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Lactonization of dyes promoted by a coordination cage facilitates cavity-induced chromism as ion mobile detector

Science China Chemistry 2024年第5期67卷 1554-1560页

作者： Liangliang zhang Yu Liang Zhifeng Xiao Yuxuan Meng Jinyi Huang Xi Lin Ji Li Hong-Cai Zhou Yu fang Strait Institute of Flexible Electronics(SIFE Future Technologies)Fujian Normal University and Strait Laboratory of Flexible Electronics(SLoFE)Fuzhou 350017China State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Department of Chemistry Texas A&M UniversityCollege StationTexas 77842-3012USA State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Frontiers Science Center for Flexible Electronics(FSCFE) MIIT Key Laboratory of Flexible Electronics(KLoFE)Northwestern Polytechnical UniversityXi’an 710072China

Dye molecules often change colors(so-called “chromism”) according to the environment variation. However, they are rarely induced by a catalytic amount of cavity. Through encapsulation in the cavity of a porous coordination cage(PCC-2), Rhodamine B(1) is transformed from red quinonoid form(1q) into colorless lactone form(1l) in aprotic polar solutions. The μ4-OH groups in the cavity of PCC-2 are shown to stabilize the uncommon zwitterion intermediate(1z), followed by converting to 1l, thus accelerating the equilibrium. The chromism is catalyzed by 0.25 mol% of PCC-2, and the reaction rate is improved by 80,400times. 1@PCC-2 can be further fabricated to a sol-gel that exhibits ion recognition properties. The resulting encapsulation and stabilization of an unconventional intermediate by a catalytic amount of the coordination cage provides fundamental insights into molecular isomerization and has potential use in chemical sensing.

关键词： porous coordination cage Zwitterion intermediate cavity Rhodamine B chromism

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Run-and-Tumble Dynamics and Mechanotaxis Discovered in Microglial Migration

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Research 2024年第2期2023卷 95-103页

作者： Yiyu zhang Da Wei Xiaochen Wang Boyi Wang Ming Li Haiping fang Yi Peng Qihui Fan fangfu Ye Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical sciences University of Chinese Academy of SciencesBeijing 100049China Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejang 325000China Songshan Lake Materials Laboratory DongguanGuangdong 523808China School of Science East China University of Science and TechnologyShanghai 200237China Oujang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)WenzhouZhejiang 325000China

Microglia are resident macrophage cells in the central nervous system that search for pathogens or abnormal neural activities and migrate to resolve the *** effective search and targeted motion of macrophages mean dearly to maintaining a healthy brain,yet little is known about their migration *** this work,we study microglial motion with and without the presence of external *** discover that the cells are promptly attracted by the applied forces(i.e.,mechanotaxis),which is a tactic behavior as yet unconfirmed in ***,in both the explorative and the targeted migration,microglia display dynamics that is strikingly analogous to bacterial run-and-tumble motion.A closer examination reveals that microglial run-and-tumble is more sophisticated,e.g.,they display a short-term memory when tumbling and rely on active steering during runs to achieve mechanotaxis,probably via the responses of mechanosensitive ion *** differences reflect the sharp contrast between microglia and bacteria cells(eukaryotes ***)and their environments(compact tissue ***).Further analyses suggest that the reported migration dynamics has an optimal search efficiency and is shared among a subset of immune cells(human monocyte and macrophage).This work reveals a fruitful analogy between the locomotion of 2 remote systems and provides a framework for studying immune cells exploring complex environments.

关键词： analogy closer prompt

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The manipulation of rectifying contact of Co and nitrogen-doped carbon hierarchical superstructures toward high-performance oxygen reduction reaction

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Carbon Energy 2024年第9期6卷 338-349页

作者： Jing Li Tingyu Lu Yu fang Guangyao Zhou Mingyi zhang Huan Pang Jun Yang Yawen Tang Lin Xu Jiangsu Key Laboratory of New Power Batteries School of Chemistry and Materials ScienceJiangsu Collaborative Innovation Center of Biomedical Functional MaterialsNanjing Normal UniversityNanjingJiangsuChina College of Science Jinling Institute of TechnologyNanjingJiangsuChina Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of EducationSchool of Physics and Electronic EngineeringHarbin Normal UniversityHarbinHeilongjiangChina School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhouJiangsuChina State Key Laboratory of Multiphase Complex Systems Center of MesoscienceInstitute of Process EngineeringChinese Academy of SciencesBeijingChina

Rational design and construction of oxygen reduction reaction(ORR)electrocatalysts with high activity,good stability,and low price are essential for the practical applications of renewable energy conversion devices,such as metal-air *** modification through constructing metal/semiconductor Schottky heterointerface represents a powerful strategy to enhance the electrochemical ***,we demonstrate a concept of Schottky electrocatalyst composed of uniform Co nanoparticles in situ anchored on the carbon nanotubes aligned on the carbon nanosheets(denoted as Co@N-CNTs/NSs hereafter)toward *** experimental findings and theoretical simulation testify that the rectifying contact could impel the voluntary electron flow from Co to N-CNTs/NSs and create an internal electric field,thereby boosting the electron transfer rate and improving the intrinsic *** a consequence,the Co@N-CNTs/NSs deliver outstanding ORR activity,impressive long-term durability,excellent methanol tolerance,and good performance as the air-cathode in the Zn-air *** design concept of Schottky contact may provide the innovational inspirations for the synthesis of advanced catalysts in sustainable energy conversion fields.

关键词： Co-based electrocatalysts oxygen reduction reaction rectifying contact Zn-air batteries

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Interpretation of the Standards of Basic Dataset of Chronic Diseases Behavior Risk Factor Surveillance in Adults

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Biomedical and Environmental sciences 2024年第5期37卷 551-556页

作者： ZHAO Yan fang zhang Mei WEI Wen Qiang SUN Ke Xin LI Xin Hua WANG Li Min National Center for Chronic and Noncommunicable Disease Control and Prevention(NCNCD) Chinese Center for Disease Control and PreventionBeijing 100050China Cancer Hospital Chinese Academy of Medical SciencesBeijing 100021China Chinese Center for Disease Control and Prevention Beijing 102206China People's Medical Publishing House Beijing 100021China

BACKGROUND China’s Behavioral Risk Factor Surveillance System(BRFSS)originated from the World Bankfunded HealthⅦLoan Project in the 1990s,which conducted behavioral risk factor surveillance in seven cities and one province^([1]).Drawing on the World Health Organization’s(WHO)STEPwise approach to surveillance(STEPs)and the *** Risk Factor Surveillance System(BRFSS)^([2,3]).

关键词： funded Basic originated

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Two ABCI family transporters,OsABCI15 and OsABCI16,are involved in grain-filling in rice

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Journal of Genetics and Genomics 2024年第5期51卷 492-506页

作者： Bin Ma Xiubiao Cao Xiaoyuan Li Zhong Bian Qi-Qi zhang Zijun fang Jiyun Liu Qun Li Qiaoquan Liu Lin zhang Zuhua He Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding/Zhongshan Biological Breeding Laboratory/Key Laboratory of Plant Functional Genomics of the Ministry of Education/Jiangsu Key Laboratory of Crop Genetics and Physiology Agricultural College of Yangzhou UniversityYangzhouJiangsu 225009China Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops Jiangsu Key Laboratory of Crop Genetics and PhysiologyYangzhou UniversityYangzhouJiangsu 225009China National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology&EcologyChinese Academy of SciencesShanghai 200032China Institute of Biotechnology Hangzhou Academy of Agricultural SciencesHangzhouZhejiang 310024China Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education Yangzhou UniversityYangzhouJiangsu 225009China

Seed development is critical for plant reproduction and crop yield,with panicle seed-setting rate,grain-filling,and grain weight being key seed characteristics for yield ***,few genes are known to regulate grain ***,we identify two adenosine triphosphate(ATP)-binding cassette(ABC)I-type transporter genes,OsABCI15 and OsABCI16,involved in rice *** genes are highly expressed in developing seeds,and their proteins are localized to the plasma membrane and ***,knockout of OsABCI15 and OsABCI16 results in a significant reduction in seed-setting rate,caused predominantly by the severe empty pericarp phenotype,which differs from the previously reported low seed-setting phenotype resulting from failed *** analysis indicates that OsABCI15 and OsABCI16 participate in ion homeostasis and likely export ions between filial tissues and maternal tissues during grain ***,overexpression of OsABCI15 and OsABCI16 enhances the seed-setting rate and grain yield in transgenic plants and decreases ion accumulation in brown ***,the OsABCI15/16 orthologues in maize exhibit a similar role in kernel development,as demonstrated by their disruption in transgenic ***,ourﬁndings reveal the important roles of two ABC transporters in cereal grain filling,highlighting their value in crop yield improvement.

关键词： ABC transporters Rice Grain filling Ion homeostasis Grain yield

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Droplet Laplace valve-enabled glaucoma implant for intraocular pressure management

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Droplet 2024年第2期3卷 125-137页

作者： Yuyang Wang Zecong fang Sen Li Kexin Lin Zhifeng zhang Junyi Chen Tingrui Pan Center for Intelligent Medical Equipment and Devices(iMED) Institute for Innovative Medical DevicesUniversity of Science and Technology of ChinaHefeiChina Suzhou Institute for Advanced Research University of Science and Technology of ChinaSuzhouChina Department of Precision Machinery and Precision Instrumentation University of Science and Technology of ChinaHefeiChina Bionic Sensing and Intelligence Center(BSIC) Institute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenChina School of Engineering Hangzhou Normal UniversityHangzhouChina School of Biomedical Engineering Division of Life Science and MedicineUniversity of Science and Technology of ChinaHefeiChina Engineering Science and Mechanics Department Penn State UniversityUniversity ParkPennsylvaniaUSA Department of Ophthalmology and Visual Science Eye and ENT HospitalShanghai Medical CollegeFudan UniversityShanghaiChina NHC Key Laboratory of Myopia Chinese Academy of Medical Sciences and Shanghai Key Laboratory of Visual Impairment and Restoration(Fudan University)ShanghaiChina

Glaucoma,the leading cause of irreversible blindness worldwide,is closely linked to aqueous overaccumulation and elevated intraocular pressure(IOP).For refractory glaucoma,aqueous shunts with valves are commonly implanted for effective aqueous drainage control and IOP ***,existing valved glaucoma implants have the disadvantages of inconsistent valve opening/closing pressures,poor long-term repeatability due to their reliance on moving parts,and complex architectures and fabrication ***,we propose a novel valving concept,the droplet Laplace valve(DLV),a three-dimensional printable moving-parts-free microvalve with customizable and consistent threshold valving *** DLV uses a flow discretization unit governed by capillarity,comprising a droplet-forming nozzle,and a separated reservoir to digitize continuous flow into quantifiable *** the classic one-time-use Laplace valves,the DLV's unique design allows for its *** opening pressure is adjustable by varying the nozzle size,like the classic Laplace valves(following the Young–Laplace equation),while the closing pressure can be modified by tuning the separation distance and the reservoir *** DLVs with customizable opening pressures from 5 to 11 mmHg have been demonstrated,with opening/closing pressure differences suppressed down to0.99).Preliminary ex vivo validation in an enucleated porcine eye confirms the DLV's efficiency in aqueous shunting and prompt IOP *** DLV technology holds great promise in glaucoma implants for IOP management and various microsystems for flow control.

关键词： holds irreversible inconsistent

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Metabolomic profiling reveals decreased serum cysteine levels during gestational diabetes mellitus progression

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Journal of Molecular Cell Biology 2024年第3期16卷 35-45页

作者： Mengyu Lai Jiaomeng Li Jiaying Yang Qingli zhang Yujia Gong Yuhang Ma fang fang Na Li Yingxiang Zhai Tingting Shen Yongde Peng Jia Liu Yufan Wang Department of Endocrinology and Metabolism Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China School of Pharmacy Henan UniversityKaifeng 475004China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310058China

Gestational diabetes mellitus(GDM)is a pregnancy-related metabolic disorder associated with short-term and long-term adverse health outcomes,but its pathogenesis has not been clearly *** of the dynamic changes in metabolomic markers in different trimesters may reveal the underlying pathophysiology of GDM ***,in the present study,we analysed the metabolic profiles of 75 women with GDM and 75 women with normal glucose tolerance throughout the three *** found that the variation trends of 38 metabolites were significantly changed during GDM ***,longitudinal analyses revealed that cysteine(Cys)levels significantly decreased over the course of GDM *** study showed that Cys alleviated GDM in female mice at gestational day 14.5,possibly by inhibiting phosphoenolpyruvate carboxykinase to suppress hepatic *** together,these findings suggest that the Cys metabolism pathway might play a crucial role in GDM and Cys supplementation represents a potential new treatment strategy for GDM patients.

关键词： gestational diabetes mellitus metabolomics cysteine

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Elevated nitrogen and co-evolution history with competitors shape the invasion process of Galinsoga quadriradiata

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Journal of Plant Ecology 2024年第4期17卷 9-22页

作者： Wen-Gang zhang Xing-Jiang Song Laís Petri Gang Liu Xiao-Yan Chen Rui-Ling Liu fang-fang Huang Jia-Bin Zou Zhi-Hong Zhu College of life sciences Shaanxi Normal UniversityXi’an 710119China School for Environment and Sustainability University of MichiganAnn ArborMI 48109USA Research Center for UAV Remote Sensing Shaanxi Normal UniversityXi’an 710119China Changqing Teaching&Research Base of Ecology Shaanxi Normal UniversityXi’an 710119China Guangdong Provincial Key Laboratory of Silviculture Protection and UtilizationGuangdong Academy of ForestryGuangzhou 510520China

Invasive plants usually experience population differentiation as they expand from their initial invasive range to the ***,invasive plants usually encounter competitors which shared different co-evolutionary histories with *** factors may lead to varying responses of invasive plant populations to elevated nitrogen deposition during ***,this issue has received limited attention in prior *** address these challenges,we conducted a greenhouse experiment to investigate how population differentiation of Galinsoga quadriradiata interacts with the presence of various competitors in response to increased nitrogen *** types(new or old that shared short or long co-evolutionary history with the invader,respectively)were set to compete with the invasive central and edge populations under different nitrogen addition *** from the central population of ***,originating from the initial invasion range,showed greater total mass,reproduction and interspecific competitiveness compared with the edge *** addition improved growth and reproductive performance in both populations,and the central population had a stronger response compared with the edge *** performance of *** was inhibited more effectively by old competitors than new *** results indicate that population differentiation occurs in terms of growth and competitiveness during the range expansion of ***,with the central population exhibiting superior ***-evolutionary history with competitors is considered unfavorable for invasive plants in this *** results highlight the combined effects of population differentiation in invasive species and their co-evolution history with competitors in the context of global change factors.

关键词： Galinsoga quadriradiata central population edge population interspecific competition population differentiation elevated nitrogen

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Probing the Galactic Halo with RR Lyrae *** Radial Velocity Curve Templates of RRc Stars

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Research in Astronomy and Astrophysics 2024年第7期24卷 118-134页

作者： Yue Huang Min fang Gaochao Liu Xianzhong Zheng Sarah Ann Bird Yang Huang Jianrong Shi Jiangtao Wang Huawei zhang Haijun Tian Haotong zhang College of Science China Three Gorges UniversityYichang 443002China Center for Astronomy and Space sciences China Three Gorges UniversityYichang 443002China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesBeijing 100101China Department of Astronomy School of PhysicsPeking UniversityBeijing 100871China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China School of sciences Hangzhou Dianzi UniversityHangzhou 310018China

We present radial velocity(RV)curve templates of RR Lyrae first-overtone(RRc)stars constructed with the Mg I b triplet and Hαlines using time-domain Medium-Resolution Survey spectra of seven RRc stars from Large Sky Area Multi-Object Fiber Spectroscopic Telescope(LAMOST)Data Release ***,we derive the relation between the stellar RV curve amplitudes and g-band light curve amplitudes from Zwicky Transient Facility(ZTF)public *** those RRc stars without ZTF g-band light curves,we provide the conversions from the light curve amplitudes in ZTF r-and i-bands,Gaia G-band,and V-band from the All-Sky Automated Survey for Supernovae to those in ZTF *** validate our RV curve templates using the RRc star SV Scl and find the uncertainties of systemic RV are less than 2.11 km s~(-1)and 6.08 km s~(-1)based on the Mg I b triplet and Hαlines,*** calculate the systemic RVs of 30 RRc stars using the RV curve templates constructed with the Mg I b triplet and Hαlines and find the systemic RVs are comparable with each *** RV curve template will be particularly useful for obtaining the systemic RV of RRc using the LAMOST spectroscopy.

关键词： stars variables RR Lyrae-Stars-techniques radial velocities

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Unveiling quality of clinical trial in China:from concern to confirmation

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Cancer Communications 2024年第5期44卷 576-579页

作者： Huiyao Huang Yiru Hou Hong fang Ling Xu Yue Yu Huifang zhang Jing zhang Yu Tang Gongtao Lan Wenbao zhang Ning Li Clinical Trials Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China School of Basic Medicine and Clinical Pharmacy China Pharmaceutical UniversityNanjingJiangsuP.R.China Department of Quality Medicine Boehringer Ingelheim(China)Investment Co LtdShanghaiP.R.China Department of Clinical Development Quality Pfizer Research and Development(China)BeijingP.R.China Department of Drug Registration National Medical Products AdministrationBeijingP.R.China Bureau of Medical Administration National Health CommissionBeijingP.R.China

The cornerstone of scientifically valid and ethically sound clinical trials is in compliance with established global quality *** China has made significant progress over the past 20 years in terms of the clinical trial quantity[1],quality and participation in multiregional trials[2],there still remain concerns regarding the trial quality,which could be associated with the self-inspection initiative in 2015[3].

关键词： clinical corners confirmation

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