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Enhancing sensitivity of triple-negative breast cancer to DNA-damaging therapy through chemical inhibition of the m6A methyltransferase METTL3

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Cancer Communications 2024年第2期44卷 282-286页

作者： Bianca Cesaro Alessia Iaiza fabio piscopo Marco Tarullo Eleonora Cesari Dante Rotili Antonello Mai Alberto Diana Michela Londero Luca Del Giacco Riccardo Masetti Alba Di Leone Chiara Naro Silvia Masciarelli Giulia Fontemaggi Claudio Sette Francesco Fazi Alessandro Fatica Department of Anatomical HistologicalForensic&Orthopedic SciencesSection of Histology&Medical EmbryologySapienza University of RomeRomeItaly Department of Biology and Biotechnologies“Charles Darwin” Sapienza University of RomeRomeItaly GSTeP Organoids Research Core Facility Fondazione Policlinico A.Gemelli Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)RomeItaly Department of Drug Chemistry and Technologies Sapienza University of RomeRomeItaly Pasteur Institute Cenci-Bolognetti FoundationSapienza University of RomeRomeItaly Department of BioSciences University of MilanMilanItaly Multidisciplinary Breast Center Dipartimento Scienze della Salute della Donna e del Bambino e di SanitàPubblicaCatholic University of the Sacred HeartRomeItaly Department of Neuroscience Section of Human AnatomyCatholic University of the Sacred HeartRomeItaly Oncogenomic and Epigenetic Unit IRCCS Regina Elena National Cancer InstituteRomeItaly

Dear Editor,N 6-methyladenosine(m^(6)A)is a critical mRNA modi-fication catalyzed by the enzyme methyltransferase-like 3(METTL3),with implications in RNA ***3 upregulation is associated with cancer progres-sion,metast... 详细信息

关键词： cancer methyltransferase metastasis

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Distal femur complex fractures in elderly patients treated with megaprosthesis:Results in a case series of 11 patients

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World Journal of Orthopedics 2022年第5期13卷 454-464页

作者： fabio Zanchini Antonio piscopo Valerio Cipolloni Federico Fusini Stefano Cacciapuoti Davide piscopo Charlotte Pripp Luigi Aurelio Nasto Enrico Pola Orthopaedics and Traumatology Division Multidisciplinary Department of Medical-Surgical and Dental SpecialtiesUniversity of Campania"Luigi Vanvitelli"School of MedicineNaples 80138Italy Department of Orthopedics and Traumatology Sacro Cuore di GesùFatebenefratelli HospitalBenevento 82100Italy Spine Division Department of Orthopaedics and TraumatologyA.Gemelli IRCCS University HospitalCatholic University of RomeRome 00168Italy Department of Orthopaedic and Traumatology Regina Montis Regalis HospitalMondovì12084Italy Service de Geriatrie et réaaptation HUG H?pital de Bellerive ChemGenève 1205Switzerland

BACKGROUND Surgical treatment of complex fractures of the distal femur in the elderly is *** and pre-existent osteoarthritis are common comorbidities in the elderly which add to the need for early walking and rapid restoration of function and also pose significant obstacles to achievement of satisfactory results with standard fixation ***,several authors have suggested that primary arthroplasty could be a viable alternative option to standard fixation techniques in selected patients with complex distal femur *** To present our experience with 11 cases of distal femur fractures treated with knee arthroplasty and large femoral resection in a population of patients over the age of *** Data from 11 consecutive patients(10 females,1 male)presenting with acute intra-articular supracondylar or intercondylar distal femur fractures and with pre-existent primary osteoarthritis who were treated with primary knee arthroplasty were *** collected standard demographic data,comorbidities and patient reported outcomes including Visual Analogical Scale(VAS),Oxford Knee Score(OKS)and Barthel’s ***-operative joint range of motion(ROM)and standard radiographic data were also *** At a mean follow-up of 23.2 mo,all of the implants were well-positioned and ***,all the patients were alive and walking either independently or with walking *** was a marked improvement in pain(VAS 4.5 postop vs 1.9 at the last follow-up),OKS score(29.5 postop vs 36.81 at the last follow-up),ROM(96.2°postop vs 102°at the last follow-up)and restoration of pre-injury ambulatory status(average Barthel Index 77.3).The radiographic evaluations showed good restoration of the articular *** deaths and no complications were *** In conclusion,we believe that knee megaprosthesis in the case of complex fractures of the distal femur is a valid surgical *** is particularly true in

关键词： Knee Joint replacement Megaprosthesis Elderly Distal femur fracture

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Role of lateral soft tissues release in percutaneous hallux valgus correction:A medium term retrospective study

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World Journal of Orthopedics 2023年第12期14卷 843-852页

作者： fabio Zanchini Ottorino Catani Fabrizio Sergio Alessia Boemio Angelo Sieczak Davide piscopo Salvatore Risitano Gabriele Colò Federico Fusini Division of Orthopaedics and Traumatology Multidisciplinary Department of Medical-Surgical and Dental SpecialtiesClinical OrthopeadicsUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy Department of Foot Surgery Casa di cura Santa MariaSanta Maria Capua Vetere 81055Italy Department of Foot an Ankle Surgery Casa di cura Santa MariaSanta Maria Capua Vetere 81055Italy Multidisciplinary Department of Medical-Surgical and Dental Specialties Clinical OrthopeadicsAOU Luigi VanvitelliNapoli 80138Italy Clinical Orthopeadics University of Campania Luigi VanvitelliNaples 80138Italy Department of Orthopaedic and Traumatology Orthopaedic and Trauma CentreCittàdella Salute e della Scienza di TorinoTurin 10126Italy Department of Orthopaedics and Traumatology Regional Center for Joint ArthroplastyASO AlessandriaAlessandria 15121Italy Department of Orthopaedic and Traumatology Regina Montis Regalis HospitalCuneo 12084Italy

BACKGROUND In the field of minimally invasive surgery(MIS)for the treatment of hallux valgus(HV),different techniques have begun to emerge in the literature concerning the distal osteotomy of the first metatarsal bone,the synthesis or not of the metatarsal head,the possible association with lateral soft tissues release(LSTR)and osteotomy of the base of the first *** To evaluate the role of LSTR on percutaneous HV correction,evaluating functional and radiographical *** From January 2012 to May 2016 a total of 396 patients with mild to moderate symptomatic HV treated with the MIS technique were included in this retrospective *** technique provides no internal fixation(WOS).Patients were divided into the LSTR group and no LSTR group(LSTR N).This surgical procedure(LSTR)was reserved for insufficient HV angle(HVA)correction during fluoroscopic *** were evaluated at each follow-up by two other authors after appropriate training by senior authors(first practitioners).Clinical evaluation was performed before surgery,6 mo after surgery,and 48 mo *** Orthopaedic Foot and Ankle Society(AOFAS)and visual analog scale(VAS)score was used to evaluate pain and function,and complications were *** addition,the incidence of relapses and the degree of joint range of motion(ROM)with the association with the LSTR(capsule,adductor tendon,phalanx-sesamoid ligament,and the deep transverse metatarsal ligament)were *** parameters included HVA and intermetatarsal angle(IMA).Patient satisfaction was *** t-test and Fisher exact test were used to assess statistical *** From our study it is clear that no differences in term of HVA,VAS,IMA correction,rate of complications,and AOFAS score were found between groups,while a significant improvement of the same variables was found in each group between pre and postoperative values.A significant improvement in ROM at 6 mo(P=0.018)and 48 mo(P=0.02)of

关键词： Hallux valgus Percutaneous distal osteotomy Lateral release Minimally invasive surgery Without ostheosynthesis Range of motion

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