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Induction of chronic cholestasis without liver cirrhosis-Creation of an animal model

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World Journal of Gastroenterology 2017年第23期23卷 4191-4199页

作者： Felix Dondorf RenéFahrner Michael Ardelt Eleonora Patsenker Felix Stickel Uta Dahmen Utz Settmacher falk rauchfuβ Department of General Visceral and Vascular SurgeryJena University Hospital Division of Gastroenterology and Hepatology University Hospital Zürich

To analyze time intervals of inflammation and regeneration in a cholestatic rat liver *** 36 Lewis rats, divided into six groups of 6 animals (postoperative observation periods: 1, 2, 3, 4, 6, 8 wk), the main bile duct was ligated with two ligatures and observed for the periods mentioned above. For laboratory evaluation, cholestasis parameters (bilirubin, γ-GT), liver cell parameters (ASAT, ALAT) and liver synthesis parameters (quick, albumin) were determined. For histological analysis, HE, EvG, ASDCL and HMGB-1 stainings were performed. Furthermore, we used the mRNA of IL-33, GADD45a and p-21 for analyzing cellular stress and regeneration in cholestatic *** chemical laboratory and histological evaluation, a distinction between acute and chronic cholestatic liver injury with identification of inflammation and regeneration could be demonstrated by an increase in cholestasis (bilirubin: 1-wk group, 156.83 ± 34.12 μmol/L, P = 0.004) and liver cell parameters (ASAT: 2-wk group, 2.1 ± 2.19 μmol/L.s, P = 0.03; ALAT: 2-wk group, 1.03 ± 0.38 μmol/L.s, P = 0.03) after bile duct ligation (BDL). Histological evaluation showed an increase of bile ducts per portal field (3-wk group, 48 ± 6.13, P = 0.004) during the first four weeks after bile duct ligation. In addition to inflammation, which is an expression of acute cholestasis, there was an increase of necrotic areas in the histological sections (2-wk group, 1.38% ± 2.28% per slide, P = 0.002). Furthermore, the inflammation could be verified by ASDCL (4-wk group, 22 ± 5.93 positive cells per portal field, P = 0.041) and HMGB-1 [2-wk group, 13 ± 8.18 positive cells per field of view (FoV), P = 0.065] staining. Therefore, in summary of the laboratory evaluation and histological studies, acute cholestasis could be found during the first four weeks after bile duct ligation. Subsequently, the described parameters declined so that chronic cholestasis could be assumed. For quantification of secondary biliary ci

关键词： Rats Cholestasis Chronic cholestasis Rat liver model

Successful living donor liver transplantation in a cystic fibrosis patient with combined hepatocellular carcinoma and cholangiocarcinoma

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Hepatoma Research 2015年第1期1卷 46-48页

作者： falk rauchfuß Felix Dondorf RenéFahrner Michael Ardelt Yves Dittmar Utz Settmacher Department of General Visceral and Vascular SurgeryJena University HospitalFriedrich-Schiller-University Jena07747 JenaGermany

Combined hepatocellular carcinoma(HCC)and cholangiocarcinoma(CC)is a rare tumor *** this report,we describe a case of a young patient who developed a liver tumor in a cirrhotic liver caused by cystic fi *** diagnostic fi ndings suggested that this tumor was an *** performed living donor liver *** examination of the tumor revealed combined HCC and CC as an incidental fi *** years after the transplantation,the patient is in good clinical condition and is disease-free.

关键词： Cholangiocarcinoma cystic fi brosis hepatocellular carcinoma liver transplantation liver tumor living donation

Portable dielectrophoresis for biology:ADEPT facilitates cell trapping,separation,and interactions

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Microsystems & Nanoengineering 2024年第2期10卷 193-205页

作者： Lourdes Albina Nirupa Julius Dora Akgül Gowri Krishnan Fabian falk Jan Korvink Vlad Badilita Department Institute of Microstructure TechnologyKarlsruhe Institute of TechnologyHermann-von-Helmholtz-Platz 1Eggenstein-Leopoldshafen76344Baden-WürttembergGermany

Dielectrophoresis is a powerful and well-established technique that allows label-free,non-invasive manipulation of cells and particles by leveraging their electrical *** practical implementation of the associated electronics and user interface in a biology laboratory,however,requires an engineering background,thus hindering the broader adoption of the *** order to address these challenges and to bridge the gap between biologists and the engineering skills required for the implementation of DEP platforms,we report here a custom-built,compact,universal electronic platform termed ADEPT(adaptable dielectrophoresis embedded platform tool)for use with a simple microfluidic chip containing six *** versatility of the open-source platform is ensured by a custom-developed graphical user interface that permits simple reconfiguration of the control signals to address a wide-range of specific applications:(i)precision positioning of the single bacterium/cell/particle in the micrometer range;(ii)viability-based separation by achieving a 94%efficiency in separating live and dead yeast;(iii)phenotype-based separation by achieving a 96%efficiency in separating yeast and Bacillus subtilis;(iv)cell–cell interactions by steering a phagocytosis process where a granulocyte engulfs *** RGB-S ***,the set of experiments and the platform form a complete basis for a wide range of possible applications addressing various biological questions exploiting the plug-and-play design and the intuitive GUI of ADEPT.

关键词： Together separation separating

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利用管道机器人更加经济地焊接管道

现代制造 2024年第2期 39-40页

作者： Mikkel falk 不详

许多领域中都离不开焊接精良的管道。但现阶段企业缺少高水平的焊接技工。为了按时完成订单合同,企业必须另辟蹊径。通常情况下,自动化成为了企业解决问题的关键所在。飞溅的火花、灼热的热浪、烟雾缭绕以及不符合人体工程学的操作姿势... 详细信息

许多领域中都离不开焊接精良的管道。但现阶段企业缺少高水平的焊接技工。为了按时完成订单合同,企业必须另辟蹊径。通常情况下,自动化成为了企业解决问题的关键所在。飞溅的火花、灼热的热浪、烟雾缭绕以及不符合人体工程学的操作姿势,这些都表明焊接是一项艰苦的工作。再加上连续工作几个小时才能看到焊接后的成果,即使是经验丰富的焊工,也要付出更多的体力和技能来完成自己承担的工作。由此,人口结构的变化导致熟练的焊工成为稀缺的劳动力资源。

关键词：劳动力资源人体工程学管道机器人烟雾缭绕技工焊工解决问题订单合同

Wireless data transmission using visual codes

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Photonics Research 2014年第5期2卷 150-160页

作者： Thilo Fath falk Schubert Harald Haas Institute for Digital Communications University of EdinburghEH93JL EdinburghUK Innovation Works Germany EADS Deutschland GmbH81663 MunichGermany

In this paper,a new approach for wireless data transmission within an aircraft cabin is *** proposed application enables the transmission of data to a passenger’s user *** wireless in-flight applications are subject to strict frequency and electromagnetic compatibility(EMC)regulations,the data is transferred by optical wireless transmission,specifically by two-dimensional visual *** this end,black-and-white or colored visual code sequences are displayed on the in-flight entertainment *** visual codes are captured by the built-in camera of the passenger’s mobile device and are decoded to reconstruct the transmitted *** order to compensate for frame losses caused by effects like occlusion and motion blur,a temporal forward error correction coding scheme is *** experiments within an Airbus A330 cabin mock-up demonstrate the functionality of the implemented system under realistic conditions such as ambient illumination and geometric *** user devices are used for evaluation;specifically,a low-cost and a high-end smartphone are employed as *** evaluations show that the proposed transmission system achieves data rates of up to 120 kbit/s per individual passenger seat with these user *** the user device has no physical connection to the sensitive on-board system,the proposed transmission system provides an intrinsic safety feature.

关键词： visual illumination correction

Constructing Restricted Patterson Measures for Geometrically Infinite Kleinian Groups

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Acta Mathematica Sinica,English Series 2006年第2期22卷 431-446页

作者： Kurt falk Bernd O. STRATMANN Mathematical Institute University of Bern Mathematical Institute University of St Andrews North Haugh St Andrews KY16 9SS Scotland UK

In this paper, we study exhaustions, referred to as p-restrictions, of arbitrary nonelementary Kleinian groups with at most finitely many bounded parabolic elements. Special emphasis is put on the geometrically infinite case, where we obtain that the limit set of each of these Kleinian groups contains an infinite family of closed subsets, referred to as p-restricted limit sets, such that there is a Poincaré series and hence an exponent of convergence δp, canonically associated with every element in this family. Generalizing concepts which are well known in the geometrically finite case, we then introduce the notion of p-restricted Patterson measure, and show that these measures are non-atomic, δp-harmonic, δp-subconformal on special sets and δp-conformal on very special sets. Furthermore, we obtain the results that each p-restriction of our Kleinian group is of δp-divergence type and that the Hausdorff dimension of the p-restricted limit set is equal to δp.

关键词： Kleinian group Patterson measure Hausdorff dimension

Removal of perfluorinated surfactants from wastewater by adsorption and ion exchange--Influence of material properties,sorption mechanism and modeling

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Journal of Environmental Sciences 2017年第4期29卷 160-170页

作者： falk Schuricht Ekaterina S.Borovinskaya Wladimir Reschetilowski Institute of Industrial Chemistry Dresden University of Technology

Perfluorooctane sulfonate（PFOS） has attracted increasing concern in recent years due to its world-wide distribution, persistence, bioaccumulation and potential toxicity. The influence of sorbent properties on the adsorptive elimination of PFOS from wastewater by activated carbons, polymer adsorbents and anion exchange resins was investigated with regard to their isotherms and kinetics. The batch and column tests were combined with physicochemical characterization methods, e.g., N2 physisorption, mercury porosimetry, infrared spectroscopy, differential scanning calorimetry, titrations, as well as modeling. Sorption kinetics was successfully modelled applying the linear driving force（LDF） approach for surface diffusion after introducing a load dependency of the mass transfer coefficient β*** big difference in the initial mass transfer coefficient βs,0, when non-functionalized adsorbents and ion-exchange resins are compared, suggests that the presence of functional groups impedes the intraparticle mass transport. The more functional groups a resin possesses and the longer the alkyl moieties are the bigger is the decrease in sorption *** the selectivity for PFOS sorption is increasing when the character of the functional groups becomes more hydrophobic. Accordingly, ion exchange and hydrophobic interaction were found to be involved in the sorption processes on resins, while PFOS is only physisorptively bound to activated carbons and polymer adsorbents. In agreement with the different adsorption mechanisms, resins possess higher total sorption capacities than adsorbents. Hence, the latter ones are rendered more effective in PFOS elimination at concentrations in the low μg/L range, due to a less pronounced convex curvature of the sorption isotherm in this concentration range.

关键词： PFOS Activated carbon Anion exchange resin Sorption kinetics modeling Sorption isotherm Selectivity of sorption

Quantifying land degradation in the Zoige Basin,NE Tibetan Plateau using satellite remote sensing data

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Journal of Mountain Science 2017年第1期14卷 77-93页

作者： YU Kai-feng Frank LEHMKUHL Dimitri falk Department of Geography RWTH Aachen University Templergraben 55 52056 Aachen Germany

Considerable efforts have been dedicated to desertification research in the arid and semi-arid drylands of central Asia. However,there are few quantitative studies in conjunction with proper qualitative evaluation concerning land degradation and aeolian activity in the alpine realm. In this study,spectral information from two Landsat-5 TM scenes(04.08.1994 and 28.07.2009,respectively) was combined with reference information obtained in the field to run supervised classifications of eight landscape types for both time steps. Subsequently,the temporal and spatial patterns of the alpine wetlands/grasslands evolutions in the Zoige Basin were quantified and assessed based on these two classification maps. The most conspicuous change is the sharp increase of ~627 km^2 degraded meadow. Concerning other land-covers,shallow wetland increases ~107 km^2 and aeolian sediments(mobile dunes and sand sheets) have an increase of ~30 km^2. Considering the deterioration,an obvious decrease of ~440 km^2 degraded wetland can be observed. Likewise,decrease of deep wetland(~78 km^2),humid meadow(~80 km^2) and undisturbed meadow(~88 km^2) were determined. These entire evolution matrixes undoubtedly hint a deteriorating tendency of the Zoige Basin ecosystem,which is characterized by significantly declined proportion of intact wetlands,meadow,rangeland and a considerable increase ofdegraded meadow and larger areas of mobile dunes. In particular,not only temporal alteration of the landcover categories,the spatial and topographical characteristics of the land degradation also deserves more attention. In the alpine rangelands,the higher terraces of the river channels along with their slopes are more liable to the degradation and desertification. This tendency has significantly impeded the nomadic and agriculture activities. The set of anthropozoogenic factors encompassing enclosures,overgrazing and trampling,rodent damaging and exceedingly ditching in the wetlands are assumed to be the main co

关键词： Alpine ecosystem Wetlands Degradation Desertification Zoige Basin Driving mechanisms

Glass transition temperature prediction of disordered molecular solids

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npj Computational Materials 2021年第1期7卷 1633-1639页

作者： Kun-Han Lin Leanne Paterson falk May Denis Andrienko Max Planck Institute for Polymer Research Ackermannweg 1055128 MainzGermany Merck KGaA 64293 DarmstadtGermany

Glass transition temperature,Tg,is the key quantity for assessing morphological stability and molecular ordering of films of organic semiconductors.A reliable prediction of Tg from the chemical structure is,however,challenging,as it is sensitive to both molecular interactions and analysis of the heating or cooling *** combining a fitting protocol with an automated workflow for forcefield parameterization,we predict Tg with a mean absolute error of~20℃for a set of organic compounds with Tg in the 50–230℃*** study establishes a reliable and automated prescreening procedure for the design of amorphous organic semiconductors,essential for the optimization and development of organic light-emitting diodes.

关键词： automated prediction transition