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Synthesis, Characterization of Ruthenium Compounds and Studies of Biological Effects in MCF-7 Tumors Cell Lines

Advances in Biological Chemistry 2022年第3期12卷 61-71页

作者： Andressa Teixeira de Barros Nunes Ribeiro Claudia Cristina Sousa Adenilda Cristina Honório França Eduardo Luzia França fabricio tarso moraes Wagner Batista Santos Institute of Exact Sciences and Earth Federal University of Mato Grosso Barra do Gar&ccedil as/MT Brazil Institute of Biological and Health Sciences Federal University of Mato Grosso Barra do Gar&ccedil as/MT Brazil

This work presents the synthesis and characterization of compounds derived from the ruthenium transition metal with the nitrogenous ligand 4-aminopy- ridine (4-ampy). The synthesized compounds were characterized by FTIRmed spectroscopy and TG-DTA thermal analysis. For the cytotoxic evaluation of ruthenium compounds, a 66.0 μM aqueous solution containing the complex and the study of data observed in the biological assessment was performed using variance (ANOVA) analysis, followed by Tukey’s multiple comparisons test. Differences between treatments were considered significant when the p-value was less than 0.05 (p 3(4-ampy)(H2O)2]·1/2H2O, which, due to the low solubility in an aqueous medium, was modified to increase its solubility for biological tests. The analysis of the spectra in the medium infrared region (FTIR) for the complex [Ru(Cl)3(4-ampy)(H2O)2]·1/2H2O, shows displacements of the bands observed at 1625 - 1566 cm﹣1 ν(C=C) e (C=N), indicating that coordination to the metallic center occurred by this group. Band displacements were observed in the modified Ru (III) complex, which suggests the presence of the 4-ampy ligand and the coordination by the groups ν(C=C) and (C=N) after the modification. In recent years, researchers worldwide have concentrated on obtaining, developing, and modifying drugs used as chemotherapeutic agents. The evaluation of the cell viability of the modified Ru (III) compound demonstrated cytotoxic effects in the MCF-7 cell line (15.33% ± DP 2.7) but did not affect normal cells (PBMC), which reflects the potential for possible applications.

关键词： Ruthenium MCF-7 Cells Cytotoxic Evaluation N-Heterocyclic Ligands

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Synthesis and Characterization of a New Compound of Cobalt Ⅱ with Isonicotinamide and Evaluation of the Bactericidal Potential

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Open Journal of Inorganic Chemistry 2019年第2期9卷 11-22页

作者： Anderson Dourado Galvao fabricio tarso de moraes Claudia Cristina de Sousa Katia Meirelles Duarte de Sousa Patricia Gelli Feres de Marchi Adenilda Cristina Honorio Franca Eduardo Luzia Franca Wagner Batista dos Santos Federal University of Mato Grosso—Barra do Garcas/MT Brazil

In this work, the isonicotinamide was coordinated to the Cobalt ion in oxidation state +2. The relevance of this work is the investigation of the in vitro bactericidal potential of the synthesized complex when tested in Gram-positive and negative bacteria strains. This study is motivated by the need to obtain new materials that have antibiotic properties and that, in the future, may become an effective drug against resistant bacteria. A new coordination compound of Cobalt and isonicotinamide, [Co(H2O)(isn)3](BF4)2, was synthesized and described. The compound was characterized by thermoanalytical techniques TG-DTG and TG-DSC, where it was possible to propose the mechanism of thermal decomposition. Through the spectroscopy in the region of the medium infrared (FTIR), it is possible to infer the site of connection between isonicotinamide and metal. The bactericidal activity of [Co(H2O)(isn)3](BF4)2, CoCl2 and free Isonicotinamide were tested for the bacteria Streptococcus mutans (Gram+) and Escherichia coli (Gram−) and the synthesized compound showed to be sensitive for both bacteria.

关键词： Cobalt Isonicotinamide Spectroscopy Infrared TG/DTG and TG/DTA Bactericidal Activity

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Theoretical and Comparative Study of the Complex[RuCl_(3)(H_(2)O)_(2)(Gly)]by Density Functional Theory

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Open Journal of Inorganic Chemistry 2018年第1期8卷 43-53页

作者： Katia Meirelles D.de Sousa Marcio Adriano S.Chagas Jesyca Mayra F.D.dos Santos Anderson D.Galvao fabricio tarso de moraes Andressa Teixeira Barros Nunes Ribeiro Dario Batista Fortaleza Kelly Aparecida da Encarnacao Amorim Wagner B.dos Santos Materials Research Lab Federal University of Mato Grosso—Campus ⅡBarra do GarcasBrazil Institute of Chemistry Brasilia UniversityUNBBrasíliaBrazil

In this work, the use of computational methods was essential to distinguish the three possible isomeric structures of the [RuCl3(H2O)2(Gly)] molecule. The characterization of these molecules was performed using IR, NMR and UV-VIS simulations. Some calculations related to the optimization of structures and properties such as chemical hardness and dipole moment were also conducted. The fac-cis isomer presented promising data when compared to the experimental data, indicating that this is the likely experimentally synthesized isomer. This study demonstrates the technical utility of the computational calculations by virtue of situations that prevent the realization of X-ray diffraction.

关键词： Computational Methods Isomeric Structures Simulations

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Synthesis, Characterization and Analysis of Leishmanicide Ability of the Compound [Ru(Cl)3(H2O)2(gly)]

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Open Journal of Inorganic Chemistry 2017年第4期7卷 89-101页

作者： Marcio Adriano S. Chagas Anderson Dourado Galvã o fabricio tarso de moraes A. T. B. N. Ribeiro Adriano Buzutti de Siqueira I. C. C. de Assis Salama Wagner Welber Arrais-Silva Katia Meirelles Duarte de Sousa Claudia Cristina de Sousa Pereira Wagner Batista dos Santos Federal University of Mato Grosso Barra do Gar&ccedil as Brazil Federal University of Sergipe S&atilde o Cristovã o Brazil

Studies of coordinated compounds containing ruthenium (Ru2+ and Ru3+) have shown very effective in vitro results for the treatment of cancer and neglected diseases such as leishmaniasis. In this paper, we present the synthesis of the compound [Ru(Cl)3(H2O)2(gly)], which was characterized by spectroscopic (Ultraviolet-visibleand infrared) and thermal analysis (Thermogravimetry/Derived Thermogravimetry and Thermogravimetry/Differential Thermal Analysis). The analysis of the compound in the Ultraviolet-visibleregion showed a 290 nm band λmax (ε= 1.685 × 103 L·cm-1·mol-1), attributed to the ligand metal charge transfer (LMCT). The spectroscopy (IR) showed major vibrational bands at δa (-COO-) 1664 cm-1, δs (-COO-) 1388 cm-1, δs () 1571 cm-1 and δs (CCN) 889 cm-1. The thermal analysis by TG/DTG and TG-DTA indicated that the complex has five consecutive stages of decomposition: at 115°C (TG = 12.18%;Calculated = 11.32%) H2O (coordinating water), exothermic peaks at 230°C, 307°C, 440°C and 463°C due to oxidative decomposition of glycine, followed by the formation of RuClO residue at 665°C (TG = 41.11%;Calculated = 40.81%). The thermal characterization suggested the stoichiometry of the complex [RuCl3(H2O)2(gly)]. The antileishmanial capacity of this compound was also evaluated and the results indicated a 31% decrease in the parasitic infection of macrophages and a 1.5 to 3 fold reduction in the number of parasites per cell after treatment with 100 μg/mL of the complex. These results support the possible use of this compound as a therapeutic alternative against medical and veterinary parasites.

关键词： Ruthenium Glycine Spectroscopy Infrared TG/DTG and TG/DTA Amino Acid

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Carpal Tunnel Syndrome: A Marker for Amyloidosis

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World Journal of Neuroscience 2024年第3期14卷 92-101页

作者： Luciana León Cejas Miguel Saucedo Mayra Aldecoa Gustavo Teruya fabricio Silva Alvaro Muratore Gonzalo Viollaz Cintia Marchesoni Ana Pardal Pablo Dezanzo Alejandro Iotti Ricardo Reisin Neurology Department Hospital Britnico de Buenos Aires Buenos Aires Argentina Orthopedics Department Hospital Britnico de Buenos Aires Buenos Aires Argentina Pathology Department Hospital Britnico de Buenos Aires Buenos Aires Argentina

Introduction: Amyloidosis are systemic conditions and carpal tunnel syndrome (CTS) precedes the principal systemic complications and can be used as an early marker. Our objective was to determine the frequency of amyloid deposition in idiopathic CTS and its systemic impact. Methods: We retrospectively evaluated patients with CTS between September 2019 to January 2020. Samples from the anterior carpal ligament were pathologically evaluated and amyloid deposition was confirmed by apple-green birefringence on polarized light using Congo red stain. When amyloid was detected we performed genetic testing for transthyretin variants (ATTRv), immunofixation electrophoresis in serum and urine for light chains and multidisciplinary evaluation. Results: Thirty consecutive patients were included, 19 women, 11 men, mean age 70 years old (range 42 - 89 years). We identified 3 patients (10%) with amyloid deposits (mean age: 78.6 years, 2 men, 1 woman). Genetic testing for ATTRv and light chains studies were negative. During follow-up: The first patient required aortic valve replacement. The second patient developed progressive cardiac failure with syncopal episodes, atrioventricular block and atrial fibrillation and required a pacemaker and anticoagulation. The third patient had unexplained chronic edemas. The cardiac evaluation in all 3 patients revealed left ventricular hypertrophy and myocardial uptake (Perugini Score > 2) in their nuclear bone scintigraphies with technetium pyrophosphate. Two patients were treated with tafamidis and one patient died due to refractory cardiac insufficiency. Discussion: Our findings underline the importance of investigating amyloidosis in idiopathic CTS. The identification of deposits allows early diagnosis of cardiac amyloidosis leading to timely intervention and treatment.

关键词： Carpal Tunnel Amyloid Transthyretin Amyloid Cardiac Transthyretin Variants Light Chains

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Impact of Cascade Disconnection of Distributed Energy Resources on Bulk Power System Stability:Modeling and Mitigation Requirements

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Journal of Modern Power Systems and Clean Energy 2023年第2期11卷 412-420页

作者： fabricio Andrade Mourinho Tatiana Mariano Lessa Assis Electrical Engineering Department of the Federal University of Rio de Janeiro(COPPE/UFRJ) Rio de JaneiroRJBrazil

This work presents a new approach to establishing the minimum requirements for anti-islanding protection of distributed energy resources(DERs)with focus on bulk power system *** proposed approach aims to avoid cascade disconnection of DERs during major disturbances in the transmission network and to compromise as little as possible the detection of real islanding *** proposed approach concentrates on the rate-of-change of frequency(RoCoF)protection function and it is based on the assessment of dynamic security regions with the incorporation of a new and straightforward approach to represent the disconnection of DERs when analyzing the bulk power system ***,the impact of disconnection of DERs on the Brazilian Interconnected Power System(BIPS)stability is analyzed,highlighting the importance of modeling such disconnection in electromechanical stability studies,even considering low penetration levels of ***,the proposed approach is applied to the BIPS,evidencing its benefits when specifying the minimum requirements of anti-islanding protection,without overestimating them.

关键词： Anti-islanding protection bulk power system stability distributed energy resource(DER) dynamic security region(DSR)

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Roles of eIF5A in the immunosurveillance of cellular senescence

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Cancer Biology & Medicine 2022年第11期19卷 1523-1527页

作者： Xiangli Jiang fabricio Loayza-Puch Department of Thoracic Oncology Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China Translational Control and Metabolism German Cancer Research Center(DKFZ)Heidelberg 69120Germany

Senescence is a cellular stress response program that prevents the proliferation of oncogenically activated, genetically unstable, and/or damaged cells. Senescence was first described in 1961, when normal cultured human fibroblasts were found to enter irreversible growth arrest after multiple cell divisions, in a process known as replicative senescence1. Several types of senescence have since been identified, such as stress-induced senescence, oncogene-induced senescence, and virus-induced senescence. Despite having distinct features due to their different triggers, senescent cells share several key features.

关键词： unstable SASP senescence

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Laparoscopic resection for hepatocellular carcinoma: eastern and western experiences

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Chinese Journal of Cancer Research 2014年第3期26卷 234-236页

作者： Paulo Herman fabricio Ferreira Coelho Liver Surgery Unit Department of GastroenterologyUniversity of Sao Paulo Medical School

Hepatocellular carcinoma （HCC） is the most common primary liver cancer （1）. The incidence is rising in the last decades due to many factors, especially hepatitis C, alcoholic liver disease and non-alcoholic steatohepatitis. Moreover, the introduction of screening programs in patients with chronic liver disease has led to an increase in HCC diagnosis （1,2）. In the western world, 80% to 90% of HCC eases occur in patients with liver cirrhosis （3） while this proportion is lower in some regions in Asia and sub-Saharian Africa, where hepatitis B remains as an important etiologic factor for chronic liver disease （2,4）. In 1990, the annual world frequency of HCC was 437,000 cases/year （1）, and in 2012 the number reached 782,200 cases/year being responsible for 746,000 deaths （5）. Nowadays, HCC represents the 6th most frequent neoplastic disease in the world and the 3rd in mortality （5）.

关键词： HCC eastern and western experiences Laparoscopic resection for hepatocellular carcinoma

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On the numerical solution to the truncated discrete SPH formulation of the hydrostatic problem

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Journal of Hydrodynamics 2020年第4期32卷 699-709页

作者： Pablo Eleazar Merino-Alonso fabricio Macia Antonio Souto-Iglesias Mathematical Modeling Analysisand Simulation Applied to Engineering Research Group(M2ASAI)Universi dad politecnica de Madrid(UPM)School of marine engineering(ETSIN)MadridSpain Marine and Hydrodynamical Model Basin Research Group(CEHINAV) Universidad Politecnica de Madrid(UPM)School of Marine Engineering(ETSIN)MadridSpain

The aim of this work is to study the solution of the smoothed particle hydrodynamics(SPH)discrete formulation of the hydrostatic problem with a free *** problem,in which no time dependency is considered,takes the form of a system of linear *** particular,the problem in one dimension is *** focus is set on the convergence when both the particle spacing and the smoothing length tend to zero by keeping constant their *** of this ratio of the order of one,corresponding to a limited number of neighbors,are of practical ***,the problem in which each particle has one single neighbor at each side is *** explicit expressions of the numerical solution and the quadratic error are provided in this *** expression of the quadratic error demonstrates that the SPH solution does not converge to the exact one in general under the specified *** this case,the error converges to a residue,which is in general large compared to the norm of the exact *** cases with two and three neighbors are also *** analytical study in the case of two neighbors is performed,showing how the kernel influences the accuracy of the solution through modifying the condition number of the referred system of linear *** addition to that,a numerical investigation is carried out using several Wendland kernel *** two and three neighbors are involved it is found that the error tends in most cases to a small limiting value,different from zero,while divergent solutions are also found in the case of two neighbors with the Wendland Kernel *** cases with more neighbors are also *** general,the Wendland Kernel C2 turns out to be the worst choice,as the solution is divergent for certain values of the ratio between the particle spacing and the smoothing length,associated with an ill-conditioned matrix.

关键词： Smoothed particle hydrodynamics(SPH) convergence water-at-rest problem hydrostatic tank,free surface kernel truncation

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Yet Another Intelligent Code-Generating System： A Flexible and Low-Cost Solution

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Journal of Computer Science & Technology 2018年第5期33卷 940-965页

作者： Joao fabricio Filho Luis Gustavo Araujo Rodriguez Anderson Faustino da Silva Department of Informatics State University of Maringd Maringd-PR 87020-900 Brazil Federal University of Technology -- Parand Campo Mourao-PR 87301-899 Brazil

Modern compilers apply various code transformation algorithms to improve the quality of the target code. However, a complex problem is to determine which transformation algorithms must be utilized. This is difficult because of three reasons： a number of transformation algorithms, various combination possibilities, and several configuration possibil- ities. Over the last few years, various intelligent systems were presented in the literature. The goal of these systems is to search for transformation algorithms and thus apply them to a certain program. This paper proposes a flexible, low-cost and intelligent system capable of identifying transformation algorithms for an input program, considering the program＇s specific features. This system is flexible for parameterization selection and has a low-computational cost. In addition, it has the capability to maximize the exploration of available computational resources. The system was implemented under the Low Level Virtual Machine infrastructure and the results indicate that it is capable of exceeding, up to 21.36%, performance reached by other systems. In addition, it achieved an average improvement of up to 17.72% over the most aggressive compiler optimization level of the Low Level Virtual Machine infrastructure.

关键词： compiler code transformation iterative compilation knowledge representation machine learning

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