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Relation of uric acid levels to aortic root dilatation in hypertensive patients with and without metabolic syndrome

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第8期11卷 592-598页

作者： Li-jiang TANG Jian-jun jiang xiao-feng CHEN Jian-an wang xian-fang LIN Yu-xi DU Cong-feng fang Zhao-xia PU Department of Cardiology Taizhou Hospital Wenzhou Medical College Taizhou 317000 China Department of Cardiology Hangzhou 310009 China Cardiovascular Key Lab of Zhejiang Province the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Department of Echocardiography Taizhou Hospital Wenzhou Medical College Taizhou 317000 China

Objective:Uric acid(UA) is considered to be a powerful predictor of cardiovascular risk and hyperuricemia might be involved in the metabolic syndrome(MS).This study aims to investigate the relation between UA levels and aortic root ***:A total of 348 hypertensive patients [age(67.5±9.8) years] with or without MS were included in the *** aortic root diameters at the aortic annulus,the sinuses of Valsalva,the sinotubular junction,and the proximal part of the ascending aorta were measured using a two-dimensional(2D) *** UA levels were also measured for all ***:A high UA level is independently associated with aortic root diameters at the sinuses of Valsalva(P=0.001) and the proximal ascending aorta(P<0.0001) in the hypertensive patients without *** contrast,aortic root diameters were not significantly related to UA levels in the hypertensive patients with ***,increased UA levels were associated with an increased risk for aortic root dilatation in the patients without MS(sex-adjusted hazard ratio 1.75,95% confidence intervals(CI) 1.27-2.41),but not in those with ***:This study demonstrated an independent relationship between the aortic root dimensions and increased levels of serum UA in the hypertensive patients without *** understanding of the mechanisms underlying these associations may allow a clearer interpretation of the potential value of specific urate-lowering treatment on cardiovascular disease.

关键词： Aortic root Uric acid Hypertension Metabolic syndrome

Stable Boron-Containing Blue-Photoluminescent Radicals

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Chinese Journal of Chemistry 2021年第5期39卷 1297-1302页

作者： Zhongtao feng Yuanyuan Chong Shuxuan Tang Huapeng Ruan yong fang Yue Zhao jun jiang xinping wang State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjingJiangsu 210093China Hefei National Laboratory for Physical Sciences at the Microscale CAS Center for Excellence in NanoscienceSchool of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefeiAnhui 230026China

It is highly urgent to develop synthetic strategies to make new category of stable luminescent radicals with desired emission *** this study,we have isolated two dioxoborocyclic radicals(3 and 4)by a direct synthetic *** were characterized by UV,EPR spectroscopy and SQUID *** structures were obtained by single-crystal X-ray *** radicals produce blue-photoluminescence(458 nm for 3 and 478 nm for 4)by radiative decay from higher excited states(D_(2)/D_(3))to the ground state(D_(0))based on theoretical calculation,breaking Kasha *** work records a new kind of radical emitters and the first stable radicals with blue emission bands.

关键词： Boron Borocyclic radical Radical emitter Blue-photoluminescence X-Ray structure

Facile and Cost-Efficient Synthesis of Photovoltaic Polymers via Direct Arylation Coupling

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Chinese Journal of Polymer Science 2023年第11期41卷 1663-1685,I0004页

作者： xiao-Chen wang Yuan Zhang Jia-xin Yang Jin-jun Shao Ming-feng wang yong-fang Li School of Materials Science and Engineering Shaanxi Normal UniversityXi'an 710119China Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) School of Flexible Electronics(Future Technologies)Nanjing Tech UniversityNanjing 211816China School of Science and Engineering The Chinese University of Hong KongShenzhen 518172China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China

As the high calibre candidate of lightweight and flexible solar cells,polymer solar cells(PSCs)have made tremendous progress in recent ***,the active photovoltaic materials in PSCs are mainly synthesized by metal-mediated coupling reaction requiring harsh reaction conditions,multiple-step synthesis,and cumbersome purification,which is not cost-efficient and may bring toxicity *** is not favorable to the production of photovoltaic polymers and PSC devices on a large scale,and therefore unsuitable for the PSCs *** arylation coupling reaction via aromatic C―H bonds activation enables the synthesis of conjugated polymers under mild conditions and simultaneously reduces synthetic steps,difficulty,and toxic reaction *** review provides an overview of the history of preparing representative photovoltaic polymers utilized in PSCs through direct arylation reactions and discusses the activity and selectivity of C―H bonds in typical building blocks under different reaction ***,the impact of direct arylation condition on defect formation and photovoltaic performance of the photovoltaic polymers is addressed and compared with conventional Stille coupling methods.

关键词： Photovoltaic polymers Direct arylation coupling C―H bonds activation Polymer solar cells(PSCs) Organic solar cells(OSCs) Low-cost

Protecting User Privacy in a Multi-Path Information-Centric Network Using Multiple Random-Caches

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Journal of Computer Science & Technology 2017年第3期32卷 585-598页

作者： Wei-Bo Chu Li-fang wang Ze-jun jiang Chin-Chen Chang School of Computer Science and Technology Northwestern Polytechnical University Xi'an 710072 China Department of Information Engineering and Computer Science Feng Chia University Taichung Taiwan 40724 China

In-network caching is a fundamental mechanism advocated by information-centric networks （ICNs） for efficient content delivery. However, this new mechanism also brings serious privacy risks due to cache snooping attacks. One effective solution to this problem is random-cache, where the cache in a router randomly mimics a cache hit or a cache miss for each content request/probe. In this paper, we investigate the effectiveness of using multiple random-caches to protect cache privacy in a multi-path ICN. We propose models for characterizing the privacy of multi-path ICNs with random-caches, and analyze two different attack scenarios： 1） prefix-based attacks and 2） suffix-based attacks. Both homogeneous and heterogeneous caches are considered. Our analysis shows that in a multi-path ICN an adversary can potentially gain more privacy information by adopting prefix-based attacks. Furthermore, heterogeneous caches provide much better privacy protection than homogeneous ones under both attacks. The effect of different parameters on the privacy of multi-path random-caches is further investigated, and the comparison with its single-path counterpart is carried out based on numerical evaluations. The analysis and results in this paper provide insights in designing and evaluating multi-path ICNs when we take privacy into consideration.

关键词： information-centric network (ICN) user privacy cache snooping random-cache multi-path

Germline mutational profile of Chinese patients under 70 years old with colorectal cancer

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Cancer Communications 2020年第11期40卷 620-632页

作者： Teng-Jia jiang fang wang Ying-Nan wang Jia-Jia Hu Pei-Rong Ding jun-Zhong Lin Zhi-Zhong Pan Gong Chen Jian-yong Shao Rui-hua Xu Qi Zhao feng wang State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineDepartment of OncologySun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Molecular Diagnosis Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Experimental Research Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Colorectal Surgery Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China

Background:Inherited susceptibility accounts for nearly one-third of colorectal cancer(CRC)predispositions and has an 80%-100%lifetime risk of this ***,there are few data about germline mutations of hereditary CRC-related genes in Chinese patients with *** study aimed to assess the prevalence of gene mutations related to cancer susceptibility among Chinese patients with CRC,differences between Chinese and Western patients,and the phenotypegenotype ***:We retrospectively collected tumor samples from 526 patients with CRC under 70 years old who underwent hereditary CRC genetic testing.A series of bioinformatic analyses,as well as statistical comparisons,were ***:We found that 77 patients(14.6%)harbored functional variants of the 12 *** mutation frequencies of the top 5 mutated genes were 6.5%for MutL homolog 1(MLH1),5.1%for MutS homolog 2(MSH2),1.0%for MSH6,0.8%for PMS1 homolog 2(PMS2),and 0.8%for APC regulator of the WNT signaling pathway(APC).Our data showed much higher rates of mutations of MSH6 and PMS2 genes among all mismatch repair(MMR)genes as compared with those in Western *** in MLH1,MSH2,and MSH6 were found to be mutually *** with MLH1 or MSH2 mutations had higher frequencies of personal history of cancer(MLH1:20.6%vs.8.7%;MSH2:25.9%vs.8.6%)and family history of cancer than those without these mutations(MLH1:73.5%vs.48.4%;MSH2:70.4%vs.48.9%),and the lesions were more prone to occur on the right side of the colon than on the left side(MLH1:73.5%vs.29.3%;MSH2:56.0%vs.31.0%).The proportion of stage I/II disease was higher in patients with MLH1 mutations than in those without MLH1 mutations(70.6%vs.50.7%),and the rate of polyps was higher in patients withAPC mutations than in those with wild-type APC(75.0%vs.17.4%).Conclusion:These results provide a full-scale landscape of hereditary susceptibility over 12 related genes in CRC patients and suggest that a comprehensive multi-ge

关键词： colorectal cancer genetic testing germline mutation hereditary CRC syndromes

Load Balance Strategy of Data Routing Algorithm Using Semantics for Deduplication Clusters

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Journal of Electronic Science and Technology 2017年第3期15卷 277-282页

作者： Ze-jun jiang Zhi-Ke Zhang Li-fang wang Chin-Chen Chang Li Liu School of Computer Science Northwestern Polytechnical University Xi'an 710072 IBM China Systems &Technology Lab Beijing 100193 Department of Information Engineering and Computer Science Feng Chia University Taichung 40724

The backup requirement of data centres is tremendous as the size of data created by human is massive and is increasing *** node deduplication cannot meet the increasing backup requirement of data centres.A feasible way is the deduplication cluster,which can meet it by adding storage *** data routing strategy is the key of the deduplication ***（data routing strategy using semantics） improves the storage utilization of MCS（minimum chunk signature） data routing strategy a ***,for the large deduplication cluster,the load balance of DRSS is worse than *** improve the load balance of DRSS,we propose a load balance strategy used for DRSS,namely *** a node is overloaded,DRSSLB iteratively migrates the current smallest container of the node to the smallest node in the deduplication cluster until this overloaded node becomes non-overloaded.A container is the minimum unit of data *** files sharing the same features or file names are stored in the same *** ensures the similar data groups are still in the same node after rebalancing the *** use the dataset from the real world to evaluate *** results show that,for various numbers of nodes of the deduplication cluster,the data skews of DRSSLB are under predefined value while the storage utilizations of DRSSLB do not nearly increase compared with DRSS,with the low penalty（the data migration rate is only6.5% when the number of nodes is 64）.

关键词： Index Terms--Data routing strategy deduplicationcluster semantics load balance.

Common mtDNA variations at C5178a and A249d/T6392C/G10310A decrease the risk of severe COVID-19 in a Han Chinese population from Central China

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Military Medical Research 2022年第1期9卷 53-62页

作者： Yi Wu xian-Hui wang xi-Hua Lif Li-Yuan Song Shi-Long Yu Zhi-Cheng fang Yu-Quan Liu Le-yong Yuan Chun-Yan Peng Shen-Yi Zhang wang Cheng Hong-Chao Ma Li-feng wang jun-Ming Tang Yun-Fu wang Fu-Yun Ji Department of Medical Biology School of Basic Medical ScienceHubei University of MedicineShiyan 442000HubeiChina Institute of Biomedical Research Hubei University of MedicineShiyan 442000HubeiChina Institute of Human Respiratory Disease Xinqiao HospitalThe Army Medical University(Third Military Medical University)400037 ChongqingChina Department of Emergency Medicine Taihe HospitalHubei University of MedicineShiyan 442000HubeiChina department of Geriatric Medicine Taihe HospitalHubei University of MedicineShiyan 442000HubeiChina Department of Immunology School of Basic Medical SciencesHubei University of MedicineShiyan 442000HubeiChina department of Laboratory Medicine Taihe HospitalHubei University of MedicineShiyan 442000HubeiChina Hubei Key Laboratory of Embryonic Stem Cell Research School of Basic Medical ScienceHubei University of MedicineShiyan 442000HubeiChina Department of Neurology Taihe HospitalHubei University of MedicineShiyan 442000HubeiChina.

Background:Mitochondria have been shown to play vital roles during severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection and coronavirus disease 2019(COVID-19)***,it is unclear whether mitochondrial DNA(mtDNA)variants,which define mtDNA haplogroups and determine oxidative phosphorylation performance and reactive oxygen species production,are associated with COVID-19 ***:A population-based case-control study was conducted to compare the distribution of mtDNA variations defining mtDNA haplogroups between healthy controls(n=615)and COVID-19 patients(n=536).COVID-19 patients were diagnosed based on molecular diagnostics of the viral genome by qPCR and chest X-ray or computed tomography *** exclusion criteria for the healthy controls were any history of disease in the month preceding the study *** variants defining mtDNA haplogroups were identified by PCR-RFLPs and HVS-I sequencing and determined based on mtDNA phylogenetic analysis using Mitomap ***’s t-test was used for continuous variables,and Pearson’s chi-squared test or Fisher’s exact test was used for categorical *** assess the independent effect of each mtDNA variant defining mtDNA haplogroups,multivariate logistic regression analyses were performed to calculate the odds ratios(OR)and 95%confidence intervals(CI)with adjustments for possible confounding factors of age,sex,smoking and diseases(including cardiopulmonary diseases,diabetes,obesity and hypertension)as determined through clinical and radiographic ***:Multivariate logistic regression analyses revealed that the most common investigated mtDNA variations(>10%in the control population)at C5178 a(in NADH dehydrogenase subunit 2 gene,ND2)and A249 d(in the displacement loop region,D-loop)/T6392 C(in cytochrome c oxidase I gene,CO1)/G10310 A(in ND3)were associated with a reduced risk of severe COVID-19(OR=0.590,95%CI 0.428–0.814,P=0.001;and OR=0.654,95%CI 0.45

关键词： Mitochondrial DNA variations Severe acute respiratory syndrome coronavirus 2 Coronavirus disease 2019 Risk Han Chinese

Acquired immune thrombotic thrombocytopenic purpura(TTP)associated with inactivated COVID-19 vaccine CoronaVac

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Frontiers of Medicine 2024年第4期18卷 744-751页

作者： Zhangbiao Long Suyu jiang Honglei xin Lu Zhang Ruinan Lu fengqi Liu yong Xu Linv wang jun wang Xuezhong Zhang Hui Liao Jinning Shi Xue Yan xiang Zhu Ruonan Shao Zijian Li Yilin Zhu Han Yan Jiao Wu Chao fang xiaodong xi xiaofeng Shi Department of Hematology The First Affiliated Hospital of Anhui Medical UniversityHefei230022China Department of Hematology The Second Affiliated Hospital of Nanjing Medical UniversityNanjing210003China Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing210029China Department of Hematology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing210008China Department of Hematology The Affiliated Hospital of Nanjing University of Chinese MedicineThe First Clinical Medical College of Nanjing University of Chinese MedicineNanjing210009China Department of Hematology Zhongda Hospital of Southeast UniversityNanjing210044China Department of Hematology Nanjing First HospitalNanjing Medical UniversityNanjing210006China Department of Hematology The Air Force Hospital of Eastern Theater commandNanjing210016China Department of Hematology Jiangning Hospital Affiliated of Nanjing Medical UniversityNanjing211199China Department of Hematology Nanjing Hospital of Chinese MedicineNanjing210006China Department of Pharmacology School of Basic MedicineTongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious DiseasesHuazhong University of Science and TechnologyThe Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei ProvinceWuhan430030China Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200025China

Corona virus disease 2019(COVID-19)due to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has affected the whole *** thrombotic thrombocytopenic purpura(TTP)has been reported after administration of mRNA-or adenoviral vector-based COVID-19 vaccines,including ***2-S,BNT162b2,mRNA-1273,and ChAdOx1 ***,whether inactivated vaccines,such as CoronaVac,could cause TTP and whether the symptoms in TTPs caused by inactivated vaccines are different from previously reported cases are *** this study,two cases were *** cases developed TTP after the second CoronaVac vaccination shot,but not the *** demonstrated symptoms of fever,neurological abnormalities,renal dysfunction,thrombocytopenia,and *** patients achieved complete remission through several sessions of plasma exchanges and immune *** incidence of TTP in Nanjing area was *** number of patients with TTP was 12 in 2019,6 in 2020,16 in 2021,and 19 in *** the authors’knowledge,this report is the first report of TTP associated with inactivated COVID-19 vaccine(CoronaVac).The rarity and delayed onset may be due to the relatively milder immune response caused by the inactivated vaccines than mRNA-based *** plasma exchange is a vital treatment for CoronaVac-related TTP,similar to activated vaccine-related TTP.

关键词： thrombotic thrombocytopenia purpura(TTP) corona virus disease 2019(COVID-19) CoronaVac acute respiratory syndrome coronavirus 2(SARS-CoV-2) vaccine

Generation of Femtosecond Laser Pulse at 1.43 GHz from an Optical Parametric Oscillator Based on LBO Crystal

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Chinese Physics Letters 2019年第12期36卷 43-46页

作者： Jia-jun Song xiang-Hao Meng Zhao-Hua wang xian-Zhi wang Wen-Long Tian jiang-feng Zhu Shao-Bo fang Hao Teng Zhi-Yi Wei Bejjing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190 University of Chinese Academy of Sciences Beijing 100049 Songshan Lake Materials Laboratory Dongguan 523808 School of Physics and Optoelectronic Engineering Xiandian UniversityXi'an 710071

A femtosecond LBO optical parametric oscillator(OPO)with widely adjustable repetition rate by fractionally decrement of the cavity length is *** repetition rate of 755 MHz to 1.43 GHz at an interval of 75.5 MHz is realized,which is 10 to 19 times that of the pump *** properties of output signal at 750 nm at different repetition rates are *** power of signal decreases with increasing the repetition *** maximum power of 194 mW at the repetition rate of 755 MHz and the minimum power of 22 mW at repetition rate of 1.43 GHz for the signal at 750 nm are obtained for the pump power of 3 W.

关键词： pump Femto repetition