检索结果-南通市图书馆

Ghrelin inhibits autophagy mediated by AKT/mTOR pathway to ameliorate retinal angiogenesis induced by high glucose stress

引用

International Journal of Ophthalmology(English edition) 2024年第5期17卷 785-793页

作者： Jiang-Li fan Rong Li Min Zhang Chao Chen Guo-Min Yao Ling-Xiao zhou Department of Ophthalmology Gongshu District People’s Hospital of Integrated Traditional Chinese and Western MedicineHangzhou 310004Zhejiang ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Xi’an Medical UniversityXi’an 710077Shaanxi ProvinceChina Department of Endocrinology the First Affiliated Hospital of Xi’an Medical UniversityXi’an 710077Shaanxi ProvinceChina Department of General Surgery the First Affiliated Hospital of Xi’an Medical UniversityXi’an 710077Shaanxi ProvinceChina

AIM:To observe the effect of ghrelin,a growth hormonereleasing peptide,on retinal angiogenesis in vitro under high glucose(HG)stress and to explore the possible mechanism of ***:Human retinal microvascular endothelial cells(HRMECs)were treated with high concentration of glucose alone or in combination with *** cell migration,tube formation and the expression of the autophagy-related proteins LC3-II/I,Beclin-1,p62,phosphorylated AKT(p-AKT)/AKT and phosphorylated mammalian target of rapamycin(p-mTOR)/mTOR were ***,to clarify the correlation between ghrelin effect and autophagy,AKT inhibitor VIII was adopted to treat HRMECs,and cell migration,tube formation as well as the protein expressions of LC3-II/I,Beclin-1 and p62 were ***:Under HG stress,ghrelin inhibited migration and tube formation of *** inhibited the increases in the protein levels of LC3-II/I,Beclin-1 and the decreases in the protein levels of p62,p-AKT/AKT and p-mTOR/mTOR induced by HG ***,under the action of AKT/mTOR pathway inhibitors,the effects of ghrelin on migration and tube formation were both *** addition,the expression of LC3-II/I and Beclin-1 were significantly up-regulated and the expression of p62 was ***:Retinal angiogenesis under in vitro HG stress can be inhibited by ghrelin through activating AKT/mTOR pathway to inhibit autophagy.

关键词： ghrelin retinal endothelial cell angiogenesis autophagy stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High-entropy rare earth stannate ceramics:Acid corrosion resistant radiative cooling materials with high atmospheric transparency window emissivity and high near-infrared solar reflectivity

引用

Journal of Advanced Ceramics 2024年第5期13卷 630-640页

作者： Tao Chen Yanyan He Yanyu Pan Kaixian Wang Minzhong Huang Liyan Xue Yazhu Li fan Yang Yanchun zhou Heng Chen Fujian Institute of Research on the Structure of Matter Chinese Academy of SciencesFuzhou 350002China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350117China Xiamen Institute of Rare Earth Materials Haixi InstitutesChinese Academy of SciencesXiamen 361021China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstitutesChinese Academy of SciencesXiamen 361021China Key Laboratory of Rare Earths Ganjiang Innovation AcademyChinese Academy of SciencesGanzhou 341000China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China

In response to the development of the concepts of“carbon neutrality”and“carbon peak”,it is critical to developing materials with high near-infrared(NIR)solar reflectivity and high emissivity in the atmospheric transparency window(ATW;8–13μm)to advance zero energy consumption radiative cooling *** regulate emission and reflection properties,a series of high-entropy rare earth stannate ceramics(HE-RE_(2)Sn_(2)O_(7):(Y_(0.2)La_(0.2)Nd_(0.2)Eu_(0.2)Gd_(0.2))_(2)Sn_(2)O_(7),(Y_(0.2)La_(0.2)Sm_(0.2)Eu_(0.2)Lu_(0.2))_(2)Sn_(2)O_(7),and(Y_(0.2)La_(0.2)Gd_(0.2)Yb_(0.2)Lu_(0.2))_(2)Sn_(2)O_(7))with severe lattice distortion were prepared using a solid phase reaction followed by a pressureless sintering method for the first *** distortion is accomplished by introducing rare earth elements with different cation radii and *** as-synthesized HE-RE_(2)Sn_(2)O_(7)ceramics possess high ATW emissivity(91.38%–95.41%),high NIR solar reflectivity(92.74%–97.62%),low thermal conductivity(1.080–1.619 W·m^(−1)·K^(−1)),and excellent chemical *** the one hand,the lattice distortion intensifies the asymmetry of the structural unit to cause a notable alteration in the electric dipole moment,ultimately enlarging the ATW *** the other hand,by selecting difficult excitation elements,HE-RE_(2)Sn_(2)O_(7),which has a wide band gap(Eg),exhibits high NIR solar ***,the multi-component design can effectively enhance radiative cooling ability of HE-RE_(2)Sn_(2)O_(7)and provide a novel strategy for developing radiative cooling materials.

关键词： radiative cooling materials high-entropy ceramics(HECs) rare earth stannate(RE_(2)Sn_(2)O_(7)) high atmospheric transparency window emissivity high near-infrared(NIR)solar reflectivity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Quantitative method to predict the energetics of helium-nanocavities interactions in metal systems based on electrophobic interaction

引用

Journal of Materiomics 2024年第3期10卷 725-737页

作者： Fengping Luo Bowen Zhang Zhiying Gao Jia Huang Hong-Bo zhou guang-Hong Lu Fei Gao Yugang Wang Chenxu Wang State Key Laboratory of Nuclear Physics and Technology Center for Applied Physics and TechnologyPeking UniversityBeijing100871China Department of Physics Beihang UniversityBeijing100191China Department of Nuclear Engineering and Radiological Science University of MichiganAnn ArborMI48109USA

Energetics of helium-nanocavities interactions are crucial for unveiling underlying mechanisms of nanocavity evolution in nuclear ***,it becomes intractable and even not feasible to obtain these energetics via atomic simulations with increasing nanocavity size and increasing helium content in ***,a universal scaling law of helium-induced interaction energies in nanocavities in metal systems is proposed based on electrophobic interaction of *** on this scaling law and ab-initio calculations,a predictive method for binding energies of helium and displacement defects to nanocavities of arbitrary sizes and with different helium/vacancy ratios is established for BCC iron as a representative and validated by atomic *** predictive method reveals that the critical helium/vacancy ratio for helium-enhanced vacancy binding to nanocavities in-creases with increasing nanocavity size,and the helium/vacancy ratio giving the highest stability of nanocavities is about *** Ostwald ripening of nanocavities is delayed by helium to higher temper-atures due to reduced vacancy de-trapping rates from *** proposed scaling law can be generalized to many metal systems studied in the nuclear materials *** readily coupled into mesoscale models of irradiation damages,this predictive method facilitates clarifying helium role in cavity swelling of metallic nuclear materials.

关键词： Nanocavities Helium Electrophobic interaction Predictive method

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phase reconfiguration of heterogeneous CoFeS/CoNiS nanoparticles for superior battery-type supercapacitors

引用

Journal of Energy Chemistry 2024年第9期96卷 217-225页

作者： Lina Ma fan Li Min zhou Jidong Dong Hao Luo Wei Zhang Wenchao Zhao Xinliang Li Zaixing Jiang Yudong Huang College of Chemistry and Chemical Engineering Qingdao UniversityQingdao 266071ShandongChina School of Materials Science and Engineering Xiamen University of TechnologyXiamen 361024FujianChina Co-Innovation Center of Efficient Processing and Utilization of Forest Resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037JiangusChina Key Laboratory of Material Physics Ministry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052HenanChina MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Laboratory of Urban Water Resource and EnvironmentSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001HeilongjiangChina Material Science and Engineering College Northeast Forestry UniversityHarbin 150040HeilongjiangChina

Developing advanced battery-type materials with abundant active sites,high conductivity,versatile morphologies,and hierarchically porous structures is crucial for realizing high-quality hybrid ***,heterogeneous FeS@NiS is synthesized by cationic Co doping via surface-structure *** density functional theory(DFT)theoretical calculations are firstly performed to predict the advantages of Co dopant by improving the OH^(−)adsorption properties and adjusting electronic structure,benefiting ions/electron *** dynamic surface evolution is further explored which demonstrates that CoFeS@CoNiS could be quickly reconstructed to Ni(Co)Fe_(2)O_(4)during the charging process,while the unstable structure of the amorphous Ni(Co)Fe_(2)O_(4)results in partial conversion to Ni/Co/FeOOH at high potentials,which contributes to the more reactive active site and good structural ***,the free-standing electrode reveals excellent electrochemical performance with a superior capacity(335.6 mA h g^(−1),2684 F g^(−1))at 3 A g^(−1).Furthermore,the as-fabricated device shows a quality energy density of 78.1 W h kg^(−1)at a power density of 750 W kg^(−1)and excellent cycle life of 92.1%capacitance retention after 5000 *** work offers a facile strategy to construct versatile morphological structures using electrochemical activation and holds promising applications in energy-related fields.

关键词： In-situ reconfiguration Heterogeneous design Battery-type supercapacitors Superior performance Sulphide

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

青藏高原年日照时数的年代际变化趋势

引用

长江流域资源与环境 2009年第12期18卷 1149-1155页

作者：华维范广洲陈权亮周定文成都信息工程学院高原大气与环境研究中心四川成都610225

利用1961~2007年青藏高原68个气象台站日照时数观测资料,通过统计方法分析了近47 a来青藏高原年日照时数的年代际变化趋势,得到以下几点初步认识：青藏高原年日照时数整体上呈现自东南向西北增加的特点,并且其空间变化趋势也存在明显的... 详细信息

利用1961~2007年青藏高原68个气象台站日照时数观测资料,通过统计方法分析了近47 a来青藏高原年日照时数的年代际变化趋势,得到以下几点初步认识：青藏高原年日照时数整体上呈现自东南向西北增加的特点,并且其空间变化趋势也存在明显的区域差异。青藏高原东南部、西藏中部和西藏西南部以及青海北部地区年日照时数减少较为明显,高原西部、西藏中东部地区和青海南部年日照时数呈增加趋势;近47 a来青藏高原年日照时数具有明显的年代际变化特征,年日照时数增加区和减少区分别存在12.1和21.1 a左右的时间尺度;增加区在20世纪60年代至80年代年日照时数处于偏多阶段,90年代至21世纪初日照时数呈明显的减少趋势;减少区则表现为20世纪60年代至70年代年日照时数有所增加,90年代日照时数开始急剧减少,21世纪初达到最低值。各年代之间年日照时数变化特点同样具有明显的区域差异。

关键词：青藏高原年日照时数年代际变化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spectral observation of symmetry-protected selection rules for dynamical high-dimensional parity in alignment magnetic resonance

引用

Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 1-11页

作者： Xu-Xing Geng Kai Jin Lu zhou Wang-Wang Tang Guoqing Yang Shangqing Liang Shao-Ping Wu guang-Ming Huang Gao-Xiang Li Department of Physics Huazhong Normal UniversityWuhan 430079China College of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China State Key Laboratory of Precision Spectroscopy School of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China

Multidimensional Floquet-driven alignment systems with dynamical symmetry present various exotic phenomena and ***,there are challenges in directly characterizing large-spin dynamical symmetry from ***,we first observe the symmetry-protected selection rules of dynamical high-dimensional parity in a large-spin(F=4)*** theoretically construct a Floquet-driven alignment system that can be used to reveal high-dimensional spatiotemporal *** the experiment,the system is implemented in Cs atomic gas subjected to two-dimensional Floquet-modulated magnetic resonance *** developing Floquet detection protocols of alignment double-sided spectra,we directly verify symmetry-protected selection rules of dynamical high-dimensional parity for large-spin *** work advances the exploration of dynamical symmetry to large spins,and unravels a universal Floquet scheme for the investigation of symmetry-protected selection rules.

关键词： dynamical high-dimensional symmetry symmetry-protected selection rules large-spin alignment magnetic resonance,Floquet two-mode detection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Circulating cell-free mtDNA as a new biomarker for cancer detection and management

引用

Cancer Biology & Medicine 2024年第2期21卷 105-110页

作者： fan Peng Siyuan Wang Zehui Feng Kaixiang zhou Huanqin Zhang Xu Guo Jinliang Xing Yang Liu State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and Xijing Hospital of Digestive Diseases Fourth Military Medical UniversityXi’an 710032China Department of Clinical Diagnosis Tangdu HospitalFourth Military Medical UniversityXi’an 710038China

Cancer is a major cause of death worldwide,and was responsible for 19.29 million new cases and 9.96 million deaths in 2020 *** total number of patients with cancer worldwide is estimated to reach 28 million by *** Ame... 详细信息

关键词： Cancer cancer death

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Health State Prediction Model Based on Belief Rule Base and LSTM for Complex Systems

引用

Intelligent Automation & Soft Computing 2024年第1期39卷 73-91页

作者： Yu Zhao Zhijie zhou Hongdong fan Xiaoxia Han JieWang Manlin Chen High-Tech Institute of Xi’an Xi’an710025China

In industrial production and engineering operations,the health state of complex systems is critical,and predicting it can ensure normal *** systems have many monitoring indicators,complex coupling structures,non-linear and time-varying characteristics,so it is a challenge to establish a reliable prediction *** belief rule base(BRB)can fuse observed data and expert knowledge to establish a nonlinear relationship between input and output and has well modeling *** each indicator of the complex system can reflect the health state to some extent,the BRB is built based on the causal relationship between system indicators and the health state to achieve the prediction.A health state prediction model based on BRB and long short term memory for complex systems is proposed in this ***,the LSTMis introduced to predict the trend of the indicators in the ***,the Density Peak Clustering(DPC)algorithmis used todetermine referential values of indicators for BRB,which effectively offset the lack of expert ***,the predicted values and expert knowledge are fused to construct BRB to predict the health state of the systems by ***,the effectiveness of the model is verified by a case study of a certain vehicle hydraulic pump.

关键词： Health state predicftion complex systems belief rule base expert knowledge LSTM density peak clustering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Is appendoscope a new option for the treatment of acute appendicitis?

引用

World Journal of Gastroenterology 2024年第28期30卷 3386-3392页

作者： Shu-Jiong Feng Yi-Feng zhou Jian-Feng Yang Hong-Zhang Shen guang-Xing Cui Xiao-Feng Zhang Department of Gastroenterology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhou 310000Zhejiang ProvinceChina Department of Gastroenterology Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang ProvinceHangzhou 310000Zhejiang ProvinceChina Department of Gastroenterology Hangzhou Institute of Digestive DiseasesHangzhou 310000Zhejiang ProvinceChina

Acute appendicitis is a common surgical *** is commonly caused by obstruction of the appendiceal lumen due to fecaliths,tumors,or lymphoid *** over a century,appendectomy has been the primary treatment for acute *** Groves performed the first open appendectomy in *** 1983,Kurt Semm completed the first laparoscopic appendectomy,heralding a new era in ***,appendectomy is associated with certain complications and a rate of negative *** have suggested controversy over the impact of appendectomy on the development of inflammatory bowel disease and Parkinson’s disease,but an increasing number of studies indicate a possible positive correlation between appendectomy and colorectal cancer,gallstones,and cardiovascular *** the recognition that the appendix is not a vestigial organ and the advancement of endoscopic technology,Liu proposed the endoscopic retrograde appendicitis *** is an effective minimally invasive alternative for treating uncomplicated acute *** team has developed an appendoscope with a disposable digital imaging system operated through the biopsy channel of a colonoscope and successfully applied it in the treatment of *** article provides an overview of the progress in endoscopic treatment for acute appendicitis and offers a new perspective on the future direction of appendiceal disease treatment.

关键词： Acute appendicitis Endoscopic technology Endoscopic retrograde appendicitis therapy Appendoscope Appendiceal disease treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dual-responsive supramolecular photodynamic nanomedicine with activatable immunomodulation for enhanced antitumor therapy

引用

Acta Pharmaceutica Sinica B 2024年第2期14卷 765-780页

作者： Siqin He Lulu Wang Dongxu Wu fan Tong Huan Zhao Hanmei Li Tao Gong Huile Gao Yang zhou Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikou 570200China Key Laboratory of Drug-Targeting and Drug Delivery System West China School of PharmacySichuan UniversityChengdu 610041China Revvity Inc. WalthamMA 02451USA School of Food and Biological Engineering Chengdu UniversityChengdu 610106China

A major challenge facing photodynamic therapy(PDT) is that the activity of the immuneinduced infiltrating CD8^(+)T cells is subject to the regulatory T lymphocytes(Tregs), leaving the tumor at risk of recurrence and metastasis after the initial ablation. To augment the antitumor response and reprogram the immunosuppressive tumor microenvironment(TME), a supramolecular photodynamic nanoparticle(DACss) is constructed by the host-guest interaction between demethylcantharidin-conjugated β-cyclodextrin(DMC-CD) and amantadine-terminated disulfide-conjugated FFVLGGGC peptide with chlorin e6 decoration(Ad-ss-pep-Ce6) to achieve intelligent delivery of photosensitizer and immunomodulator for breast cancer treatment. The acid-labile β-carboxamide bond of DMC-CD is hydrolyzed in response to the acidic TME, resulting in the localized release of DMC and subsequent inhibition of *** guest molecule Ad-ss-pep-Ce6 can be cleaved by a high level of intracellular GSH, reducing photosensitizer toxicity and increasing photosensitizer retention in the tumor. With a significant increase in the CTL/Treg ratio, the combination of Ce6-based PDT and DMC-mediated immunomodulation adequately achieved spatiotemporal regulation and remodeling of the TME, as well as improved primary tumor and in situ lung metastasis suppression with the aid of PD-1 antibody.

关键词： Photodynamic therapy Immunosuppressive microenvironment Immunomodulator Dual-responsive Supramolecularassembly Checkpointblockade

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：