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B族链球菌携带及感染孕妇外周血单核细胞炎症因子的水平变化

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中国妇产科临床杂志 2022年第1期23卷 57-59页

作者：樊金焱方云云纪艳珍李玮杨德胜张华青岛市海慈医疗集团门诊部 266033 青岛市海慈医疗集团门诊综合服务部青岛市海慈医疗集团检验科青岛市海慈医疗集团妇科

目的分离培养B族链球菌(GBS)感染孕妇外周血单核细胞,探究GBS感染后炎症因子的变化。方法选择2017年6月至2018年12月在青岛市海慈医疗集团产科分娩的GBS阳性孕妇和正常孕妇,以及育龄期妇女作为研究对象,分离培养受试者外周血单核细胞,探... 详细信息

目的分离培养B族链球菌(GBS)感染孕妇外周血单核细胞,探究GBS感染后炎症因子的变化。方法选择2017年6月至2018年12月在青岛市海慈医疗集团产科分娩的GBS阳性孕妇和正常孕妇,以及育龄期妇女作为研究对象,分离培养受试者外周血单核细胞,探究IL-1、IL-6、IL-8、TNF-α、CRP的m RNA及蛋白表达量的变化。结果GBS感染组外周血单核细胞IL-6(102.22±98.62)ng/L和IL-8(98.17±87.12)ng/L的水平显著高于正常孕妇组IL-6(24.62±53.14)ng/L、IL-8(20.25±30.11)ng/L和育龄期妇女组IL-6(22.13±56.23)ng/L、IL-8(17.12±20.63)ng/L(P<0.001)。GBS感染组新生儿发病率为20.0%,显著高于正常孕妇组(0.0%;P<0.05)。结论GBS感染阳性孕妇外周血单个核细胞中,IL-6和IL-8炎症因子表达显著上升,且新生儿发病风险增加,临床上应给予重视。

关键词：妊娠期 B族链球菌感染单个核细胞炎症因子

老年人健康管理现状及对互联网+老年健康管理APP的使用意向调查与分析

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中国医药导报 2020年第33期17卷 65-67,73页

作者：陈俊聪范金燕刘月生钟雪萍刘艺代凤玲西南医科大学护理学院四川泸州64600

目的调查老年人健康管理现状以及对互联网+老年健康管理APP的使用需求,为APP的研发与推广提供参考依据。方法采用自设问卷,于2018年12月—2019年2月在四川省5市选取老年人进行问卷调查,观察老年人目前健康管理现状、对健康管理APP的服... 详细信息

目的调查老年人健康管理现状以及对互联网+老年健康管理APP的使用需求,为APP的研发与推广提供参考依据。方法采用自设问卷,于2018年12月—2019年2月在四川省5市选取老年人进行问卷调查,观察老年人目前健康管理现状、对健康管理APP的服务功能及服务方式需求。结果共发放250份问卷,回收有效问卷235份,有效回收率为94.00%。多数调查对象对健康管理意识尚不足;调查对象对健康管理APP功能需求的占比最多的是协助挂号,缩短排队时间,提供养生知识及保健方法;在服务方式的需求方面形式呈多样化,包括定点服务、24 h在线联系、定期上门服务等。结论互联网+背景下老年健康管理APP的应用,需提升老年人健康管理理念,重视健康管理服务质量,并且建立有效的行业管理与监督机制。

关键词：互联网+ 老年人健康管理使用需求

Interaction of arterial proteoglycans with low density lipoproteins(LDLs):From theory to promising therapeutic approaches

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Medicine in Novel Technology and Devices 2019年第3期3卷 1-8页

作者： Hongyan Kang jinyan Lu Jiali Yang Yubo fan Xiaoyan Deng Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China Beijing Advanced Innovation Centre for Biomedical Engineering Beihang UniversityBeijing100083China

Although atherosclerosis is a multifactorial process,proteoglycans mediated lipoprotein(LDL)retention at the subendothelial space is a necessary and sufficient event in provoking lesion ***(PGs)are usually composed of one core protein backbone with one or more glycosaminoglycan chains(GAGs)covalently linked,mainly include perlecan,biglycan,versican,and *** interaction between LDL and proteoglycans is apparently mediated by the basic amino acids in apoB-100,the moiety of LDL,electrostatic interacting with the negatively charged GAGs(sulfate or carbohydrate groups)of proteoglycans or though some bridge molecules like sphingomyelinase(SMase)or lipoprotein lipase(LpL).In the later section,we collate the promising therapeutic approaches that have been proposed up to now,targeting LDL-PGs *** should be concluded that previous studies on interaction between LDL and PGs mainly focused on perlecan,biglycan,decorin,and versican that all located in the extracellular matrix(ECM),future studies should pay more attention to the endothelial surface glycocalyx and its interaction with LDLs,seeking promising therapeutic targets more specifically.

关键词： Proteoglycans Low-density lipoprotein Atherosclerosis Endothelial glycocalyx

Sand barrier morphological evolution based on time series remote sensing images:a case study of Anhaiao,Pingtan

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Acta Oceanologica Sinica 2020年第12期39卷 121-134页

作者： Heshan Lin Xingguang Yu Zhigang Yu Yikang Gao jinyan Xu Aiping Feng Zhijun Liu Degang Jiang fan Yu College of Environmental Science and Engineering Ocean University of ChinaQingdao 266100China Island Research Center Ministry of Natural ResourcesPingtan 350400China Third Institute of Oceanography Ministry of Natural ResourcesXiamen 361005China Ministry of Natural Resources Beijing 100812China

The morphological evolution of the sand barrier in the Anhaiao coastal zone of Pingtan from 1996 to 2018 was *** correction was used to refine the location of the coastline.A standard deviation ellipse method was applied to further analyze the movement of the barrier head with the axis and rotation angle.A natural neighbor interpolation(NNI)method was carried out to calculate the terrain of the intertidal area,and the erosion and deposition characteristics were illustrated based on the *** results showed that the northern part of the sand barrier facing the lagoon area was deposited over the whole studied period,while erosion has always occurred in the southern part of the sand barrier facing the open *** erosion and deposition were slightly different on both sides of the barrier head due to hydrodynamic *** middle sand barrier moved 102.60 m away from its original location in 1996,and the end of the barrier moved 65.45 *** head of the sand barrier continued moving 379 m to the ***,the preliminary morphological evolution of the sand barrier corresponding to the distance and direction of movement was detected.

关键词： sand barrier dynamic evolution movement reclamation

Production of Two Elite Glutinous Rice Varieties by Editing Wx Gene

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Rice science 2019年第2期26卷 118-124页

作者： FEI Yunyan YANG Jie WANG fangquan fan fangjun LI Wenqi WANG Jun XU Yang ZHU jinyan ZHONG Weigong Institute of Food Crops Jiangsu Academy of Agricultural Sciences/Nanjing Branch of Chinese National Center for Rice Improvement/Jiangsu High Quality Rice Research & Development Center Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops Yangzhou University

The waxy gene(Wx) in rice, which encodes the granule bound starch synthase enzyme, is responsible for amylose synthesis. Glutinous(sticky) rice has little or no amylose that can be used in various applications, such as brewing. In this study, knockout of the Wx gene with CRISPR/Cas9 technology was conducted in two elite japonica rice lines, Huaidao 5(HD5) and Suken 118(SK118), aiming to develop elite sticky rice varieties. We achieved six homozygous T_0 plants with more than 200 bp deletion in the Wx gene, as well as 36 wx-HD5 and 18 wx-SK118 homozygous transgene-free plants in the T_1 generation. The seeds of all the mutants were white and opaque, similar to those of sticky rice, and contained only 2.6%–3.2% amylose. Results of scanning electron microscopy showed that the quality of rice did not change. In conclusion, we successfully developed two elite sticky rice varieties.

关键词： amylose CRISPR Cas9 rice starch Wx

Phylogenetic analyses and antigenic characterization of foot-and-mouth disease virus PanAsia lineage circulating in China between 1999 and 2023

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Virologica Sinica 2024年第5期39卷 747-754页

作者： Xiangle Zhang Weimin Ma Baohong Liu Chaochao Shen fan Yang Yamin Yang Lv Lv jinyan Wu Yongjie Liu Youjun Shang Jianhong Guo Zixiang Zhu Xiangtao Liu Haixue Zheng Jijun He State Key Laboratory for Animal Disease Control and Prevention College of Veterinary MedicineLanzhou UniversityLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou 730046China WOAH/National Reference Laboratory for Foot-and-mouth Disease Lanzhou 730046China

Foot-and-mouth disease(FMD)is one of the most important transboundary animal diseases caused by foot-andmouth disease virus(FMDV),leading to signiﬁcant economic losses ***ﬁrst report of PanAsia lineage of FMDV in China was in *** 2011,18 outbreaks attributed to PanAsia lineage viruses have been reported across 7 provinces or municipality in *** analysis indicated that these PanAsia strains were clustered into three distinct clades(clade 1,clade 2,and clade 3),with nucleotide homology ranging from 91.4%to 100%.The outbreaks of FMD caused by clade 1 strains occurred around 1999 when this lineage was prevalent *** 2 strains dominated from 2011 to 2013,while clade 3 strains were prevalent during 2018–2019,sharing only 93%homology with clade 2 strains and 91%with clade 1 *** analysis showed that these outbreaks represented 3 distinct introductions of PanAsia viruses into *** neutralization tests(VNT)have demonstrated that current commercial vaccines are effective to protect susceptible animals against these strains(r1>0.3).However,the growing demand for livestock has promoted animal movement and encouraged the exchange of products,services,and materials between countries,thereby heightening the risk of exotic strain ***,it is imperative to reinforce border controls and limit animal movements among various Asian countries continually to reduce the risk of new transboundary diseases,such as FMD ***,PanAsia-2 strains need to be taken seriously to prevent its incursions,and the relevant vaccines against PanAsia-2 strains need to be stockpiled in preparation for any possible incursion.

关键词： Foot-and-mouth disease virus(FMDV) Epidemiology Nucleotide homology Prevention Vaccine

Integration of serum pharmacochemistry with network pharmacology to reveal the potential mechanism of Yangqing Chenfei formula(养清尘肺方) for the treatment of silicosis

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Journal of Traditional Chinese Medicine 2024年第4期44卷 784-793页

作者： HU Yuanyuan LIU Xinguang ZHAO Peng WU jinyan YAN Xinhua HOU Runsu WANG Xiangcheng YANG fan TIAN Xinrong LI Jiansheng Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai 200032China Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan and Education Ministry of P.R.China.Zhengzhou 450046China Henan Key Laboratory of Chinese Medicine for Respiratory Disease Henan University of Chinese MedicineZhengzhou 450046China

OBJECTIVE:To explore the mechanisms of Yangqing Chenfei formula(养清尘肺方,YCF)in the treatment of silicosis through a comprehensive strategy consisting of serum pharmacochemistry,network pharmacology analysis,and in vitro ***:An ultrahigh-performance liquid chromatography-tandem mass spectrometry method was used to confirm the active components in YCF-medicated ***,we obtained targets for active components and genes for silicosis from multiple ***,a protein-protein interaction network was constructed,and Kyoto Encyclopedia of Genes and Genomes pathway and biological process analyses were conducted to elucidate the mechanisms of YCF for the treatment of ***,we validated the important components and mechanisms in ***:Altogether,19 active components were identified from rat serum after YCF *** identified 724 targets for 19 components,which were mainly related to inflammation[phosphatidy linositol 3 kinase/protein kinase B,forkhead box O,hypoxia inducible factor,and T-cell receptor signaling pathway,nitric oxide biosynthetic process],fibrotic processes[vascular endothelial growth factor signaling pathway,extracellular signal regulated kinase(ERK)1 and ERK2 cascade,smooth muscle cell proliferation],and apoptosis(negative regulation of apoptotic process).In addition,218 genes for silicosis were identified and were mainly associated with the inflammatory response and immune process[cytokine-cytokine receptor interaction,tumor necrosis factor alpha(TNF-α),toll-like receptor,and nucleotide binding oligomerization domain-like receptor signaling pathway].Taking an intersection of active component targets and silicosis genes,we obtained 61 common genes that were mainly related to the inflammatory response and apoptosis,such as the phosphatidylinositol-3-kinase/protein kinase B signaling pathway,mitogen activated protein kinases signaling pathway,TNF signaling pathway,toll-like receptor signaling pathway,b

关键词： silicosis network treatment

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微机械陀螺零位误差的研究

西安交通大学学报 2006年第4期40卷 480-483页

作者：潘金艳朱长纯樊建民西安交通大学电子与信息工程学院西安710049 西安陆星惯性技术有限责任公司西安710068

针对微机械陀螺仪零位误差严重影响制导系统的定位精度问题，提出了时间分段的零位补偿方法．该方法将零住校准时闯进行分段，在准备时间段采用均值滤波，将静态零偏值一次性基本校除，在工作初始时间段内根据特性建立一阶或高阶补偿模... 详细信息

针对微机械陀螺仪零位误差严重影响制导系统的定位精度问题，提出了时间分段的零位补偿方法．该方法将零住校准时闯进行分段，在准备时间段采用均值滤波，将静态零偏值一次性基本校除，在工作初始时间段内根据特性建立一阶或高阶补偿模型校零，对准静态零偏值进行校除．经实验验证，该方法使零偏值比校正前降低了90％以上．为进一步提高补偿精度，提出了应用传递对准这一零位补偿方法，即结合载体高精度方位信号校正微型陀螺仪测量组件系统初始零位值，有效地提高了校零的时效性．仿真实验表明：传递对准最佳起始时刻在陀螺仪稳定工作后10-30ms后，主、子系统传递对准时间长度可在几百毫秒内，零住误差在载体抖动频率范围内可以被限定在0．01（°）／s以下，主、子系统同步时差所引起的误差项呈毫秒级周期性变化．

关键词：零住误差传递对准惯性测量组件

Analysis of Products Related to Vegetation Blanket

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Asian Agricultural Research 2018年第6期10卷 88-89页

作者： Shengxu CAO jinyan YIN Dan QIAN Xiaoqing HUANG Ming GUO Duping fan Xinjie HE Techand Ecological Construction Co. Ltd. Shenzhen 518035 China Shenzhen Techand Ecology & Environment Co. Ltd. Shenzhen 518035 China Jiangxi Shuiping Decoration Co. Ltd. Nanchang 330000 China

Roof greening has gradually become an important component of urban greening. Because of the advantages of low building load and low price,vegetation blanket roof greening has gradually become a widely spread technology of roof greening. In this paper,the characteristics of vegetation blanket roof greening technology are analyzed and summarized,and reasonable suggestions are provided for construction.

关键词： Roof greening Vegetation blanket Process characteristics