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Association between adiponectin concentrations and diabetic retinopathy in patients with type 2 diabetes： a meta analysis

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Chinese Medical Journal 2014年第4期127卷 765-771页

作者： fan XH Wu qh Hao YH Ning N Kang Z Cui Y Liu RH Department of Social Medicine School of Public Health Harbin Medical University Harbin Heilongjiang 150081 China Second Hospital of Harbin City Harbin Heilongjiang 150081 China Department of Social Medicine School of Public Health Harbin Medical University Harbin Heilongjiang 150081 China

Background Numerous studies have investigated the association between adiponectin concentrations and diabetic retinopathy （DR） caused by type 2 diabetic ***,the results remain *** performed a metaanalysis to explore the relationship between adiponectin concentrations and risk of DR caused by type 2 diabetic mellitus from published *** A published literature search was performed through the PubMed,Cochrane Library,EMBASE,Science Citation Index Expanded database,Chinese CNKI,and Chinese Wan fang databases for articles published in English and *** standardized mean differences （SMDs） and 95% confidence intervals （95% Cls） were calculated using random or fixed effects *** between studies was assessed using the Cochrane Q test and/2 *** Nineteen studies with a total of 1 545 cases and 1 502 controls were *** original meta-analysis found a significant difference in the adiponectin concentrations between the DR and non-DR （NDR） *** excluding the high heterogeneity studies,the second meta-analysis also demonstrated the significant association （SMD （95% CI） =-0.62 （-0.80 to-0.44）,P=0.0001）.According to the available data,there was statistical significance in the adiponectin concentrations considering non-proliferative DR （NPDR） versus NDR,PDR versus NPDR in Chinese populations with high *** Adiponectin concentrations are correlated with DR; however,the relationship between adiponectin concentrations and DR needs more in-depth investigations with larger sample sizes.

关键词： adiponectin concentrations meta-analysis diabetic retinopathy type 2 diabetic mellitus

Association of polymorphisms in the vascular endothelial growth factor gene and its serum levels with diabetic retinopathy in Chinese patients with type 2 diabetes： A cross-sectional study

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Chinese Medical Journal 2014年第4期127卷 651-657页

作者： fan XH Wu qh Li Y Hao YH Ning N Kang Z Cui Y Liu RH Department of Social Medicine School of Health ManagementHarbin Medical University Harbin Heilongjiang 150081 China Second Hospital of Harbin Heilongjiang 150001 China Second Hospital of Harbin Heilongjiang i50001 China Wenhua Community Clinics Qiqihar Heilongjiang 161005 China

Background Vascular endothelial growth factor （VEGF） is a major mediator of angiogenesis,and plays a key role in the pathogenesis of diabetic retinopathy （DR）.This study was designed to identify the possible role of VEGF gene polymorphisms in the development of DR in type 2 diabetic patients in Chinese and clarify the relationship between VEGF serum levels and the risk of *** This cross-sectional study included 1 040 Chinese subjects with type 2 diabetes *** were 372 patients diagnosed with DR in the case group and 668 patients without DR in the control *** from each patient was analyzed for VEGF polymorphisms of-2578A/C （rs699947）,-1154G/A （rs1570360）,-460C/T （rs833061）,＋405C/G （rs2010963）,and ＋936C/T （rs3025039） using MassARRAY compact *** VEGF serum levels were quantified by enzyme-linked immunosorbent assay （ELISA）.Results No evidence of association was observed between-2578 A/C （rs699947）,＋405C/G （rs2010963）,＋936C/T （rs3025039）,and DR risk under stringent Bonferroni＆#39;s ***,VEGF serum levels were significantly higher in DR patients than those of control *** genetic variation of VEGF polymorphisms influenced VEGF serum levels; subjects carrying the VEGF-2578 C/C （rs699947） genotype had greater VEGF serum levels than those carrying the C/A genotype and VEGF serum levels were significantly higher in CC genotype of the ＋405C/G （rs2010963） compared with those of the other *** The data did not suggest significant association between the VEGF polymorphisms and DR risk under stringent Bonferroni＆#39;s ***,our study indicated that DR patients have higher VEGF levels than diabetic patients without retinopathy,and-2578A/C （rs699947） and ＋405C/G （rs2010963） may be important factors in determining serum VEGF levels.

关键词： vascular endothelial growth factor polymorphism genetics diabetic retinopathy

Identifying the role of apolipoprotein A-I in prostate cancer

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Asian Journal of Andrology 2021年第4期23卷 400-408页

作者： Jing Wang Ling-fan Xu Cheng Liu Tao Huang Chao-Zhao Liang Yi-Dong fan Department of Urology Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012China Department of Urologic Oncology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036China Department of Urology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022China

Although localized prostate cancer(PCa)can be cured by prostatectomy and radiotherapy,the development of effective therapeutic approaches for advanced prostate cancer,including castration-resistant PCa(CRPC)and neuroendocrine PCa(NEPC),is lagging far *** a novel prognostic and diagnostic biomarker for early diagnosis and intervention is an urgent clinical ***,we report that apolipoprotein A-I(ApoA-I),the major component of high-density lipoprotein(HDL),is upregulated in PCa based on both bioinformatics and experimental *** fact that advanced PCa shows strong ApoA-I expression reflects its potential role in driving therapeutic resistance and disease progression by reprogramming the lipid metabolic network of tumor ***,ApoA-I is regulated by MYC,a frequently amplified oncogene in late-stage ***,our findings have revealed a novel indicator to predict prognosis and recurrence,which would benefit patients who are prone to progress to metastasis or even NEPC,which is the lethal subtype of PCa.

关键词： advanced prostate cancer apolipoprotein A-I lipid metabolism MYC

Effects of dynamic recrystallization in extruded and compressed AZ31 magnesium alloy

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Acta Metallurgica Sinica(English Letters) 2010年第5期23卷 334-342页

作者： Xiaohui fan Weiqin TANG Shaorui ZHANG Dayong LI Yinghong PENG School of Mechanical Engineering Shanghai Jiao Tong University Shanghai 200240 China

Commercial AZ31 billets were extruded to round rods at three extrusion velocities of 0.8 m/min, 1.4 m/min and 2.2 m/min, at 643 K, 673 K and 703 K, respectively. The microstructure and texture evolution at different conditions were investigated by optical microscopy （OM） and electron backscattered diffraction （EBSD） techniques. The average grain size is reduced significantly after the hot extrusion, and the microstructure is obviously inhomogeneous due to dynamic recrystallization, which is confirmed by uni-axial compression experiments at elevated temperatures with different strain rates. The uni-axial compression leads to a fibre texture, and {110}010 texture is the major texture in extruded rods due to non-basal slip. As the extrusion temperature is elevated, the main texture becomes weak and other texture components appear.

关键词： AZ31 Extrusion Dynamic recrystallization Microstructure Stress-strain Texture

Establishment and Validation of a Four-stress Granule-related Gene Signature in Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2024年第1期12卷 1-14页

作者： Mengzhu Li Xiude fan Jiajun Zhao Dawei Wang Department of Endocrinology Shandong Provincial HospitalShandong UniversityJinanShandongChina Key Laboratory of Endocrine Glucose&Lipids Metabolism and Brain Aging Ministry of EducationDepartment of EndocrinologyShandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina Shandong Key Laboratory of Endocrinology and Lipid Metabolism JinanShandongChina Shandong Institute of Endocrine and Metabolic Diseases JinanShandongChina

Background and Aims:Stress granules(SGs)as membrane-less cytoplasmic foci formed in response to unfavorable external stimuli could promote cancer cells to adapt to hostile *** carcinoma(HCC)is prone to be highly aggressive once diagnosed,which markedly reduces patient survival ***,it is crucial to develop valid diagnostic markers to prognosticate HCC patient prognosis,which promotes individualized precision therapeutics in *** the pro-tumorigenic activity of SGs,it is of great potential value to construct a prognostic tool for HCC based on the expression profiles of SG-related genes(SGGs).Methods:Bioinformatic analysis was employed to establish an SGG-based prognostic *** blotting and realtime polymerase chain reaction assays were used to assess the expression patterns of the related ***-of-function experiments were performed to analyze the effect of the SGGs on SG formation and cell ***:A four-SGG signature(KPNA2,MEX3A,WDR62,and SFN)targeting HCC was established and validated to exhibit a robust performance in predicting HCC ***,all four genes were further found to be highly expressed in human HCC *** important,we demonstrated that individually knocking down the four SGGs significantly reduced HCC cell proliferation and metastasis by compromising the SG formation ***:We developed an SGG-based predictive signature that can be used as an independent prognostic tool for *** strong predictive power of this signature was further elucidated by the carcinogenic activity of KPNA2,MEX3A,WDR62,and SFN in HCC cells by regulating SG formation.

关键词： Hepatocellular carcinoma Stress granules Prognostic factor G3BP1

A highly sensitive chemiluminescence sensor for detecting mercury(Ⅱ) ions: a combination of Exonuclease Ⅲ-aided signal amplification and graphene oxide-assisted background reduction

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Science China Chemistry 2015年第3期58卷 514-518页

作者： Yang Tian Yue Wang Yan Xu Yang Liu Di Li Chunhai fan College of Life and Environmental Science Minzu University of China Division of Physical Biology & Bioimaging Center Shanghai Synchrotron Radiation Facility Shanghai Institute of Applied PhysicsChinese Academy of Sciences Department of Chemistry Beijing Key Laboratory for Analytical Methods and Instrumentation Tsinghua University

In this paper, we report a highly sensitive chemiluminescence(CL) sensor for Hg2+ ions based on thymine-Hg2+-thymine(T-Hg2+-T) coordination chemistry. We designed a thymine rich oligonucleotide as a capture probe and a signal probe that includes two functional domains: a horseradish peroxidase-mimicking DNAzyme domain for the generation of CL, and a recognition domain. Graphene oxide(GO) was introduced to adsorb the signal probe via π-π interaction, which brought the DNAzyme domain and GO into close proximity and quenches CL. In the presence of Hg2+ ions, the coordination of Hg2+ with the capture probe yielded a hairpin complex, triggers cascaded strand displacement reactions and Exonuclease III-assisted signal amplifications. As a result, accumulated amounts of DNAzyme were generated and released from GO, leading to an enhanced CL signal. This strategy combines enzyme-based signal amplification and GO as a background reducer, leads to a limit of detection(LOD) of 2 nmol/L. This simple detection system provides a label-free yet sensitive approach for detection of Hg2+ ions.

关键词： graphene oxide chemiluminescence mercury(II) ions DNAzyme

Using physical examinations to estimate age in elementary school children:A Chinese population-based study

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Journal of Sport and Health Science 2017年第3期6卷 352-358页

作者： Lei Shi fan Jiang Fengxiu Ouyang Jun Zhang Xiaoming Shen Xinhua Hospital Shanghai Jiao Tong University School of MedicineShanghai 200092China Shanghai Children's Medical Center Shanghai Jiao Tong University School of MedicineShanghai 200025China MOE-Shanghai Key Laboratory of Children's Environmental Health Shanghai 200092China

Background:Designing a simple and accessible approach to age estimation in children and youth is a great challenge in the fields of sports and physical activity(PA).This study was designed to develop and validate a physical-examination-based method of estimating age in young ***:In a cross-sectional study conducted in 2014,we performed physical examinations and assessed PA among 14,970 elementary school children 7–12 years old in Shanghai,*** biological information on the children's height and birth date was ascertained through their *** indicators were applied to develop a gender-specific age estimation equation:The percentage of predicted mature height(PPMH) and the Tanner *** equation was validated through a k-fold cross-validation *** check for estimation accuracy,the association between the discrepancy of estimated age(EA) and chronological age and PA was ***:The gender-specific equations of EA were as follows:EA_(boy) = –6.071 + 6.559 Tanner 2 + 13.315 Tanner 3 + 14.130 Tanner 4 + 0.190 PPMH – 0.071 Tanner 2 × PPMH – 0.146 Tanner 3 × PPMH – 0.155 Tanner 4 × PPMH;EA_(girl) = –4.524 – 1.251 Tanner 2 + 2.504 Tanner 3 + 8.752 Tanner 4 + 11.893 Tanner 5 + 0.158 PPMH + 0.017 Tanner 2 × PPMH – 0.024 Tanner 3 × PPMH – 0.087 Tanner 4 × PPMH – 0.118 Tanner5 × *** mean absolute error was 0.60 years for boys and 0.59 years for *** discrepancy score was negatively and weakly associated with self-reported moderate-to-vigorous PA in both genders(r_(boy) = –0.09,p < 0.001;r_(girl) = –0.12,p < 0.001).Conclusion:Findings suggest that physical examinations could provide a valid and reliable approach for estimating age in young Chinese children.

关键词： Age estimation Growth and maturation Physical activity Physical examination Skeletal age Sports

Autophagy： a stumbling block of androgen inhibition to treat benign prostatic hyperplasia or prostate cancer

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Asian Journal of Andrology 2016年第4期18卷 654-656页

作者： Li Zhang Jun Zhou Song fan Chao-Zhao Liang Department of Urology The First Affiliated Hospital of Anhui Medical University Hefei China Institute of Urology Anhui Medical University Hefei China

Dear Editor, Benign prostatic hyperplasia （BPH） and prostate cancer （PCa） are the two most common prostatic disorders affecting elderly males and represent significant burdens for health-care systems worldwide.1 BPH and PCa exhibit important differences in terms of histology and localization, and to date, no causal relationship between the two prostatic diseases has been demonstrated, but BPH and PCa indeed share traits such as androgen-dependent growth and response to hormonal therapy.

关键词： @@

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师范大学生压力来源及特征

中国组织工程研究与临床康复 2007年第52期11卷 10530-10533页

作者：黄欣范丰慧张庆林谢琴红西南师范大学心理学院重庆市400715 遵义医学院临床心理学系贵州省遵义市563003

目的:调查师范生压力的主要来源及其特征,以期为学校心理健康工作提供理论依据。方法:施测于2005-03-18/04-08在西南师范大学3个校区完成。采用分层抽样,在原西南师范大学本科、专科和高职自考类师范生中按随机数字表法抽取640名被试,... 详细信息

目的:调查师范生压力的主要来源及其特征,以期为学校心理健康工作提供理论依据。方法:施测于2005-03-18/04-08在西南师范大学3个校区完成。采用分层抽样,在原西南师范大学本科、专科和高职自考类师范生中按随机数字表法抽取640名被试,所有调查对象均知情同意。采用青少年生活事件量表对师范生进行无记名调查,整个问卷必须在10min内自主完成,当场收回。量表由27项可能给青少年带来心理反应的负性生活事件构成,共包括6个因子:①人际关系。②学习压力。③受惩罚。④丧失。⑤健康适应。⑥其他。分析师范生的主要压力来源,并对不同学制(本科/专科/高职自考)、学科(文/理)、性别(男/女)和户籍(农村/城镇)的师范生压力特点进行差异显著性检验。结果:收回内容详实问卷627份。①师范生的压力来源依次为学习压力、人际关系、受惩罚、健康、其他及丧失。造成心理影响的压力事件中,排在前3位的依次是:考试压力、学习负担重和升学就业压力。②性别、文理科、户籍和学制4个维度上的主效应显著(F=0.002～0.024,P<0.05);且学制和文理科、学制和户籍维度上有交互作用(F=0.002,0.043,P<0.05)。③本科文科生的压力感大于专科和高职自考文科生(P<0.05),本科和专科的文科生压力均显著大于理科生(P<0.05),高职自考的文科生压力小于理科生(P<0.05)。农村学生的压力感均大于城镇学生(P<0.05)。④文科师范生的人际关系压力、受惩罚压力显著大于理科师范生(P<0.05)。男生的其他压力大于女生(P<0.05)。农村师范生的学习压力大于城镇学生(P<0.05)。结论:①学习压力和人际关系压力是学生的主要压力来源,对学生造成心理影响的压力事件中,排在前3位的依次是考试压力、学习负担重和就业压力。②师范生的心理压力在学制、学科(文/理)、性别和户籍4个维度上有显著差异。③师范生的心理压力在学制和学科、学制和户籍之间有交互作用。

关键词：压力学生生活变动事件