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ERK1 and ERK2 are involved in recruitment and maturation of human mesenchymal stem cells induced to adipogenic differentiation

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分子细胞生物学报:英文版 2011年第2期3卷 123-131页

作者： Elisabetta Donzelli Caterina Lucchini Elisa Ballarini Arianna Scuteri fabrizio Carini Giovanni Tredici Mariarosaria Miloso Department of Neuroscience and Biomedical Technologies University of Milano-BicoccaVia Cadore 48-20052Monza(MB)Italy Reproductive Medicine Nuova Villa Claudia ClinicVia Flaminia Nuova 280RomeItaly

Adipocytes’biology and the mechanisms that control adipogenesis have gained importance because of the need to develop therapeutic strategies to control obesity and the related *** mesenchymal stem cells(hMSCs),undifferentiated stem cells present in the bone marrow that are physiological precursors of adipocytes,were induced to adipogenic *** molecular mechanisms on the basis of the adipogenesis were evaluated,focusing on the MAPKinases ERK1 and ERK2,which are involved in many biological and cellular ***1 and ERK2 phosphorylation was reduced with different timing and intensity for the two isoforms in treated hMSCs in comparison with control cells until day 10 and then at 14–28 days,it reached the level of untreated *** total amount of ERK1 was also decreased up to day 10 and then was induced to the level of untreated cultures,whereas the expression of ERK2 was not changed following adipogenic *** with the specific ERK1/2 inhibitor U0126 during the whole differentiation period hampered hMSCs’adipogenic differentiation,as lipid droplets appeared in very few cells and were reduced in number and *** U0126 was administered only during the initial phase of differentiation,the number of hMSCs recruited to adipogenesis was reduced while,when it was administered later,hMSCs did not acquire a mature adipocytic ***1 and ERK2 are important for hMSC adipogenic differentiation since any alteration to the correct timing of their phosphorylation affects either the recruitment into the differentiation program and the extent of their maturation.

关键词： mesenchymal stem cells ERK adipogenesis MAPK obesity differentiation

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A Damage Scenario for the 2012 Northern Italy Earthquakes and Estimation of the Economic Losses to Residential Buildings

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International Journal of Disaster Risk Science 2017年第3期8卷 326-341页

作者： fabrizio Meroni Thea Squarcina Vera Pessina Mario Locati Marco Modica Roberto Zoboli Istituto Nazionale di Geofisica e Vulcanologia(INGV) Sezione di MilanoVia Bassini 15MilanItaly Istituto di Ricerca sulla Crescita Economica Sostenibile(IRCrES) Via Corti1220131 MilanItaly

In May 2012 a seismic sequence occurred in Northern Italy that was characterized by two main shocks with a magnitude range between 5.5 and 6. These shocks represent a good case study by which to quantify the monetary losses caused by a moderate earthquake in a densely populated and economically well-developed *** loss estimation accounts for damage to residential buildings, and considers the full effect of all the seismic aftershock events that lasted for nearly a month. The building damage estimation is based on the European Macroseismic Scale(EMS-98) definitions, which depict the effects of an earthquake on built-up areas in terms of observed intensities. Input data sources are the residential building census provided by Istituto Nazionale di Statistica—the Italian National Institute of Statistics(ISTAT)—and the official market value of real estate assets, obtained from the Osservatorio del Mercato Immobiliare—the Real Estate Market Observatory(OMI). These data make it possible to quantify the economic losses due to earthquakes, an economic indicator updated yearly. The proposed multidisciplinary method takes advantage of seismic,engineering, and economic data sets, and is able to provide a reasonable after the event losses scenario. Data are not gathered for each single building and the intensity values are not a simple hazard indicator, but, notwithstanding its coarseness, this method ensures both robust and reproducible results. As the local property value is availablethroughout the Italian territory, the present loss assessment can be effortlessly repeated for any area, and may be quickly reproduced in case of future events, or used for predictive economic estimations.

关键词： Earthquake damage Economic losses EMS-98 intensity Northern Italy 20 May 2012 earthquake

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Chasing the right path: tips, tricks and challenges of robotic approach to posterior segments

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Hepatobiliary Surgery and Nutrition 2019年第5期8卷 512-514页

作者： fabrizio Di Benedetto Giuseppe Tarantino Paolo Magistri Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit University of Modena and Reggio EmiliaModenaMOItaly

The advent of minimally invasive technologies to approachliver diseases changed some paradigms of liver surgeryduring the last two *** allow to safely treatpatients with poor liver function,portal hypertension andcirrhosis,reducing the risk of decompensation(1).However,those potential benefits resulted to be in contrast with theactual application of such technologies in the real-life(2,3).

关键词： liver diseases surgery

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Use of robotics in liver donor right hepatectomy

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Hepatobiliary Surgery and Nutrition 2018年第3期7卷 231-232页

作者： fabrizio Di Benedetto Paolo Magistri Karim JHalazun Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit University of Modena and Reggio EmiliaModenaMOItaly Department of Medical and Surgical Sciences and Translational Medicine Faculty of Medicine and PsychologySapienza University of RomeRomeRMItaly Division of Liver Transplantation and Hepatobiliary Surgery Department of SurgeryWeill Cornell Medical CollegeNew YorkNYUSA

We read with great interest the paper by Chen and colleagues entitled "Use of robotics in liver donor right hepatectomy" (1). The authors currently represent the leading group performing robotic living donor liver pro... 详细信息

关键词： donor liver hepatectomy

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Bloating and functional gastro-intestinal disorders: Where are we and where are we going?

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World Journal of Gastroenterology 2014年第39期20卷 14407-14419页

作者： Paola Iovino Cristina Bucci fabrizio Tremolaterra Antonella Santonicola Giuseppe Chiarioni Gastrointestinal Unit Department of Medicine and SurgeryUniversity of Salerno 84081 Baronissi Salerno Italy IRCCS Centro di riferimento Oncologico di Basilicata Rionero in Vulture 85100 Potenza Italy Division of Gastroenterology of the University of Verona Azienda Ospedaliera Universitaria Integrata di Verona 37100 Verona Italy Division of Gastroenterology and Hepatology and Center for functional GI and Motility Disorders University of North Carolina at Chapel HillChapel HillNC 27599 United States

Bloating is one of the most common and bothersome symptoms complained by a large proportion of patients. This symptom has been described with various definitions, such as sensation of a distended abdomen or an abdominal tension or even excessive gas in the abdomen, although bloating should probably be defined as the feeling (e.g. a subjective sensation) of increased pressure within the abdomen. It is usually associated with functional gastrointestinal disorders, like irritable bowel syndrome, but when bloating is not part of another functional bowel or gastrointestinal disorder it is included as an independent entity in Rome III criteria named functional bloating. In terms of diagnosis, major difficulties are due to the lack of measurable parameters to assess and grade this symptom. In addition, it is still unclear to what extent the individual patient complaint of subjective bloating correlates with the objective evidence of abdominal distension. In fact, despite its clinical, social and economic relevance, bloating lacks a clear pathophysiology explanation, and an effective management endorsement, turning this common symptom into a true challenge for both patients and clinicians. Different theories on bloating etiology call into questions an increased luminal contents (gas, stools, liquid or fat) and/or an impaired abdominal empting and/or an altered intra-abdominal volume displacement (abdomino-phrenic theory) and/or an increased perception of intestinal stimuli with a subsequent use of empirical treatments (diet modifications, antibiotics and/or probiotics, prokinetic drugs, antispasmodics, gas reducing agents and tricyclic antidepressants). In this review, our aim was to review the latest knowledge on bloating physiopathology and therapeutic options trying to shed lights on those processes where a clinician could intervene to modify disease course.

关键词： Bloating Functional gastro-intestinal disorders Irritable bowel syndrome Constipation Diarrhea

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Enteropathic spondyloarthropathy:A common genetic background with inflammatory bowel disease?

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World Journal of Gastroenterology 2009年第20期15卷 2456-2462页

作者： Elisabetta Colombo Anna Latiano Orazio Palmieri fabrizio Bossa Angelo Andriulli Vito Annese Unit of Gastroenterology Department of Medical Sciences IRCCS-CSS Hospital Laboratory of Genetic Research Department of Medical Sciences IRCCS-CSS Hospital Unit of Digestive Endoscopy Department of Medical SciencesIRCCS-CSS Hospital

The association between spondyloarthropathy and in flammatory bowel disease(IBD) is largely established, although prevalence is variable because of different population selection and diagnostic *** studies indicate that as many as 10%15% of cases of IBD are complicated by ankylosing spondylitis(AS) or other forms of spondylarthritis(SpA).Of note, ileal inflammation resembling IBD has been reported in up to two thirds of cases of SpA, and it has been suggested that the presence of ileitis is associated with the chronic ity of articular *** this observation is of interest to unravel the pathophysiology of the disease, systematic screening of patients with SpA by ileocolonos copy is not indicated in the absence of gut symptoms, as only a small proportion of patients with subclinical gut inflammation will develop overt IBD over *** existence of familial clustering of both IBD and AS, the coexistence of both conditions in a patient, the evidence of an increased risk ratio among f irstand seconddegree relatives of affected AS or IBD patients and f inally, the increased crossrisk ratios between AS and IBD, strongly suggest a shared genetic *** far, however, IL23R is the only identified susceptibility gene shared by both IBD and *** functional studies are still needed to better understand its pathogenic role, great ef fort is being spent therapeutically targeting this pathway that may prove effective for both disorders.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn's disease Ankylosing spondlitis Sacroiliitis Spondyloarthropathy

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Hepatocellular carcinoma with complete response to the immunotherapy:the oncologist’s dilemma

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 119-122页

作者： Mansour Al-Moundhri Antonio Cubisino fabrizio Panaro Medical Oncology Department Sultan Qaboos Comprehensive Cancer CenterSultan Qaboos UniversityMuscatOman Department of Surgery University of Illinois at ChicagoChicagoILUSA Department of Surgery Montpellier University HospitalMontpellierFrance Surgical Oncology Department Sultan Qaboos Comprehensive Cancer CenterSultan Qaboos UniversityMuscatOman

Hepatocellular carcinoma(HCC)is the seventh most common cancer and the fourth leading cause of cancer-related death worldwide(1).During the last decade,many efforts have been made to improve patient survival by conducting clinical trials investigating local and systemic treatment options for patients with unresectable ***,despite significant research efforts,only few treatment approaches have been validated for HCC.

关键词： cancer immunotherapy clinical

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Exploratory analysis of structural diversity indicators at stand level in three Italian beech sites and implications for sustainable forest management

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Journal of Forestry Research 2019年第1期30卷 121-127页

作者： Giada Bertini Claudia Becagli Ugo Chiavetta fabrizio Ferretti Gianfranco Fabbio Luca Salvati CREA Research Centre for Forestry and Wood

The present study introduces an exploratory data analysis based on structural indicators with the aim to assess the effect of silvicultural practices on tree stand structure. The study was carried out in three Italian beech forests of different ages with stand structures that originated from dissimilar regeneration and cultivation techniques(Cansiglio, northern Italy, Chiarano, central Italy,and Mongiana, southern Italy). Ten structural indicators were considered when investigating the latent multivariate relationship between stand structure attributes before and after thinning operations by using a multiway factor analysis(MFA). The MFA results identified the older stand at Cansiglio as more homogeneous for cultivation regimes,and more stable to practices when compared with the younger sites(Chiarano and Mongiana). Heterogeneous stands were sensitive to silvicultural practice thus suggesting their possible impact on forest attributes. The proposed approach proved to be an operational tool to evaluate comprehensively the response of forest structure to planned interventions.

关键词： Forest diversity Multiway factor analysis Silviculture Structural diversity indicators Tree stand structure

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Cytotoxic synergism of Clostridioides difficile toxin B with proinflammatory cytokines in subjects with inflammatory bowel diseases

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World Journal of Gastroenterology 2023年第4期29卷 582-596页

作者： Gabrio Bassotti Alessandro Fruganti fabrizio Stracci Pierfrancesco Marconi Katia Fettucciari Department of Medicine and Surgery GastroenterologyHepatology&Digestive Endoscopy Section University of Perugia Medical SchoolPiazza Lucio SeveriPerugia 06132Italyand Santa Maria della Misericordia HospitalGastroenterology&Hepatology Unit Perugia 06156Italy School of Biosciences and Veterinary Medicine University of CamerinoMatelica 62024Italy Medicine and Surgery Hygiene and Public Health SectionUniversity of PerugiaPerugia 06123Italy Medicine and Surgery Biosciences&Medical Embryology SectionUniversity of PerugiaPerugia 06132Italy

Clostridioides difficile(***)is progressively colonizing humans and animals living with *** this process,hypervirulent strains and mutated toxin A and B of ***(TcdA and TcdB)are originating and *** in healthy subjects colonization by *** becomes a risk after the use of antibiotics that alter the microbiome,other categories of people are more susceptible to infection and at risk of relapse,such as those with inflammatory bowel disease(IBD).Recent in vitro studies suggest that this increased susceptibility could be due to the strong cytotoxic synergism between TcdB and proinflammatory cytokines the tumor necrosis factor-alpha and interferon-gamma(CKs).Therefore,in subjects with IBD the presence of an inflammatory state in the colon could be the driver that increases the susceptibility to *** infection and its progression and *** is internalized in the cell via three receptors:chondroitin sulphate proteoglycan 4;poliovirus receptor-like 3;and Wnt receptor frizzled *** sulphate proteoglycan 4 and Wnt receptor frizzled family are involved in cell death by apoptosis or necrosis depending on the concentration of TcdB and cell types,while poliovirus receptor-like 3 induces only *** is possible that cytokines could also induce a greater expression of receptors for TcdB that are more involved in necrosis than in ***,in subjects with IBD there are the conditions:(1)For greater susceptibility to *** infection,such as the inflammatory state,and abnormalities of the microbiome and of the immune system;(2)for the enhancement of the cytotoxic activity of TcdB+Cks;and(3)for a greater expression of TcdB receptors stimulated by cytokines that induce cell death by necrosis rather than *** only therapeutic approach currently possible in IBD patients is monitoring of *** colonization for interventions aimed at reducing tumor necrosis factor-alpha and interfero

关键词： Inflammatory bowel diseases Clostridioides difficile infection Cytokines Tumor necrosis factor-alpha Interferon-gamma Necrosis Apoptosis Cytotoxic synergism

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Stem cells sources for intervertebral disc regeneration

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World Journal of Stem Cells 2016年第5期8卷 185-201页

作者： Gianluca Vadalà fabrizio Russo Luca Ambrosio Mattia Loppini Vincenzo Denaro Department of Orthopedic and Trauma Surgery University Campus Bio-Medico of Rome

Intervertebral disc regeneration field is rapidly growing since disc disorders represent a major health problem in industrialized countries with very few possible ***, current available therapies are symptomatic, and surgical procedures consist in disc removal and spinal fusion, which is not immune to regardable concerns about possible comorbidities, cost-effectiveness, secondary risks and long-lasting outcomes. This review paper aims to share recent advances in stem cell therapy for the treatment of intervertebral disc degeneration. In literature the potential use of different adult stem cells for intervertebral disc regeneration has already been reported. Bone marrow mesenchymal stromal/stem cells, adipose tissue derived stem cells, synovial stem cells, muscle-derived stem cells, olfactory neural stem cells, induced pluripotent stem cells, hematopoietic stem cells, disc stem cells, and embryonic stem cells have been studied for this purpose either in vitro or in vivo. Moreover, several engineered carriers(e.g., hydrogels), characterized by full biocompatibility and prompt biodegradation, have been designed and combined with different stem cell types in order to optimize the local and controlled delivery of cellular substrates in situ. The paper overviews the literature discussing the current status of our knowledge of the different stem cells types used as a cell-based therapy for disc regeneration.

关键词： Stem cells Intervertebral disc degeneration Spine Tissue engineering Cell therapy

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