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羟基磷灰石复合骨形态发生蛋白2人工骨的理论及其应用特征

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中国组织工程研究与临床康复 2007年第26期11卷 5207-5210页

作者：张麒云范存义上海交通大学附属第六人民医院骨科上海市200233

目的:系统回顾当前国内外关于骨形态发生蛋白2复合羟基磷灰石人工骨的研究进展。资料来源:应用计算机检索Pubmed 1965-01/2007-03关于骨形态发生蛋白2符合羟基磷灰石人工骨的文章。检索词“BMP-2,hydroxyapatite”并限定文章的语言种类... 详细信息

目的:系统回顾当前国内外关于骨形态发生蛋白2复合羟基磷灰石人工骨的研究进展。资料来源:应用计算机检索Pubmed 1965-01/2007-03关于骨形态发生蛋白2符合羟基磷灰石人工骨的文章。检索词“BMP-2,hydroxyapatite”并限定文章的语言种类为English。同时利用计算机检索万方数据库2002-09/2005-07的相关文章,限定文章语言种类为中文,检索词“骨形态发生蛋白2,羟基磷灰石”。资料选择:纳入标准:①骨形态发生蛋白2复合羟基磷灰石人工骨的动物实验及临床运用。②骨形态发生蛋白2的分子生物学,成骨机制。③羟基磷灰石成骨作用。④能获取文章的全文。排除标准:①较陈旧文献。②重复性研究。资料提炼:共收集到50篇与骨形态发生蛋白2复合羟基磷灰石人工骨有关的文章,45篇符合纳入标准。其中研究内容相似的,以近7年发表在较权威杂志者优先。排除的15篇为较陈旧的文献及重复研究;对符合标准的30篇文献进行分析。资料综合:由于骨形态发生蛋白2弥散能力较强,单独植入体内会很快弥散被吸收,需要一种合适的载体吸附骨形态发生蛋白2,而羟基磷灰石具有与松质骨相类似的多孔支架结构,无抗原性,为理想的骨形态发生蛋白载体系统。虽然此种材料的应用尚处于实验阶段,但应用前景广阔,其必将成为具有主导性的人工骨材料。结论:生物组织工程学的发展,为骨缺损的修复提供了契机,也提出了挑战,即要求有一种生物相容性更好、又满足生物力学需要的载体材料。在这一方面骨形态发生蛋白2复合羟基磷灰石人工骨有着广阔的研究、开发前景。

关键词：骨形态发生蛋白2 羟基磷灰石人工骨

Tackling the microlensing wave effects of strong lensing gravitational waves with TAAH

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 257-258页

作者： Zuhui fan South-Western Institute for Astronomy Research Yunnan University

The rapid development of gravitational wave（GW） observations since their first detection in 2015 [1] has opened a completely new window for exploring the Universe. Consequently, astronomical research has entered the multimessenger era, allowing us to use different tracers to view the cosmos from various perspectives. Among others, the appealing application of gravitational wave events from compact binary mergers is that they can act as standard sirens to determine absolute cosmic distances entirely independent of standard candles. This approach is one of the most promising means to solve the current H0tension problem.

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Soluble epoxide hydrolase:a next-generation drug target for Alzheimer's disease and related dementias

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Neural Regeneration Research 2025年第9期20卷 2585-2586页

作者： Andrew Gregory Chengyun Tang fan fan Department of Physiology Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World Health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

关键词： Alzheimer population drug

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小肠黏膜下层粘接交联制作小口径血管支架

中国组织工程研究与临床康复 2007年第32期11卷 6374-6378页

作者：刘生和王建广范存义莫秀梅上海交通大学附属第六人民医院骨科上海市200233 东华大学生物科学与技术研究所上海市201620

目的:探讨将小肠黏膜下层粘接交联制作小口径血管支架的可行性。方法:实验于2006-04/12在上海交通大学附属第六人民医院中心实验室和四肢显微外科研究所完成。①实验材料:小肠黏膜下层膜按Abraham法制备;清洁级雄性新西兰大白兔24只,2.8... 详细信息

目的:探讨将小肠黏膜下层粘接交联制作小口径血管支架的可行性。方法:实验于2006-04/12在上海交通大学附属第六人民医院中心实验室和四肢显微外科研究所完成。①实验材料:小肠黏膜下层膜按Abraham法制备;清洁级雄性新西兰大白兔24只,2.8～3.2kg。②实验过程:以胶原蛋白-硫酸软骨素共混溶液将猪小肠黏膜下层膜粘接成小口径(内径3.0mm)管型支架,并用碳化二亚胺交联,得到粘接交联小肠黏膜下层管。取24只兔,手术造成颈总动脉缺损,随机平分为2组,对照组采用缝制小肠黏膜下层管桥接修复缺损;实验组采用粘接交联小肠黏膜下层管桥接修复缺损。③实验评估:通过爆破压测定检测支架的粘接强度、通过体外溶血试验和细胞毒性试验检测支架的生物相容性;于术后1,2周和1,2个月做血管彩色多普勒超声检测其通畅性;以组织学苏木精-伊红染色、Masson染色观察组织生长情况,评价支架的血液相容性和组织再生能力。结果:①粘接交联的小肠黏膜下层血管支架爆破压:在湿润状态的爆破压可达22.1kPa;溶血率为1.4%;细胞毒性评级为0～1级。②支架溶血率和细胞毒性:体外溶血及细胞毒性试验均表明碳化二亚胺交联小肠黏膜下层管具有良好的生物相容性,完全符合医用生物材料的应用要求。③植入兔体内后支架通畅性和组织学表现:植入替代兔颈总动脉缺损后2个月,粘接交联支架的通畅率为83.3%(10/12),明显高于缝制支架的33.3%(4/12)(P<0.05);在通畅血管中动脉瘤样扩张的发生率,缝制支架为100%(4/4),粘接交联支架仅为20%(2/10)。所有通畅的血管在术后1个月时均有完整平滑的内膜形成和平滑肌细胞长入;2个月时平滑肌细胞增多,小肠黏膜下层的胶原纤维也明显减少;无炎症反应、血管破裂发生。结论:粘接交联法可用于小肠黏膜下层小口径血管支架的制作,可保持支架的良好生物相容性并改善血管重建过程中小肠黏膜下层的力学性质,从而显著提高小肠黏膜下层用于修复小口径血管缺损的成功率。

关键词：肠粘膜血管支架组织构建

Effect of a Carbon Fibre-steel Fibre-graphite Conductive Filler on the Electrothermal Properties of Cementitious Materials

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 141-151页

作者： fan Yanan WEI Hong ZHENG Hongyong DU Hongxiu Department of Architecture and Environmental Engineering Taiyuan UniversityTaiyuan 030032China College of Civil Engineering Taiyuan University of TechnologyTaiyuan 030032China

Carbon fibre,steel fibre and graphite were used as conductive fillers to prepare cementitious materials with excellent electrothermal *** electrically conductive cementitious materials with different volume dosages were analysed through compressive and flexural strength,electrochemical impedance spectroscopy and temperature rise *** equivalent circuit model was established to study the electrically conductive heat generation mechanism in the electrically conductive cementitious *** results indicate that the mechanical properties of cementitious composite materials with a ternary conductive phase are better than those of pristine cementitious materials because the fibrous filler improves their mechanical ***,the incorporation of graphite in the material reduces its *** fibrous and point-like conductive phase materials into the cementitious material enhances the overall conductive pathway and considerably reduces the electrical resistance of the cementitious material,enhancing its conductive *** volume ratios of carbon fibre,steel fibre and graphite that achieve an optimal complex doping in the cementitious material were 0.35%,0.6%and 6%,*** was determined using the mutation point of each circuit element parameter as the percolation *** addition,at a certain safety voltage,there is a uniform change between the internal and surface temperatures of the conductive cementitious material,and the heating effect in this materialis is considerably better than that in the pristine cementitious material.

关键词： cementitious composites conductive fillers electrothermal properties electrochemical impedance spectroscopy

Endoscopy-assisted lightweight diagnosis system based on transformers for colon polyp detection

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Optoelectronics Letters 2025年第1期21卷 57-64页

作者： fan Weiming YU Jiahui JU Zhaojie School of Automation and Electrical Engineering Shenyang Ligong University Department of Biomedical Engineering Zhejiang University School of Computing University of Portsmouth

The integration of endoscopy has significantly propelled the diagnosis and treatment of gastrointestinal diseases, with colonoscopy establishing itself as the primary method for early diagnosis and preventive care in colorectal cancer(CRC). Although deep learning holds promise in mitigating missed polyp rates, modern endoscopy examinations pose additional challenges, such as image blurring and atomizing. This study explores lightweight yet powerful attention mechanisms, introducing the spatial-channel transformer(SCT), an innovative approach that leverages spatial channel relationships for attention weight calculation. The method utilizes rotation operations for inter-dimensional dependencies, followed by residual transformation, encoding inter-channel and spatial information with minimal computational overhead. Extensive experiments on the CVC-Clinic DB polyp detection dataset, addressing endoscopy pitfalls, underscore the superiority of our SCT over other state-of-the-art methods. The proposed model maintains high performance, even in challenging scenarios.

关键词： Endoscopy

Macro-mechanics and Microstructure of Nanomaterial-modified Geopolymer Concrete: A Comprehensive Review

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 204-214页

作者： WANG Tao fan Xiangqian GAO Changsheng QU Chiyu The National Key Laboratory of Water Disaster Prevention Nanjing Hydraulic Research InstituteNanjing 210024China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China School of Water Conservancy and Transportation Zhengzhou UniversityZhengzhou 450001China

We have described in detail the effects of nano-SiO_(2),nano-CaCO_(3),carbon nanotubes,and nano-Al_(2)O_(3) on geopolymer concrete from the perspectives of macro mechanics and *** existing research results show that the mechanism of nano-materials on geopolymer concrete mainly includes the filling effect,nucleation effect,and bridging effect,the appropriate amount of nano-materials can be used as fillers to reduce the porosity of geopolymer concrete,and can also react with Ca(OH)2 to produce C-S-H gel,thereby improving the mechanical properties of geopolymer *** optimum content of nano-SiO_(2) is between 1.0%and 2.0%.The optimum content of nano-CaCO_(3) is between 2.0%and 3.0%.The optimum content of carbon nanotubes is between 0.1%and 0.2%.The optimum content of nano-Al_(2)O_(3) is between 1.0%and 2.0%.The main problems existing in the research and application of nanomaterial-modified geopolymer concrete are summarized,which lays a foundation for the further application of nanomaterial in geopolymer concrete.

关键词： nanomaterials low carbon geopolymer concrete macro-mechanics microstructure

Unmasking Social Robots’Camouflage:A GNN-Random Forest Framework for Enhanced Detection

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Computers, Materials & Continua 2025年第1期82卷 467-483页

作者： Weijian fan Chunhua Wang Xiao Han Chichen Lin School of Data Science and Intelligent Media Communication University of ChinaBeijing100024China School of Computer and cyber Sciences Communication University of ChinaBeijing100024China Institute of Communication Studies Communication University of ChinaBeijing100024China State Key Laboratory of Media Convergence and Communication Communication University of ChinaBeijing100024China

The proliferation of robot accounts on social media platforms has posed a significant negative impact,necessitating robust measures to counter network anomalies and safeguard content *** robot detection has emerged as a pivotal yet intricate task,aimed at mitigating the dissemination of misleading *** graphbased approaches have attained remarkable performance in this realm,they grapple with a fundamental limitation:the homogeneity assumption in graph convolution allows social robots to stealthily evade detection by mingling with genuine human *** unravel this challenge and thwart the camouflage tactics,this work proposed an innovative social robot detection framework based on enhanced HOmogeneity and Random Forest(HORFBot).At the core of HORFBot lies a homogeneous graph enhancement strategy,intricately woven with edge-removal techniques,tometiculously dissect the graph intomultiple revealing ***,leveraging the power of contrastive learning,the proposed methodology meticulously trains multiple graph convolutional networks,each honed to discern nuances within these tailored *** culminating stage involves the fusion of these feature-rich base classifiers,harmoniously aggregating their insights to produce a comprehensive detection *** experiments on three social robot detection datasets have shown that this method effectively improves the accuracy of social robot detection and outperforms comparative methods.

关键词： Social robot detection graph neural networks random forest homophily heterophily

Coordinated Control Strategy of New Energy Power Generation System with Hybrid Energy Storage Unit

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Energy Engineering 2025年第1期122卷 167-184页

作者： Yun Zhang ZifenHan Biao Tian Ning Chen Yi fan School of Mechano-Electronic Engineering Xidian UniversityXi’an710071China Electric Power Control Center State Grid Gansu Electric Power CompanyLanzhou730030China Electric Power Control Center State Grid Gansu Electric Power Company Zhangye Power Supply BranchZhangye734000China

The new energy power generation is becoming increasingly important in the power *** as photovoltaic power generation has become a research hotspot,however,due to the characteristics of light radiation changes,photovoltaic power generation is unstable and random,resulting in a low utilization rate and directly affecting the stability of the power *** solve this problem,this paper proposes a coordinated control strategy for a newenergy power generation system with a hybrid energy storage unit based on the lithium iron phosphate-supercapacitor hybrid energy storage ***,the variational mode decomposition algorithm is used to separate the high and low frequencies of the power signal,which is conducive to the rapid and accurate suppression of the power fluctuation of the energy storage ***,the fuzzy control algorithm is introduced to balance the power between energy *** this paper,the actual data is used for simulation,and the simulation results show that the strategy realizes the effective suppression of the bus voltage fluctuation and the accurate control of the internal state of the energy storage unit,effectively avoiding problems such as overshoot and over-discharge,and can significantly improve the stability of the photovoltaic power generation systemand the stability of the Direct Current *** is of great significance to promote the development of collaborative control technology for photovoltaic hybrid energy storage units.

关键词： Photovoltaic power suppression hybrid energy storage unit variationalmodal decomposition fuzzy control power distribution control