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Human liver tissue metabolic profiling research on hepatitis B virus-related hepatocellular carcinoma

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World Journal of Gastroenterology 2013年第22期19卷 3423-3432页

作者： shu-Ye Liu Rikki-Lei Zhang hua kang zhi-Juan fan zhi Du Department of Hepatobiliary Surgery Tianjin Third Central Hospital

AIM: To select characteristic endogenous metabolites in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients and to identify their molecular mechanism and potential clinical value. METHODS: An ultra performance liquid chromatography and linear trap quadrupole-Orbitrap XL-mass spectrometry platform was used to analyze endogenous metabolites in the homogenate of central tumor tissue, adjacent tissue and distant tissue obtained from 10 HBV-related HCC patients. After pretreatment with Mzmine software, including peak detection, alignment and normalization, the acquired data were treated with Simca-P+software to establish multivariate statistical analysis based on a pattern recognition technique and characteristic metabolites highly correlated with changing trends in metabolic profiling were selected and further identified. RESULTS: Based on data acquired using Mzmine software, a principal component analysis model (R2X = 66.9%, Q2 = 21.7%) with 6 principal components and an orthogonal partial least squares discriminant analy-sis model (R2X = 76.5%, R2Y = 93.7%, Q2 = 68.7%) with 2 predicted principal components and 5 orthogonal principal components were established in the three tissue groups. Forty-nine ions were selected, 33 ions passed the 2 related samples nonparametric test (P < 0.05) and 14 of these were further identified as characteristic metabolites that showed significant differences in levels between the central tumor tissue group and distant tumor tissue group, including 9 metabolites (L -phenylalanine, glycerophosphocholine, lysophosphatidylcholines, lysophosphatidylethanolamines and chenodeoxycholic acid glycine conjugate) which had been reported as serum metabolite biomarkers for HCC diagnosis in previous research, and 5 metabolites (betasitosterol, quinaldic acid, arachidyl carnitine, tetradecanal, and oleamide) which had not been reported before. CONCLUSION: Characteristic metabolites and metabolic pathways highly related to HCC pathogen

关键词： Hepatocellular carcinoma Metabolomics Characteristic metabolites Potential biomarker Ultra performance liquid chromatography-mass spectrometry

Efficacy,safety and treatment satisfaction of transition to a regimen of insulin degludec/aspart:A pilot study

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World Journal of Diabetes 2025年第1期16卷 65-73页

作者： Na Yang Lu Lv shu-Meng Han Li-Yun He Zi-Yi Li Yu-Cheng Yang fan Ping Ling-Ling Xu Wei Li hua-Bing Zhang Yu-Xiu Li Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Allergy Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic DiseasesNational Clinical Research Center for Dermatologic and Immunologic DiseasesPeking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China

BACKGROUND There is a lack of clinical evidence on the efficacy and safety of transitioning from a thrice-daily pre-mixed insulin or basal-prandial regimen to insulin degludec/aspart(IDegAsp)therapy,with insufficient data from the Chinese *** To demonstrate the efficacy,safety,and treatment satisfaction associated with the transition to IDegAsp in type 2 diabetes mellitus(T2DM).METHODS In this 12-week open-label,non-randomized,single-center,pilot study,patients with T2DM receiving thrice-daily insulin or intensive insulin treatment were transitioned to twice-daily injections of insulin *** doses,hemoglobin A1c(HbA1c)levels,fasting blood glucose(FBG),hypoglycemic events,a Diabetes Treatment Satisfaction Questionnaire,and other parameters were assessed at baseline and *** This study included 21 participants.A marked enhancement was observed in the FBG level(P=0.02),daily total insulin dose(P=0.03),and overall diabetes treatment satisfaction(P<0.01)in the participants who switched to *** was a decrease in HbA1c levels(7.6±1.1 vs 7.4±0.9,P=0.31)and the frequency of hypoglycemic events of those who switched to IDegAsp decreased,however,there was no statistically significant *** The present findings suggest that treatment with IDegAsp enhances clinical outcomes,particularly FBG levels,daily cumulative insulin dose,and overall satisfaction with diabetes treatment.

关键词： Insulin degludec/aspart Type 2 diabetes management Basal-bolus insulin therapy Pre-mixed insulin Diabetes treatment satisfaction questionnaire

Physiology and defense responses of wheat to the infestation of different cereal aphids

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Journal of Integrative Agriculture 2020年第6期19卷 1464-1474页

作者： LIU fang-hua kang zhi-wei TAN Xiao-ling fan Yong-liang TIAN Hong-gang LIU Tongxian State Key Laboratory of Crop Stress Biology for Arid Areas Northwest A&F UniversityYangling 712100P.R.China Key Laboratory of Northwest Loess Plateau Crop Pest Management Ministry of Agriculture and Rural AffairsNorthwest A&F UniversityYangling 712100P.R.China State Key Laboratory of Integrated Management of Pest and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101P.R.China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193P.R.China

Cereal aphids are major insect pests of wheat,which cause significant damages to wheat *** studies mainly focused on the resista nee of differe nt wheat varieties to one specific aphid ***,reports on the physiology and defense responses of wheat to different cereal aphids are basically *** this work,we studied the feeding behavior of three cereal aphids:the grain aphid,Sitobion avenae(Fabricius),the greenbugs,Schizaphis graminum(Ron dani),and the bird cherry-oat aphid,Rhopalosiphum padi(Linn aeus)on win ter wheat,and the physiology and defense responses of wheat to the infestation of these cereal aphids with focus on how these cereal aphids utilize divergent strategies to optimize their nutrition requirement from wheat *** results indicated that *** and *** were better adapted to penetrating phloem tissue and to collect more nutrition than *** harm on wheat physiology committed by *** and *** was severer than that by ***,through reducing chlorophyll concentration and interfering metabolism ***,cereal aphids manipulated the plant nutrition metabolism by increasing the relative concentration of major amino acids and percentage of essential amino *** addition,different cereal aphids triggered specific defense response in *** of these results suggested that different cereal aphids utilize diverge nt strategies to cha nge the physiological and defe nse resp on ses of their host plants in order to optimize their nutriti on absorption and requireme *** fin dings not only exte nd our current knowledge on the insect-pla nt in teractions but also provide useful clues to develop no vel biotech no logical strategies for enhancing the resistance and toleranee of crop plants against phloem-feeding insects.

关键词： cereal aphids feeding behavior nutrition physiology defense response

Performance of AC-LGAD strip sensors designed for the DarkSHINE experiment

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Nuclear Science and Techniques 2024年第11期35卷 152-163页

作者： kang Liu Meng-Zhao Li Jun-hua Zhang Wei-Yi Sun Yun-Yun fan zhi-Jun liang Yu-Feng Wang Mei Zhao Kun Liu Tsung‑Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 201210China Key Laboratory for Particle Astrophysics and Cosmology(MOE) Shanghai Key Laboratory for Particle Physics and Cosmology(SKLPPC)Shanghai 200240China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Institute of Nuclear and Particle Physics School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China

The DarkSHINE experiment proposes a novel approach to single-electron-on-fixed-target exploration that focuses on the search for dark photons through their invisible decay into dark matter *** to this initiative is an advanced tracking detector designed to achieve exceptional sensitivity in the detection of light dark matter *** study evaluates the performance of several prototype AC-coupled low-gain avalanche diode(AC-LGAD)strip sensors specifically developed for the DarkSHINE tracking *** electrical properties of the sensors from two batches of wafers with different n^(+)doses are thoroughly *** and temporal resolutions are measured using an infrared laser *** spatial resolutions range from 6.5 to 8.2μm and from 8.8 to 12.3μm for the sensors from two distinct dose batches,each with a 100μm pitch ***,the sensors demonstrate time resolutions of 8.3 and 11.4 ps,underscoring the potential of AC-LGAD technology in enhancing the performance of the DarkSHINE tracking detector.

关键词： The DarkSHINE experiment Silicon-strip detector AC-LGAD sensor Spatial resolution Timing resolution

脂质转移蛋白SiLTP1基因参与谷子耐盐响应初探

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作物学报 2025年第1期51卷 58-67页

作者：孟凡花刘敏沈傲刘炜山东省农业科学院农作物种质资源研究所山东济南250100 上海应用技术大学生态技术与工程学院上海201418

土壤盐渍化严重制约农业生产发展,通过提高植物耐盐性进行盐碱地综合利用,对于保障粮食安全,提升农业生产效率具有重要意义。脂质转移蛋白是一类在高等植物中广泛存在的小分子蛋白质,能够参与植株生长、信号转导以及多种生物和非生物胁... 详细信息

土壤盐渍化严重制约农业生产发展,通过提高植物耐盐性进行盐碱地综合利用,对于保障粮食安全,提升农业生产效率具有重要意义。脂质转移蛋白是一类在高等植物中广泛存在的小分子蛋白质,能够参与植株生长、信号转导以及多种生物和非生物胁迫过程。前期本课题组克隆到一个谷子中编码脂质转移蛋白的基因SiLTP1,本研究通过构建其原核表达载体和植物双元过表达载体,获得了该基因的原核表达蛋白及同源转化过表达阳性植株,经进一步筛选获得4个纯合株系。体外耐盐性试验显示, SiLTP1的原核表达蛋白具有一定耐盐性;转基因植株苗期耐盐生理指标测定显示,SiLTP1过表达植株在遭受盐胁迫时,植株体内MDA积累减少,抗氧化酶含量升高,可积累更少的过氧化氢,从而降低胁迫对植株的氧化损伤,显示基因过表达植株具有更好的耐盐性。本研究结果初步揭示, SiLTP1可正向调控谷子的耐盐性,其在谷子耐盐抗逆方面具有潜在功能,为耐盐谷子品种改良及新品种培育提供了理论基础和候选基因资源。

关键词：脂质转移蛋白 SiLTP1 盐胁迫谷子耐盐响应

Automatic image segmentation method for cotton leaves with disease under natural environment

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Journal of Integrative Agriculture 2018年第8期17卷 1800-1814页

作者： ZHANG Jian-hua KONG fan-tao WU Jian-zhai HAN shu-qing ZHAI zhi-fen Agricultural Information Institute Chinese Academy of Agricultural Sciences/Key Laboratory of Agricultural Big DataMinistry of AgricultureBeijing 100081P.R.China Chinese Academy of Agricultural Engineering Beijing 100125P.R.China

In order to improve the image segmentation performance of cotton leaves in natural environment, an automatic segmentation model of diseased leaf with active gradient and local information is proposed. Firstly, a segmented monotone decreasing edge composite function is proposed to accelerate the evolution of the level set curve in the gradient smooth region. Secondly, canny edge detection operator gradient is introduced into the model as the global information. In the process of the evolution of the level set function, the guidance information of the energy function is used to guide the curve evolution according to the local information of the image, and the smooth contour curve is obtained. And the main direction of the evolution of the level set curve is controlled according to the global gradient information, which effectively overcomes the local minima in the process of the evolution of the level set function. Finally, the Heaviside function is introduced into the energy function to smooth the contours of the motion and to increase the penalty function Φ(x) to calibrate the deviation of the level set function so that the level set is smooth and closed. The results showed that the model of cotton leaf edge profile curve could be obtained in the model of cotton leaf covered by bare soil, straw mulching and plastic film mulching, and the ideal edge of the ROI could be realized when the light was not uniform. In the complex background, the model can segment the leaves of the cotton with uneven illumination, shadow and weed background, and it is better to realize the ideal extraction of the edge of the blade. Compared with the Geodesic Active Contour(GAC) algorithm, Chan-Vese(C-V) algorithm and Local Binary Fitting(LBF) algorithm, it is found that the model has the advantages of segmentation accuracy and running time when processing seven kinds of cotton disease leaves images, including uneven lighting, leaf disease spot blur, adhesive diseased leaf, shadow, complex b

关键词： local binary fitting model natural environment cotton disease leaves image segmentation

Gaussian Integral Formula for Quaternions Based on Class Operator's Formula of Rotation Group

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Communications in Theoretical Physics 2008年第10期50卷 861-863页

作者： fan Hong-Yi XU zhi-hua Department of Physics Shanghai Jiao Tong University Shanghai 200030 China Department of Material Science and Engineering University of Science and Technology of China Hefei 230026 China

Abstract There exists rare integration formulas over quaternions due to the noncommutativity of quarternions multplication. Based on the class operator＇s formula of rotation group we derive a Gaussian integral formul... 详细信息

关键词： Gaussian integration for quaternions rotation group class operator

Two-order Hermite vector-interpolating subdivision schemes

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第9期7卷 1566-1571页

作者： fan Min kang Bao-sheng ZHAO hua Beijing Institute of Tracking and Telecommunication Technology Beijing 100094 China Department of Computer Sctence Northwest University Xi＇an 710069 China

A family of two-order Hermite vector-interpolating subdivision schemes is proposed and its convergence and con- tinuity are analyzed. The iterative level can be estimated for given error. The sufficient conditions of C2 continuity are proved. Geometric features of subdivision curves, such as line segments, cusps and inflection points, are obtained by appending some conditions to initial vectorial Hermite sequence. An algorithm is presented for generating geometric features. For an initial se- quence of two-order Hermite elements from unit circle, the numerical error of the 4th subdivided level is O(10?4).

关键词： Two-order vectorial Hermite element Hermite-interpolating subdivision schemes Geometric features

Coherent interaction and action–counteraction theory in small polaron systems,and ground state properties

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Chinese Physics B 2022年第11期31卷 474-481页

作者： zhi-hua Luo Chao-fan Yu School of Physics and Information Engineering Guangdong University of EducationGuangzhou 510303China

Based on the coherent interaction and action–counteraction principles,we investigate the ground state properties for small polaron systems,the coherent-squeezed fluctuation correction,and the anomalous lattice quantum fluctuation,with the new variational generator containing correlated squeezed-coherent coupling and quantum *** tha t-2t is the ***,for the coherent interaction effect,we find the ground-state energy E_(0)to be-2.428t,in which the coherent squeezed fluctuation correction-A_(0)t is-0.463t(where t is the hopping integral,ωis the phonon frequency),with the electron–one-phonon coupling constant g=1 and the electron–two-phonon coupling constant g_(1)=-***,as a result of the action–counteraction effect,E_(0)is-2.788t,but-E_(0)t *** to the polaron binding energy(EP),for the coherent interaction effect,E_(P) is-1.38ω,but for the action–counteraction effect,E_(P) is-1.88ω.In particular,the electron–two-phonon interaction noticeably enlarges the coherent interaction and the coherent squeezed quantum fluctuation *** intervening with the quantum entanglement,the evolutions of the squeezed coherent state and the lattice quantum fluctuation begin to take *** that time,we encounter a new quantum phase coherence phenomenon—the collapse and revival of inversion repeatedly for the coherent state in the entangled evolution.

关键词： coherent interaction and action-counteraction correlated representation variational approach entangled-squeezed coherent state interaction of electron with the coherent squeezed fluctuation