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Risk factors for developing osteoporosis in diabetic kidney disease and its correlation with calcium-phosphorus metabolism,FGF23,and Klotho

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World Journal of Diabetes 2025年第1期16卷 49-57页

作者： fan yang Yan Wu Wei Zhang Department of Endocrinology Wuhu Second People's HospitalWuhu 241000Anhui ProvinceChina Department of Nephrology Wuhu Second People's HospitalWuhu 241000Anhui ProvinceChina

BACKGROUND The progression of diabetic kidney disease(DKD)affects the patient’s kidney glomeruli and tubules,whose normal functioning is essential for maintaining normal calcium(Ca)and phosphorus(P)metabolism in the *** risk of developing osteoporosis(OP)in patients with DKD increases with the aggravation of the disease,including a higher risk of fractures,which not only affects the quality of life of patients but also increases the risk of *** To analyze the risk factors for the development of OP in patients with DKD and their correlation with Ca-P metabolic indices,fibroblast growth factor 23(FGF23),and *** One hundred and fifty-eight patients with DKD who were admitted into the Wuhu Second People’s Hospital from September 2019 to May 2021 were selected and divided into an OP group(n=103)and a normal bone mass group(n=55)according to their X-ray bone densitometry *** data and differences in Ca-P biochemical indices,FGF23,and Klotho were *** correlation of Ca-P metabolic indices with FGF23 and Klotho was discussed,and the related factors affecting OP in patients with DKD were examined by multivariate logistic regression *** The OP group had a higher proportion of females,an older age,and a longer diabetes mellitus duration than the normal group(all P<0.05).Patients in the OP group exhibited significantly higher levels of intact parathyroid hormone(iPTH),blood P,Ca-P product(Ca×P),fractional excretion of phosphate(FeP),and FGF23,as well as lower estimated glomerular filtration rate,blood Ca,24-hour urinary phosphate excretion(24-hour UPE),and Klotho levels(all P<0.05).In the OP group,25-(OH)-D3,blood Ca,and 24-hour UPE were negatively correlated with FGF23 and positively correlated with *** contrast,iPTH,blood Ca,Ca×P,and FeP exhibited a positive correlation with FGF23 and an inverse association with Klotho(all P<0.05).Moreover,25-(OH)-D3,iPTH,blood Ca,FePO4,FGF23,Klotho,age,and female gender were key fa

关键词： Diabetic kidney disease Osteoporosis Calcium-phosphorus metabolism FGF23 Klotho

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Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-Lian Wang Yun-Feng Wang fan yang Jian-Qin Liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

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Bandgap characteristics analysis and graded design of a novel metamaterial for flexural wave suppression

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Applied Mathematics and Mechanics(English Edition) 2025年第01期 1-24页

作者： fan yang Zhaoyang MA Xingming GUO Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Institute of Applied Mathematics and Mechanics School of Mechanics and Engineering ScienceShanghai University Shanghai Institute of Aircraft Mechanics and Control

A novel elastic metamaterial is proposed with the aim of achieving lowfrequency broad bandgaps and bandgap regulation. The band structure of the proposed metamaterial is calculated based on the Floquet-Bloch theorem, and the boundary modes of each bandgap are analyzed to understand the effects of each component of the unit cell on the bandgap formation. It is found that the metamaterials with a low elastic modulus of ligaments can generate flexural wave bandgaps below 300 Hz. Multi-frequency vibrations can be suppressed through the selective manipulation of bandgaps. The dual-graded design of metamaterials that can significantly improve the bandgap width is proposed based on parametric studies. A new way that can regulate the bandgap is revealed by studying the graded elastic modulus in the substrate. The results demonstrate that the nonlinear gradient of the elastic modulus in the substrate offers better bandgap performance. Based on these analyses, the proposed elastic metamaterials can pave the way for multi-frequency vibration control, low-frequency bandgap broadening, and bandgap tuning.

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金属卤素钙钛矿CsPbBr3的电声耦合输运特性研究

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原子与分子物理学报 2025年第2期42卷 169-174页

作者：杨帆周贤中广东工业大学集成电路学院广州510006

金属卤素钙钛矿CsPbBr_(3)在发光方面(Light emitter)的优良表现吸引了许多人把它作为下一代发光、显示与量子信息的可选材料,但其关键的漂移迁移率会受到声子限制.本文将以第一性原理计算得到CsPbBr_(3)的包括极性光学声子(Polar optic... 详细信息

金属卤素钙钛矿CsPbBr_(3)在发光方面(Light emitter)的优良表现吸引了许多人把它作为下一代发光、显示与量子信息的可选材料,但其关键的漂移迁移率会受到声子限制.本文将以第一性原理计算得到CsPbBr_(3)的包括极性光学声子(Polar optical phonon)在内的电声耦合特性,然后使用线性玻尔兹曼方程给出在电场下的解,从而得出漂移迁移率.在论文详述中会给出CsPbBr_(3)的各向异性载流子输运特性的研究,为金属卤素钙钛矿的应用提供一些必要信息.

关键词：第一性原理计算电子-声子耦合漂移迁移率

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A gating mechanism of K2P channels by their selectivity filter

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Journal of Molecular Cell Biology 2022年第3期14卷 1-2页

作者： fan yang Department of Biophysics and Kidney Disease Center of the First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310058 China

Cellular excitability is determined by the flow of different ions across the cell membrane,which is in turn controlled by the opening and closing of ion-permeable pores,the ion channels(Hille,2001).For instance,in neurons,the opening of voltage-gated sodium channels allows the outward flow of intracellular sodium ions,so that the membrane potential is increased(depolarization)to fire the action potential,which encodes and delivers neuronal *** membrane depolarization,voltage-gated potassium(Kv)channels are opened,so that the extracellular potassium ions flow into the cell to decrease the membrane potential and terminate one firing of the action potential(Sigworth,1994).The two-pore potassium(K2P)channels,unlike Kv channels,are not activated by the membrane potential but by mechanical forces when the cell membrane is stretched(Honore,2007).Such‘leaky’K2P channels control cell excitability by setting the resting potential in cells(Gonzalez et al.,2012).Therefore,understanding how K2P channels are opened or closed(gating)is critical.

关键词： potassium selectivity flow

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Robust Adaptive Attitude Control for Non-rigid Spacecraft With Quantized Control Input

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IEEE/CAA Journal of Automatica Sinica 2020年第2期7卷 472-481页

作者： Yun Li fan yang School of Engineering New York UniversityNew York 11201 USA Beijing National Research Center for Information Science and Technology(BNRist) the Department of AutomationTsinghua UniversityBeijing 100084China

In this paper,an adaptive backstepping control scheme is proposed for attitude tracking of non-rigid spacecraft in the presence of input quantization,inertial uncertainty and external *** control signal for each actuator is quantized by sector-bounded quantizers,including the logarithmic quantizer and the hysteresis *** describing the impact of quantization in a new affine model and introducing a smooth function and a novel form of the control signal,the influence caused by input quantization and external disturbance is properly compensated ***,with the aid of the adaptive control technique,our approach can achieve attitude tracking without the explicit knowledge of inertial *** existing attitude control schemes for spacecraft,in this paper,the quantization parameters can be unknown,and the bounds of inertial parameters and disturbance are also not *** addition to proving the stability of the closed-loop system,the relationship between the control performance and design parameters is *** results are presented to illustrate the effectiveness of the proposed scheme.

关键词： Adaptive control attitude control input quantization spacecraft time-varying inertial parameter

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An Improved Enthalpy-Based Lattice Boltzmann 3D Model with Added Probability Function for the Growth Characteristics of Frost Layer

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Journal of Thermal Science 2019年第2期28卷 378-392页

作者： CUI Jing yang Tinghao yang fan yang Guangfeng Airport College Civil Aviation University of China

In this paper, the effects of different surface properties on the growth of frost layer were numerically studied from the mesoscopic scale using the lattice Boltzmann method. The improved enthalpy method and nucleation probability model were combined to establish a three-dimensional lattice Boltzmann model based on nucleation probability theory. The model was used to carry out numerical research on frost layer formation and growth process on cold wall surface. The model could not only simulate the gradual densification and thickening process of frost layer growth from the macro scale, but also describe the change process of the frost layer structure caused by ice branch growth on the micro scale. The average thickness, average density and the amount of the frost layer could be obtained. Through this model, the temporal and spatial evolution characteristics of the topography of the frost layer were obtained. The model was used to analyze the effects of cold wall surface temperature, relative humidity and cold surface wettability on the frosting characteristics. The average thickness, frost average density, frost quality and average solid volume fraction of frost at different times were obtained by calculation.

关键词： lattice Boltzmann model improved enthalpy model nucleation probability model three-dimensional frost surface wettability

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Lee–yang zeros in the Rydberg atoms

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Frontiers of physics 2023年第2期18卷 197-204页

作者： Chengshu Li fan yang Institute for Advanced Study Tsinghua UniversityBeijing 100084China

Lee–yang (LY) zeros play a fundamental role in the formulation of statistical physics in terms of (grand) partition functions, and assume theoretical significance for the phenomenon of phase transitions. In this paper, motivated by recent progress in cold Rydberg atom experiments, we explore the LY zeros in classical Rydberg blockade models. We find that the distribution of zeros of partition functions for these models in one dimension (1d) can be obtained analytically. We prove that all the LY zeros are real and negative for such models with arbitrary blockade radii. Therefore, no phase transitions happen in 1d classical Rydberg chains. We investigate how the zeros redistribute as one interpolates between different blockade radii. We also discuss possible experimental measurements of these zeros.

关键词： Lee-yang zeros Rydberg atom statistical mechanics

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Exo-LSTM: traffic flow prediction based on multifractal wavelet theory

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The Journal of China Universities of Posts and Telecommunications 2021年第5期28卷 102-110页

作者： yang fan Jiang Mengya State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing 100876China Purple Mountain Laboratories Nanjing 211111China

In order to predict traffic flow more accurately and improve network performance, based on the multifractal wavelet theory, a new traffic prediction model named exo-LSTM is proposed. Exo represents exogenous sequence used to provide a detailed sequence for the model, LSTM represents long short-term memory used to predict unstable traffic flow. Applying multifractal traffic flow to the exo-LSTM model and other existing models, the experiment result proves that exo-LSTM prediction model achieves better prediction accuracy.

关键词： long-short term memory(LSTM) exogenous sequences multifractal wavelet model

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珠江三角洲城市群留鸟多样性格局及其驱动机制

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中山大学学报（自然科学版）（中英文） 2025年第1期64卷 218-227页

作者：叶俊宏刘珍环杨帆魏莱周义广东省粤北岩溶区碳水耦合野外科学观测研究站/中山大学地理科学与规划学院广东广州510006

鸟类是反映城市生境和生物多样性变化的重要指标,城市鸟类多样性分布格局模拟与预测是当前城市生物多样性保护研究中重点关注的难题。珠江三角洲城市群经历了快速的城市化过程,景观变化显著,给城市生境和生物多样性保护带来了巨大挑战... 详细信息

鸟类是反映城市生境和生物多样性变化的重要指标,城市鸟类多样性分布格局模拟与预测是当前城市生物多样性保护研究中重点关注的难题。珠江三角洲城市群经历了快速的城市化过程,景观变化显著,给城市生境和生物多样性保护带来了巨大挑战。为解析城市鸟类多样性与城市生境之间的空间关联机制,构建“单物种分布预测-物种多样性聚类-多样性的影响归因”的空间综合途径,开展珠江三角洲城市群留鸟空间格局与形成机制研究。结果表明:1)珠江三角洲城市群的87种留鸟构成的多样性与适宜性具有高度的城-乡梯度分布模式;将留鸟的空间适宜性聚类可分为8类,总体上留鸟的中高适宜区占比小于30%。2)结构方程模型的解析可以发现,人类活动显著地正向影响了鸟类多样性的空间分布格局,影响系数介于0.28~1.94;而植被、气候、地形的正向或负向效应差异明显。研究可为城市生物多样性保护,调控鸟类多样性的生境影响因素,开展城市生态建设与管理提供科学依据。

关键词：城市生物多样性鸟类 MaxEnt模型结构方程模型

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