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Characterization of spatial relationships between three remotely sensed indirect indicators of biodiversity and climate:a 21years’data series review across the Canadian boreal forest

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International Journal of Digital Earth 2016年第7期9卷 676-696页

作者： Liliana Perez Trisalyn Nelson Nicholas C.Coops fabio Fontana C.Ronnie Drever Laboratory of Environmental Geosimulation(LEDGE) Department of GeographyUniversity of MontrealMontrealQCCanada spatial Pattern Analysis&Research(sPAR)Lab Department of GeographyUniversity of VictoriaVictoriaBCCanada Department of Forest Resources Management University of British ColumbiaVancouverBCCanada The Nature Conservancy OttawaONCanada

Climate drives ecosystem processes and impacts *** patterns over large areas,such as Canada’s boreal,can be monitored using indirect indicators derived from remotely sensed *** this paper,we characterized the historical space–time relationships between climate and a suite of indirect indicators of biodiversity,known as the Dynamic Habitat Index(DHI)to identify where climate variability is co-occurring with changes in biodiversity *** represented biodiversity using three indirect indicators generated from 1987 to 2007 National Oceanic and Atmospheric Administration Advanced Very High Resolution Radiometer *** quantifying and clustering temporal variability in climate data,we defined eight homogeneous climate variability zones,where we then analyzed the *** identified unique areas of change in climate,such as the Hudson Plains,that explain significant variations in *** variability in temperatures and growing season index had a strong influence on observed vegetation productivity and seasonality changes throughout Canada’s *** in precipitation,for most of the area,was not associated with DHI *** methodology presented here enables assessment of spatial–temporal relationships between biodiversity and climate variability and characterizes distinctive zones of variation that may be used for prioritization and planning to ensure long-term biodiversity conservation in Canada.

关键词： Climate change biodiversity boreal forest spatial–temporal analysis fPAR DHI

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Mesenchymal stem cells secretome:current trends and future challenges

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Neural Regeneration Research 2020年第1期15卷 75-77页

作者： fabio G.Teixeira Antonio J.salgado Life and Health sciences Research Institute(ICVs) School of MedicineUniversity of MinhoBragaPortugalICVS/3B’s Associate LabPT Government Associated LabBraga/GuimaraesPortugal

Mesenchymal stem cells(MsCs)secretome:a good candidate for medical biotechnology?Medical biotechnology is currently defined as the application of biotechnological tools for producing multiple technologies and products to health care,becoming an important bridge between different fields,namely neuroscience,regenerative medicine,pharmacology and bio-engineering(Pham,2018).The use and manipulation of stem cells can potentially represent a medical biotechnology breakthrough that brings regenerative medicine to a new ***,over the last decade,the use of stem cells has remarkably been proposed as a regenerative tool,and within it,MsCs have emerged as a promising therapeutic option.

关键词： manipulation breakthrough becoming

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Extremely low frequency electromagnetic fields stimulation modulates autoimmunity and immune responses：a possible immuno-modulatory therapeutic effect in neurodegenerative diseases

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Neural Regeneration Research 2016年第12期11卷 1888-1895页

作者： fabio Guerriero Giovanni Ricevuti Department of Internal Medicine and Medical Therapy Section of Geriatrics University of Pavia Pavia Italy Azienda di servizi alia Persona Istituto di Cura Santa Margherita of Pavia Pavia Italy

Increasing evidence shows that extremely low frequency electromagnetic fields（ELF-EMFs） stimulation is able to exert a certain action on autoimmunity and immune cells. In the past, the efficacy of pulsed ELFEMFs in alleviating the symptoms and the progression of multiple sclerosis has been supported through their action on neurotransmission and on the autoimmune mechanisms responsible for demyelination. Regarding the immune system, ELF-EMF exposure contributes to a general activation of macrophages, resulting in changes of autoimmunity and several immunological reactions, such as increased reactive oxygen species-formation, enhanced phagocytic activity and increased production of chemokines. Transcranial electromagnetic brain stimulation is a non-invasive novel technique used recently to treat different neurodegenerative disorders, in particular Alzheimer＇s disease. Despite its proven value, the mechanisms through which EMF brain-stimulation exerts its beneficial action on neuronal function remains unclear. Recent studies have shown that its beneficial effects may be due to a neuroprotective effect on oxidative cell damage. On the basis of in vitro and clinical studies on brain activity, modulation by ELF-EMFs could possibly counteract the aberrant pro-inflammatory responses present in neurodegenerative disorders reducing their severity and their onset. The objective of this review is to provide a systematic overview of the published literature on EMFs and outline the most promising effects of ELF-EMFs in developing treatments of neurodegenerative disorders. In this regard, we review data supporting the role of ELF-EMF in generating immune-modulatory responses, neuromodulation, and potential neuroprotective benefits. Nonetheless, we reckon that the underlying mechanisms of interaction between EMF and the immune system are still to be completely understood and need further studies at a molecular level.

关键词： electromagnetic fields Alzheimer's disease transcranial magnetic stimulation autoimmunity immunomodulation

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利用强子探针研究奇特原子核的点质子分布半径及强子探针效应

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science Bulletin 2024年第11期69卷 1647-1652页

作者：张寂潮孙保华 Isao Tanihata Rituparna Kanungo Christoph scheidenberger satoru Terashima 王枫 Frederic Ameil Joel Atkinson Yassid Ayyad soumya Bagchi Dolores Cortina-Gil Iris Dillmann Alfredo Estradé Alexey Evdokimov fabio Farinon Hans Geissel Giulia Guastalla Rudolf Janik satbir Kaur Ronja Knöbel Jan Kurcewicz Yury Litvinov Michele Marta Magdalena Mostazo Ivan Mukha Chiara Nociforo Hooi Jin Ong stephane Pietri Andrej Prochazka Branislav sitar Peter strmen Maya Takechi Junki Tanaka Jossitt Vargas Helmut Weick John stuart Winfield school of Physics Beihang UniversityBeijing 100191China Research Center for Nuclear Physics(RCNP) Osaka UniversityOsaka 567-0047Japan Astronomy and Physics Department Saint Mary’s UniversityHalifax B3H 3C3Canada TRIUMF Vancouver V6T 4A3Canada GsI Helmholtzzentrum für schwerionenforschung Darmstadt D-64291Germany Justus-Liebig University Gießn 35392Germany Helmholtz Research Academy Hesse for FAIR(HFHF) GSI Helmholtz Center for Heavy Ion ResearchGießn 35392Germany Universidad de santiago de Compostela Santiago de Compostella E-15706Spain Department of Physics Indian Institute of Technology(Indian School of Mines)Dhanbad 826004India Faculty of Mathematics and Physics Comenius UniversityBratislava 84215Slovakia Department of Physics and Atmospheric science Dalhousie UniversityHalifax B3H 4R2Canada

We report the charge-changing cross sections(σ_(cc))of 24 p-shell nuclides on both hydrogen and carbon at about 900A MeV,of which^(8,9)Li,^(10–12)Be,^(10,14,15)B,^(14,15,17–22)N and^(16)O on hydrogen and^(8,9)Li on carbon are for the first *** from the data set,we found a new and robust relationship between the scaling factor of the Glauber model calculations and the separation energies of the nuclei of interest on both *** allows us to deduce proton radii(R_p)for the first time from the cross sections on *** identical R_p values are deduced from both target data for the neutron-rich carbon isotopes;however,the R_p from the hydrogen target is systematically smaller in the neutron-rich nitrogen *** calls for further experimental and theoretical investigations.

关键词： Exotic nuclei Nuclear size Reaction cross section Glauber model Radioactive ion beam

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Control of flowering in rice through synthetic microProteins

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Journal of Integrative Plant Biology 2020年第6期62卷 730-736页

作者： Tenai Eguen Jorge Gomez Ariza Vittoria Brambilla Bin sun Kaushal Kumar Bhati fabio Fornara stephan Wenkel Copenhagen Plant science Centre University of Copenhagen1871Frederiksberg CDenmark Department of Plant and Environmental sciences University of Copenhagen1871Frederiksberg CDenmark Department of Biosciences Universitàdegli Studi di Milano20133MilanoItaly

Photoperiod-dependent flowering in rice is regulated by HEADING DATE 1(Hd1),which acts as both an activator and repressor of flowering in a daylengthdependent *** investigate the use of microProteins as a tool to modify rice sensitivity to the photoperiod,we designed a synthetic Hd1 micro Protein(Hd1miP)capable of interacting with Hd1 protein,and overexpressed it in *** OX-Hd1 miP plants flowered significantly earlier than wild type plants when Breakt grown in non-inductive long day *** results show the potential of microProteins to serve as powerful tools for modulating crop traits and unraveling protein function.

关键词： function. inductive flowering

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Microbiota-gut-brain axis and its affect inflammatory bowel disease:Pathophysiological concepts and insights for clinicians

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World Journal of Clinical Cases 2020年第6期8卷 1013-1025页

作者： Emanuele sinagra Erika Utzeri Gaetano Cristian Morreale Carlo Fabbri fabio Pace Andrea Anderloni Gastroenterology and Endoscopy Unit Fondazione Istituto Giuseppe GiglioContrada Pietra Pollastra PisciottoCefalù90015Italy Euro-Mediterranean Institute of science and Technology Palermo 90100Italy Nuova Casa di Cura di Decimomannu Cagliari 09100Italy section of Gastroenterology S.Elia-Raimondi HospitalCaltanissetta 93100Italy Gastroenterology and Digestive Endoscopy Unit Forlì-CesenaAzienda USL RomagnaForlì47121Italy Unit of Gastroenterology Bolognini HospitalBergamo 24100Italy Digestive Endoscopy Unit Division of GastroenterologyHumanitas Research HospitalRozzano 20089Italy

Despite the bi-directional interaction between gut microbiota and the brain not being fully understood,there is increasing evidence arising from animal and human studies that show how this intricate relationship may facilitate inflammatory bowel disease(IBD)pathogenesis,with consequent important implications on the possibility to improve the clinical outcomes of the diseases themselves,by acting on the different components of this system,mainly by modifying the *** the emergence of precision medicine,strategies in which patients with IBD might be categorized other than for standard gut symptom complexes could offer the opportunity to tailor therapies to individual *** aim of this narrative review is to elaborate on the concept of the gutbrain-microbiota axis and its clinical significance regarding IBD on the basis of recent scientific literature,and finally to focus on pharmacological therapies that could allow us to favorably modify the function of this complex system.

关键词： Irritable bowel syndrome Inflammatory bowel disease Gut-brain axis Therapy

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Comparing shoulder maneuvers to magnetic resonance imaging and arthroscopic findings in patients with supraspinatus tears

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World Journal of Orthopedics 2022年第1期13卷 102-111页

作者： fabio Anauate Nicolao Joao Alberto Yazigi Junior fabio Teruo Matsunaga Nicola Archetti Netto Joao Carlos Belloti Marcel Jun sugawara Tamaoki Orthopedics and Traumatology Department Escola Paulista de Medicina–Universidade Federal de São Paulo–UNIFESPSao Paulo 04038-001Brazil Orthopedics and Traumatology Discipline Universidade de Santo Amaro–UNISASao Paulo 04829-300Brazil

BACKGROUND shoulder maneuvers and magnetic resonance imaging(MRI)are performed to diagnose supraspinatus tendon tears regardless of arthroscopy *** there are many studies on this subject,there is a lack of studies comparing the sensitivity(se)and specificity(sp)of shoulder maneuvers and MRI to arthroscopic findings(intact,partial,or full thickness supraspinatus tendon tear).AIM To compare the diagnostic values of shoulder maneuvers with MRI for supraspinatus tendon tears in patients undergoing shoulder *** A total of 199 consecutive patients from four orthopedic centers met the eligibility criteria of shoulder pain persisting for at least four *** were prospectively enrolled in this study from April 2017 to April *** clinical tests(full can,empty can,drop arm,Hawkins’,painful arc,Neer’s sign and resisted external rotation)and MRI were performed,and all were compared with surgical *** can,empty can and resisted external rotation tests were interpreted as positive in the case of pain and/or *** assessed the se,sp,accuracy,positive predictive value(PPV)and negative predictive value(NPV),positive and negative likelihood ratio and diagnostic odds ratio for overall,partial and fullthickness supraspinatus *** MRI had the highest se for overall(0.97),partial(0.91)and full-thickness(0.99)tears;moreover,MRI had the highest NPV:0.90,0.88 and 0.98 for overall,partial and full-thickness tears,*** overall supraspinatus tears,the se and PPV were:Painful arc(se=0.85/PPV=0.91),empty can(pain)(se=0.80/PPV=0.89),full can(pain)(se=0.78/PPV=0.90),resisted external rotation(pain)(se=0.48/PPV=0.87),drop arm(se=0.19/PPV=0.97),Neer’s sign(se=0.78/PPV=0.93)and Hawkins’(se=0.80/PPV=0.88).MRI had the highest PPV(0.99).The Hawkin’s test had the highest false positive rate in patients with intact tendons(0.36).The sp of the empty can and full can(both tests positive for pain and weakness),drop arm and MRI were:0.93,

关键词： Rotator cuff injuries Physical examination Magnetic resonance imaging Arthroscopy

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Mechanisms and consequences of COVID-19 associated liver injury: What can we affirm?

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World Journal of Hepatology 2020年第8期12卷 413-422页

作者： Carlos Antunes Brito fabio Marinho Barros Edmundo Pessoa Lopes Department of Internal Medicine Center of Medical Sciences of Federal University of PernambucoRecifePernambuco 50740600Brazil Clinical Hospital of Federal University of Pernambuco RecifePernambuco 50740900Brazil Post-graduation Program of Tropical Medicine of Federal University of Pernambuco RecifePernambuco 50670901Brazil Autoimmune Research Institute RecifePernambuco 52011010Brazil Português Hospital of Pernambuco RecifePernambuco 52010075Brazil

since the first reports of coronavirus disease 2019(COVID-19)cases in December 2019 in China,numerous papers have been published describing a high frequency of liver injury associated with severe acute respiratory syndrome coronavirus 2 infection,many of them proposing a link between these findings and patient *** in serum aminotransferase levels(ranging from 16%to 62%)and bilirubin levels(ranging from 5%to 21%)have been reported and seem to be more often observed in patients with severe forms of *** absolute changes in these parameters are frequently seen,other variables,such as the ratio above the upper limit of normal,the onset of liver injury as a complication in severe cases and histopathological findings,reinforce that liver changes are of dubious clinical relevance in the course of this *** factors must also be considered in these analyses,such as the repercussions of hemodynamic changes,the presence of thrombotic events,and,mainly,the possible drug-induced liver injury with the current,yet off-label,*** paper aimed to analyze the currently available data on liver injury in patients with COVID-19.

关键词： COVID-19 sARs-CoV-2 Liver injury Liver enzymes Drug induced liver injury Pandemic

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Experimental characterization of Ti6AI4V T joints welded through linear friction welding technique： microstructure and NDE

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Advances in Manufacturing 2016年第4期4卷 305-313页

作者： Antonello Astarita Mario Coppola sergio Esposito Mariacira Liberini Leandro Maio Ilaria Papa fabio scherillo Antonino squillace Department of Chemical Materials and ProductionEngineering University of Naples "Federico II" PiazzaleTecchio 80 80125 Naples Italy Fox Bit srl viale Luraghi presso consorzio I1 Sole80038 Pomigliano d'Arco NA Italy Leonardo Company s.p.A.- Aircraft Division Engineering -AT&D Manufacturing and Assembly Research andDevelopment Viale dell'Aeronantica s/n80038 Pomigliano d'Arco NA Italy Department of Industrial Engineering - Aerospace Division University of Naples "Federico II" Via Claudio 21 NaplesItaly

Linear friction welding （LFW） is an innovative solid-state welding technique that allows to manufacture joints with high mechanical properties. This technology has various applications in the aerospace field; in particular it is used to weld massive structural components made of Ti6A14V. This paper deals with the experimental study of Ti6A14V T-joints welded through LFW, with particular focus on the effectiveness of ultrasonic control in detecting and distinguishing welding defects within the joints. Aiming to this scope, joints with different properties were manufactured and tested： some were free from defects but with different metallurgy, and some had different types of defects. The results obtained proved that the ultrasonic control was an effective method to detect and identify defects in linear friction welded titanium joints, moreover it was possible to get information regarding the microstructure and in particular the extension of the different metallurgical zones induced by the welding process.

关键词： Ti6A14V Ultrasonic control Linear frictionwelding (LFW) Microstructure Defects

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Quantifying water stress effect on daily light use efficiency in Mediterranean ecosystems using satellite data

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International Journal of Digital Earth 2017年第6期10卷 623-638页

作者： sergio sanchez-Ruiz Alvaro Moreno Maria Piles fabio Maselli Arnaud Carrara steven Running Maria Amparo Gilabert Departament de Fisica de la Terra i Termodinamica Facultat de FisicaUniversitat de ValenciaBurjassotSpain Numerical Terradynamic simulation Group University of MontanaMissoulaMTUSA Barcelona Expert Center Institut de Ciencies del MarICM-CSICBarcelonaSpain IBIMET-CNR Sesto FiorentinoItaly Fundacion CEAM PaternaSpain

The capacity of six water stress factors(ε′(i))to track daily light use efficiency(ε)of water-limited ecosystems was *** factors are computed with remote sensing operational products and a limited amount of ground data:ε′1 uses ground precipitation and air temperature,and satellite incoming global solar radiation;ε′(2) uses ground air temperature,and satellite actual evapotranspiration and incoming global solar radiation;ε′_(3) uses satellite actual and potential evapotranspiration;ε′_(4) uses satellite soil moisture;ε′_(5) uses satellite-derived photochemical reflectance index;and ε′_(6) uses ground vapor pressure *** factors were implemented in a production efficiency model based on Monteith’s approach in order to assess their performance for modeling gross primary production(GPP).Estimated GPP was compared to reference GPP from eddy covariance(EC)measurements(GPP EC)in three sites placed in the Iberian Peninsula(two open shrublands and one savanna).ε′_(i) were correlated to ε,which was calculated by dividing GPP EC by ground measured photosynthetically active radiation(PAR)and satellite-derived fraction of absorbed *** results were achieved by ε′(1),ε′(2),ε′(3) and ε′(4) explaining around 40% and 50% of ε variance in open shurblands and savanna,*** terms of GPP,R^(2)≈0.70 were obtained in these cases.

关键词： Light use efficiency water stress GPP Monteith Mediterranean ecosystems

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