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Methyl gallate isolated from Mangifera pajang kernel induces proliferation inhibition and apoptosis in MCF-7 breast cancer cells via oxidative stress

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Asian Pacific Journal of Tropical Biomedicine 2022年第4期12卷 175-184页

作者： Ranneh Yazan Abu Bakar Mohd Fadzelly Rahim Azlen-Che Kassim Nur Kartinee Stanslas Johnson Teh Yuan-Han fadel abdulmannan Ellulu Mohammed S Department of Technology and Natural Resources Faculty of Applied Science and TechnologyUniversiti Tun Hussein Onn MalaysiaPagoh CampusKM1 Panchor RoadMuar JohorMalaysia Department of Chemistry Faculty of ScienceUniversiti Putra MalaysiaSerdang 43300Malaysia Department of Medicine Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSelangorMalaysia Sport and Exercises Sciences School Faculty of ScienceLiverpool John Moores UniversityLiverpoolUK Department of Clinical Nutrition Faculty of Applied Medical SciencesAl-Azhar University of GazaGaza CityState of Palestine

Objective:To determine the lead bioactive compound in kernel extract of Mangifera pajang and its anti-cancer activity against human breast cancer cell lines with positive estrogen receptor(MCF-7).Methods:The methanolic extract of dried powder kernel of Mangifera pajang was exposed to column chromatography for *** structural elucidation of the isolated compound was characterized using infrared,nuclear magnetic resonance,mass ***,cytotoxicity,morphological changes,flow cytometry and cell cycle arrest analyses were performed to examine the mechanism of anti-proliferation and apoptosis induced by methyl gallate against ***:One compound was isolated from the methanolic extract of Mangifera pajang kernel and identified as methyl *** flow cytometric results demonstrated induction of apoptosis in MCF-7 cells by three concentrations of methyl *** cell cycle arrest showed a significant(P<0.05)decrease in cell progression at G2/M phase of MCF-7 after treatment with 100μM of methyl *** cell percentage of early and late apoptosis was significant at 10 and 100μM of methyl ***,methyl gallate treatment induced up-regulation of reactive oxygen species levels in MCF-7 cells with a reduction in superoxide dismutase ***:These findings indicate that isolated methyl gallate from Mangifera pajang kernel extracts induces growth inhibition and apoptosis in MCF-7 cells via up-regulating oxidative stress pathway.

关键词： Mangifera pajang Methyl gallate Breast cancer Cell cycle Apoptosis Oxidative stress

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