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RPRD1B/CREPT facilitates the progression of diffuse large B-cell lymphoma by inhibiting apoptosis through the NF-κB signaling pathway

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Asian Pacific Journal of Tropical Biomedicine 2024年第7期14卷 307-318页

作者： Lu Xu Zhi-Hao Xie Jun Li Shi Tao fang-Li Ren Yin-Yin Wang Zhi-Jie Chang Xin-Bao Hao department of Hematology The First Affiliated Hospital of Hainan Medical UniversityHaikou570102China State Key Laboratory of Membrane Biology School of MedicineTsinghua UniversityBeijing 100084China Heya beijing Med-Biotech Inc. Beijing 100084China department of Hematology Roswell Park Comprehensive Cancer CenterNY 14263USA

Objective:To investigate the role of RPRD1B in the progression of diffuse large B-cell lymphoma(DLBCL)and its potential as a therapeutic ***:This study analyzed RPRD1B expression in DLBCL and normal tissues using public databases and assessed its prognostic impact through survival *** vitro and in vivo experiments were conducted to explore the mechanisms by which RPRD1B influences tumor growth and ***:RPRD1B expression was significantly elevated in DLBCL compared to normal tissues and was associated with poor *** vitro and in vivo experiments demonstrated that RPRD1B promoted lymphoma cell proliferation and inhibited apoptosis through the NF-κB signaling ***:RPRD1B plays a critical role in the progression of DLBCL by modulating apoptosis and cellular *** RPRD1B may offer a novel therapeutic strategy for DLBCL,suggesting its potential as a prognostic marker and therapeutic target in hematological malignancies.

关键词： RPRD1B RNAPⅡ Diffuse large B-cell lymphoma NF-κB Apoptosis

The role of 99mTc-EHIDA hepatobiliary scintigraphy in the diagnosis of gallbladder motility and gallstone formation in patients with Liver cirrhosis

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The role of 99mTc-EHIDA hepatobiliary scintigraphy in the di...

首届全国分子核医学暨分子影像学学术交流会

作者： YANG Ji-gang, LI Chun-lin, HAO Rui-rui,WANG Hui-ji,ZOU Lan-fang Nuclear Medicine department, beijing Friendship Hospital Affiliated to Capital university of Medical Sciences Comprehensive department, beijing Friendship Hospital, beijing 100050,china.

Aims To investigate the gallbladder motility in patients with liver cirrhosis and the relationship between gallbladder motility function and gallstone, then provide basis in choosing suitable method in the diagnosis of gallbladder motility disorder, prevention and cure liver cirrhosis combination gallstones. Subjects and Methods The study included two groups: 14 normal subjects, 62 patients with cirrhosis, 15 cirrhosis patients with gallstones, 47 cirrhosis patients without gallstone. Patients were divided into cirrhosis with gallstones and without gallstone through B ultrasound. Every normal subject received inquisition, physical examination, and B ultrasound in the condition of fasting. All normal subjects didn’t have the history of liver disease, pancreas and biliary tract system diseases, without peptic ulcer, abdomen operation and diabetes mellitus history et al. There were no significances in age and sex between cirrhosis patients and normal subjects. All subjects received 99mTc-EHIDA hepatobiliary scintigraphy in nuclear medicine department of beijing friendship hospital between June 2004 and February 2005. After an 8-12-hour fast, each subject was given 185MBq(5mCi) of 99mTc-EHIDA intravenously. 60mins after injection, every subject lies supine under a large-field γ-camera fitted with a low-energy parallel collimator. Serial hepatobiliary analog images were taken for 65mins at 1-min intervals. These patients ate a standard 200ml liquid fatty meal within l-2mins in 3mins after acquisition. Two regions on interest (ROIs) were chosen: ROI1, over the entire gallbladder;ROI2, over the entire liver. Time-activity curves were generated for both ROIs and the counts were corrected for physical decay: latent period (LP), ejection period (EP), gallbladder ejection fraction (GBEF), and ejection rate (ER). Results The image of liver 60mins after injection is clear with high background counts and the counts of gallbladder region are high in cirrhosis patients, the liver i

关键词： Cirrhosis Gallbladder Motility Gallstone Hepatobiliary scintigraphy

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青藏高原地区水土流失时空分异特征

水土保持学报 2004年第1期18卷 58-62页

作者：罗利芳张科利孔亚平陈济丁北京师范大学资源与环境科学系北京100875 交通部科学研究院北京100029

青藏高原的自然地理环境十分独特却也非常脆弱,水土流失的潜在危害性大。在全球变化和西部大开发的背景下,研究青藏高原水土流失规律具有重要意义。从自然地理条件出发,总结了青藏高原水土流失具有侵蚀类型多样,区域分异明显,人为作用... 详细信息

青藏高原的自然地理环境十分独特却也非常脆弱,水土流失的潜在危害性大。在全球变化和西部大开发的背景下,研究青藏高原水土流失规律具有重要意义。从自然地理条件出发,总结了青藏高原水土流失具有侵蚀类型多样,区域分异明显,人为作用较弱但潜在危害性大等特点。通过分析青藏高原河流泥沙资料,对土壤侵蚀强度的区域分异和水土流失的年内变化进行了初步研究。可以看出区内输沙模数的区域差异较大,输沙模数的大小主要决定于降雨条件和地表覆盖(包括地表物质组成和植被覆盖)。输沙模数的分布也一定程度上反映了土壤侵蚀强度的区域差异。青藏高原地区水土流失在一年中较为集中,7、8月份输沙量占全年的65%左右,6～9月份输沙量占全年的90%左右。由于夏季冰雪融水作用,径流泥沙可比降雨提前到达峰值。

关键词：青藏高原地区水土流失时空分异特征输沙模数

Inhibition of the RXRA-PPARα-FABP4 signaling pathway alleviates vascular cellular aging by an SGLT2 inhibitor in an atherosclerotic mice model

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Science china Life Sciences 2024年

作者： Weiwei Zhang Linghuan Wang Yujia Wang Yan fang Ruihua Cao Zhiyi fang Dong Han Xu Huang Zhenghui Gu Yingjie Zhang Yan Zhu Yan Ma Feng Cao department of Cardiology The Second Medical Centre Chinese PLA General Hospital National Clinical Research Center for Geriatric Diseases School of Medicine Nankai University department of Cardiology Beijing Friendship Hospital Capital Medical University

Atherosclerosis is the pathological cause of atherosclerotic cardiovascular disease （ASCVD）, which rapidly progresses during the cellular senescence. Sodium-glucose cotransporter 2 inhibitors （SGLT2is） reduce major cardiovascular events in patients with ASCVD and have potential antisenescence effects. Here, we investigate the effects of the SGLT2 inhibitor dapagliflozin on cellular senescence in atherosclerotic mice. Compared with ApoE-/-control mice treated with normal saline, those in the ApoE-/-dapagliflozin group, receiving intragastric dapagliflozin （0.1 mg kg-1d-1） for 14 weeks, exhibited the reduction in the total aortic plaque area （48.8%±6.6%vs. 74.6%±8.0%,P<0.05）, the decrease in the lipid core area (（0.019±0.0037） mm2vs.（0.032±0.0062） mm2, P<0.05) and in the percentage of senescent cells within the plaques （16.4%±3.7%vs. 30.7%±2.0%, P<0.01）, while the increase in the thickness of the fibrous cap (（21.6±2.1）μm vs.（14.6±1.5）μm, P<0.01). Transcriptome sequencing of the aortic arch in the mice revealed the involvement of the PPARα and the fatty acid metabolic signaling pathways in dapagliflozin’s mechanism of ameliorating cellular aging and plaque progression. In vitro, dapagliflozin inhibited the expression of PPARα and its downstream signal FABP4, by which the accumulation of senescent cells in human aortic smooth muscle cells （HASMCs） was reduced under high-fat conditions. This effect was accompanied by a reduction in the intracellular lipid content and alleviation of oxidative stress. However, these beneficial effects of dapagliflozin could be reversed by the PPARα *** analysis and molecular docking simulations revealed that dapagliflozin might exert its effects by directly interacting with the RXRA protein, thereby influencing the expression of the PPARα signaling pathway. In conclusion, the cellular senescence of aortic smooth muscle cells is potentially altered by dapagliflozin through the suppression of the RXRA-PPARα-FABP4 s

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小学生对情绪社会调节作用的理解

心理发展与教育 2002年第3期18卷 34-39页

作者：罗峥郭德俊方平首都师范大学教科院心理系北京100089

考察了小学二、四、六年级学生对情绪社会调节作用理解的特点。结果表明 :小学生认为愤怒、悲伤和恐惧情绪标志着表达者不同的人际地位 ,会诱发接受者不同的情绪和后继行为 :愤怒情绪标志着表达者的支配地位 ,会诱发出接受者的恐惧情绪... 详细信息

考察了小学二、四、六年级学生对情绪社会调节作用理解的特点。结果表明 :小学生认为愤怒、悲伤和恐惧情绪标志着表达者不同的人际地位 ,会诱发接受者不同的情绪和后继行为 :愤怒情绪标志着表达者的支配地位 ,会诱发出接受者的恐惧情绪和道歉认错行为 ;悲伤和恐惧标志着表达者的非支配地位 ,会诱发出接受者的悲伤情绪和目标恢复行为 ,恐惧情绪有时还会诱发接受者的高兴情绪。在对愤怒、悲伤和恐惧情绪反映表达者的社会目标的理解上 ,没有差异 ,都反映了表达者期待接受者采取目标恢复的社会行为。高年级学生在区分不同情绪表达的支配性以及诱发接受者的情绪上 ,存在着差别 ;

关键词：诱发表达悲伤行为情绪伤情愤怒理解小学生高年级学生

对儿童认知发展水平诊断工具IPDT的信度效度检验

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心理学报 2004年第1期36卷 96-102页

作者：方富熹盖笑松龚少英刘国雄中国科学院心理研究所心理健康重点实验室东北师范大学教育科学学院心理学系长春130024 湖南师范大学教育科学学院心理学系长沙410000

修订了以皮亚杰认知发展理论为基础的儿童认知发展诊断工具IPDT的信度效度资料 ,在 390名北京小学生样本中的修订结果表明 ,该测验具有稳定的信度、良好的效度、适当的难度和理想的区分度 ,适合作为小学生认知发展诊断工具。对应用的范... 详细信息

修订了以皮亚杰认知发展理论为基础的儿童认知发展诊断工具IPDT的信度效度资料 ,在 390名北京小学生样本中的修订结果表明 ,该测验具有稳定的信度、良好的效度、适当的难度和理想的区分度 ,适合作为小学生认知发展诊断工具。对应用的范围、存在的问题和未来的研究需要进行了讨论。

关键词：认知发展皮亚杰测验

An Autocatalytic Synthetic Route to[5]Ferrocenophane and its Mechanism Investigation

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An Autocatalytic Synthetic Route to[5]Ferrocenophane and its...

中国化学会第十届全国有机合成化学学术研讨会

作者： Jian-chun Wang,Zhen-min Chen,Zhong-feng Li,Xiao-fang Wu,Xiao-lan Jiao,Ke-xin Zhang department of Chemistry,Capital normal university,100048,beijing,P.R.china

An easy and reliable synthetic route to[5]ferrocenophane was found unexpectedly and *** novel[5]ferrocenophanes were synthesized from 1-(1-Chloro-2-formylvinyl)- 1’-(1-chlorovinyl)-ferrocene 1 with primary,secondary and tertiary *** ferrocenophanes were characterised by elemental analysis,IR,H NMR and *** single crystals of three [5]ferrocenophanes were obtained and the crystal structures were determined by X-ray diffraction. Meanwhile in situ H NMR was employed to study the reaction mechanism of the compound 1 and *** results show that the reaction are related with alcohol acidity and steric *** stronger is the alcohol acidity,the faster is the reaction,and the speed of primary alcohol with the compound 1 is the fastest,then followed by the secondary alcohol,the reaction of tertiary alcohol with the compound 1 can not happen.

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初中生集合概念发展特点的研究

数学教育学报 2003年第2期12卷 55-58页

作者：朱文芳刘仁权北京师范大学数学系北京100875 北京中医药大学信息中心北京100029

初中生集合概念的发展水平特点主要表现为:初中3个年级学生集合概念的发展并非是上升的趋势,而是在初二有所下降;性别差异不显著;虽然年级、学校单独作用,或者是性别与年级交互作用时,对学生集合概念的发展具有显著影响.采用多重比较分... 详细信息

初中生集合概念的发展水平特点主要表现为:初中3个年级学生集合概念的发展并非是上升的趋势,而是在初二有所下降;性别差异不显著;虽然年级、学校单独作用,或者是性别与年级交互作用时,对学生集合概念的发展具有显著影响.采用多重比较分析进行年级间的差异检验结果表明,只在初二与初三之间存在显著差异(P<0.05),初一与初二之间不存在显著差异;学生所受教育的质量,直接影响初中生集合概念的发展状况.

关键词：初中生集合概念方差分析初中二年级数学教学教育研究教学改革

High nitrogen fertilizer input enhanced the microbial network complexity in the paddy soil

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Soil Ecology Letters 2024年第2期6卷 97-109页

作者： Yanan Chen Yan Li Tianyi Qiu Haoran He Ji Liu Chengjiao Duan Yongxing Cui Min Huang Chunyan Wu Linchuan fang The Research Center of Soil and Water Conservation and Ecological Environment Chinese Academy of Sciences and Ministry of EducationYangling712100China State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Institute of Soil and Water Conservation CAS and MWRYangling712100China university of Chinese Academy of Sciences Beijing100049China Institute of Environment Resource and Soil Fertilizer Zhejiang Academy of Agricultural SciencesHangzhou310021China College of Natural Resources and Environment Northwest A&F UniversityYangling712100China Hubei Province Key Laboratory for Geographical Process Analysis and Simulation Central China Normal UniversityWuhan430079China department of Ecohydrology Leibniz Institute of Freshwater Ecology and Inland FisheriesBerlin12587Germany Sino-French Institute for Earth System Science College of Urban and Environmental SciencesPeking UniversityBeijing100871China College of Resources and Environmental Engineering Wuhan University of TechnologyWuhan430070China CAS Center for Excellence in Quaternary Science and Global Change Xi’an710061China

N fertilizer altered bacterial community compositions by changing soil nutrients.•Bacterial ammonia oxidation became predominated with the increasing N rate.•Excessive N input caused the information of a more complex microbial network.•Intensified microbial competition by excessive N was due to negative link ***(N)fertilization drives the structure and function of soil microbial communities,which are crucial for regulating soil biogeochemical cycling and maintaining ecosystem *** the N fertilizer effects on soil microbial composition and diversity have been widely investigated,it is generally overlooked that ecosystem processes are carried out via complex associations among microbiome ***,we examined the effects of five N fertilization levels(0,135,180,225,and 360 kg N ha−1)on microbial co-occurrence networks and key functional taxa such as ammonia-oxidizers in paddy *** results showed that N addition altered microbial community composition,which were positively related to soil total N and available phosphorus(P)*** abundance of ammonia-oxidizing archaea(AOA)significantly decreased after N addition,whereas ammonia-oxidizing bacteria(AOB)increased in N360 *** with low-N group(N0 and N135),the high-N group(N225 and N360)shaped more complex microbial webs and thus improved the stability of the microbial *** least squares path modeling further revealed that N fertilizer had a higher effect on microbial network complexity in the high-N group(0.83)than the low-N group(0.49).Although there were more positive links across all microbial networks,the proportion of negative links significantly increased in the high-N network,suggesting that excess N addition aggravated the competition among microbial *** these interactions between microbial communities and N fertilization advances our understanding of biogeochemical processes in paddy soils and their effects on nutrient supply to

关键词： nitrogen fertilizer paddy soil co-occurrence network microbial interaction