univariate and multivariate regression *** A total of 397 cases were found in 89 counties in Yunnan *** number of cases in the top three prefectures were Dali(38.1%),Diqing(10.1%),and Kunming(8.3%),and the top five counties were Jianchuan(9.1%),Shangri La(8.3%),Eryuan(7.6%),Heqing(6.9%),and Dali Districts(5.0%).There were significant differences between the different *** case reporting rate by CISDCP(33.8%)was low;the first case was reported by CISDCP in 2002,and the highest number of cases was 50(2017).Confirmed and clinical cases accounted for 62.5%and 37.5%,***,90.9%of the cases of hydatid disease were reported by the hospital system,and only 9

关键词： Echinococcosis Cases Epidemiological analysis Yunnan province

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“手—眼”式多关节机器人视觉控制方法的研究

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哈尔滨工业大学学报 1989年第4期21卷 93-99页

作者：李严范伟吴林哈尔滨工业大学焊接教研室

本文提出了一个适用于多关节机器人用的视觉系统.同时对基本的视觉控制方法进行了研究与分析.这项研究使机器人可以根据视觉控制获得的信息进行工作.比示教再现方式具有更多的优越性.可以进行平板焊缝轨迹的自动识别及零件的识别与分类.

关键词：机器人手眼式多关节视觉控制法

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Critical care pharmacist reducing antimicrobial dosing errors for critically ill patients receiving continuous renal replacement therapy

Critical care pharmacist reducing antimicrobial dosing error...

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2013年浙江省医院药学学术年会

作者： Sai-Ping Jiang wei-fang wu Xing-Guo Zhang Xiao-Yang Lu Department of Pharmacy the First Affiliated HospitalCollege of MedicineZhejiang University Intensive Care Unit the First Affiliated HospitalCollege of MedicineZhejiang University

Objective:Appropriate antimicrobials dosing adjustment for critically illness patients receiving continuous renal replacement therapy(CRRT) is *** study aimed to evaluate the effect of critical care pharmacist antimicrobials dosing adjustment on reducing antimicrobials dosing errors(ADEs). Methods:A single-centered,two-phased(pre-/post-intervention) design was performed in an intensive care unit(ICU) of a university-affiliated *** illness patients receiving CRRT in the postintervention phase received antimicrobials dosing adjustment service from clinical pharmacists,whereas patients in the pre-intervention phase received routine medical care without involving *** two phases were compared to evaluate the outcomes of pharmacist ***:Pharmacists made 269 antimicrobial dosing adjustment interventions for 123 admitted patients receiving CRRT,238(88.48%) interventions were accepted by *** in CRRT-related variables(188,69.89%) were the most common risk factors for dosing errors,whereas(3—lactams(139,51.67%) were the most common antimicrobial associated with dosing *** dosing adjustment resulted in incidence of ADEs reduced from 230.35 per 1000 patient-days to 58.10 per 1000 patient-days(P <0.001).ADEs for patients receiving CRRT can be categorized as eight types which were from type A to type H,ADEs per 1000 patient-days from type A to type H were also remarkably decreased after pharmacist dosing adjustment(P < 0.001).Conclusions:The involvement of pharmacist antimicrobials dosing adjustment for critically ill patients receiving CRRT is associated with significantly reducing of *** may consider employing ICU clinical pharmacists.

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Self-Organizing Approach for Finding Borders of DNA Coding Regions

Self-Organizing Approach for Finding Borders of DNA Coding R...

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CCAST“复杂性问题”研讨会

作者： fang wu and wei-Mou Zheng Institute of Theoretical Physics, Academia Sinica, Beijing 100080, China

＜正＞ Motivation: A good estimation of the borders of coding regions by a composition based algorithm will help signal-based algorithms to refine the annotation. The entropic segmentation approach has its limitations. A sell-organizing approach is proposed based on the model of codon usage for coding regions and positional preference for noncoding regions. Results: The symmetry between the direct together with reverse coding regions and phaseshifting are adopted for both reducing the number of parameters to as few as 63+3 and uniquely inferring noncoding regions and the 6 phases of coding regions. Without requiring prior training, parameters can be estimated by iteration. A multi-sampling technique from sliding windows is used to select segments with high confidence, which can provide a training set for other sophisticated algorithms. A mixed-window model is then used to find borders between the accurately inferred segments. Contact: zheng@***

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含叶酸功能端基Pluronic F127的合成及其在水中的形态

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化学学报 2008年第1期66卷 138-140页

作者：邵芳可吴唯查刘生张琰超细材料制备与应用教育部重点实验室华东理工大学材料科学与工程学院上海200237 东华大学分析测试中心上海200051

将三嵌段共聚物Pluronic F127依次与对甲苯磺酰氯、邻苯二甲酰亚胺化钾及乙二胺反应,使端羟基转化为端氨基,然后与具有生物活性的大分子叶酸反应,使其作为靶向配体接到F127的端基上.利用1HNMR和IR对叶酸封端的F127嵌段共聚物(F127-fola... 详细信息

将三嵌段共聚物Pluronic F127依次与对甲苯磺酰氯、邻苯二甲酰亚胺化钾及乙二胺反应,使端羟基转化为端氨基,然后与具有生物活性的大分子叶酸反应,使其作为靶向配体接到F127的端基上.利用1HNMR和IR对叶酸封端的F127嵌段共聚物(F127-folate)的结构进行了表征.用透析法制备胶束溶液,利用TEM研究了F127-folate在水溶液中的形态,结果表明F127-folate在水溶液中形成了胶束结构.

关键词： Pluronic F127 叶酸胶束

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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng wei Tan Xingxing Chen Shuyuan Bai Qiong wu Yushan Chen Zhen wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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A mild, configurable, flexible CoNi-LDH（v）/Zn battery based on H-vacancy-induced reversible Zn2+ intercalation

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Journal of Energy Chemistry 2025年第1期100卷 498-508页

作者： Xinyue Cheng Dingsheng wu Hao Gao Qingqing Wang Pengfei Lv Sam S.Yoon Qufu wei Key Laboratory of Eco-textiles Ministry of Education Jiangnan University School of Mechanical Engineering Korea University

Flexible Zn-based batteries have attracted increasing research interest as essential components of wearable energy storage ***,the advancement of flexible aqueous Zn-based batteries based on Co-Ni layered double hydroxide （CoNi-LDH） as the cathode material is hampered by their poor cycling stability and the corrosiveness of alkaline ***,CoNi-LDH nanosheets enriched with H vacancies (CoNi-LDH（v）) were constructed on a flexible carbon cloth （CC） substrate via electrochemical deposition and *** Zn-based battery comprising CoNi-LDH（v）@CC as the cathode exhibited highly reversible conversion reactions and stable operation in 3 M ZnSO4electrolyte （pH=4）.The battery delivered an excellent specific capacity (225 mA h g-1,0.26 mA h cm-2),acceptable cycling stability（53.9%,900 cycles）,and high discharging *** abundant H vacancies served as active sites for the reversible intercalation of Zn2+and the extravasation of NO3-generated channels and space for Zn2+transport and storage,together enabling an excellent Zn2+storage ***,a sandwich-structured solid-state CoNi-LDH（v）@CC//Zn@CC battery was fabricated and was found to exhibit a noteworthy electrochemical performance and mechanical *** a proof of concept,the unencapsulated battery powered a digital watch under various deformation conditions and operated stably for 80 ***,the flexible battery displayed outstanding customizability,maintaining an open-circuit voltage of 1.42 V even after being cut *** proposed engineering strategy contributes to the realization of textiles with truly wearable energy-storage devices.

关键词： CoNi/Zn battery H vacancies Mild aqueous electrolyte Tailorable battery Wearable energy storage device

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