检索结果-南通市图书馆

Journal of Iron and Steel Research International 2013年第12期20卷 47-52页

作者： YANG Jing-jing fan li-xia JIA Juan WU Run SONG Xin-li JIANG li-li School of Materials and Metallurgy Wuhan University of Science and Technology

High-strength interstitial-free steel sheets have very good deep drawability when processed to have { 111 } recrystallization texture. The microtexture evolution and grain boundary character distribution of interstitial-free steels as a function of moderate levels of cold rolling reductions were investigated by the metallographic microscopy and electron backscatter diffraction technique. The results showed that there was a close relationship between micro- texture and grain boundary character distribution for interstitial-free steel, especially the distribution and features of some specific types of coincident-site lattice boundaries. In addition, a-fiber texture was weakened to vanish while 7- fiber texture strengthened gradually as cold rolling reduction was increased from 20% to 75 % for cold rolled and an- nealed samples. Accordingly, increasing the rolling reduction from 20 % to 750% would lead to a significant increase in the proportion of ∑3 boundaries. Also, it was found that the microtexture of 20% cold rolled sample would induce a high frequency of ∑11 grain boundaries, but the microtexture of 75% cold rolled sample would produce more ∑7 and ∑17 grain boundaries. It was suggested that texture played a significant role in the formation of grain boundary character distribution.

关键词： interstitial-free steel mierotexture evolution grain boundary character distribution electron backscatter diffraction

Different gap junction-propagated effects on cisplatin transfer result in opposite responses to cisplatinin normal cells versus tumor cells

在线全文

学校读者我要写书评

暂无评论

中国药理学与毒理学杂志 2016年第10期30卷 1076-1077页

作者： ZHANG Yuan WANG Qin fan li-xia PENG Yue-xia YANG Ke-fan ZHAO Yi-fan SONG Qi TAO liang Department of Pharmacology Zhongshan School of MedicineSun Yat-Sen University

OBJECTIVE Previous work has shown that gap junction intercel ular communication(GJIC)enhances cisplatin(Pt)toxicity in testicular tumor cells but decreases it in non-tumor testicular *** this study,these different GJIC-propagated effects were demonstrated in tumor versus non-tumor cells from other organ tissues(liver and lung).METHODS We use several different mani pulations(no cell contact,pharmacological inhibition,and si RNA suppression)to down-regulate GJIC *** in vivo results using xenograft tumor models were consistent with those from the above-mentioned *** better understand the mechanism(s)involved,we studied the effects of GJIC on Pt accumulation in tumor and non-tumor cells from the liver and *** The intracel ular Pt and DNA-Pt adduct contents clearly increased in non-tumor cells but decreasedin tumor cells when GJIC was *** analysis indicated that the opposite effectsof GJIC on Pt accumulation in normal versus tumor cells from the liver were due to its different effects on copper transporter1 and multidrug resistance-associated protein2,membrane transporters attributed to intracellular Pt *** GJIC protects normal organs from cisplatin toxicity while enhancing it in tumor cells via its different effects on intracellular Pt transfer.

关键词： tumor cells non-tumor cells GJIC cisplatin copper transporter 1 multidrug resistance-associated protein 2

Synthesis and study of λ-MnO_2 supported Pt nanocatalyst for methanol electro-oxidation

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2010年第2期29卷 187-192页

作者： XIE Jia, li xiang, YU Zhihui, ZHANG lijuan, li fan, and xia Dingguo College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100124, China College of Environmental and Energy Engineering Beijing University of Technology

A λ-MnO2 supported Pt nanocatalyst（5 wt.% Pt/λ-MnO2） was synthesized using a facile approach.X-ray diffraction（XRD）, X-ray photoelectron spectroscopy（XPS）, scanning electronic microscope（SEM）, transmission electron microscopy（TEM）, and energy disperse spectroscopy（EDS） were used for catalyst structure and morphology characterization, which showed that the metallic Pt particles were attached on a λ-MnO2 surface through the interaction between Pt and λ-*** voltammetry（CV） was used to test the catalytic activity of Pt/λ-MnO2 toward methanol oxidation, which showed that Pt/λ-MnO2 catalyst has much higher catalytic activity than baseline Pt/C catalyst.

关键词： electrochemistry composite catalyst MnO2 Pt methanol oxidation

Mechanical allodynia and affective behavior are improved by INI-0602,a gap junction hemichannel inhibitor,in a rat model of neuropathic pain induced by sciatic nerve injury

在线全文

学校读者我要写书评

暂无评论

中国药理学与毒理学杂志 2016年第10期30卷 1027-1028页

作者： ZHANG xiao-min fan li-xia PENG Yue-xia SONG Qi xiaNG Yu-ke WU Wei-li WANG Qin TAO liang Department of Pharmacology Zhongshan School of MedicineSun Yat-Sen University

OBJECTIVE To investigated the effects of INI-0602 on nociceptive reflex,depression-associated andanxiety-related behaviors caused by neuropathic pain in sciatic nerve injury *** Male rat were subjected to sciatic nerve injury(SNI)or sham *** received daily treatment with INI-0602 intrathecally,at a dose of 0.25μg/10μ*** response frequency to mechanical allodynia in animals was measured with von Frey hairs on day 1,3,5,7,14,*** were evaluated in the forced swimming test(FST)test,tail suspension test(TST),sucrose preference test(SPT)for depression-like *** performed open field test(OFT)and elevated plus-maze test(EPM)to evaluate anxiety-associated ***,we investigated the alterations of NMDA receptor and the brain-derived neurotrophic factor(BDNF)and also the expression of connexin43 and connexin32,structure protein of gap junction channel,on the protein level and the number of activated astrocyte showed by *** The SNI procedure produced mechanical allodynia and accompanied with depressive-like and anxiety-like *** with INI-0602 produced a significant analgesic effect in SNI rats at day 7(model+NS:11.017±1.506 g;model+INI-0602:31.157±1.532 g,Plief of pain,the alterations of NMDA receptor and the brain-derived neurotrophic factor(BDNF),involved in central sensitization and synaptic plasticity,were ***-0602 not only could inhibited spared nerve injury induced up-regulated of NR2B and phosphorylation NR2B in early and late neuropathic pain(early phase:Nr2b:2.897±0.228,P<0.01;p-Nr2b:2.984±0.236,P<0.01;late phase:Nr2b:2.594±0.187,P<0.01;p-Nr2b:3.124±0.330,P<0.01),but also could inhibit the increased of BDNF in the early(model+NS:3.637±0.381,model+INI-0602:1.148±0.

关键词： INI-0602 gap junction hemichannel inhibitor neuropathic pain depression anxiety

在线全文

学校读者我要写书评

暂无评论

身管冷径向锻造残余应力的模拟研究

兵工学报 2012年第11期33卷 1291-1297页

作者：刘力力樊黎霞徐诚南京理工大学机械工程学院江苏南京210094

身管是自动武器的核心部件,冷径向锻造是制造自动武器身管的一项新工艺。冷径向锻造后的身管通常需要后续的机械加工,且身管在动态的高温高压载荷下射击,锻后身管中的残余应力将直接影响身管后续加工中的尺寸精度及身管使用时的疲劳寿... 详细信息

身管是自动武器的核心部件,冷径向锻造是制造自动武器身管的一项新工艺。冷径向锻造后的身管通常需要后续的机械加工,且身管在动态的高温高压载荷下射击,锻后身管中的残余应力将直接影响身管后续加工中的尺寸精度及身管使用时的疲劳寿命。为了预测冷径向锻造身管内的残余应力分布及影响残余应力分布的各参数,建立了模拟身管的冷径向锻造及回弹过程的轴对称模型,得到了回弹后身管内的残余应力分布,并分析了各工艺参数对锻后身管内残余应力分布的影响规律,为进一步控制锻后身管内残余应力的分布提供了参考。

关键词：机械制造工艺与设备冷径向精锻残余应力轴对称模型工艺参数

Chemoradiotherapy followed by surgery could improve the efficacy of treatments in patients with resectable esophageal carcinoma

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2013年第16期126卷 3138-3145页

作者： WANG Feng WANG Ya-mei HE Wei li xiang-ke PENG fang-hui YANG xiao-li fan Qing-xia Department of Oncology First Affiliated Hospital of ZhengzhouUniversity Zhengzhou Henan 450052 China

Background The effectiveness of chemoradiotherapy followed by surgery （CRTS） in patients with resectable esophageal carcinoma remains *** performed a systematic review of the literature with *** Electronic databases were used to identify published studies between January 1992 and April *** relative risk （RR） with 95％ confidence interval （95％ CI） was utilized to estimate the strength of the association between CRTS and surgery alone （SA） survival of the resectable esophageal carcinoma *** and publication bias were also assessed in the present *** The final analysis of 2755 resectable esophageal carcinoma cases from 21 randomized controlled trials （RCTs） are *** to the SA group,the 1,3-and 5-year survival rates were significantly higher in the CRTS group （all P ＜0.05）; the 3-and 5-year survival rates for the Eastern patients,Western patients,patients undergoing concurrent chemoradiotherapy,patients with squamous cell carcinoma,patients undergoing High-dose radiotherapy （≥40 Gy）,and patients given either ＂cisplatin ＋ Fluorouracil＂ or ＂cisplatin ＋ paclitaxel＂ chemotherapy were significantly higher in the CRTS group （all P ＜0.05）.There were no statistical significances in the 3-and 5-year survival rates for patients undergoing sequential chemoradiotherapy or patients with adenocarcinoma between the two groups （all P ＞0.05）.Compared to the RCTS group,the surgery rate in the SA group was higher （P ＜0.05）,while the CRTS group had significantly higher radical resection rate,R0 resection rate and lower postoperative local recurrence rate （all P ＜0.05）.The differences in postoperative complication incidence,post-operative distant metastasis and postoperative mortality rate were not statistically significant between the two groups （all P ＞0.05）.Conclusion CRTS can significantly improve the survival and surgical conditions of patients with resectable esophageal carcinoma.

关键词： oesophageal carcinoma chemoradiotherapy followed by surgery surgery alone randomized controlled trial meta-analysis

在线全文

学校读者我要写书评

暂无评论

弹丸挤进过程的有限元模拟与分析

兵工学报 2011年第8期32卷 963-969页

作者：樊黎霞何湘玥南京理工大学机械工程学院江苏南京210094

本文针对依靠观察和实验难以解决的弹丸在枪管挤进过程中带有过盈摩擦大变形接触的难题,建立了弹丸挤进枪管的有限元分析模型,运用动态显式算法以及网格自适应技术,通过数值模拟研究了铅芯弹丸的挤进过程,展示了弹丸上膛线压痕的形成过... 详细信息

本文针对依靠观察和实验难以解决的弹丸在枪管挤进过程中带有过盈摩擦大变形接触的难题,建立了弹丸挤进枪管的有限元分析模型,运用动态显式算法以及网格自适应技术,通过数值模拟研究了铅芯弹丸的挤进过程,展示了弹丸上膛线压痕的形成过程和材料的流动情况,分析了挤进前后弹头壳和铅芯的变形特征,以及挤进结束后弹丸的残余应力,从而为改进射击精度提供理论参考依据。

关键词：机械设计弹丸挤进有限元模拟弹丸变形

在线全文

学校读者我要写书评

暂无评论

技术效率、技术进步与粮食生产率增长

经济经纬 2016年第3期33卷 31-36页

作者：范丽霞武汉轻工大学经济与管理学院湖北武汉430023

笔者采用1978年-2012年国内省域面板数据，结合非径向、非角度的SBM方向性距离函数模型，借鉴GlobalMalmquist生产率指数的构造思路，提出一种新的测度模型SBM—Global Malmquist生产率指数，对中国粮食全要素生产率（TFP）进行核算与... 详细信息

笔者采用1978年-2012年国内省域面板数据，结合非径向、非角度的SBM方向性距离函数模型，借鉴GlobalMalmquist生产率指数的构造思路，提出一种新的测度模型SBM—Global Malmquist生产率指数，对中国粮食全要素生产率（TFP）进行核算与分解。实证表明，与Global Malmquist生产率指数相比，传统的Malmquist指数容易导致“技术倒退”，致使粮食TFP的估算“被动”提高；我国粮食TFP的空间非均衡性明显，西部地区粮食TFP增长水平最高，东部地区稍低一点，中部地区最低；我国粮食TFP呈上升趋势，且表现出“U”型波动变化特征；我国粮食TFP增长的源泉主要是前沿技术进步，技术效率改善对粮食TFP增长的推动作用不明显。

关键词：粮食全要素生产率(TFP) SBM模型 GlobalMalmquist生产率指数

盲孔法测定径向锻造身管表面残余应力方法研究

在线全文

学校读者我要写书评

暂无评论

兵工学报 2012年第6期33卷 712-717页

作者：刘力力樊黎霞董雪花南京理工大学机械工程学院江苏南京210094 南京理工大学理学院江苏南京210094

为了找到一种准确简便的测定径向锻造身管表面残余应力的方法,将盲孔法测定平板表面残余应力的理论应用到径向锻造身管表面残余应力的测量中。应用有限元软件计算盲孔释放系数的方法,对比在相同材料、受力情况与钻孔条件下的身管表面盲... 详细信息

为了找到一种准确简便的测定径向锻造身管表面残余应力的方法,将盲孔法测定平板表面残余应力的理论应用到径向锻造身管表面残余应力的测量中。应用有限元软件计算盲孔释放系数的方法,对比在相同材料、受力情况与钻孔条件下的身管表面盲孔的释放系数与平板表面盲孔的释放系数,得到了盲孔法测定径向锻造身管表面残余应力的适用性范围;结合有限元法计算释放系数的优越性,提出了一种通过直接修正释放系数来修正由钻孔偏心所引起的误差方法。并应用盲孔法测定了某锻后身管表面的残余应力。

关键词：机械制造工艺与设备盲孔法残余应力有限元释放系数钻孔偏心

高温引起的弹头壳铜被甲材料性能变化对弹头膛内运动影响

在线全文

学校读者我要写书评

暂无评论

兵工学报 2018年第6期39卷 1074-1081页

作者：杨宇召徐诚樊黎霞南京理工大学机械工程学院江苏南京210094

为了研究高温下铜被甲弹头在膛内运动状况,通过高温拉伸试验得到枪管材料和弹头壳铜被甲材料的力学性能参数,建立了铜被甲弹头在全枪管中的挤进运动有限元模型。该模型考虑了枪管在重力作用下的预弯曲以及铜被甲材料在不同温度时的力学... 详细信息

为了研究高温下铜被甲弹头在膛内运动状况,通过高温拉伸试验得到枪管材料和弹头壳铜被甲材料的力学性能参数,建立了铜被甲弹头在全枪管中的挤进运动有限元模型。该模型考虑了枪管在重力作用下的预弯曲以及铜被甲材料在不同温度时的力学性能。通过数值模拟研究了弹头挤进过程以及弹头在膛内运动姿态,分析了铜被甲弹头在不同温度下的挤进阻力、材料流动及变形。计算结果表明,温度越高,弹头在膛内变形越大,前进阻力也越大,弹头头部铜被甲弯曲程度越厉害;对弹头运动姿态进行分析后发现,温度越高,弹头在膛内摆动角越大,说明了热枪状态下铜被甲弹头的射击精度会下降,射弹散布变大。

关键词：弹头铜被甲弹头挤进弹头受力变形膛内运动