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Cytotoxicity, Toxicity and Anticancer Activity of m.nuka Honey, Saudi’s Honey and Peganum.harm.la Plant against Cancer Cells

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Journal of Biosciences and m.dicines 2024年第2期12卷 311-325页

作者： Naif m. alhawiti Elber-Lewis m.les Anaif m. Alhewaitey Yousef m. Alm.tairi fadhah m. alhawiti CAHFS University of California Davis Davis USA Departm.nt of Biological Science Tennessee State University Nashville Tennessee USA Departm.nt of Chem.stry University of Tabuk Tabuk Saudi Arabia m.nistry of Health East Jeddah General Hospital Jeddah Saudi Arabia

Cancer occurs when the body’s cells grow beyond the usual control. Norm.l body cells m.ltiply in a controlled m.nner and undergo apoptosis when the body no longer needs them. Different types of cancers exist, and the com.on ones include breast, cervical, prostate, lung, colon, and skin cancers. Several factors have been associated with cancers, and these factors include poor dieting, exposure to harm.ul chem.cals and radiation, weak im.une system. and genetics. Cancer presents an enorm.us health threat in the m.dern world and thus the need to identify an effective treatm.nt. The conventional treatm.nts used in the m.nagem.nt of cancer include chem.therapy and physiotherapy. These form. of cancer treatm.nts usually have enorm.us side effects on the subjects. In this respect, an alternative form.of treatm.nt would be effective in m.naging cancer patients. A substantial num.er of natural products have been observed to be effective in the m.nagem.nt of cancer. These natural products include plants and other natural substances such as honey. This study focuses on the efficiency of natural products in the treatm.nt of cancer. Also, the anticancer effects of Peganum.harm.la, m.nuka honey, and Saudi honey will be analyzed. Bee honey and Peganum.harm.la have been traditionally used in the treatm.nt of cancer. The extracts from.Peganum.harm.la plant have also been shown to exhibit divers’ antitum.r effects sim.lar to the m.de of action of a vast num.er of anticancer agents. These established hypotheses thus give the rationale for this study. In this experim.nt, extracts were obtained from.Peganum.harm.la leaves and exposed to cervical, lung, and prostate cancer cells. Sim.larly, solutions of m.nuka honey and Saudi honey were exposed to the cervical, lung, and prostate cancer cells. The experim.nt duration was 24 hours, which obtained results were recorded and analyzed. Peganum.harm.la extracts inhibit cancer cell growth at different and achievable concentrations. m.nuka honey

关键词： Peganum.harm.la m.nuka Honey Saudi Honey Anticancer Apoptosis Natural Products

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