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Neck-MRI experience for investigation of survived strangulation victims

Forensic Sciences Research 2020年第2期5卷 113-118页

作者： Christine Bruguier Pia Genet Jean-Baptiste Zerlauth fabrice Dedouit Jochen Grimm Reto Meuli Tony Fracasso Silke Grabherr University Center of Legal Medicine Lausanne–Geneva University Hospital LausanneLausanneSwitzerland Department of Diagnostic and Interventional Radiology University Hospital LausanneLausanneSwitzerland Clinique Cecile LausanneSwitzerland

For the medicolegal evaluation of victims of survived strangulation,a neck-magnetic resonance imaging(MRI)can be performed for assessing lesions in the inner soft tissues(fat,muscles or lymph nodes,for example).In our institute,such MRI examinations have been performed for a test period of 4 years with the aim of evaluating the use of this tool by forensic pathologists and identifying medicolegal indicators for the performance of neck-MRI in surviving victims of *** retrospectively reviewed medicolegal reports from all victims examined during the test *** extracted objective lesions(***,bruising and abrasions)and reported clinical symptoms(*** disorder,dysphasia)from the *** findings were compared to those reported from the *** total,112 victims were clinically examined after suspected *** of these victims underwent an MRI examination of the ***-four of the victims presented objective lesions during the clinical examination,with eight showing signs of both petechiae and ***-MRI was performed in four of these eight victims and three of them showed lesions visible in *** 76 victims with bruising as the only objective finding,66 victims described clinical *** those 66 victims,seven were examined by MRI and two demonstrated lesions in *** MRI was performed,relevant findings were detected in 45%of the *** leads to the suspicion that many more findings could have been detected in the other victims,if an MRI had been performed in those *** results lead us to the conclusion that an MRI examination of victims of suspected strangulation is useful,and strict indications for its application should be established.

关键词： Forensic sciences forensic pathology neck-MRI radiological findings medicolegal evaluation strangulation survivors

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Effects of Soursop flowers(Annona muricata L.)extract on chemical changes of refined palm olein stored at frying temperature

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Food Science and Human Wellness 2017年第4期6卷 187-194页

作者： Tonfack Djikeng fabrice Womeni Hilaire Macaire Bala Krishna Marrapu Mallampalli Sri Lakshmi Karuna Rachapudi Badari Narayana Prasad Linder Michel School of Agriculture and Natural Resources Catholic University Institute of BueaP.O BOX 563BueaCameroon Department of Biochemistry Faculty of ScienceUniversity of DschangP.O BOX 67DschangCameroon CSIR-Indian Institute of Chemical Technology Centre for Lipid ResearchTarnakaHyderabad 500007India Biomolecular Engineering Laboratory(LIBio) University of LorraineENSAIAVandoeuvre-les-NancyFrance

In this study,the antioxidant activity of soursop flowers extract in delaying palm olein oxidation at frying temperature was *** oil was supplemented with the extract at concentrations 200–1800 ppm,and stored in the oven at 180◦C for 6 days(4 h heating per day).Palm olein containing butylated hydroxytoluene(BHT)served as positive control while the same oil without antioxidant(Control)served as negative one,in order to monitor changes in *** each two heating days,oil samples were collected,and their chemical indexes were ***,para-anisidine,TOTOX,thiobarbituric acid and iodine values were the parameters ***,the evolution of the fatty acid composition of each oil sample during the storage was assessed by gas-chromatography using a flame ionization detector(GC/FID).Generally,palm olein samples containing the natural extract have exhibited the lowest rate of oxidation,and were efficient in limiting the destruction of unsaturated fatty acids in oil at frying *** order of effectiveness in inhibiting oil oxidation was the following:PO+AnM1800ppm>PO+AnM1400ppm>PO+AnM1000ppm>PO+An.M600ppm>PO+An.M200ppm>PO+BHT200ppm=*** these results,it can be concluded that soursop flowers are a potent sources of natural antioxidants for stabilization of palm olein.

关键词： Soursop flowers Stabilization Natural antioxidant Palm olein Frying Oxidative stability

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Identification of Low Density Polyurethane Foam Properties by the Digital Image Correlation Measurement and the Virtual Fields Method

Identification of Low Density Polyurethane Foam Properties b...

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International Conference on Experimental Mechanics 2008 (ICEM 2008)

作者： fabrice Pierron LMPF ENSAMRue St DominiqueBP 50851006 Ch■lons-en-Champagne CedexFrance

＜正＞This paper deals with the identification of the constitutive behavior of low density polyurethane foam using digital image correlation（DIC） and the virtual fields *** the so-called Iosipescu flexion tests in t... 详细信息

关键词： low density polyurethane foam digital image correlation great deformation image processing virtual fields method auxetic

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Experimental evidence for ovarian hypofunction in sparrow hybrids

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Chinese Birds 2016年第1期7卷 79-83页

作者： fabrice Eroukhmanoff Melissah Rowe Emily R.A.Cramer Fredrik Haas Jo S.Hermansen Anna Runemark Arild Johnsen Glenn-Peter Saetre Department of Biosciences Center for Ecological and Evolutionary SynthesisUniversity of Oslo Natural History Museum University of Oslo Department of Biology Ecology BuildingLund University

Background: Postzygotic isolation in the form of reduced viability and/or fertility of hybrids may help maintain species boundaries in the face of interspecific gene flow. Past hybridization events between house sparrows(Passer domesticus) and Spanish sparrows(P. hispaniolensis) have given rise to a homoploid hybrid species, the Italian sparrow(P. italiae). Although genetic incompatibilities are known to isolate these three species, the biological consequences of these incompatibilities are still unknown in early generation ***: We investigated whether F1 hybrids between house and Spanish sparrows experience reduced viability or fertility. More specifically, we generated hybrids through controlled crosses in aviaries, and compared ovaries of female hybrids with female of pure?species ***: We found that overall, hybrid ovaries were underdeveloped and that half of all female hybrids exhibited symptoms of ovarian hypofunction(ovarian atrophy and complete absence of developed follicles).Conclusions: Fertility in hybrids is a common consequence or post?zygotic barriers between species. We discuss these results in light of previous findings on genetic incompatibilities between the parent species and the potential role of incompatibilities in hybrid speciation, a rare evolutionary process in birds.

关键词： Hybrid fitness Hybridization Ovary Sparrows Speciation

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CT-scan vs.3D surface scanning of a skull:first considerations regarding reproducibility issues

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Forensic Sciences Research 2017年第2期2卷 93-99页

作者： Stella Fahrni Lorenzo Campana Alejandro Dominguez Tanya Uldin fabrice Dedouit Olivier Deleemont Silke Grabherr School of Criminal Justice University of LausanneLausanne-DorignySwitzerland Department of Forensic Imaging University Centre for Legal Medicine Lausanne-GenevaLausanneSwitzerland Department of Technological Radiology Health School of Sciences Vaud-HESAVLausanneSwitzerland

Three-dimensional surface scanning(3DSS)and multi-detector computed tomography(MDCT)are two techniques that are used in legal medicine for digitalizing objects,a body or body parts such as *** these techniques are more and more commonly employed,surprisingly little information is known about the quality rendering of digitalized three-dimensional(3D)models provided by each of *** paper presents findings related to the measurement precision of 3D models obtained through observation of a study case,where a fractured skull reconstructed by an anthropologist was digitalized using both post-mortem imaging *** tomography(CT)scans were performed using an 8-row MDCT unit with two different slice *** variability of 3D CT models superimposition allowed to assess the reproducibility and robustness of this digitalization ***,two 3D surface scans were done using a professional high resolution 3D *** comparison of 3D CT-scans with 3D surface scans by superimposition demonstrated several regions with significant differences in topology(average difference between+1.45 and-1.22 mm).When comparing the reproducibility between these two digitalizing techniques,it appeared that MDCT 3D models led in general to greater variability for measurement precision between scanned ***,the reproducibility was better achieved with the 3D surface digitizer,showing 3D models with fewer and less pronounced differences(from+0.32 to-0.31 mm).These experiments suggest that MDCT provides less reproducible body models than 3D surface *** further studies must be undertaken in order to corroborate this first impression,and possibly explain the reason for these findings.

关键词： Forensic imaging multi-detector computed tomography(MDCT) 3D surface scanning anthropology

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Liver X receptors and epididymal epithelium physiology

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Asian Journal of Andrology 2007年第4期9卷 574-582页

作者： fabrice Saez Eléore Chabory Rémi Cadet Patrick Vernet Silvère Baron2 Jean-Marc A. Lobaccaro Joeol R. Drevet Laboratoire Epididyme et Maturation des Gamètes and Centre de Recherche en Nutrition Humaine d＇Auvergne Université Blaise Pascal CNRS UMR 6547 Aubiere Cedex 63177 France Laboratoire de Physiologie Cellulaire et d＇Endocrinologie Moléculaire and Centre de Recherche en Nutrition Humaine d＇Auvergne Université Blaise Pascal CNRS UMR 6547 Aubiere Cedex 63177 France

Aim： To investigate the roles of liver X receptors （LXR） in the lipid composition and gene expression regulation in the murine caput epididymidis. LXR are nuclear receptors for oxysterols, molecules derived from cholesterol metabolism that are present in mammals as two isoforms： LXRα, which is more specifically expressed in lipid-metabolising tissues, such as liver, adipose and steroidogenic tissues, and macrophages, whereas LXRβ is ubiquitous. Their importance in reproductive physiology has been sustained by the fact that male mice in which the function of both LXR has been disrupted have fertility disturbances starting at the age of 5 months, leading to complete sterility by the age of 9 months. These defects are associated with epididymal epithelial degeneration in caput segments one and two, and with a sperm midpiece fragility, leading to the presence of isolated sperm heads and flagella when luminal contents are recovered from the cauda epididymidis. Methods： The lipid composition of the caput epididymidis of wild-type and LXR-deficient mice was assessed using oil red O staining on tissue cryosections and lipid extraction followed by high performance liquid chromatography or gas chromatography. Gene expression was checked by quantitative real time polymerase chain reaction. Results： Using LXR-deficient mice, we showed an alteration of the lipid composition of the caput epididymidis as well as a significantly decreased expression of the genes encoding SREBPlc, SCD1 and SCD2, involved in fatty acid metabolism. Conclusion： Altogether, these results show that LXR are important regulators of epididymal function, and play a critical role in the lipid maturation processes occurring during sperm epididymal maturation. （Asian J Androl 2007 July; 9： 574-582）

关键词： epididymis liver X receptors nuclear receptors lipids cholesterol gene expression

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Mutants, Overexpressors, and Interactors of Arabidopsis Plastocyanin Isoforms： Revised Roles of Plastocyanin in Photosynthetic Electron Flow and Thylakoid Redox State

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Molecular Plant 2009年第2期2卷 236-248页

作者： Paolo Pesaresi Michael Scharfenberg Martin Weigel Irene Granlund Wolfgang R Schroder Giovanni Finazzi fabrice Rappaport Simona Masiero Antonella Furini Peter Jahns Dario Leister Dipartimento di Produzione Vegetale Universita degli studi di Milano c/o Parco Tecnologico Padano Via Einstein Loc Cascina Codazza 1-26900 Lodi Italy Lehrstuhl fur Botanik Department Biologie I Ludwig-Maximilians-Universitat Munchen GroBhaderner Str. 2 D-82152 Planegg-Martinsried Germany Abteilung fhr Pflanzenzuchtung und Genetik Max-Planck-lnstitut fur Zhchtungsforschung Carl-von-Linne-Weg 10 D-50829 Koln Germany Institute of Chemistry and Umea Plant Science Centre (UPSC) Umea University SE-901 87 Umea Sweden Institut de Biologie Physico-Chimique UMR 7141 CNRS-Universite R et M. Curie 13 rue Pierre et Marie Curie F-75005 Paris France Dipatimento di Biologia Universita degli studi di Milano Via Celoria 26 L-20133 Milano Italy Dipartimento Scientifico e Tecnologico Universita degli studi di Verona Strade le Grazie 15 1-37134 Verona Italy Institut fur Biochemie der Pflanzen Heinrich-Heine-Universitat Dusseldorf Universitatsstr. 1 D-40225 Dusseldorf Germany

Two homologous plastocyanin isoforms are encoded by the genes PETE1 and PETE2 in the nuclear genome of Arabidopsis thaliana. The PETE2 transcript is expressed at considerably higher levels and the PETE2 protein is the more abundant isoform. Null mutations in the PETE genes resulted in plants, designated pete1 and pete2, with decreased plastocyanin contents. However, despite reducing plastocyanin levels by over -90%, a pete2 null mutation on its own affects rates of photosynthesis and growth only slightly, whereas pete1 knockout plants, with about 60-80% of the wild-type plastocyanin level, did not show any alteration. Hence, plastocyanin concentration is not limiting for photosynthetic elec- tron flow under optimal growth conditions, perhaps implying other possible physiological roles for the protein. Indeed, plastocyanin has been proposed previously to cooperate with cytochrome C6A （Cyt C6A） in thylakoid redox reactions, but we find no evidence for a physical interaction between the two proteins, using interaction assays in yeast. We observed homodimerization of Cyt C6A in yeast interaction assays, but also Cyt C6A homodimers failed to interact with plastocyanin. Moreover, phenotypic analysis of atc6-1 pete1 and atc6-1 pete2 double mutants, each lacking Cyt C6A and one of the two piastocyanin-encoding genes, failed to reveal any genetic interaction. Overexpression of either PETE1 or PETE2 in the pete1 pete2 double knockout mutant background results in essentially wild-type photosynthetic performance, excluding the possibility that the two plastocyanin isoforms could have distinct functions in thylakoid electron flow.

关键词： Mutants Overexpressors nteractors of Arabidopsis Plastocyanin Isoforms

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Direct measurement of electrocaloric effect in P(VDF-TrFE-CFE)film using infrared imaging

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Journal of Materiomics 2023年第2期9卷 256-260页

作者： Ashwath Aravindhan Pierre Lheritier Alvar Torello Uros Prah Youri Nouchokgwe Asmaa El Moul Xavier Chevalier fabrice Domingues Dos Santos Emmanuel Defay Veronika Kovacova Materials Research and Technology Department Luxembourg Institute of Science and Technology(LIST)41 Rue du BrillL-4422BelvauxLuxembourg University of Luxembourg 2 Avenue de l’UniversiteEsch-sur-AlzetteL-4365Luxembourg Arkema e Piezotech CRRA Rue Henri Moissan69493Pierre Benite CedexFrance

Poly(vinylidene fluoride-trifluoroethylene-chlorofluoroethylene)P(VDF-TrFE-CFE)is a relaxor ferroelectric polymer,which exhibits a temperature-independent electrocaloric effect at room *** this work,the electrocaloric effect in P(VDF-TrFE-CFE)film was directly analysed using infrared imaging.P(VDF-TrFE-CFE)64.8%/27.4%/7.8%(in mole)film of(15±1)mm thickness was deposited on polyethylene naphthalate *** ECE of P(VDF-TrFE-CFE)film was measured from 15 to 35C at different electric fields.A maximum adiabatic temperature change(DTad)of 3.58 K was measured during the cooling cycle at a field of 100 V/mm at 30*** element analysis of temperature dissipation through the sample estimated that the actual temperature change within P(VDF-TrFE-CFE)film was 4.3 *** the thermal mass of the substrate,a substantial ECE was observed in P(VDF-TrFE-CFE)*** electrocaloric terpolymer composition could be of interest for electrocaloric cooling applications.

关键词： Direct measurement Electrocaloric effect P(VDF-TrFE-CFE) Relaxor ferroelectric polymer Infrared imaging Finite element analysis

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Chemical characterization of fine and ultrafine PM, direct and indirect genotoxicity of PM and their organic extracts on pulmonary cells

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Journal of Environmental Sciences 2018年第9期30卷 168-178页

作者： Sylvain Billet Yann Landkocz Perrine J. Martin Anthony Verdin Frederic Ledoux Capucine Lepers Veronique Andre fabrice Cazier Francois Sichel Pirouz Shirali Pierre Gosset Dominique Courcot University of the Littoral Opal Coast Unit of Environmental Chmistry and Interactions with Liuing Organisms UCEIV EA4492 SFR Condorcet FR CNRS 3417 Dunkerque France Normandy Uniu UNICAEN ABTE EA4651 Caen France University of the Littoral Opal Coast Common Centre of Measurements CCM Dunkerque France Centre Francois Baclesse Caen France Department of Anatomy and Pathological Cytologly Saint-Vincent Hospital Catholic Hospital Lille France

Particulate matter in ambient air constitutes a complex mixture of fine and ultrafine particles composed of various chemical compounds including metals, ions, and organics. A multidisciplinary approach was developed by studying physico-chemical characteristics and mechanisms involved in the toxicity of particulate atmospheric pollution. PM0.3-2.s and PM2.5 including ultrafine particles were sampled in Dunkerque, a French industrialized seaside city. PM samples were characterized from a chemical and toxicological point of view. Physico-chemical characterization evidenced that PM2.5 comes from several sources： natural ones, such as soil resuspension and marine sea-salt emissions, as well as anthropogenic ones, such as shipping traffic, road traffic, and industrial activities. Human BEAS-2B tung cells were exposed to PM0.3-2.5, or to the Extractable Organic Matter （EOM） of PM0.3-2.5 and PM2.s. These exposures induced several mechanisms of action implied in the genotoxicity, such as oxidative DNA adducts and DNA Damage Response. The toxicity of PM-EOM was higher for the sample including the ultrafine fraction （PM2.5） containing also higher concentrations of polycyclic aromatic hydrocarbons. These results evidenced the major role of organic compounds in the toxicity of PM.

关键词： Air pollution particulate matter PM2.5 Ultrafine particles Physico-chemical characterization Biotransformation Genotoxicity

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Pressure and Temperature Conditions Recorded by the Beni-Bousera Ultramafic Body and the Overlying Lower-crustal Rocks(Rif,Morocco)

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地学前缘 2009年第S1期16卷 203-204页

作者： El Atrassi Fatima fabrice Brunet Vincent Bonneau Christian Chopin Mohamed Bouybaouene Gilles Chazot Laurent Jolivet Laboratoire de Geologie ENS-CNRS UMR-8538Paris(France)Departement des Sciences de la Terre Faculte des Sciences BP 1014 Laboratoire de Geologie Département des Sciences de la Terre Faculté des Sciences BP 1014 UMR-6538 Domaines OcéaniquesUniversité de Bretagne Occidentale Laboratoire de Tectonique

The Beni Bousera massif(Rifean belt,northern Morocco)is predominantly composed of spinel lherzolite with subordinate garnet pyroxenite and garnet peridotite *** formed an antiformal dome which was overlain by graphite-sillimanite-garnet gneisses(kinzigites)equilibrated at around 1 GPa and 750℃.Within these kinzigites,kyanite-bearing basic granulites record somewhat higher PT conditions of around 1.6-2.0 GPa and 760-820℃.Garnet clinopyroxenite(either graphite-bearing or graphi-

关键词： garnet exsolution periodotite pyrox-enite UHP conditions Beni Bousera Rif

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