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World Journal of Clinical Cases 2024年第22期12卷 4973-4982页

作者： Ru-Jie Wang Ying Wang jin-fang Wu Ting-Ting Si Department of Burns and Plastic Surgery 903rd Hospital of PLAHangzhou 310013Zhejiang ProvinceChina Department of Dermatology Shanghai Fourth People’s HospitalTongji University School of MedicineShanghai 200434China

BACKGROUND Nasolabial fold(NLF)depression can affect the facial appearance of patients to some extent and increase their psychological *** recent years,autologous fat grafting(AFG)combined with botulinum toxin A(BTX-A)injection(AFG+BTX-A injection)has been gradually applied in the treatment of patients with NLF *** studies have been conducted on the efficacy and safety of AFG+BTX-A injection in treating NLF depression,the experimental design,observational indicators,and sample enrollment criteria vary remarkably,making it difficult to draw convincing and consistent ***,further relevant research is *** To assess the esthetic improvement,efficacy,and safety of AFG+BTX-A injections in patients with NLF *** This study included 60 patients with NLF depression who were treated in our hospital from February 2019 to April *** patients were categorized into control(n=30)and observation(n=30)*** observation group received AFG+BTX-A injection,whereas the control group underwent AFG *** patients were evaluated using the wrinkle severity rating scale(WSRS)and global aesthetic improvement *** compactness of facial contours,skin evaluation indexes,adverse reactions,and satisfaction of the two groups were evaluated 3 months *** The WSRS scores of the observation group at 1,3,and 6 months postoperatively were lower than those of the control group(P0.05).CONCLUSION AFG+BTX-A injection is a highly safe,cos

关键词： Nasolabial fold depression Botulinum toxin A Autologous fat grafting Esthetics Safety

融合特征编码和短语交互感知的隐式篇章关系识别

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电子学报 2024年第4期52卷 1377-1388页

作者：王秀利金方焱中央财经大学信息学院北京102206 国家金融安全教育部工程研究中心北京102206

隐式篇章关系识别难度大、普遍性高.从论元编码和论元交互角度入手,提出了一种融合特征编码和短语交互感知的隐式篇章关系识别模型.该模型兼顾了论元本身特征和论元间交互特征的作用,并分别进行了优化.论元编码部分整合了双向长短时记... 详细信息

隐式篇章关系识别难度大、普遍性高.从论元编码和论元交互角度入手,提出了一种融合特征编码和短语交互感知的隐式篇章关系识别模型.该模型兼顾了论元本身特征和论元间交互特征的作用,并分别进行了优化.论元编码部分整合了双向长短时记忆网络和循环注意力卷积神经网络,能够更全面地捕获论元全局和局部特征;论元交互部分从短语层级考虑论元间的语义关系建模,构建了短语级交互注意力机制,并利用神经张量网络深入挖掘其中的关系模式,更能体现出论元间潜在的更深层次的关联关系.在宾州篇章树库数据集上的实验结果表明,该模型F1值均优于其他模型.

关键词：隐式篇章关系识别双向长短时记忆网络循环注意力卷积神经网络短语级交互注意力神经张量网络

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素养导向下数学单元整体教学的设计向度

教学与管理 2024年第2期 50-53页

作者：芮金芳江苏省溧阳市外国语小学

素养立意背景下,发展学生核心素养是当前课程改革的目标旨归和愿景追求,单元整体教学是落实学科核心素养培育的一条重要路径。设计数学单元整体教学时,可从知识向度、方法向度、实践向度统筹实施,突出大概念统摄设计,体现单元知识结构... 详细信息

素养立意背景下,发展学生核心素养是当前课程改革的目标旨归和愿景追求,单元整体教学是落实学科核心素养培育的一条重要路径。设计数学单元整体教学时,可从知识向度、方法向度、实践向度统筹实施,突出大概念统摄设计,体现单元知识结构的一致性;彰显大任务整体架构,体现单元思想方法的关联性;设计大项目规划推进,体现单元跨界整合的综合性。

关键词：小学数学单元整体教学知识向度方法向度实践向度

Intestinal glucagon-like peptide-1:A new player associated with impaired counterregulatory responses to hypoglycaemia in type 1 diabetic mice

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World Journal of Diabetes 2024年第8期15卷 1764-1777页

作者： fang-Xin jin Yan Wang Min-Ne Li Ru-Jiang Li Jun-Tang Guo Department of Histology and Embryology Key Laboratory of Universities in Shandong ProvinceShandong Second Medical UniversityWeifang 261053Shandong ProvinceChina Department of Pathological Physiology Shandong Second Medical UniversityWeifang 261053Shandong ProvinceChina

BACKGROUND Impaired hypoglycaemic counterregulation has emerged as a critical concern for diabetic patients who may be hesitant to medically lower their blood glucose levels due to the fear of potential hypoglycaemic ***,the pathogenesis of hypoglycaemic counterregulation is still ***-like peptide-1(GLP-1)and its analogues have been used as adjunctive therapies for type 1 diabetes mellitus(T1DM).The role of GLP-1 in counterregulatory dysfunction during hypoglycaemia in patients with T1DM has not been *** To explore the impact of intestinal GLP-1 on impaired hypoglycaemic counterregulation in type 1 diabetic *** T1DM was induced in C57BL/6J mice using streptozotocin,followed by intraperitoneal insulin injections to create T1DM models with either a single episode of hypoglycaemia or recurrent episodes of hypoglycaemia(DH5).Immunofluorescence,Western blot,and enzyme-linked immunosorbent assay were employed to evaluate the influence of intestinal GLP-1 on the sympathetic-adrenal reflex and glucagon(GCG)*** GLP-1 receptor agonist GLP-1(7-36)or the antagonist exendin(9-39)were infused into the terminal ileum or injected intraperitoneally to further investigate the role of intestinal GLP-1 in hypoglycaemic counterregulation in the model *** The expression levels of intestinal GLP-1 and its receptor(GLP-1R)were significantly increased in DH5 *** instances of excess of intestinal GLP-1 weakens the sympathetic-adrenal reflex,leading to dysfunction of adrenal counterregulation during ***5 mice showed increased pancreaticδ-cell mass,cAMP levels inδcells,and plasma somatostatin concentrations,while cAMP levels in pancreaticαcells and plasma GCG levels ***,GLP-1R expression in islet cells and plasma active GLP-1 levels were significantly increased in the DH5 *** experiments involving terminal ileal infusion and intraperitoneal injection in the model mice demonstra

关键词： Glucagon-like peptide-1 Impaired hypoglycaemic counterregulation Type 1 diabetes Intestine Pancreas

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点击化学在功能纺织品制备中的应用研究进展

纺织学报 2024年第3期45卷 227-235页

作者：方进张广知徐珍珍安徽工程大学纺织服装学院安徽芜湖241000

为进一步推动点击化学技术在纺织品领域的应用进程,就近年来国内外在点击化学制备功能纺织品方面的相关研究和发展现状进行了综述。简要介绍了点击化学的基本概念及其在纺织品表面功能修饰方面的优势;阐述了利用点击化学技术制备功能纺... 详细信息

为进一步推动点击化学技术在纺织品领域的应用进程,就近年来国内外在点击化学制备功能纺织品方面的相关研究和发展现状进行了综述。简要介绍了点击化学的基本概念及其在纺织品表面功能修饰方面的优势;阐述了利用点击化学技术制备功能纺织品的方法及分类,包括巯基-烯、巯基-环氧、巯基-卤素、巯基-异氰酸酯、巯基-马来酰亚胺以及叠氮-炔等;重点围绕点击化学在制备疏水、抗菌、电磁屏蔽、环境响应以及防毡缩等不同类型功能纺织品中的作用机制和优缺点进行了探讨。分析了通过点击化学手段制备功能纺织品的发展潜力和局限性;并针对当前点击化学在制备功能纺织品方面所面临的问题,提出了可能的解决方案,以期为点击化学在纺织品领域的广泛应用提供理论支持和技术参考。

关键词：点击化学功能纺织品疏水阻燃抗菌防皱电磁屏蔽

论中华民族共同体视野下的民族团结法律规范构建--“民族团结促进法”的立法建议

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华中科技大学学报（社会科学版） 2024年第2期38卷 1-13页

作者：汪习根方路锦华中科技大学铸牢中华民族共同体意识研究基地华中科技大学法学院

在中华民族共同体语境下,适时出台一部全国性民族团结促进法,建构民族团结法律规范体系,具有重大理论与现实意义。在本体论上,民族团结具有多元内涵与多维外延,明确这一概念是立法之前提;在价值论上,以“三个转变”统筹协调自由与秩序... 详细信息

在中华民族共同体语境下,适时出台一部全国性民族团结促进法,建构民族团结法律规范体系,具有重大理论与现实意义。在本体论上,民族团结具有多元内涵与多维外延,明确这一概念是立法之前提;在价值论上,以“三个转变”统筹协调自由与秩序、平等与团结、自治与统一是立法之关键;在立法论上,“民族团结促进法”应采全国性“促进型”立法模式,以“总则-分则”结构呈现,具体包括总则、职责分工、实施机制、法律责任四大板块内容。

关键词：民族团结中华民族共同体意识民族团结促进法

一维耦合腔晶格中磁子-光子拓扑相变和拓扑量子态的调制

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物理学报 2024年第4期73卷 170-177页

作者：李锦芳何东山王一平咸阳师范学院物理与电子工程学院咸阳712000 西北农林科技大学理学院杨凌712100

本文提出了基于耦合腔的一维晶格理论方案,其中每个晶胞包含微波腔光子和磁子,通过调控磁子与微波光子的耦合来研究系统中的拓扑相变和拓扑量子通道.首先,分析了在奇偶晶格数情况下,系统能谱和边缘态的特征,并发现边缘态分布可以展示反... 详细信息

本文提出了基于耦合腔的一维晶格理论方案,其中每个晶胞包含微波腔光子和磁子,通过调控磁子与微波光子的耦合来研究系统中的拓扑相变和拓扑量子通道.首先,分析了在奇偶晶格数情况下,系统能谱和边缘态的特征,并发现边缘态分布可以展示反转过程,可以实现多通道拓扑量子态传输;其次,考虑存在缺陷和无序的扰动,发现它们在较小值范围内,可以使能带产生波动和翻转现象,但边缘状态对其是鲁棒的,这表明边缘态受到系统的拓扑保护.该研究结果为研究拓扑磁子-光子提供了一条新途径,将在量子信息处理中有着广阔的应用前景.

关键词：量子光学腔量子电动力学拓扑绝缘体量子态

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基于Lasso-Huber的近红外光谱特征波长选择方法及应用

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光谱学与光谱分析 2024年第3期44卷 737-743页

作者：郭拓徐凤捷马晋芳肖环贤陕西科技大学电子信息与人工智能学院陕西西安710021 暨南大学光电系广东广州510632 江西保利制药有限公司江西赣州341900

在近红外光谱(NIRS)波长筛选过程中,当变量数目远大于样本量时,特征波长的选择是一个极具挑战性的问题。Lasso与Elastic Net算法虽被用于大维小样本数据的变量选择,但二者均以最小平方误差作为损失函数的度量方法来选择特征变量。因此,... 详细信息

在近红外光谱(NIRS)波长筛选过程中,当变量数目远大于样本量时,特征波长的选择是一个极具挑战性的问题。Lasso与Elastic Net算法虽被用于大维小样本数据的变量选择,但二者均以最小平方误差作为损失函数的度量方法来选择特征变量。因此,当样本中含有异常点时,经两种算法建立的模型对异常点更加敏感,导致模型向异常点偏移,鲁棒性降低。针对上述问题,采用Huber函数作为损失函数,提出了Lasso-Huber法进行近红外特征波长选择,结合偏最小二乘(PLS)方法建立安胎丸质控指标成分的定量校正模型,并与全波长建模、 Lasso与Elastic-Net方法波长选择后建模的模型性能进行对比。本实验采集21批安胎丸的近红外光谱数据共116条,其中101条数据作为校正集,采用留一交叉验证法对模型进行内部验证,另外15条数据则作为验证集用于外部验证。对于校正集中的异常光谱,使用基于主成分分析(PCA)的马氏距离法(MD)进行检测。以安胎丸的质控指标成分之一阿魏酸为例,采用Lasso、 Elastic-Net和Lasso-Huber方法分别筛选了安胎丸样品无异常光谱中69、 155和87个特征波长。其中Lasso-Huber法结合PLS建立的预测模型效果最佳,外部验证的RP2和SEP分别为0.953 1和0.058 7。此外,通过对校正集中是否包含异常光谱的校正模型预测性能对比发现,Lasso-Huber法在包含异常光谱的建模中更具优势。结果显示,Lasso-Huber算法优选出最佳波长点数为88,结合PLS建立的模型性能R_(v)^(2)为0.967 3,而Lasso方法的R_(v)^(2)为0.840 5, Elastic-Net方法的R_(v)^(2)为0.834 7,全波长建模的R_(v)^(2)为0.852 0。可见,在含有异常光谱的样本中,Lasso-Huber法不仅减少了特征波段的数量,同时降低了算法对异常光谱的敏感性,提高了模型的准确度和鲁棒性。从简化模型的角度上比较,Lasso法和Elastic-Net法的建模时间分别为61.826 0和79.959 9 s,而Lasso-Huber建模时间仅为1.360 8 s,因此,该算法更有望未来集成于实际生产应用的近红外光谱建模软件中。

关键词：近红外光谱波长选择大维小样本定量校正模型 Lasso-Huber

Expert consensus on pediatric orthodontic therapies of malocclusions in children

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International Journal of Oral Science 2024年第2期16卷 186-196页

作者： Chenchen Zhou Peipei Duan Hong He jinlin Song Min Hu Yuehua Liu Yan Liu Jie Guo fang jin Yang Cao Lingyong Jiang Qingsong Ye Min Zhu Beizhan Jiang Wenhua Ruan Xiao Yuan Huang Li Rui Zou Yulou Tian Li Gao Rui Shu Jianwei Chen Renkai Liu Shujuan Zou Xiaobing Li State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Orthodontics West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration&Key Laboratory of Oral Biomedicine Ministry of Education&Hubei Key Laboratory of Stomatology&Department of Orthodontics&Center for Dentofacial Development and Sleep Medicine School and Hospital of StomatologyWuhan UniversityWuhanChina Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences&Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Stomatological Hospital of Chongqing Medical UniversityChongqing Medical University&College of StomatologyChongqing Medical UniversityChongqingChina Department of Orthodontics Hospital of StomatologyJilin UniversityChangchunChina Department of Orthodontic&Oral Biomedical Engineering Laboratory Shanghai Stomatological HospitalFudan UniversityShanghaiChina Department of Orthodontics Central LaboratoryPeking University School and Hospital for Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental Materials&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijingChina Department of Orthodontics School and Hospital of StomatologyCollege of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Laboratory for Dental Materials and Oral Tissue

Malocclusion,identified by the World Health Organization(WHO)as one of three major oral diseases,profoundly impacts the dental-maxillofacial functions,facial esthetics,and long-term development of~260 million children in *** its physical manifestations,malocclusion also significantly influences the psycho-social well-being of these *** intervention in malocclusion can foster an environment conducive to dental-maxillofacial development and substantially decrease the incidence of malocclusion or reduce the severity and complexity of malocclusion in the permanent dentition,by mitigating the negative impact of abnormal environmental influences on the *** orthodontic treatment encompasses accurate identification and treatment of dental and maxillofacial morphological and functional abnormalities during various stages of dental-maxillofacial development,ranging from fetal stages to the early permanent dentition *** an economic and societal standpoint,the urgency for effective early orthodontic treatments for malocclusions in childhood cannot be overstated,underlining its profound practical and social *** consensus paper discusses the characteristics and the detrimental effects of malocclusion in children,emphasizing critical need for early *** elaborates on corresponding core principles and fundamental approaches in early orthodontics,proposing comprehensive guidance for preventive and interceptive orthodontic treatment,serving as a reference for clinicians engaged in early orthodontic treatment.

关键词： permanent stated children

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纤维-地聚物混凝土力学性能及耐久性能研究

兰州理工大学学报 2024年第2期50卷 24-30页

作者：公晋芳任永祥许昌职业技术学院河南许昌461000

为改善地聚物混凝土的力学性能和耐久性,通过掺入不同长度和掺量的聚丙烯纤维,对地聚物混凝土的力学性能、抗冻性、抗氯离子侵蚀性及抗裂性进行了研究,并基于SEM试验,从微观角度进一步解释聚丙烯纤维的作用机理.结果表明:聚丙烯纤维的... 详细信息

为改善地聚物混凝土的力学性能和耐久性,通过掺入不同长度和掺量的聚丙烯纤维,对地聚物混凝土的力学性能、抗冻性、抗氯离子侵蚀性及抗裂性进行了研究,并基于SEM试验,从微观角度进一步解释聚丙烯纤维的作用机理.结果表明:聚丙烯纤维的掺入能够提高地聚物混凝土的力学性能和耐久性能,当纤维掺量为0%~0.6%时,随着纤维掺量的增加,地聚物混凝土的改善效果越明显.当掺量超过0.6%时,其力学性能和耐久性开始下降.通过SEM分析也表明,聚丙烯纤维能够提高基体内部的整体性和密实性,从而显著改善地聚物混凝土的力学性能和耐久性.最终推荐掺量0.6%长度为12 mm的聚丙烯纤维为最佳掺量.

关键词：聚丙烯纤维地聚物混凝土力学性能抗冻性能抗氯离子侵蚀性