检索结果-南通市图书馆

LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2022年第1期11卷 869-882页

作者： Shirley Yin-Yu Pang Rachel Cheuk Nam Lo Philip Wing-Lok Ho Hui-Fang Liu Eunice Eun Seo Chang Chi-Ting Leung Yasine Malki Zoe Yuen-Kiu Choi Wing Yan wong Michelle Hiu-Wai Kung David Boyer Ramsden Shu-Leong Ho Division of Neurology Department of MedicineQueen Mary HospitalUniversity of Hong KongHong KongChina School of Biomedical Sciences Li Ka Shing Faculty of MedicineUniversity of Hong KongHong KongChina Institute of Metabolism and Systems Research University of BirminghamBirminghamUK.

Mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA) represent two most common genetic causes of Parkinson’s disease (PD). Both genes are important in the autophagic-lysosomal pathway (ALP), defects of which are associated with α-synuclein (α-syn) accumulation. LRRK2 regulates macroautophagy via activation of the mitogen activated protein kinase/extracellular signal regulated protein kinase (MAPK/ERK) kinase (MEK) and the calcium-dependent adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathways. Phosphorylation of Rab GTPases by LRRK2 regulates lysosomal homeostasis and endosomal trafficking. Mutant LRRK2 impairs chaperone-mediated autophagy, resulting in α-syn binding and oligomerization on lysosomal membranes. Mutations in GBA reduce glucocerebrosidase (GCase) activity, leading to glucosylceramide accumulation, α-syn aggregation and broad autophagic abnormalities. LRRK2 and GBA influence each other: GCase activity is reduced in LRRK2 mutant cells, and LRRK2 kinase inhibition can alter GCase activity in GBA mutant cells. Clinically, LRRK2 G2019S mutation seems to modify the effects of GBA mutation, resulting in milder symptoms than those resulting from GBA mutation alone. However, dual mutation carriers have an increased risk of PD and earlier age of onset compared with single mutation carriers, suggesting an additive deleterious effect on the initiation of PD pathogenic processes. Crosstalk between LRRK2 and GBA in PD exists, but its exact mechanism is unclear. Drugs that inhibit LRRK2 kinase or activate GCase are showing efficacy in pre-clinical models. Since LRRK2 kinase and GCase activities are also altered in idiopathic PD (iPD), it remains to be seen if these drugs will be useful in disease modification of iPD.

关键词： Parkinson’s disease Interaction LRRK2 GBA GCase Mutation Autophagy α-Synuclein

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

香港地区肿瘤护理的发展历程

中国护理管理 2022年第7期22卷 980-985页

作者：麦素珊黄嘉辉李剑洪苏帼慧麦玮智车锡英唐华根香港医院管理局新界东联网医院临床肿瘤科香港特别行政区999077 香港威尔斯亲王医院临床肿瘤科中国香港香港中文大学那打素护理学院中国香港香港医院管理局总办公室中国香港

回顾了香港地区肿瘤专科护士的角色、培训、教育、实践和服务的发展历程。重点介绍了过去20多年香港地区肿瘤护理的发展和转型。反映了肿瘤科护士在癌症控制和癌症护理质量方面所做的重要贡献。提出了未来香港地区肿瘤护理的培训和实践... 详细信息

回顾了香港地区肿瘤专科护士的角色、培训、教育、实践和服务的发展历程。重点介绍了过去20多年香港地区肿瘤护理的发展和转型。反映了肿瘤科护士在癌症控制和癌症护理质量方面所做的重要贡献。提出了未来香港地区肿瘤护理的培训和实践的具体方向,及对未来护理实践发展至关重要的方向和所需要发挥的作用,这需要临床、学术和专业机构不断努力以实现这一目标。

关键词：肿瘤护理护理角色护理实践护士诊所高级培训专科教育香港特别行政区

r-tPA治療腦室內血腫價值及相關併發症研究

在线全文

学校读者我要写书评

暂无评论

镜湖医学 2017年第2期17卷 5-8页

作者：鄉志雄廖挺梁美霞范耀華黃登輝澳門鏡湖醫院神經外科中国

目的通過總結鏡湖醫院神經外科治療的腦室內血腫患者的資料,明確r-tPA治療腦室內血腫的价值及併發症發生率。方法收集2009年1月~2017年1月期間鏡湖醫院神經外科治療的121例腦室內血腫患者中,其中使用r-t P A治療的有56例,單純腦室外引... 详细信息

目的通過總結鏡湖醫院神經外科治療的腦室內血腫患者的資料,明確r-tPA治療腦室內血腫的价值及併發症發生率。方法收集2009年1月~2017年1月期間鏡湖醫院神經外科治療的121例腦室內血腫患者中,其中使用r-t P A治療的有56例,單純腦室外引流或開顱血腫清除+置管引流(稱“對照組”)的65例,分別收集兩組病人的GCS評分,mRS評分、GOS評分,腦室內血腫清除的情況及各種併發症發生率相關進行總結。結果r-tPA注射組中,4/56(7%)例病人的死亡,對照組中,11/65(16.9%)例死亡。腦室內血腫清除72h G r a e b評分r-t P A注射組為3.00±1.92,對照組為9.00±2.78。G O S評分為1~2分患者在r-t P A注射組為28/56(50%),對照組為21/65(32.3%)。r-t P A注射組患者並發新鮮出血6/56例(10.7%),對照組術後並發新鮮出血的病人1/65例(1.5%)。r-t P A注射組注射r-t P A後顱內壓升高6/56例(10.7%)、併發心律失常4/56例(7.1%),併發引流管堵塞1/56例(1.8%),對照組引流管堵塞7/65例(10.8%)。注射r-t P A治療結束後出現腦積水需要行腦室腹腔分流的9/56例(16.1%)。而對照組有27/65例(41.5%)。結論經腦室外引流管注射r-tPA治療腦室內積血是一種有效的治療措施,能加快腦室內血腫的溶解排除,減少引流管堵塞,降低病人腦積水併發症。然而部份病人在開顱血腫清除、去除顱骨減壓或引流管放置在血腫腔內均增加繼發出血風險。同時需控制注射藥物的液體總量及注射溶液的溫度,避免I C P升高或並發心率失常、抽搐等併發症。

关键词：腦出血腦室內出血腦室外引流術 r-tPA治療

散光人工晶狀體矯正白内障合併角膜散光的療效

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

镜湖医学 2022年第1期22卷 44-46页

作者：鄧麗賢李慧菁黃詠恒陳濱暉賴一凡澳門鏡湖醫院眼科中国澳门

目的觀察白内障患者植入散光人工晶狀體(Toric intraocular lens,Toric IOL)後角膜散光及殘餘散光的變化以及術後視力情況,評估Acrysof IQ Toric IOL的效果和穩定性。方法選取白内障合併角膜散光(≥1.5D)的連續患者,實驗組共59人(72眼)... 详细信息

目的觀察白内障患者植入散光人工晶狀體(Toric intraocular lens,Toric IOL)後角膜散光及殘餘散光的變化以及術後視力情況,評估Acrysof IQ Toric IOL的效果和穩定性。方法選取白内障合併角膜散光(≥1.5D)的連續患者,實驗組共59人(72眼)行白内障超聲乳化吸出聯合Acrysof IQ Toric IOL植入術,對照組共29人(36眼)行白内障超聲乳化吸出聯合單焦IOL植入術,術後平均隨訪時間6個月。主要觀察指標:患者的一般資料、術前角膜散光的大小及軸位、術後裸眼視力及最佳矯正視力、術後角膜散光及殘餘散光的大小及軸位。結果實驗組與對照組患者術前平均角膜散光分別為2.18±0.82D和2.01±0.73D;術後平均殘餘散光分別為0.89±0.54D和2.25±0.72D,兩組術後平均殘餘散光的差別有統計學意義(P=0.006)。實驗組術後平均裸眼視力約0.8,對照組術後平均裸眼視力約0.4。結論Acrysof IQ Toric IOL能有效矯正白内障患者合併角膜散光,可提高術後裸眼視力,且術後平均殘餘散光越少,裸眼視力越好。

关键词：白内障角膜散光散光人工晶狀體視力

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

最新兩代血流導向裝置治療動脈瘤的比較

镜湖医学 2020年第2期20卷 31-33,64页

作者：廖挺黃宇鑫鄉志雄黃登輝梁美霞蔣霞鄭瑾璇段麗芳陳秀玲澳門鏡湖醫院外科中國澳門鏡湖醫院神經内科中國澳門鏡湖醫院放射科中國

目的通過比較單一中心連續使用第二代血流導向裝置Pipeline Embolization Device(PED)Flex同第三代PED Shield治療顱内未破裂動脈瘤的情況,評價兩代產品在使用上的安全性及有效性。方法回顧鏡湖醫院2015年1月~2019年3月間分別使用PED F... 详细信息

目的通過比較單一中心連續使用第二代血流導向裝置Pipeline Embolization Device(PED)Flex同第三代PED Shield治療顱内未破裂動脈瘤的情況,評價兩代產品在使用上的安全性及有效性。方法回顧鏡湖醫院2015年1月~2019年3月間分別使用PED Flex及PED Shield治療顱内未破裂動脈瘤的患者,分析兩種方法治療病例的栓塞率、圍手術期及術後中期併發症發生率及近期預後情況進行分析。結果兩組共42例,其中Flex治療26例26個動脈瘤,Shield治療16例17個動脈瘤。PED Flex及PED Shield完全閉塞率分別是84.6%,88.2%;術中技術性併發症發生率分別是3.8%,6.2%;術後併發症發生率分別是3.8%,0%;載瘤動脈或穿支血管閉塞發生率分別是7.6%,0;近期療效(mRS:0-2)96.2%,100%。隨訪1年後,兩組患者無動脈瘤再破裂,無遲發出血或梗塞、死亡病例。經統計學檢驗未顯示出兩代產品在治療效果及併發症的統計學差異。結論顱内未破裂動脈瘤使用PED治療是安全及有效的,PED Flex存在的栓塞事件在PED Shield上得到改進。

关键词：未破裂動脈瘤血流導引裝置 PED 血管内介入治療

Impact of exercise on neuro-cognitive function and hippocampal plasticity in early psychosis—a preliminary data analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of exercise on neuro-cognitive function and hippocamp...

澳门老年人用药行为及对社区药学服务需求的调查分析

中华医学会精神病学分会第九次全国学术会议

作者： LIN Jing-xia,~1 May Mei-Ling Lam,~1 Kit-Wa Chan,~1 Wing-Chung Chang,~1 Glen Joe,~2 Gloria Hoi-Yan wong,~1 Cindy Pui-Yu Chiu,~1 Pek-Lan Khong,~3 William G Honer,Wayne Su,~4 Cecilia Lai-Wan Chan,~5 Kwok-fai So,~6 Michael Tse~2 and Eric Yu-Hai Chen~1 1 Department of Psychiatry,the University of Hong Kong 2 Institute of Human Performance,the University of Hong Kong 3 Department of Diagnostic Radiology,the University of Hong Kong 4 Department of Psychiatry,University of British Columbia,Vancouver,Canada 5 Department of Social Work and Social Administration,the University of Hong Kong 6 Department of Anatomy,the University of Hong Kong

Objectives Hippocampal volume is lower in schizophrenic patients than in normal *** present study aimed to investigate whether physical exercise would increase hippocampal volume in patients with early psychosis,and whether this effect would be related to improved neuro-cognitive functions. Methods A total of 60 female psychosis patients aged 18-55 years old with less than 5 years illness duration were

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

中国医药导报 2018年第21期15卷 40-43页

作者：刘政坚黄淑尼刘敬权陈德超陈雅珊郭潮辉冯荣楷孟丽荣澳门理工学院高等卫生学校澳门999078 澳门卫生局药物事务厅澳门999078 镜湖医院药剂科澳门999078

目的探讨澳门老年人的用药行为与其相关因素,并了解他们对社区药学服务的需求。方法以60岁或以上居民为对象,于2015年10月采用配额抽样方式在澳门花地玛堂区、花王堂区、风顺堂区、离岛区、望德堂与大堂区进行问卷调查,收集健康状况、... 详细信息

目的探讨澳门老年人的用药行为与其相关因素,并了解他们对社区药学服务的需求。方法以60岁或以上居民为对象,于2015年10月采用配额抽样方式在澳门花地玛堂区、花王堂区、风顺堂区、离岛区、望德堂与大堂区进行问卷调查,收集健康状况、用药行为、购药依据、对药学服务需求等数据。结果本次调查共发放问卷401份,有效问卷共398份,有效率99.3%。当中30.4%受访者定期使用5种或以上药品,Morisky量表结果显示60.6%受访者的总体依从性欠佳。曾自行加减药量的为14.1%,重复用药8.5%,两种不合理用药行为与多重用药有关。大部分受访者对开展社区药学服务表示支持。结论澳门老年人对社区药学服务的需求迫切,药师可参考本调查数据开展不同模式的药学服务,充分发挥促进老年人合理用药的作用。

关键词：社区需求老年人澳门用药依从性用药行为药学服务

在线全文

学校读者我要写书评

暂无评论

雙通道脊髓電刺激治療帶狀皰疹神經痛1例

镜湖医学 2021年第1期21卷 71-71页

作者：吳朝興黃鍇亮錢曉暉澳門鏡湖醫院疼痛科中國

患者男性,74歲,既往有2型糖尿病病史。因“右腰腹、大腿及臀部皮疹伴疼痛2月”於2019年12月27日入院。患者入院2月前無明顯誘因下出現右側腰腹、大腿及臀部皮疹,呈紅斑樣,病初未見疼痛,於皮膚科就診診斷帶狀皰疹,予藥物治療後皰疹漸癒合... 详细信息

患者男性,74歲,既往有2型糖尿病病史。因“右腰腹、大腿及臀部皮疹伴疼痛2月”於2019年12月27日入院。患者入院2月前無明顯誘因下出現右側腰腹、大腿及臀部皮疹,呈紅斑樣,病初未見疼痛,於皮膚科就診診斷帶狀皰疹,予藥物治療後皰疹漸癒合,但疼痛逐漸加重,發展至觸碰即可誘發明顯疼痛,門診予聯合服用多種止痛藥物(Tramal+Neurontin+Lyrica)治療,效果不佳,嚴重影響日常生活,不能入睡,VAS評9分。

关键词： 2型糖尿病臀部皮疹患者入院治療腰腹疼痛

Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia UniversitéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro RioBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung University Hsinchu National United University Miao-Li Department of Physics National T

The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main *** of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 background events are *** large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment.

关键词： neutrino oscillation solar neutrino JUNO