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Direct anterior approach hip arthroplasty:How to reduce complications-A 10-years single center experience and literature review

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World Journal of Orthopedics 2022年第4期13卷 388-399页

作者： fabrizio rivera Luca C Comba Alessandro Bardelli Department of Orthopedic Trauma SS Annunziata HospitalSavigliano 12038Italy Department of Orthopedic Trauma Universitàdegli Studi di TorinoTorino 10124Italy

BACKGROUND The direct anterior approach for total hip arthroplasty(DAA-THA)is increasing in popularity due to some advantages such as less surgical trauma,minimal dissection of soft tissues,shorter rehabilitation times,faster return to daily activities,lower incidence of *** the other hand,the literature reports a high rate of intraoperative complications,with many different rates and complication types in the published *** To analyze our complications comparing results with the literature;to report measures that we have taken to reduce complications *** All DAA-THA patients with one year minimum follow up who were operated at a single high-volume centre,between January 2010 and December 2019 were included in this retrospective *** surgeries were performed using cementless short anatomical or straight stems and press fit ***’followup was performed,at 6 wk,3 mo,then annually post-surgery with clinical and radiological *** outcomes were stem revision for aseptic loosening and all-cause stem *** outcome was intra-operative and post-operative complications *** A total of 394 patients underwent DDA-THA from January 2010 and December 2019,for a total of 412 hips;twelve patients lost to follow-up and one patient who died from causes not related to surgery were excluded from the *** average age at the time of surgery was 61 years(range from 28 to 78 years).Mean follow-up time was 64.8 mo(range 12-120 mo).Seven stems were *** cortical perforation,one trochanteric and lateral cortical wall intraoperative fracture,one diaphyseal fracture,three clinically symptomatic early subsidence and one late aseptic *** also observed 3 periprosthetic fractures B1 according to the Vancouver *** minor complications not requiring stem revision were 5 un-displaced fractures of the calcar region treated with preventive cerclage,one early infection,one case of late pos

关键词： Hip arthroplasty Direct anterior approach Short hip stem Minimally invasive surgery Complications

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A Modified Iterative Learning Control Approach for the Active Suppression of Rotor Vibration Induced by Coupled Unbalance and Misalignment

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 242-253页

作者： Yifan Bao Jianfei Yao fabrizio Scarpa Yan Li College of Mechanical and Electrical Engineering Beijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of High-end Compressor and System Technology Beijing 100029China Beijing Key Laboratory of High-end Mechanical Equipment Health Monitoring and Self-Recovery Beijing University of Chemical TechnologyBeijing 100029China Key Lab of Engine Health Monitoring-Control and Networking of Ministry of Education Beijing University of Chemical TechnologyBeijing 100029China Bristol Composites Institute(ACCIS) University of BristolBristol BS81TRUK Dynamics and Control Research Group(DCRG) University of BristolBristol BS81TRUK

This paper proposes a modified iterative learning control(MILC)periodical feedback-feedforward algorithm to reduce the vibration of a rotor caused by coupled unbalance and parallel *** control of the vibration of the rotor is provided by an active magnetic actuator(AMA).The iterative gain of the MILC algorithm here presented has a self-adjustment based on the magnitude of the *** filters are adopted to extract the synchronous(1×Ω)and twice rotational frequency(2×Ω)components of the rotor *** the notch frequency of the filter and the size of feedforward storage used during the experiment have a real-time adaptation to the rotational *** method proposed in this work can provide effective suppression of the vibration of the rotor in case of sudden changes or fluctuations of the rotor *** and experiments using the MILC algorithm proposed here are carried out and give evidence to the feasibility and robustness of the technique proposed.

关键词： Rotor vibration suppression Modified iterative learning control Unbalance Parallel misalignment Active magnetic actuator

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Navigating the autophagic landscape:Epigenetic modulation in gastrointestinal cancer

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World Journal of Gastroenterology 2024年第31期30卷 3628-3634页

作者： Davide Ramoni Federico Carbone fabrizio Montecucco Department of Internal Medicine University of GenoaGenoa 16132Italy Department of Internal Medicine University of Genoa and IRCSS Policlinico San MartinoGenoa 16132Italy

This editorial comments on the manuscript by Chang et al,focusing on the still elusive interplay between epigenetic regulation and autophagy in gastrointestinal diseases,particularly ***,essential for cellular homeostasis,exhibits diverse functions ranging from cell survival to death,and is particularly implicated in physiological gastrointestinal cell ***,its role in pathological backgrounds remains intricate and *** underscore the dual nature of autophagy in cancer,where its early suppressive effects in early stages are juxtaposed with its later promotion,contributing to *** discrepancy is attributed to the dysregulation of autophagy-related genes and their intricate involvement in cellular *** modifications and regulations of gene expression,including non-coding RNAs(ncRNAs),emerge as critical players in exerting regulatory control over autophagy flux,influencing treatment responses and tumor *** epigenetic mechanisms and improving strategies involving the inhibition or induction of autophagy through pharmacological or genetic means present potential avenues to sensitize tumor cells to ***,nanocarrier-based delivery of ncRNAs offers innovative therapeutic *** the intricate interaction between autophagy and ncRNA regula-tion opens avenues for the development of targeted therapies,thereby improving the prognosis of gastrointestinal malignancies with poor outcomes.

关键词： Epigenetic regulation Autophagy Gastrointestinal cancer Non-coding RNAs Target therapies

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Digital twin-and extended reality-based telepresence for collaborative robot programming in the 6G perspective

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Digital Communications and Networks 2024年第2期10卷 315-327页

作者： Davide Calandra F.Gabriele Pratticò Alberto Cannavò Claudio Casetti fabrizio Lamberti Politecnico di Torino Department of Control and Computer EngineeringCorso Duca Degli Abruzzi2410129TurinItaly

In the context of Industry 4.0,a paradigm shift from traditional industrial manipulators to Collaborative Robots(CRs)is ongoing,with the latter serving ever more closely humans as auxiliary tools in many production *** this scenario,continuous technological advancements offer new opportunities for further innovating robotics and other areas of next-generation *** example,6G could play a prominent role due to its human-centric view of the industrial *** particular,its expected dependability features will pave the way for new applications exploiting highly effective Digital Twin(DT)-and eXtended Reality(XR)-based *** this work,a novel application for the above technologies allowing two distant users to collaborate in the programming of a CR is *** approach encompasses demanding data flows(e.g.,point cloud-based streaming of collaborating users and robotic environment),with network latency and bandwidth *** obtained by analyzing this approach from the viewpoint of network requirements in a setup designed to emulate 6G connectivity indicate that the expected performance of forthcoming mobile networks will make it fully feasible in principle.

关键词： 6G Digital twin Telepresence Collaborative robots Industry 4.0 Augmented reality Virtual reality Point cloud streaming

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Facing ethical concerns in the age of precise gene therapy:Outlook on inherited arrhythmias

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World Journal of Cardiology 2024年第2期16卷 64-66页

作者： Federico Carbone fabrizio Montecucco Department of Internal Medicine University of GenoaGenoa 16132Italy IRCCS Ospedale Policlinico San Martino Genoa Italian Cardiovascular NetworkGenoa 16132Italy

This editorial,comments on the article by Spartalis et al published in the recent issue of the World Journal of *** here provide an outlook on potential ethical concerns related to the future application of gene therapy in the field of inherited *** monogenic diseases with no or few therapeutic options available through standard care,inherited arrhythmias are ideal candidates to gene therapy in their *** with inherited arrhythmias typically have a poor quality of life,especially young people engaged in agonistic *** genome editing for treatment of inherited arrhythmias still has theoretical application,advances in CRISPR/Cas9 technology now allows the generation of knock-in animal models of the ***,clinical translation is somehow expected soon and this make consistent discussing about ethical concerns related to gene editing in inherited *** off-target activity is a known technical issue,but its relationship with ethnical and individual genetical diversity raises concerns about an equitable ***,the costeffectiveness may further limit an equal distribution of gene *** economic burden of gene therapies on healthcare systems is is increasingly recognized as a pressing concern.A growing body of studies are reporting uncertainty in payback periods with intuitive short-term effects for insurance-based healthcare systems,but potential concerns for universal healthcare systems in the long term as ***,those aspects strongly indicate a need of regulatory entities to manage those issues.

关键词： Ethics Inherited arrhythmias CRISPR/Cas9 Gene therapy Equitable accessibility

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Unveiling field-coupled nanocomputing:Leaning molecules to shape readable bits

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Nano Research 2024年第9期17卷 8447-8454页

作者： Yuri Ardesi Giuliana Beretta fabrizio Mo Chiara Elfi Spano Gianluca Piccinini Mariagrazia Graziano Corso Duca degli Abruzzi Department of Electronics and TelecommunicationsPolitecnico di TorinoTurin 10129Italy Corso Duca degli Abruzzi Department of Applied Science and TechnologyPolitecnico di TorinoTurin 10129Italy

Molecular field-coupled nanocomputing(molFCN)encodes information in the molecule charge distribution and elaborates it through electrostatic *** the advantageous sub-nanometric size and low-power dissipation,only a few attempts have been made to validate the technology *** of the obstacles is the difficulty in measuring molecule charges to validate information encoding or integrate molFCN with complementary-metal-oxide-semiconductor(CMOS).In this work,we propose a paradigm preserving the advantages of molFCN,which exploits the position of waiving molecules to augment the information *** validate the paradigm,named bend-boosted molFCN,with density functional theory using 6-(ferrocenyl)hexanethiol *** demonstrate that the encoded information can be electrically read by constituting a molecular *** paradigm is compatible with the charge-based molFCN,thus acting as a readout *** obtained results favor the experimental assessment of the molFCN principle through scanning probe microscopy techniques and the design of molFCN-CMOS heterogeneous circuits.

关键词： nanoelectronics molecular electronics field-coupled nanocomputing electronics beyond-complementary-metal-oxidesemiconductor(CMOS)

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Early cholecystectomy cannot be regarded as a mortality risk factor in moderate and severe acute biliary pancreatitis

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 109-111页

作者： Bader Al Taweel Stylianos Tzedakis fabrizio Panaro Digestive Surgery and Transplantation Montpellier University HospitalUniversity of MontpellierMontpellierFrance Chirurgie Digestive APHP Paris ParisFrance

We read with great interest the article by Di Martino et al.(1)on the timing of cholecystectomy after moderately severe and severe acute biliary pancreatitis(ABP).In this retrospective study,the authors analyzed data from the MANCTRA-1 *** 5,304 patients,3,696 met the inclusion criteria(cholecystectomy performed and stage of pancreatitis known)and were included in the *** aim of this study was to assess the impact of early cholecystectomy(EC)on morbidity and mortality in ABP,particularly in moderately severe and severe forms according to the modified Atlanta classification(2).EC was defined as removal of the gallbladder within 14 days of admission,and was compared with delayed cholecystectomy(DC).

关键词： Cholecystectomy severe pancreatitis morbidity mortality

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Transanal eco-Doppler evaluation after hemorrhoidal artery embolization

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World Journal of Gastroenterology 2024年第17期30卷 2332-2342页

作者： Roberta Tutino Tommaso Stecca fabrizio Farneti Marco Massani Giulio Aniello Santoro Dipartimento Chirurgia Generale e Specialistica AOU Cittàdella Salute e della Scienza di TorinoTorino 10126Italy Division of General Surgery 1 Treviso Regional HospitalAULSS 2 Marca TrevigianaTreviso 31100Italy Division of Radiology Treviso Regional HospitalAULSS 2 Marca TrevigianaTreviso 31100Italy Tertiary Referral Pelvic Floor Center Division of General Surgery 2AULSS 2 Marca TrevigianaTreviso 31100Italy

BACKGROUND Hemorrhoidal artery embolization(Emborrhoid)is a novel method for the treatment of severe hemorrhoidal *** having a technical success rate of 93%-100%,the clinical success ranges between 63%and 94%,with a rebleeding rate of 13.6%.AIM To evaluate the effectiveness of this procedure in reducing hemorrhoidal flow and hemorrhoidal *** This prospective observational pilot study was conducted at Division of General Surgery 1 and Tertiary Referral Pelvic Floor Center,Treviso Regional Hospital,*** a 2 months period(February-March 2022),consecutive patients with hemorrhoidal bleeding scores(HBSs)≥4,Goligher scores of II or III,failure of non-operative management,and a candidate for Emborrhoid were *** ultrasound with eco-Doppler was performed preoperatively and 1 month after the *** primary endpoint was to quantify the changes in arterial hemorrhoidal flow after *** secondary endpoint was to evaluate the correlation between the flow changes and the *** Eleven patients underwent *** overall pretreatment mean systolic peak(MSP)was 14.66 cm/*** highest MSP values were found in the anterior left lateral(17.82 cm/s at 1 o’clock and 15.88 cm/s at 3 o’clock)and in the posterior right lateral(14.62 cm/s at 7 o’clock and 16.71 cm/s at 9 o’clock)quadrants of the anal *** treatment,the overall MSP values were significantly reduced(P=0.008)although the correlation between MSP and HBS changes was weak(P=0.570).A statistical difference was found between distal embolization compared with proximal embolization(P=0.047).However,the coil landing zone was not related to symptoms improvement(P=1.000).A significant difference in MSP changes was also reported between patients with type 1 and type 2 superior rectal artery(SRA)anatomy(P=0.040).No relationship between hemorrhoidal grades(P=1.000),SRA anatomy(P=1.000)and treatment outcomes was *** The preliminary findings of this pilo

关键词： Hemorrhoidal artery embolization Hemorrhoidal embolization Hemorrhoidal vascularization Transanal eco-Doppler Transanal ultrasound

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Ultrasound unveiling:Decoding venous congestion in heart failure for precision management of fluid status

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World Journal of Cardiology 2024年第6期16卷 306-309页

作者： Davide Ramoni Federico Carbone fabrizio Montecucco Department of Internal Medicine University of GenoaGenoa 16132Italy Department of Internal Medicine IRCCS Ospedale Policlinico San MartinoGenoa 16132Italy

This editorial discusses the manuscript by Di Maria et al,published in the recent issue of the World Journal of *** here focus on the still elusive pathophysiological mechanisms underlying cardio-renal syndrome(CRS),despite its high prevalence and the substantial worsening of both kidney function and heart *** the measure of right atrial pressure through right cardiac catheterization remains the most accurate albeit invasive and costly procedure,integrating bedside ultrasound into diagnostic protocols may substantially enhance the staging of venous congestion and guide therapeutic *** particular,with the assessment of Doppler patterns across multiple venous districts,the Venous Excess Ultrasound(VExUS)score improves the management of fluid overload and provides insight into the underlying factors contributing to cardio-renal *** specific echocardiographic parameters,particularly those concerning the right heart,may thus improve the VExUS score sensitivity,offering perspective into the nuanced comprehension of cardio-renal dynamics.A multidisciplinary approach that consistently incorporates the use of ultrasound is emerging as a promising advance in the understanding and management of CRS.

关键词： Cardio-renal syndrome Fluid overload Heart failure Ultrasound assessment Venous congestion Venous excess ultrasound score

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Therapeutic advances in neural regeneration for Huntington’s disease

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Neural Regeneration Research 2024年第9期19卷 1991-1997页

作者： Francesco D’Egidio Vanessa Castelli Giorgia Lombardozzi fabrizio Ammannito Annamaria Cimini Michele d’Angelo Department of Life Health and Environmental SciencesUniversity of L’AquilaL’AquilaItaly

Huntington’s disease is a neurodegenerative disease caused by the expansion mutation of a cytosine-adenine-guanine triplet in the exon 1 of the HTT gene which is responsible for the production of the huntingtin (Htt) protein. In physiological conditions, Htt is involved in many cellular processes such as cell signaling, transcriptional regulation, energy metabolism regulation, DNA maintenance, axonal trafficking, and antiapoptotic activity. When the genetic alteration is present, the production of a mutant version of Htt (mHtt) occurs, which is characterized by a plethora of pathogenic activities that, finally, lead to cell death. Among all the cells in which mHtt exerts its dangerous activity, the GABAergic Medium Spiny Neurons seem to be the most affected by the mHtt-induced excitotoxicity both in the cortex and in the striatum. However, as the neurodegeneration proceeds ahead the neuronal loss grows also in other brain areas such as the cerebellum, hypothalamus, thalamus, subthalamic nucleus, globus pallidus, and substantia nigra, determining the variety of symptoms that characterize Huntington’s disease. From a clinical point of view, Huntington’s disease is characterized by a wide spectrum of symptoms spanning from motor impairment to cognitive disorders and dementia. Huntington’s disease shows a prevalence of around 3.92 cases every 100,000 worldwide and an incidence of 0.48 new cases every 100,000/year. To date, there is no available cure for Huntington’s disease. Several treatments have been developed so far, aiming to reduce the severity of one or more symptoms to slow down the inexorable decline caused by the disease. In this context, the search for reliable strategies to target the different aspects of Huntington’s disease become of the utmost interest. In recent years, a variety of studies demonstrated the detrimental role of neuronal loss in Huntington’s disease condition highlighting how the replacement of lost cells would be a reasonable strategy to o

关键词： cell therapy exosomes extracellular vesicles Huntingtin Huntington’s disease medium spiny neurons neurodegenerative disease neurogenesis neuronal loss stem cells

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