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Effects of lens extirpation with anterior vitrectomy on vitreous three-dimensional mesh structure

International Journal of Ophthalmology(English edition) 2017年第6期10卷 840-846页

作者： Yan zhao Long-fang Zhou hong Yang Department of Ophthalmology Tongji Hospital Tongji Medical College of Huazhong University of Science and Technology Wuhan 430030 Hubei Province China Department of Fundus Diseases Wuhan Aier Eye Hospital Wuhan 430060 Hubei Province China

AIM： To investigate the changes in vitreous gel structure after lens extirpation combined with anterior vitrectomy in rabbit eyes. METHODS： Twenty-eight chinchilla rabbits were divided into three groups. The control group （Group I） included 16 eyes from eight rabbits who did not receive any treatment. Group II included 20 eyes from 10 rabbits that underwent lens aspiration only. Group III included 20 eyes from 10 rabbits that underwent lens aspiration combined with posterior capsulotomy and anterior vitrectomy. Eyes were harvested on the 30th and 60th day postoperatively, respectively. Changes in vitreous gel stretch length due to gravity and the rate of vitreous liquefaction were observed. The collagen content in the vitreous body was examined using the L-hydroxyproiine test. Electronic microscopic images were obtained from each eyeball. RESULTS： On both the 30th and 60th day postoperatively, the vitreous gel length of group III was significantly shorter than group I and group II （P〈0.05）, while the rate of liquefaction of the vitreous body in group III was significantly higher than group I and group II （P〈0.05）. The collagen content in group Ul was also higher than that in group I and group II （P〈0.05）. CONCLUSION： Loss of vitreous gel mass is more likely to occur in the eyes of rabbits receiving anterior vitrectomy. Lensectomy combined with anterior vitrectomy may damage the stable three-dimensional mesh structure of collagen, which could aggravate vitreous gel liquefaction.

关键词： lens extirpation anterior vitrectomy vitreousbody vitreous liquefaction

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氢化物发生-原子荧光光谱法测定牛肉中的硒含量

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中国畜牧兽医 2015年第9期42卷 2399-2404页

作者：刘丽娜徐发婷赵方红秦顺义姚婉刘佳李玉竹天津农学院动物科学与动物医学学院天津300384

本试验采用了氢化物发生—原子荧光光谱法测定牛肉中的硒,通过消解液、预还原剂、介质酸的选择等优化了试验条件并测定其检出限、精密度、加标回收率等。结果显示本试验选用2∶1的混合酸作为消解液,6mol/L HCl作为预还原剂,体积比为10%... 详细信息

本试验采用了氢化物发生—原子荧光光谱法测定牛肉中的硒,通过消解液、预还原剂、介质酸的选择等优化了试验条件并测定其检出限、精密度、加标回收率等。结果显示本试验选用2∶1的混合酸作为消解液,6mol/L HCl作为预还原剂,体积比为10%的HCl作为介质酸。硒在0~8μg/L的范围内呈良好的线性关系,相关系数为0.9999,检出限为0.01ng/mL。在20、30和40μg/L 3个添加水平下牛肉的回收率为94%~104%,相对标准偏差（RSD）为3.80%。该方法具有简便、有效等特点,对肉制品中硒的测定具有一定的参考意义。

关键词：硒牛肉氢化物发生—原子荧光光谱法

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Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng Lin Tianyuan fang Yuyu Zhou Chuxia Zhang Jianghui Shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

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A United Framework for Large-Scale Resource Description Framework Stream Processing

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Journal of Computer Science & Technology 2019年第4期34卷 762-774页

作者： hong fang Bo zhao Xiao-Wang Zhang Xuan-Xing Yang College of Arts and Sciences Shanghai Polytechnic UniversityShanghai 201209China College of Intelligence and Computing Tianjin UniversityTianjin 300350China Tianjin Key Laboratory of Cognitive Computing and Application Tianjin 300350China

Resource description framework(RDF)stream is useful to model spatio-temporal *** this paper,we propose a framework for large-scale RDF stream processing,LRSP,to process general continuous queries over large-scale RDF ***,we propose a formalization(named CT-SPARQL)to represent the general continuous queries in a unified,unambiguous ***,based on our formalization we propose LRSP to process continuous queries in a common white-box way by separating RDF stream processing,query parsing,and query ***,we implement and evaluate LRSP with those popular continuous query engines on some benchmark datasets and real-world *** to the architecture of LRSP,many efficient query engines(including centralized and distributed engines)for RDF can be directly employed to process continuous *** experimental results show that LRSP has a higher performance,specially,in processing large-scale real-world data.

关键词： resource description framework(RDF)stream continuous query united framework stream processing large-scale RDF stream processing(LRSP)

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THE SPECTRAL RADIUS OF UNIFORM HYPERGRAPH DETERMINED BY THE SIGNLESS LAPLACIAN MATRIX

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数学杂志 2025年第1期45卷 1-12页

作者： HE fang-guo College of Mathematics and Statistics Huanggang Normal UniversityHuBei 438000

This paper studies the problem of the spectral radius of the uniform hypergraph determined by the signless Laplacian *** upper bound of the spectral radius of a uniform hypergraph is obtained by using Rayleigh principle and the perturbation of the spectral radius under moving the edge operation,and the extremal hypergraphs are characterized for both supertree and unicyclic *** spectral radius of the graph is generalized.

关键词： spectral radius uniform hypergraph Signless Laplasian matrix

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Simultaneous optimization of phononic and electronic transport in two-dimensional Bi2O2Se by defect engineering

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Science China(Information Sciences) 2023年第6期66卷 87-93页

作者： fang YANG hong Kuan NG Jing WU Yunshan zhao Junpeng LU School of Physics Southeast University Institute of Materials Research and Engineering Agency for ScienceTechnology and Research NNU-SULI Thermal Energy Research Center (NSTER) & Center for Quantum Transport and Thermal Energy Science (CQTES) School of Physics and TechnologyNanjing Normal University

Defect engineering represents one degree of freedom to tune the physical and chemical properties of two-dimensional (2D)***,we demonstrate that the thermal and electronic properties of 2D Bi2O2Se can be optimized simultaneously by introducing oxygen defects.2D Bi2O2Se and its oxygendeficient counterpart (Bi2Ox Se,x<2)can be controllably synthesized by the chemical vapor deposition(CVD)*** introducing oxygen defects,the thermal conductivity of 2D Bi2O2Se is reduced by nearly three times,achieving an extremely low thermal conductivity of 0.68±0.06 W/mK at room temperature via the thermal bridge *** low thermal conductivity is enabled by the scattering of phonons by targeting of high-,mid-,and low-frequency phonons due to oxygen defects,strong anharmonicity,and nanostructure boundaries,***,the mobility is also improved to 260–500 cm2·V-1·s-1and the usual polar optical phonon scattering in 2D Bi2O2Se is weakened owing to the introduction of oxygen *** results promise potential applications for thermoelectric design,nanoelectronics,and thermal barrier coating devices based on emerging 2D materials.

关键词： 2D Bi$_2$O$_2$Se thermal conductivity oxygens defects phonon scattering mobility

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Clinical application of pedicled myocutaneons flap for reconstruction of oral and maxillofacial defect after ablative surgery of neoplasm

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中国口腔颌面外科杂志 2008年第B5期6卷 190-190页

作者： Hai Bin Wang Xin Ming Li Xin Guang Han Wei He Ming Lei Sun Jun fang zhao Wei hong Xie Department of Oral & Maxillofacial Surgery First AffiliatedHospital Zhengzhou University Zhengzhou 450052 China

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有渗流时地热换热器温度响应的解析解

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山东建筑工程学院学报 2003年第3期18卷 1-5页

作者：刁乃仁李琴云方肇洪山东建筑工程学院地源热泵研究所山东济南250014

为确定地下水渗流对竖直埋管地热换热器的影响,建立了多孔介质中有渗流时的换热能量方程,得到了有渗流时无限大介质中线热源温度响应的解析解。归纳得出影响这一传热过程的无量纲量,并分析了地下水渗流对地热换热器中温度场的影响。分... 详细信息

为确定地下水渗流对竖直埋管地热换热器的影响,建立了多孔介质中有渗流时的换热能量方程,得到了有渗流时无限大介质中线热源温度响应的解析解。归纳得出影响这一传热过程的无量纲量,并分析了地下水渗流对地热换热器中温度场的影响。分析计算的结果表明:适度的地下水渗流对原一维温度场的影响明显。地下水渗流越大,温度场变形越显著,达到稳态的时间越短,稳态过余温度越低。

关键词：地下水渗流地源热泵地热换热器传热数学模型温度场

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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao fang Junfan fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

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中药治疗腰椎椎体间融合术后发热的炎症信号通路

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中国组织工程研究 2025年第21期29卷 4568-4575页

作者：方雨婷彭宏庞玉洁南阳市中医院河南省南阳市473000

背景:术后发热是后路腰椎椎体间融合后常见临床症状之一,目前没有明确的病因病机,患者术后体温易反复,病程较久,西药治疗效果欠佳,影响患者术后恢复。目的:综述总结炎症信号通路和术后发热的关联及中药防治后路腰椎椎体间融合后发热的机... 详细信息

背景:术后发热是后路腰椎椎体间融合后常见临床症状之一,目前没有明确的病因病机,患者术后体温易反复,病程较久,西药治疗效果欠佳,影响患者术后恢复。目的:综述总结炎症信号通路和术后发热的关联及中药防治后路腰椎椎体间融合后发热的机制,为研究术后发热继续探索新的治疗药物。方法:检索CNKI中国期刊全文数据库、万方数据库和PubMed数据库2006年6月至2023年12月收录的文献,中文检索词为“中药,术后发热,炎症,白细胞介素1,白细胞介素6,白细胞介素8,干扰素γ,肿瘤坏死因子,前列腺素E2,p38丝裂原活化蛋白激酶,核因子κB,Toll样受体,Janus激酶/信号转导和转录激活因子,Notch信号通路”;英文检索词为“medicinal herb,postoperative fever,inflammation,interleukin-1,interleukin-6,interleukin-8,γ-interferon,tumor necrosis factor,Prostaglandin E2,p38 mitogen-activated protein kinase,nuclear factor-κB,toll-like receptor,janus kinases/signal transducer and activator of transcription,notch signaling pathway”。阅读文章剔除研究内容不相关、质量差的文献,纳入100篇文献进行归纳总结。结果与结论:(1)手术造成软组织创伤促使机体释放炎症因子,促炎因子作用于下丘脑前部的体温调节中心,促使发热;(2)术后切口内出血及渗液等的吸收,吞噬细胞吞噬坏死细胞的蛋白分解产物后,产生内生致热原(白细胞介素、肿瘤坏死因子、干扰素等)导致发热;(3)细胞因子通过炎症信号通路发挥致炎作用,促使发热;(4)中药或中药复方可以调控炎症信号通路发挥抗炎解热作用防治术后发热;目前中药作用机制尚无定论,应深入研究阐明中医药防治术后发热的相关信号通路,运用现代技术把细胞分子技术与中医药药理作用机制联系起来,以便指导临床医生用药,促进患者术后恢复;(5)中药联合西药治疗术后发热是未来的研究热点,应充分发挥中医药优势,明确不同证型应用中药单体或有效成分提取物和中药汤剂的靶点作用机制。

关键词：中药腰椎椎体间融合术后发热炎症白细胞介素干扰素γ 肿瘤坏死因子信号通路

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