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事件提示和时间提示对新异干扰的影响--来自听视跨通道和听通道的证据

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心理科学进展 2012年第6期20卷 815-824页

作者：李毕琴 PARMENTIER fabrice B. R. 张明东北师范大学心理学系长春130024 贵州师范大学心理学系贵阳550001 Department of Psychology University of the Balearic Islands Palma 07122 Spain Department of Psychology University of Western Australia Perth 6009 Australia

采用Oddball范式考察听视跨感觉通道和听感觉通道中"无关刺激"或"无关属性"的信号提示对新异干扰的影响。实验1和实验2分别比较了听视跨通道和听通道中时间事件提示、时间提示和事件提示三种条件。结果表明:(1)时间提示条件下新异干扰... 详细信息

采用Oddball范式考察听视跨感觉通道和听感觉通道中"无关刺激"或"无关属性"的信号提示对新异干扰的影响。实验1和实验2分别比较了听视跨通道和听通道中时间事件提示、时间提示和事件提示三种条件。结果表明:(1)时间提示条件下新异干扰效应消失,而事件提示条件下新异干扰效应仍存在。无关刺激意外变化引起的靶任务行为受损,不仅与偏差刺激的小概率和新颖性有关,而且与干扰刺激与靶子间提示信号关联有关,这种提示关联中事件发生的提示功能比时间间隔的提示功能更为重要。(2)听通道下新异干扰与视听跨通道结果一致,无关属性也会起到提示信号作用,同样事件提示功能比时间提示功能更重要。

关键词：新异干扰事件提示时间提示听视跨通道听通道

In vivo anti-salmonella activity of aqueous extract of Euphorbia prostrata Aiton(Euphorbiaceae) and its toxicological evaluation

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Asian Pacific Journal of Tropical Biomedicine 2015年第4期5卷 310-318页

作者： Donald Sédric Tala Donatien Gatsing Siméon Pierre Chegaing Fodouop Charles Fokunang fabrice Kengni Merline Namekong Djimeli Department of Biochemistry Faculty of Science University of Dschang Department of Biomedical Sciences University of Ngaoundéré Faculty of Medicine and Biomedical Sciences University of Yaoundé I

Objective: To investigate the in vivo anti-salmonella activity and the safety of aqueous extract of Euphorbia prostratra(E. prostratra), a plant commonly used in Cameroon by traditional ***: A Salmonella typhimurium-infected rat model was used for the study. The physiological, biochemical and histopathological markers of possible side effects of this extract were studied using standard ***: The extract had a significant effect on the number of viable Salmonella typhimurium recovered from faeces, and could stop salmonellosis after 8 and 10 days of treatment for male and female rats, respectively, with non-toxic doses. However, the biochemical and histopathological analyses revealed that at relatively high doses(≥ 73.48 mg/kg for female and ≥ 122.71 mg/kg for male) the extract could induce liver damage, as illustrated by a rise of serum transaminases' levels and significant inflammation of the parenchyma and portal *** effects were also observed on the kidneys, as shown by both serum and urinary creatinine,and urinary ***: The overall results indicate that the aqueous extract of E. prostrata has the potential to provide an effective treatment for salmonellosis, including typhoid fever. However,it is necessary to extrapolate these results in large animals, in further studies.

关键词： Euphorbia prostrata Ait. Typhoid fever Salmonella Safety

Targeted Sub-Attomole Cancer Biomarker Detection Based on Phase Singularity 2D Nanomaterial-Enhanced Plasmonic Biosensor

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Nano-Micro Letters 2021年第6期13卷 284-294页

作者： Yuye Wang Shuwen Zeng Aurelian Crunteanu Zhenming Xie Georges Humbert Libo Ma Yuanyuan Wei Aude Brunel Barbara Bessette Jean-Christophe Orlianges fabrice Lalloué Oliver GSchmidt Nanfang Yu Ho-Pui Ho Department of Biomedical Engineering The Chinese University of Hong KongShatinNew TerritoriesHong KongPeople’s Republic of China CNRS XLIM Research InstituteUMR 7252University of Limoges123Avenue Albert ThomasLimogesFrance Department of Applied Physics and Applied Mathematics Columbia UniversityNew York CityNYUSA Institute for Integrative Nanosciences IFW DresdenHelmholtzstr.20DresdenGermany Faculty of Medicine University of LimogesEA3842-CAPTuRGEIST2 rue du Dr MarclandLimogesFrance

Detection of small cancer biomarkers with low molecular weight and a low concentration range has always been challenging yet urgent in many clinical applications such as diagnosing early-stage cancer,monitoring treatment and detecting ***,a highly enhanced plasmonic biosensor that can overcome this challenge is developed using atomically thin two-dimensional phase change *** precisely engineering the configuration with atomically thin materials,the phase singularity has been successfully achieved with a significantly enhanced lateral position shift *** on our knowledge,it is the first experimental demonstration of a lateral position signal change>340μm at a sensing interface from all optical *** this enhanced plasmonic effect,the detection limit has been experimentally demonstrated to be 10^(-15) mol L^(−1) for TNF-α cancer marker,which has been found in various human diseases including inflammatory diseases and different kinds of *** as-reported novel integration of atomically thin Ge_(2)Sb_(2)Te_(5) with plasmonic substrate, which results in a phase singularity and thus a giant lateral position shift, enables the detection of cancer markers with low molecular weight at femtomolar level. These results will definitely hold promising potential in biomedical application and clinical diagnostics.

关键词： 2D nanomaterials Cancer marker detection Phase singularity Surface plasmon

High tacrolimus intra-patient variability is associated with graft rejection,and de novo donor-specific antibodies occurrence after liver transplantation

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World Journal of Gastroenterology 2018年第16期24卷 1795-1802页

作者： Arnaud Del Bello Nicolas Congy-Jolivet Marie Danjoux fabrice Muscari Laurence Lavayssière Laure Esposito Anne-Laure Hebral Julie Bellière Nassim Kamar Department of Nephrology and Organ Transplantation CHU RangueilToulouse 31000France Université Paul Sabatier Toulouse 31000France Molecular Immunogenetics Laboratory Facultéde Médecine PurpanIFR150(INSERM)Montréal H3G 1Y6France Department of Immunology CHU de ToulouseHopital de RangueilCHU de ToulouseToulouse 31000France Department of Pathology Institut Universitaire du CancerCHU Toulouse 31000France Department of Surgery and Liver Transplantation Toulouse 31000France INSERM IFR-BMTCHU PurpanToulouse 31000France

AIM To investigate the role of tacrolimus intra-patient variability(IPV) in adult liver-transplant *** We retrospectively assessed tacrolimus variability in a cohort of liver-transplant recipients and analyzed its effect on the occurrence of graft rejection and de novo donor-specific antibodies(dn DSAs), as well as graft survival during the first 2 years posttransplantation. Between 02/08 and 06/2015, 116 patients that received tacrolimus plus mycophenolate mofetil(with or without steroids) were included. RESULTS Twenty-two patients(18.5%) experienced at least one acute-rejection episode(BPAR). Predictive factors for a BPAR were a tacrolimus IPV of > 35% [OR = 3.07 95%CI(1.14-8.24), P = 0.03] or > 40% [OR = 4.16(1.38-12.50), P = 0.01), and a tacrolimus trough level of 35% [OR = 4.83, 95%CI(1.39-16.72), P = 0.01] and > 40% [OR = 9.73, 95%CI(2.65-35.76), P = 0.001] were identified as predictors to detect dn DSAs. IPV did not impact on patient-or graft-survival rates during the follow-up. CONCLUSION Tacrolimus-IPV could be a useful tool to identify patients with a greater risk of graft rejection and of developing a de novo DSA after liver

关键词： Variability Liver transplantation Donorspecific antibodies Immunosuppression

Degradation of PAI/PEI Enamel under High Temperature (Up to 400°C)

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Materials Sciences and Applications 2022年第1期13卷 1-21页

作者： fabrice Aymonino Thierry Lebey David Malec Dominique Mary LAboratoire PlAsma et Conversion d’Energie (LAPLACE) Université de Toulouse Toulouse France

This work deals with the understanding of the degradation of the primary insulation (PEI/PAI) of rotating machines working temporarily under high-temperature. The main domain of application of these motors is the smoke extraction either from tunnels or underground parking when a fire occurs. In such a critical situation, the internal temperature of the motor winding may reach temperatures up to 400°C. Under such very high thermal stresses, the behaviour of the electrical insulation is not well understood. This work proposes an analysis of the decomposition gases under very high temperatures and the corresponding degradation pathway. A simple method is proposed to identify whether the insulation of such motors has been strongly damaged during the working time at very high temperatures, thus allowing estimating if it can still continue to operate.

关键词： Polyesterimide (PEI) Polyamide-Imide (PAI) Enamel Electrical Insulation Rotating Machine High Temperature Thermal Degradation

Transient analysis of a fluid bu er driven by a birth and death process

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Transient analysis of a fluid bu er driven by a birth and de...

Option Pricing Models and Volatility Using Excel-VBA 1

The 19th International Teletraffic Congress-ITC19

作者： fabrice Guillemin Bruno Sericola Fabrics Guillemin France Telec:om 2 Avenue Pierre Marzin 22300 Lannion France Bruno Sericola INRIA-IRISA Campus de Beaulieu 35042 Rennes Cedex Prance

＜正＞We analyze the transient behavior of a uid queue when the instantaneous rate of the input process is governed by a general birth and death process. These uid ows models are widely used in the performance analysis of telecommunication systems. The transient analysis of such models has already been considered in earlier works with a nite state space background process. We consider in this paper a in nite state space driving process and we study the uid queue by using results from spectral theory.

关键词： Fluid bu er spectral theory orthogonal polynomials transient analysis

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Microfluidic actuators based on temperature-responsive hydrogels

丛书名： Wiley Finance

2007年

作者： fabrice D. Rouah Gregory Vainberg

ISBN: (数字)9780470125755

ISBN: (纸本)9780471794646;9780470125755;9781118429204

This comprehensive guide offers traders, quants, and students the tools and techniques for using advanced models for pricing options. The accompanying website includes data files, such as options prices, stock prices, or index prices, as well as all of the codes needed to use the option and volatility models described in the book. Praise for Option Pricing Models & Volatility Using Excel-VBA''Excel is already a great pedagogical tool for teaching option valuation and risk management. But the VBA routines in this book elevate Excel to an industrial-strength financial engineering toolbox. I have no doubt that it will become hugely successful as a reference for option traders and risk managers.''—Peter Christoffersen, Associate Professor of Finance, Desautels Faculty of Management, McGill University''This book is filled with methodology and techniques on how to implement option pricing and volatility models in VBA. The book takes an in-depth look into how to implement the Heston and Heston and Nandi models and includes an entire chapter on parameter estimation, but this is just the tip of the iceberg. Everyone interested in derivatives should have this book in their personal library.''—Espen Gaarder Haug, option trader, philosopher, and author of Derivatives Models on Models''I am impressed. This is an important book because it is the first book to cover the modern generation of option models, including stochastic volatility and GARCH.''—Steven L. Heston, Assistant Professor of Finance, R.H. Smith School of Business, University of Maryland

关键词： Options (Finance)--Prices Capital investments--Evaluation--Mathematical models Options (Finance)--Mathematical models

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Microsystems & Nanoengineering 2018年第1期4卷 534-540页

作者： Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne fabrice Monti Yvette Tran Patrick Tabeling MMN IPGGMicrofluidiqueMEMSNanostructures(MMN)Institut Pierre-Gilles de Gennes(IPGG)GulliverEcole Supérieure de Physique et Chimie Industrielles(ESPCI Paris)PSL Research University10 rue VauquelinParis 75005France SIMM ESPCI ParisSciences et Ingénierie de la Matière Molle(SIMM)Ecole Supérieure de Physique et Chimie Industrielles(ESPCI Paris)PSL Research University10 rue VauquelinParis 75005France Microfactory 8 rue Jean CalvinParis 75005France

The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two *** patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until *** this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,*** applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s *** performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets.

关键词： actuator high throughput hydrogel microfluidics single cell valve

Electrochemical Sensors Based on Modification of Carbon Fiber Microelectrode by Nickel Phthalocyanine Polymer for 3-Methyl-4-Nitrophenol Analysis in Water

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Materials Sciences and Applications 2017年第11期8卷 798-810页

作者： Yibor fabrice Roland Bako Boukare Kabore Issa Tapsoba Laboratoire de Chimie Analytique Environnementale et Bio-organique (LCAEBiO) Département de Chimie Université Ouaga 1 Pr Joseph Ki-Zerbo Ouagadougou Burkina Faso Bureau des Mines et de la Géologie du Burkina (BUMIGEB) Ouagadougou Burkina Faso

3-methyl-4-nitrophenol (MNP) is the main by-product of the organophosphate insecticide fenitrothion (FT), used in locust control. MNP is highly toxic because it is an endocrine disruptor and then may cause adverse in the biological systems. Then, it is necessary to develop analytical methods for determination of this pollutant in the environment. In this sense, we reported herein the development of an electrochemical sensor for the detection of 3-methyl-4-nitrophenol (MNP), one of the metabolites of fenitrothion (FT), by using naked and modified carbon fiber microelectrode (CFME) by nickel tetrasulfonated phthalocyanine polymer (CFME/p-NiTSPc). The voltammogram showed that MNP presents one irreversible anodic peak corresponding to the oxidation of the phenol group at 0.9 V vs Ag/AgCl. The effect of pH of the buffer on the peak current and SWV parameters such as frequency, scan increment and pulse amplitude were investigated in order to optimize the electrochemical response of the sensor. The obtained results lead to the following optimum value: pH = 6;frequency = 25 Hz, pulse amplitude = 50 mV, scan increment = 10 mV. With these optimum values, the calibration curves show that the peak current varied linearly upon MNP concentration leading to a limit of detection (LoD) for naked CFME close to 3 μg/L whereas for CFME modified by p-NiTSPc, it reaches 0.75 μg/L. This results prove that the presence of p-NiTSPc increasing the sensitivity of the sensor could be used to monitor 3-methyl-4-nitrophenol residue in real matrix.

关键词： 3-Methyl-4-Nitrophenol Carbon Fiber Microelectrode Nickel Tetrasulfonated Phthalocyanine Film Cyclic Voltammetry Square Wave Voltammetry