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Milk fat globule epidermal growth factor 8 alleviates liver injury in severe acute pancreatitis by restoring autophagy flux and inhibiting ferroptosis in hepatocytes

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World Journal of Gastroenterology 2024年第7期30卷 728-741页

作者： Qing Cui Hang-Cheng Liu Wu-Ming Liu Feng Ma yi Lv Jian-Cang Ma Rong-Qian Wu yi-fan ren Department of Cardiology Xi’an Central Hospital Affiliated to Xi’an Jiaotong UniversityXi’an 710003Shaanxi ProvinceChina Department of General Surgery The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina National Local Joint Engineering Research Center for Precision Surgery&Regenerative Medicine Shaanxi Provincial Center for Regenerative Medicine and Surgical EngineeringFirst Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Vascular Surgery The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina

BACKGROUND Liver injury is common in severe acute pancreatitis(SAP).Excessive autophagy often leads to an imbalance of homeostasis in hepatocytes,which induces lipid peroxidation and mitochondrial iron deposition and ultimately leads to *** previous study found that milk fat globule epidermal growth factor 8(MFG-E8)alleviates acinar cell damage during SAP via binding toαvβ3/5 ***-E8 also seems to mitigate pancreatic fibrosis via inhibiting chaperone-mediated *** To speculate whether MFG-E8 could also alleviate SAP induced liver injury by restoring the abnormal autophagy *** SAP was induced in mice by 2 hly intraperitoneal injections of 4.0 g/kg L-arginine or 7 hly injections of 50μg/kg cerulein plus ***8-knockout mice were used to study the effect of MFG-E8 deficiency on SAPinduced liver ***,a specificαvβ3/5 integrin inhibitor,was used to investigate the possible mechanism of *** The results showed that MFG-E8 deficiency aggravated SAP-induced liver injury in mice,enhanced autophagy flux in hepatocyte,and worsened the degree of *** MFG-E8 reduced SAP-induced liver injury in a dose-dependent ***,MFG-E8 mitigated excessive autophagy and inhibited ferroptosis in liver *** abolished MFG-E8’s beneficial effects in SAP-induced liver *** MFG-E8 acts as an endogenous protective mediator in SAP-induced liver ***-E8 alleviates the excessive autophagy and inhibits ferroptosis in hepatocytes by binding to integrinαVβ3/5.

关键词： Autophagy flux Ferroptosis Liver injury Milk fat globule epidermal growth factor 8 αvβ3/5 integrins Acute pancreatitis

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Neutrophil-to-lymphocyte ratio predicts acute kidney injury occurrence after gastrointestinal and hepatobiliary surgery

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World Journal of Gastrointestinal Surgery 2020年第7期12卷 326-335页

作者： Jian-Bin Bi Jia Zhang yi-fan ren Zhao-Qing Du Zheng Wu yi Lv Rong-Qian Wu National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine Shaanxi Provincial Center for Regenerative Medicine and Surgical EngineeringInstitute of Advanced Surgical Technology and EngineeringFirst Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061 Shaanxi Province China Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061 Shaanxi Province China

BACKGROUND Postoperative acute kidney injury(AKI) is a complex pathological process involved intrarenal and systemic inflammation caused by renal hypoperfusion, nephrotoxic drugs and urinary obstruction. Neutrophil-to-lymphocyte ratio(NLR) is a marker of inflammation reflecting the progress of many diseases. However, whether NLR at admission can predict the occurrence of AKI after surgery in the intensive care unit(ICU) remains *** To clarify the relationship between NLR and the occurrence of AKI in patients with gastrointestinal and hepatobiliary surgery in the *** A retrospective analysis of 282 patients receiving surgical ICU care after gastrointestinal and hepatobiliary surgery in our hospital from December 2014 to December 2018 was *** Postoperative AKI occurred in 84 patients(29.79%) in this cohort. NLR by the multivariate analysis was an independent risk factor for occurrence of postoperative AKI in patients with gastrointestinal and hepatobiliary surgery in the ICU. In this cohort, receiver operating characteristic curves of AKI occurrence showed that the optimal cut-off value of NLR was 8.380. NLR was found to be significantly correlated with the white blood cell count, neutrophil count, lymphocyte count, arterial lactate and dialysis(P rence in patients with gastrointestinal and hepatobiliary surgery in ICU. NLR should be included in the routine assessment of AKI occurrence.

关键词： Neutrophil-to-lymphocyte ratio Acute kidney injury Gastrointestinal and hepatobiliary surgery Surgical intensive care unit Arterial lactate Sepsis

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Irisin attenuates intestinal injury,oxidative and endoplasmic reticulum stress in mice with L-arginine-induced acute pancreatitis

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World Journal of Gastroenterology 2019年第45期25卷 6653-6667页

作者： yi-fan ren Meng-Zhou Wang Jian-Bin Bi Jia Zhang Lin Zhang Wu-Ming Liu Sha-Sha Wei yi Lv Zheng Wu Rong-Qian Wu National Local Joint Engineering Research Center for Precision Surgery&Regenerative Medicine Shaanxi Provincial Center for Regenerative Medicine and Surgical EngineeringFirst Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND Acute pancreatitis(AP)is often associated with intestinal injury,which in turn exaggerates the progression of *** recent study has shown that a low level of serum irisin,a novel exercise-induced hormone,is associated with poor outcomes in patients with AP and irisin administration protects against experimental ***,the role of irisin in intestinal injury in AP has not been *** To investigate the effect of irisin administration on intestinal injury in experimental *** AP was induced in male adult mice by two hourly intraperitoneal injections of *** 2 h after the last injection of L-arginine,irisin(50 or 250μg/kg body weight)or 1 mL normal saline(vehicle)was administered through intraperitoneal *** animals were sacrificed at 72 h after the induction of *** injury,apoptosis,oxidative and endoplasmic reticulum(ER)stress were *** Administration of irisin significantly mitigated intestinal damage,reduced apoptosis,and attenuated oxidative and ER stress in AP *** addition,irisin treatment also effectively downregulated serum tumor necrosis factor-alpha and interleukin-6 levels and alleviated injury in the pancreas,liver and lung of AP *** Irisin-mediated multiple physiological events attenuate intestinal injury following an episode of *** has a great potential to be further developed as an effective treatment for patients with AP.

关键词： Irisin Intestinal injury Oxidative stress Endoplasmic reticulum stress Acute pancreatitis Mouse model

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Fast anisotropic resistivities inversion of loggingwhile-drilling resistivity measurements in highangle and horizontal wells

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Applied Geophysics 2020年第3期17卷 390-400页

作者： Wang Lei Wu Zhen-Guant fan yi-ren Huo Li-Zhuang School of Geosciences China University of Petroleum(East China)QingdaoShandong 266580China. Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao266071China. State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Eff ective Development Beijing 100101

Information about anisotropic resistivity is essential in real-time correlation,updating of formation model and making more confi dent geosteering decisions in logging-while-drilling(LWD)***,abnormal responses such as curve separations and apparent resistivity“horns”often exist in the LWD resistivity measurements due to the infl uences of complex downhole ***,accurate formation resistivity is not readily *** this paper,we present an effi cient inversion scheme for the rapid estimation of anisotropic resistivity from LWD resistivity measurements acquired in high-angle and horizontal *** strategies are adopted in the inversion:(1)a one-dimensional(1D)simulator with a simplifi ed three-layered model guarantees the forward speed and keeps the number of inverted parameters as few as possible;(2)combined with geological and petrophysical bounds,the tool constraints derived from a detection capability analysis of LWD resistivity measurements are applied to scale down the inverted parameters’searching scope,which avoids meaningless solutions and accelerates the inversion signifi cantly;(3)multiple-initial guesses are used in the inversion to ensure a global *** results over synthetic examples demonstrate that the proposed 1D inversion algorithm is well suited for complex formation *** is also robust and fast in extracting anisotropic resistivities from LWD resistivity measurements.

关键词： logging-while-drilling resistivity logging anisotropic resistivity fast inversion high-angle/horizontal well

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Effect of low-dose aspirin administration on long-term survival of cirrhotic patients after splenectomy: A retrospective single-center study

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World Journal of Gastroenterology 2019年第28期25卷 3798-3807页

作者： Zhao-Qing Du Jun-Zhou Zhao Jian Dong Jian-Bin Bi yi-fan ren Jia Zhang Bilawal Khalid Zheng Wu yi Lv Xu-Feng Zhang Rong-Qian Wu National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine First Affiliated Hospital of Xi’an Jiaotong University Xi’an 710061 Shaanxi Province China Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong University Xi’an 710061 Shaanxi Province China

BACKGROUND Cirrhosis is a major risk factor for the development of hepatocellular carcinoma (HCC). Portal vein thrombosis is not uncommon after splenectomy in cirrhotic patients, and many such patients take oral anticoagulants including aspirin. However, the long-term impact of postoperative aspirin on cirrhotic patients after splenectomy remains unknown. AIM The main purpose of this study was to investigate the effect of postoperative long-term low-dose aspirin administration on the development of HCC and longterm survival of cirrhotic patients after splenectomy. METHODS The clinical data of 264 adult patients with viral hepatitis-related cirrhosis who underwent splenectomy at the First Affiliated Hospital of Xi’an Jiaotong University from January 2000 to December 2014 were analyzed retrospectively. Among these patients, 59 who started taking 100 mg/d aspirin within seven days were enrolled in the aspirin group. The incidence of HCC and overall survival were *** During follow-up, 41 (15.53%) patients developed HCC and 37 (14.02%) died due to end-stage liver diseases or other serious complications. Postoperative longterm low-dose aspirin therapy reduced the incidence of HCC from 19.02% to 3.40% after splenectomy (log-rank test, P=0.028). Univariate and multivariate analyses showed that not undertaking postoperative long-term low-dose aspirin therapy [odds ratio (OR)=6.211, 95% confidence interval (CI): 1.142-27.324, P=0.016] was the only independent risk factor for the development of HCC. Similarly, patients in the aspirin group survived longer than those in the control group (log-rank test, P=0.041). Univariate and multivariate analyses showed that the only factor that independently associated with improved overall survival was postoperative long-term low-dose aspirin therapy [OR = 0.218, 95%CI: 0.049- 0.960, P=0.044]. CONCLUSION In patients with viral hepatitis-related cirrhosis, long-term post-splenectomy administration of low-dose aspirin reduces th

关键词： Aspirin Splenectomy Prognosis Hepatocellular carcinoma Overall survival

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Recent Progress on Water-based Liquid Embolic Agents in Endovascular Treatment

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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 2024年第5期40卷 776-785页

作者： Qi, yi fan, Hailong Hokkaido Univ Dept Hematol Fac Med Sapporo 0608638 Japan Hokkaido Univ Grad Sch Med Sapporo 0608638 Japan Hokkaido Univ Inst Chem React Design & Discovery WPI ICReDD Sapporo 0010021 Japan

Vascular embolization treatment, a minimally invasive surgery for various blood vessel-related conditions, has emerged as a crucial method in treating such as hemorrhage, arteriovenous malformation, aneurysms, and hypervascular tumors. Liquid embolic agents are gaining prominence due to their distinct advantage in infiltrating distal regions, expanding the scope of embolization beyond the reach of solid agents. Recent strides in biomaterials and technologies have spurred the development of novel liquid embolic agents, addressing challenges posed by traditional options. This mini-review provides a concise overview of the recent progress in water-based liquid embolic agents, highlighting their potential to overcome limitations associated with current embolic materials. By presenting selected research outcomes, we illuminate advancements that enhance the efficacy of liquid embolic agents. Furthermore, the review outlines essential properties for effective liquid embolic agents, offering insights for future developments in this field.

关键词： Endovascular treatment Lquid embolic agent Hydrogel TRANSCATHETER ARTERIAL EMBOLIZATION BENIGN PROSTATIC HYPERPLASIA ELASTINLIKE PROTEIN POLYMER HEPATOCELLULAR-CARCINOMA POTENTIAL APPLICATION METHYLACRYLATE) NANOGEL VASCULAR OCCLUSION IN-VIVO PH HYDROGELS

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Characterization and identification towards dynamic-based electrical modeling of lithium-ion batteries

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Journal of Energy Chemistry 2024年第5期92卷 738-758页

作者： Chuanxin fan Kailong Liu Yaxing ren Qiao Peng School of Automation Nanjing Institute of TechnologyNanjing 211167JiangsuChina School of Control Science and Engineering Shandong UniversityJinan 250100ShandongChina School of Engineering University of LincolnLincoln LN67TSUK Information Technology Analytics&Operations GroupQueen’s University BelfastBelfast BT95EEUK

Lithium-ion batteries are widely recognized as a crucial enabling technology for the advancement of electric vehicles and energy storage systems in the *** design of battery state estimation and control algorithms in battery management systems is usually based on battery models,which interpret crucial battery dynamics through the utilization of mathematical ***,the investigation of battery dynamics with the purpose of battery system identification has garnered considerable attention in the realm of battery *** methods in terms of linear and nonlinear response of lithium-ion batteries have emerged as a prominent area of study in this *** review has undertaken an analysis and discussion of characterization methods,with a particular focus on the motivation of battery system ***,this work encompasses the incorporation of frequency domain nonlinear characterization methods and dynamics-based battery electrical *** aim of this study is to establish a connection between the characterization and identification of battery systems for researchers and engineers specialized in the field of batteries,with the intention of promoting the advancement of efficient battery technology for real-world applications.

关键词： Lithium-ion battery Battery dynamics Nonlinear characterization Nonlinear battery model

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Optical responses of metallic plasmonic arrays under the localized excitation

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Nano Research 2024年第3期17卷 1571-1577页

作者： Sen Yan Hao Ma yi-fan Bao Maofeng Cao Chuan Liu Kaifeng Zhang Xiaowei Wu Jianbo He Xiang Wang Bin ren State Key Laboratory of Physical Chemistry of Solid Surfaces Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China Research&Development Group HitachiLtd.Yokohama 244-0817KanagawaJapan Department of Electronic Science and Engineering Kyoto UniversityKyoto 615-8510Japan

The metallic plasmonic array that can support both propagating surface plasmon polaritons(PSPPs)and localized surface plasmon resonance(LSPR)possesses rich optical properties and remarkable optical performance,making it a powerful platform for applications in photonics,chemistry,and *** practical applications,the excitation spot is usually smaller than the area of metal *** is thus imperative to address“how many array units are enough?”towards a rational design of plasmonic ***,we employed focused ion beam(FIB)to precisely fabricate a series of plasmonic array structures with increased unit *** utilizing photoluminescence(PL)and surface-enhanced Raman spectroscopy(SERS),we found that the array units outside the excitation spot still have a significant impact on the optical response within the *** with the numerical simulation,we found that the boundary of the finite array leads to the loss of PSPP outside the excitation point,which subsequently affects the coupling of PSPP and LSPR in the excitation spot,leading to variations in PL and SERS *** on the findings,we further tuned the LSPR mode of the metal arrays by electrodeposition to obtain strong near-field enhancement without any influence on the PSPP *** work advances the understanding of near-field and far-field optical behavior in finite-size array structures and provides guidance for designing highly-efficient photonic devices.

关键词： plasmonic periodic array finite-size effects dark field scattering surface-enhanced Raman spectroscopy(SERS)

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Rapid Energy Exchange between In Situ Formed Bromine Vacancies and CO_(2)Molecules Enhances CO_(2)Photoreduction

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Research 2024年第2期2023卷 763-771页

作者： Qin ren Ye He Hong Wang Yanjuan Sun fan Dong Research Center for Environmental and Energy Catalysis Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengdu 611731China School of Resources and Environment University of Electronic Science and Technology of ChinaChengdu 611731China

Photocatalytic reduction of CO_(2)into fuels provides a prospective tactic for regulating the global carbon balance utilizing renewable solar ***,CO_(2)molecules are difficult to activate and reduce due to the thermodynamic stability and chemical *** this work,we develop a novel strategy to promote the adsorption and activation of CO_(2)molecules via the rapid energy exchange between the photoinduced Br vacancies and CO_(2)*** in situ continuous wave-electron paramagnetic resonance(cw-EPR)and pulsed EPR technologies,we observe that the spin-spin relaxation time(T_(2))of BiOBr is decreased by 198 ns during the CO_(2)photoreduction reaction,which is further confirmed by the broadened EPR *** result reveals that there is an energy exchange interaction between in situ formed Br vacancies and CO_(2)molecules,which promotes the formation of high-energy CO_(2)molecules to facilitate the subsequent reduction *** addition,theoretical calculations indicate that the bended CO_(2)adsorption configuration on the surface of BiOBr with Br vacancies caused the decrease of the lowest unoccupied molecular orbital of the CO_(2)molecule,which makes it easier for CO_(2)molecules to acquire electrons and get *** situ diffuse reflectance infrared Fourier transform spectroscopy further shows that the activated CO_(2)molecules are favorably converted to key intermediates of COOH*,resulting in a CO generation rate of 9.1μmol g^(-1)h^(-1)and a selectivity of 100%.This study elucidates the underlying mechanism of CO_(2)activation at active sites and deepens the understanding of CO_(2)photoreduction reaction.

关键词： reaction. adsorption activation

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Disposal of zinc extraction residues via iron ore sintering process:an innovative resource utilization

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Journal of Iron and Steel Research International 2024年第7期31卷 1636-1645页

作者： Chun-long fan Cheng-yi Ding Tao Yang Yun-fei Luo yi-fan Wang Qian Li Hong-ming Long School of Metallurgical Engineering Anhui University of TechnologyMa'anshan 243002AnhuiChina Zhongye Changtian International Engineering Co. Ltd.Changsha 410205HunanChina Key Laboratory of Metallurgical Emission Reduction and Resources Recycling(Ministry of Education) Anhui University of TechnologyMa'anshan 243002AnhuiChina

Zinc extraction residue,a solid waste generated from the treatment of zinc-containing dust in rotary kilns,is commonly stockpiled in steel companies for extended *** poses significant disposal challenges and environmental pollution *** far,research on the treatment of zinc extraction residues has been slow,inadequate,and *** this gap,a novel approach was proposed to effectively treat the zinc extraction residue via the iron ore sintering *** was feasible to add 1 wt.%of zinc extraction residues to the sintering raw *** more adequate mineralization reaction resulted in higher yield and tumbler indexes,despite a slight decrease in sintering *** this may result in a slight decrease in sintering speed,the more complete mineralization reaction leads to improved sintering yield and tumbler ***,the addition of zinc extraction residues reduced the CO and NO_(x) concentrations in the sintering flue ***,the iron ore sintering process provided a viable solution for resource utilization and environmentally friendly treatment of zinc extraction residues.

关键词： Zinc extraction residue Iron ore sintering Co-processing Waste utilization Gas pollutant reduction

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