检索结果-南通市图书馆

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 845-857页

作者： lin-Yan Huang Yi-De Zhang jie Chen Hai-Di fan Wan Wang Bin Wang ju-Yun Ma Peng-Peng li Hai-Wei Pu Xin-Yian Guo jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第1期 174-180页

作者： fan-Xiao Meng Xing-Yu Wang Ka lu ju-Song Yang Fu-Min Zhang Ai-jun Ma Bao Du Yong-Qiang Tu State Key laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

关键词：

同方期刊数据库

Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第1期 360-368页

作者： Zheng liu Changyu Zhang Zipeng li Wanying Ma jia liu Xiang Xia Ning Xu Wen Sun jianjun Du jiangli fan Xiaojun Peng State Key laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

关键词：

同方期刊数据库

A novel approach to enhance decrepitation temperature and reducibility of ultrafine iron ore concentrate pellets

在线全文

学校读者我要写书评

暂无评论

journal of Iron and Steel Research International 2024年第11期31卷 2622-2632页

作者： B.l.Wen Z.H.fan j.X.li D.l.liu j.l.Yang School of Metallurgical Engineering Anhui University of TechnologyMa'anshan 243032AnhuiChina jianlong(liaoning)Energy Saving and Environmental Protection

Utilizing ultrafine iron ore concentrate for pellet production can expand domestic iron ore resources in China and promote the utilization of low-grade ***,a challenge arises with the low decrepitation temperature and reducibility in the preparation process of ultrafine iron ore concentrate *** address the challenge,a novel approach was proposed,which incorporated straw powder as an additive to enhance pellet porosity,thereby improving the decrepitation temper-ature and reducibility of ultrafine iron ore concentrate *** effect of varying proportions of straw powder(0.0-2.0%)on the characteristics of ultrafine iron ore concentrate pellets was *** indicate that at a 2.0%straw powder ratio,pellet decrepitation temperature notably rises from 380 to 540℃,while the reducibility index escalates from 25.7%to 48.1%.Nevertheless,the addition of straw powder results in diminished drop strength,compressive strength of green pellets,and cold crushing strength of fired *** addition,enhanced pellet reducibility leads to exacerbated reduction swelling index and reduction degradation *** these effects,all parameters remain within an acceptable range.

关键词： Ultrafine iron ore concentrate:Straw powder Green pellet quality Decrepitation temperature:Metallurgical property

Multi-objective quality control method for cold-rolled products oriented to customized requirements

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International journal of Minerals,Metallurgy and Materials 2021年第8期28卷 1332-1342页

作者： Yi-fan Yan Zhi-min lü Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China

To deal with the increasing demand for low-volume customization of the mechanical properties of cold-rolled products, a two-way control method based on mechanical property prediction and process parameter optimization(PPO) has become an effective solution. Aiming at the multi-objective quality control problem of a company's cold-rolled products, based on industrial production data, we proposed a process parameter design and optimization method that combined multi-objective quality prediction and PPO. This method used the multi-output support vector regression(MSVR) method to simultaneously predict multiple quality indices. The MSVR prediction model was used as the effect verification model of the PPO results. It performed multi-process parameter collaborative design and realized the optimization of production process parameters for customized multi-objective quality requirements. The experimental results showed that, compared with the traditional single-objective quality prediction model based on support vector regression(SVR), the multi-objective prediction model could better take into account the coupling effect between process parameters and quality index, the MSVR model prediction accuracy was higher than that of the SVR, and the optimized process parameters were more capable and reflected the influence of metallurgical mechanism on the quality index,which were more in line with actual production process requirements.

关键词： customized production quality control multi-objective prediction multi-output support vector regression process parameter optimization

Polybenzimidazolium-reinforced polyimide separators to inhibit dendrites for high-security lithium-ion batteries

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Guohua Sun jiaqi Cui Qingsong Zhang Yisong Zhou Xinluo li Yingying Zhang Zhanao Zhang Xin Zhang jiantao fan Pengpeng li lianlong Hou Nanjun Chen Hebei Key laboratory of Flexible Functional Materials School of Materials Science and Engineering Hebei University of Science and Technology State Key laboratory of Organic-Inorganic Composites Beijing University of Chemical Technology Academy for Advanced Interdisciplinary Studies Southern University of Science and Technology State Key laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical Engineering Xiamen University

lithium dendrite formation poses a significant safety hazard in lithium-ion batteries（lIBs）, severely impeding their widespread adoption and further technological advancements. Here, we present a novel quaternized polybenzimidazolium（q-PBI） to armor polyimide（PI） nanofiber separator（q-PBI@PI）, in which the q-PBI containing lithiophilicity and anionphilicity sites serves as the multifunctional nano-layers to suppress the li dendrite and reinforce the mechanical properties of PI nanofiber ***, the q-PBI@PI separator displays an unprecedented mechanical strength of 82.8 MPa, significantly outperforming previously reported PI nanofiber membranes（typically below 50.0 MPa）. Besides, we demonstrate that the q-PBI@PI separator simultaneously possesses low nucleation overpotential（59 mV） and exceptional average coulombic efficiency due to the suppression of li dendrite. Importantly, q-PBI@PI-based li||li battery enables a stable li plating-stripping at 1.0 m A cm-2for600 h. Attributing to these exceptional merits, the armored PI separator-based lIBs display remarkable specific capability and capacity retention. The density function theory calculations reveal that q-PBI is conducive to the desolvation of li+and can immobilize li+and PF6-ions near affinity sites of PI nanofibers for inhibiting the formation of li dendrites. Our work paves a new avenue for the design of next-generation high-performing separators in lIBs.

关键词：

Integration of perioperative features and intragraft TCF7l2 expression to predict lipid metabolic disorder in liver transplant recipients

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China life Sciences 2025年第1期 297-299页

作者： junbin Zhou Rongli Wei Guanghan fan Zhengxing lian Xuanyu Zhang linsong Tang Zhetuo Qi Haiyang Xie Shusen Zheng Qiang Wei Xiao Xu Department of Hepatobiliary and Pancreatic Surgery People's Hospital of LishuiAffiliated Lishui Hospital of Wenzhou Medical UniversityThe First Affiliated Hospital of Lishui University NHFPC Key laboratory of Combined Multi-Organ Transplantation Key laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryHangzhou First People's Hospital Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of Medicine Department of Urology The Second Affiliated HospitalZhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan (Hangzhou) Hospital Hangzhou Medical College Zhejiang University School of Medicine

Dear Editor, liver transplantation(lT) is the only curative therapy for patients with endstage liver disease(He et al., 2023; ling et al., 2022). Post-transplant hypertriglyceridemia(PTHT), which has an incidence of up to 32.8% in 6 months after lT, is one of the major post-transplant complications(Toshima et al., 2020).

关键词：

同方期刊数据库

新型农村集体经济促进农民共同富裕的演进逻辑和创新路径

在线全文

学校读者我要写书评

暂无评论

西北农林科技大学学报（社会科学版） 2025年第1期25卷 69-77页

作者：樊晓燕蒋明西安交通大学马克思主义学院西安710049 西安理工大学马克思主义学院西安710048

新型农村集体经济具有市场性和社区性,农民共同富裕强调发展性和共享性两个维度的目标,二者在基本原则的人民性、实现途径的互助性和目标指向的全面性上相契合,这是构建新型农村集体经济促进农民共同富裕理论分析框架的基础。理论发展... 详细信息

新型农村集体经济具有市场性和社区性,农民共同富裕强调发展性和共享性两个维度的目标,二者在基本原则的人民性、实现途径的互助性和目标指向的全面性上相契合,这是构建新型农村集体经济促进农民共同富裕理论分析框架的基础。理论发展、实践探索和现实需求是揭示新型农村集体经济促进农民共同富裕内在逻辑演进的三个方面:理论逻辑是坚持公有制基础上农村集体经济制度的理论创新;历史逻辑是中国特色农业农村现代化的发展历程;现实逻辑是发展新型农村集体经济对乡村全面振兴的重大意义。由此从产权制度、分配制度和基层治理制度创新的整体视角提出新型农村集体经济促进农民共同富裕的创新路径。坚持以人民为中心的发展理念,发挥新型农村集体经济的战略作用,探索新型农村集体经济的发展规律是新型农村集体经济促进农民共同富裕需要坚持的重要原则。

关键词：新型农村集体经济农民共同富裕制度创新

Comparison of a Full Second-Order Moment Model and an Algebraic Stress Two-Phase Turbulence Model for Simulating Bubble-liquid Flows in a Bubble Column

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Chinese journal of Chemical Engineering 2002年第2期10卷 142-148页

作者：周力行杨玟廉春英 l.S.fan D.j.l.e Department of Engineering Mechanics Tsinghua University Beijing 100084 China Department of Chemical Engineering The Ohio State University USA

A full second-order moment (FSM) model and an algebraic stress (ASM) two-phase turbulence modelare proposed and applied to predict turbulent bubble-liquid flows in a 2D rectangular bubble column. Predictiongives the bubble and liquid velocities, bubble volume fraction, bubble and liquid Reynolds stresses and bubble-liquidvelocity correlation. For predicted two-phase velocities and bubble volume fraction there is only slight differencebetween these two models, and the simulation results using both two models are in good agreement with the particleimage velocimetry (PIV) measurements. Although the predicted two-phase Reynolds stresses using the FSM are insomewhat better agreement with the PIV measurements than those predicted using the ASM, the Reynolds stressespredicted using both two models are in general agreement with the experiments. Therefore, it is suggested to usethe ASM two-phase turbulence model in engineering application for saving the computation time.

关键词： second-order moment model two-phase turbulence bubble-liquid flow bubble column