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Frontiers of Medicine 2024年第1期18卷 180-191页

作者： fang Wang Yuxing Liu Yi Dong Meifang Zhao Hao Huang Jieyuan Jin liangliang fan Rong Xiang Department of Endocrinology The Third Xiangya Hospital of Central South UniversityChangsha410013China Department of Cellular Biology School of Life SciencesKey Laboratory of Pediatric Rare DiseasesMinistry of EducationCentral South UniversityChangsha410013China

Lipin proteins including Lipin 1–3 act as transcriptional co-activators and phosphatidic acid phosphohydrolase enzymes,which play crucial roles in lipid ***,little is known about the function of Lipin3 in triglyceride(TG)***,we identified a novel mutation(NM_001301860:p.1835A>T/p.D612V)of Lipin3 in a large family with hypertriglyceridemia(HTG)and obesity through whole-exome sequencing and Sanger *** studies revealed that the novel variant altered the half-life and stability of the Lipin3 ***,we generated Lipin3 heterozygous knockout(Lipin3-heKO)mice and cultured primary hepatocytes to explore the pathophysiological roles of Lipin3 in TG *** found that Lipin3-heKO mice exhibited obvious obesity,HTG,and non-alcoholic fatty liver *** study demonstrated that the haploinsufficiency of Lipin3 in primary hepatocytes may induce the overexpression and abnormal distribution of Lipin1 in cytosol and *** increased expression of Lipin1 in cytosol may contribute to TG anabolism,and the decreased Lipin1 in nucleoplasm can reduce PGC1α,further leading to mitochondrial dysfunction and reduced TG *** study suggested that Lipin3 was a novel disease-causing gene inducing obesity and *** also established a relationship between Lipin3 and mitochondrial dysfunction.

关键词： Lipin3 Lipin1 hypertriglyceridemia obesity mitochondrial dysfunction

Identification of a novel MYO1D variant associated with laterality defects,congenital heart diseases,and sperm defects in humans

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Frontiers of Medicine 2024年第3期18卷 558-564页

作者： Zhuangzhuang Yuan Xin Zhu Xiaohui Xie Chenyu Wang Heng Gu Junlin Yang liangliang fan Rong Xiang Yifeng Yang Zhiping Tan Department of Cardiovascular Surgery The Second Xiangya Hospital of Central South UniversityChangsha410011China Clinical Center for Gene Diagnosis and Therapy The Second Xiangya Hospital of Central South UniversityChangsha410011China Department of Cell Biology School of Life SciencesCentral South UniversityChangsha410013China Department of Gynecology and Obstetrics Xiangya Hospital of Central South UniversityChangsha410008China

The establishment of left–right asymmetry is a fundamental process in animal *** with this process leads to a range of disorders collectively known as laterality defects,which manifest as abnormal arrangements of visceral *** patients with laterality defects,congenital heart diseases(CHD)are *** multiple model organisms,extant research has established that myosin-Id(MYO1D)deficiency causes laterality *** study investigated over a hundred cases and identified a novel biallelic variant of MYO1D(NM_015194:c.1531G>A;p.D511N)in a consanguineous family with complex CHD and laterality *** examination of the proband revealed asthenoteratozoospermia and shortened ***,the effects of the D511N variant and another known MYO1D variant(NM_015194:c.2293C>T;p.P765S)were *** assessment showed that both enhance the interaction withβ-actin and ***,this study revealed the genetic heterogeneity of this rare disease and found that MYO1D variants are correlated with laterality defects and CHD in ***,this research established a connection between sperm defects and MYO1D *** offers guidance for exploring infertility and reproductive health *** findings provide a critical basis for advancing personalized medicine and genetic counseling.

关键词： MYO1D laterality defect congenital heart disease sperm defect β-actin SPAG6

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Char综合征的遗传学研究进展

中华医学遗传学杂志 2024年第6期41卷 758-760页

作者：赵美方范亮亮项荣中南大学生命科学院长沙410013

Char综合征是一种罕见的常染色体显性遗传病,以动脉导管未闭、面部畸形和指/趾发育异常为主要特征,并可能合并多乳头、牙齿发育异常、睡眠障碍等表现。TFAP2B已被证实为神经嵴衍生和发育相关的基因,现已发现该基因的多种变异。骨形态发... 详细信息

Char综合征是一种罕见的常染色体显性遗传病,以动脉导管未闭、面部畸形和指/趾发育异常为主要特征,并可能合并多乳头、牙齿发育异常、睡眠障碍等表现。TFAP2B已被证实为神经嵴衍生和发育相关的基因,现已发现该基因的多种变异。骨形态发生蛋白信号在胚胎发育中发挥重要的作用,参与肢体生长和模式形成、调控神经嵴细胞的发育等。TFAP2B是骨形态发生蛋白2和4的上游调控基因,其变异可能通过影响骨形态发生蛋白的表达造成神经嵴细胞增殖异常,进而导致多器官发育不全综合征。此外,TFAP2B变异也可能仅导致动脉导管未闭、而非典型的Char综合征。

关键词： TFAP2B基因 Char综合征动脉导管未闭发病机制

Free vibration of FGM Timoshenko beams with through-width delamination

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Science China(Physics,Mechanics & Astronomy) 2014年第5期57卷 927-934页

作者： LI ShiRong fan liangliang College of Civil Science and Engineering Yangzhou University School of Aerospace Xi'an Jiaotong University

Free vibration of functionally graded beams with a through-width delamination is investigated. It is assumed that the material property is varied in the thickness direction as power law functions and a single through-width delamination is located parallel to the beam axis. The beam is subdivided into three regions and four elements. Governing equations of the beam segments are derived based on the Timoshenko beam theory and the assumption of ＇constrained mode＇. By using the differential quadrature element method to solve the eigenvalue problem of ordinary differential equations governing the free vibration, numerical re- suits for the natural frequencies of the beam are obtained. Natural frequencies of delaminated FGM beam with clamped ends are presented. Effects of parameters of the material gradients, the size and location of delamination on the natural frequency are examined in detail.

关键词： functionally graded materials beam free vibration natural frequency differential quadrature method delamination

THE EFFECTIVE ELECTROMECHANICAL PROPERTIES OF CELLULAR PIEZOELECTRET FILM:FINITE ELEMENT MODELING

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Acta Mechanica Solida Sinica 2013年第1期26卷 1-8页

作者： Yongping Wan liangliang fan Zheng Zhong School of Aerospace Engineering and Applied Mechanics Tongji University

Cellular space-charge polymer film, also called cellular piezoelectret, has very large piezoelectric effect due to their unique microvoid structure. In this article, the cellular piezoelectret film is considered to be a periodic composite material with closed-cell microvoids aligned periodically. Three dimensional finite element modeling is carried out to obtain the effective elastic modulus and piezoelectric coefficients. Sensitivity analysis was presented by modeling the effec- tive electromechanical properties with different individual variable, including material constants and void shape parameters. By assuming a relation between void shape and void volume fraction, the finite element model can simulate quite well the inflation experiments of the voided charged Polypropylene film published in literature. Finally, the finite element model is used to explore the voided charge polymer film with non-uniform distribution of the trapped charges on the internal surface of voids. It was found that the resultant overall piezoelectric coefficients will be more significant if charges are closely gathered in the central area, and sparse in the around area of the internal surface of voids.

关键词： piezoelectret electromechanical finite element methods

MULTIAXIAL BEHAVIOR OF NANOPOROUS SINGLE CRYSTAL COPPER:A MOLECULAR DYNAMICS STUDY

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Acta Mechanica Solida Sinica 2009年第6期22卷 650-656页

作者： Kejie Zhao liangliang fan Changqing Chen The MOE Key Laboratory School of Aerospace Xi＇an Jiaotong University Xi＇an 710049 China School of Engineering and Applied Science Harvard University Cambridge Massachusetts 02138 USA Department of Engineering Mechanics AML Tsinghua University Beijing 100084 China

The stress-strain behavior and copper are studied by the molecular dynamics incipient yield surface of nanoporous single crystal （MD） method. The problem is modeled by a periodic unit cell subject to multi-axial loading. The loading induced defect evolution is explored. The incipient yield surfaces are found to be tension-compression asymmetric. For a given void volume fraction, apparent size effects in the yield surface are predicted： the smaller behaves stronger. The evolution pattern of defects （i.e., dislocation and stacking faults） is insensitive to the model size and void volume fraction. However, it is loading path dependent. Squared prismatic dislocation loops dominate the incipient yielding under hydrostatic tension while stacking-faults are the primary defects for hydrostatic compression and uniaxial tension/compression.

关键词： molecular dynamics incipient yield surface size effect dislocations nanoporous single crystal copper

Numerical simulation and experimental validation of gas–solid flow in the riser of a dense fluidized bed reactor

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Particuology 2009年第4期7卷 278-282页

作者： Xueyao Wang fan Jiang xiang xu Shengdian Wang Xuezhi Wu Baoguo fan liangliang Liao Jiachang Wang Yunhan Xiao Key Laboratory of Advanced Energy and Power. Institute of Engineering Thermophysics Chinese Academy of Sciences Beijing 100190 China

Gas-solid flow in the riser of a dense fluidized bed using Geldart B particles （sand）, at high gas velocity （7.6-15.5 m/s）s） and with comparatively high solid flux （140-333.8 kg]m^2 s）, was investigated experimentally and simulated by computational fluid dynamics （CFD）, both two- and three-dimensional and using the Gidaspow, O＇Brien-Syamlal, Koch-Hill-Ladd and EMMS drag models, The results predicted by EMMS drag model showed the best agreement with experimental results. Calculated axial solids hold-up profiles, in particular, are well consistent with experimental data. The flow structure in the riser was well represented by the CFD results, which also indicated the cause of cluster formation. Complex hydrody-namical behaviors of particle cluster were observed. The relative motion between gas and solid phases and axial heterogeneity in the three subzones of the riser were also investigated, and were found to be consistent with predicted flow structure. The model could well depict the difference between the two exit configurations used, viz., semi-bend smooth exit and T-shaped abrupt exit. The numerical results indicate that the proposed EMMS method gives better agreement with the experimental results as compared with the Gidaspow, O＇Brien-Syamlal, Koch-Hill-Ladd models. As a result, the proposed drag force model can be used as an efficient aporoach for the dense zas-solid two-ohase flow.

关键词： Gas-solid flow Drag model EMMS Exit configuration

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原位固化法修复排水管网质量评估方法

广东建材 2024年第10期40卷 58-61页

作者：李换圣党彦锋武彦杰范亮亮中交建筑集团第六工程有限公司

近年来原位固化法作为一种非开挖管道修复技术已被广泛采用,其优越性表现在施工迅速,工期短,成本相对较低等方面。然而,原位固化法在我国的推广和应用起步晚,缺乏统一的质量检测与评估方法。本文针对原位固化法施工过程中可能出现的剥... 详细信息

近年来原位固化法作为一种非开挖管道修复技术已被广泛采用,其优越性表现在施工迅速,工期短,成本相对较低等方面。然而,原位固化法在我国的推广和应用起步晚,缺乏统一的质量检测与评估方法。本文针对原位固化法施工过程中可能出现的剥落、起皱和支干管连接阻塞等外观质量问题,提出了相应的解决方法。同时,总结了内衬管厚度、短期力学性能和耐腐蚀能力的取样检测方法。最后,本文探讨了功能性检验方面的闭水试验和闭气实验方法,以确保修复后的管道严密性。本研究对于解决排水系统维护成本增高问题、推动国内非开挖修复技术的发展具有重要的研究意义。

关键词：非开挖修复排水管道原位固化法

中国护士疼痛管理知识和态度的系统评价与荟萃分析

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护理实践与研究 2024年第8期21卷 1212-1219页

作者：周钒张先庚王红艳张洪刘林峰范亮亮宋志明成都中医药大学护理学院四川省成都市610075 四川护理职业学院四川省成都市610100

目的旨在对我国护士疼痛管理知识和态度进行分析、评价,以全面了解和评估当前我国护士疼痛管理的研究现状和护理实践中的局限性。方法系统检索PubMed、Embase、Cochrane Library、Web of Science、中国知网、万方数据库、维普中文科技... 详细信息

目的旨在对我国护士疼痛管理知识和态度进行分析、评价,以全面了解和评估当前我国护士疼痛管理的研究现状和护理实践中的局限性。方法系统检索PubMed、Embase、Cochrane Library、Web of Science、中国知网、万方数据库、维普中文科技期刊数据库,收集有关中国护士疼痛管理知识和态度的横断面研究,检索时间为建库至2023年6月。采用了美国卫生保健研究与质量机构(AHRQ)的质量评价标准对最终纳入文献的质量进行了严格评估,并运用Stata 15.1软件进行全面统计分析。结果本研究最终纳入35篇文献,涉及14146名护士。11篇文献为高质量文献,其余24篇文献质量均处于中等水平。结果显示,中国护士疼痛管理知识和态度问卷答对率为46%(95%CI:0.43~0.50)。亚组分析显示,研究生及以上学历、工作后继续接受疼痛教育、在肿瘤科工作的护士疼痛管理知识和态度问卷答对率越高,分别是56.70%(95%CI:43.80%~69.70%)、58.60%(95%CI:55.00%~62.20%)、58.90%(95%CI:45.20%~72.70%)。结论我国护士在疼痛管理领域的知识和态度普遍存在不足,提示护理管理者亟需认识到疼痛管理在整体护理质量中的重要性,有必要制订持续性的专业培训和教育计划,通过提供定期的疼痛管理知识更新,以提升护士对疼痛管理的认知和应对能力,进而提升护士专业素养,为疼痛患者提供更全面、人性化的治疗和关怀,从而改善疼痛患者的生活质量和治疗效果,进而提高整体护理质量。

关键词：护士疼痛管理知识和态度中国 Meta分析应对能力

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Synthesis of Biodiesel Using ZrO_2 Polycrystalline Ceramic Foam Catalyst in a Tubular Reactor

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China Petroleum Processing & Petrochemical Technology 2015年第3期17卷 67-75页

作者： Wang Yunpu fan liangliang Dai Leilei Liu Yuhuan Ruan Roger Liu Shitao Zhang Xueqin Wan Yiqin Nanchang University State Key Laboratory of Food Science and Technology Nanchang University Engineering Research Center for Biomass Conversion Ministry of Education Nanchang University School of Food Science Technology

With the help of the ceramic foam research efforts and preparation techniques, the ZrO2 polycrystalline ceramic foam catalyst was synthesized, and its characteristics, including the crystal structure, the phase composition, the acid–base properties, and the microstructure, were analyzed by XRD, SEM, Py-IR, and BET techniques. The performance of the ZrO2 polycrystalline ceramic foam catalyst in a tubular reactor was investigated via biodiesel synthesis using S. wilsoniana oil and methanol. The effects of reaction conditions(i.e., reaction temperature, reaction pressure, and volume ratio of methanol to S. wilsoniana oil) on transesterification efficiency were investigated, and the reaction conditions were optimized using RSM. The optimum reaction temperature, reaction pressure, and volume ratio of methanol to S. wilsoniana oil were determined to be 290 ℃, 10 MPa, and 4:1, respectively. Under this condition, the FAME content in the product oil reached 98.38%. The performance of the ZrO2 polycrystalline ceramic foam catalyst synthesized in this work for biodiesel synthesis from S. wilsoniana oil with a moisture content of 7.1% and an acid value of 130.697 mg KOH/g was examined, and the FAME content in the product oil was found to be 93% and 97.67%, respectively. The FAME content in the product oil exceeded 97% after five consecutive cycles(12 h per cycle of use) of the catalyst. The proposed catalyst represents a new type of solid catalyst with excellent acid resistance, water resistance, esterification efficiency, and catalytic stability.

关键词： ZrO2 polycrystalline ceramic foam catalyst tubular reactor S. wilsoniana oil biodiesel