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Communications in Theoretical Physics 2002年第8期38卷 147-150页

作者： fan hong-yi chen jun-hua Department of Material Science and Engineering University of Science and Technology of China Hefei 230026 China Department of Material Science and Engineering University of Science and Technology of China Hefei 230026 China

We find that the coherent state projection operator representation of symplectic transformation constitutesa loyal group representation of symplectic group. The result of successively applying squeezing operators on n... 详细信息

关键词： coherent state projection operator, symplectic transformation, squeezing operator

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan huang yi-De Zhang Jie chen Hai-Di fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-yian Guo Jian-Gang Shen Su-hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

On the core of the fractional Fourier transform and its role in composing complex fractional Fourier transformations and Fresnel transformations

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Frontiers of physics 2015年第1期10卷 1-6页

作者： hong-yi fan jun-hua chen Department of Physics Ningbo University Ningbo 315211 China Department of Material Science and Engineering University of Science and Technology of China Hefei 230026 China

By a quantum mechanical analysis of the additive rule Fa [Fβ[f]] = Fα＋β[f], which the fractional Fourier transformation （FrFT） Fα [f] should satisfy, we reveal that the position-momentum mutual- transformation operator is the core element for constructing the integration kernel of FrFT. Based on this observation and the two mutually conjugate entangled-state representations, we then derive a core operator for enabling a complex fractional Fourier transformation （CFrFT）, which also obeys the additive rule. In a similar manner, we also reveal the fractional transformation property for a type of Fresnel operator.

关键词： fractional Fourier transform core operator IWOP technique entangled state of con-tinuum variables Fresnel operator

A Few Remarks on Milburn Equation

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Communications in Theoretical Physics 2009年第7期52卷 85-87页

作者： chen jun-hua fan hong-yi Department of Material Science and Engineering University of Science and Technology of China Hefei 230026 China

After presenting the infinite operator-sum form solution to the Milburn equation dp/dt=γ（UρU^f - ρ）=γU[p, Uf], where U=e^-iH/hγ, and verifying that this equation preserves the three necessary conditions of density operators during time evolution, we prove that the yon Neumann entropy increases with time. We also point out that if A and B both obey the Milburn equation, then theproduct AB obeys （d/dt）（AB） = γU[AB, U^f]-（1/γ）（dA/dt）（dB/dt）, which violates the Milburn equation, this reflects that a pure state will evolve to a mixture in general

关键词： Milburn equation density operator evolution von Neumann entropy

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期68卷 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei Shu-Hui fan Li chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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Evolution law of Wigner function in laser process

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Frontiers of physics 2013年第4期8卷 381-385页

作者： Rui He jun-hua chen hong-yi fan Department of Material Science and Engineering University of Science and Technology of China Hefei 230026 China Department of Physics Shanghai Jiao Tong University Shanghai 200030 China

Based on the density operator＇s operator-sum representation recently obtained by fan and Hu for a laser process （Opt. Commun., 2008, 281： 5571; Opt. Commun., 2009, 282： 932; Phys. Lett. B, 2008, 22： 2435）, we derive the evolution law of Wigner operator, the law is concisely expressed in T exp[-2T（ate-（k-g）t - a.）（ae-（k-g）t a）]; where g the normally ordered form A（a,a＊,t） = -T/π., and a are the cavity gain and the loss, respectively, and T - （a - g）（g-t-g - 2ge-2（k-g）t）-1. When 1 exp[-2（at a＊）（a a）] which is the initial Wigner operator. Using this t = O, A（a,a＊,t） →1/π , formalism the evolution law of Wigner functions in laser process can be directly obtained.

关键词： Kraus operator Wigner operator laser process

On the entangled fractional squeezing transformation

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Frontiers of physics 2015年第2期10卷 67-71页

作者： hong-yi fan jun-hua chen Peng-Fel Zhang Department of Physics Ningbo University Ningbo 315211 China Department of Material Science and Engineering University of Science and Technology of China Hefei 230026 China Department of Modern Physics University of Science and Technology of China Hefei 230026 China

We propose an entangled fractional squeezing transformation （EFrST） generated by using two mu- tually conjugate entangled state representations with the following operator： e-iα（a1a2＋a1a2）eiπa2a2; this transformation sharply contrasts the complex fractional Fourier transformation produced by e-ia（a1a1＋a2a2）eiπa2a2 （see Front. Phys. DOI 10.1007/s11467-014-0445-x）. The EFrST is obtained by converting the triangular functions in the integration kernel of the usual fractional Fourier transformation into hyperbolic functions, i.e., tan α→ tanh α and sin α→ sinh α. The fractional property of the EFrST can be well described by virtue of the properties of the entangled state representations.

关键词： entangled fractional squeezing transformation entangled state representation squeezingoperator core operator

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing jun Wu Minmin Xiao fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui fan chen Li chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

Analysis of 3D curve expansion of conical cam with oscillating tapered roller follower

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第11期8卷 1789-1794页

作者： chen jun-hua WU yi-jie Ningbo Institute of Technology Zhejiang University Ningbo 315010 China Institute of Modern Manufacture Engineering Zhejiang University Hangzhou 310027 China

This paper focuses on the analysis of running conditions and machining processes of conical cam with oscillating follower. We point out the common errors existing in the design and machining of the widely used plane expansion method of conical cam trough-out line. We show that the motion can be divided into two parts, i.e. the oscillating motion of oscillating bar and the rotary motion of oscillating bar relative to the conical cam. By increasing the rotary motion of oscillating bar, the motion path of tapered roller on oscillating bar (i.e. contour surface of conical cam) can be expanded on the cylinder. Based on these analyses, we present a creative and effective designing and machining method for 3D curve expansion of conical cam with oscillating follower.

关键词： Oscillating follower Conical cam Tapered roller plane expansion 3D curve expansion

Research in non-equalization machining method for spatial cam

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第9期9卷 1258-1263页

作者： jun-hua chen yi-jie WU Institute of Mechanical and Electrical Engineering Ningbo Institute of Technology Zhefiang University Ningbo 315010 China Institute of Modern Manufacture Engineering Zhejiang University Hangzhou 310027 China

Many kinds of devices with cam have been widely used in various mechanical equipments. However, non-equalization machining for spatial cam trough remains to be a difficult problem. This paper focuses on the analysis of running conditions and machining processes of spatial cam with oscillating follower. We point out the common errors in the biased distance cutting. By analyzing the motion of oscillating follower of spatial cam, we present a new 3D curve expansion model of spatial cam trough-outline. Based on this model, we have proposed a machining method for trochoidal milling with non-equalization diameter cutter. This new method has led to a creative and effective way for non-equalization diameter machining for spatial cam with oscillating follower.

关键词： Oscillating follower Spatial cam 3D curve exoansion Trochoidal milling Non-eaualization diameter