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Maternal low protein diet induces persistent expression changes in metabolic genes in male rats

World Journal of Diabetes 2020年第5期11卷 182-192页

作者： Allan de Oliveira Lira JoséLuiz de Brito Alves Mariana Pinheiro Fernandes Diogo Vasconcelos david Filipe Santana João Henrique da Costa-silva Béatrice Morio Carol Góis leandro Luciano Pirola Department of Nutrition Federal University of PernambucoVitoria de Santo AntãoPernambuco 55608680Brazil Department of Nutrition Federal University of ParaíbaJoao Pessoa 74556060Brazil Henrique da Costa-silva Luciano PirolaDepartment of Physical Education and Sport SciencesFederal University of PernambucoVitoria de Santo AntãoPernambuco 55608680Brazil Carmen(Cardiology Metabolism and Nutrition)LaboratoryINSERM U1060Lyon-1 UniversitySouth Lyon Medical FacultyPierre Benite 69310France

BACKGROUND Perinatal exposure to a poor nutritional environment predisposes the progeny to the development of metabolic disease at the adult age,both in experimental models and *** adaptive responses to maternal protein restriction have been reported in metabolic ***,the expression of glucose/fatty acid metabolism-related genes in adipose tissue and liver needs to be *** To evaluate the metabolic impact of perinatal malnutrition,we determined malnutrition-associated gene expression alterations in liver and adipose *** In the present study,we evaluated the alterations in gene expression of glycolytic/Krebs cycle genes(Pyruvate dehydrogenase kinase 4 and citrate synthase),adipogenic and lipolytic genes and leptin in the adipose tissue of offspring rats at 30 d and 90 d of age exposed to maternal isocaloric low protein(LP)diet throughout gestation and *** also evaluated,in the livers of the same animals,the same set of genes as well as the gene expression of the transcription factors peroxisome proliferator-activated receptor gamma coactivator 1,forkhead box protein O1 and hepatocyte nuclear factor 4 and of gluconeogenic *** In the adipose tissue,we observed a transitory(i.e.,at 30 d)downregulation of pyruvate dehydrogenase kinase 4,citrate synthase and carnitine palmitoyl transferase 1b gene *** transcriptional changes did not persist in adult LP rats(90 d),but we observed a tendency towards a decreased gene expression of leptin(P=0.052).The liver featured some gene expression alterations comparable to the adipose tissue,such as pyruvate dehydrogenase kinase 4 downregulation at 30 d and displayed other tissue-specific changes,including citrate synthase and fatty acid synthase upregulation,but pyruvate kinase downregulation at 30 d in the LP group and carnitine palmitoyl transferase 1b downregulation at 90 *** gene alterations,together with previously described changes in gene expression in

关键词： Metabolic adaptation Phenotype plasticity Liver Adipose tissue Metabolism Maternal protein undernutrition Rats

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Contribution of the Incorporation of Poultry Litter and Limestone for the Fertility of Sandy Soil in the Brazilian Amazon

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Natural Resources 2014年第15期5卷 958-967页

作者： Juliana Guimaraes Gerola Juan Ricardo Rocha Stella Cristiani Goncalves Matoso leandro Dias da silva Agricultural Engineering Federal Institute of RondoniaCampus Colorado do OesteColorado do OesteBrazil Biodiversity and Biotechnology of the Amazon at the BIONORTE Network ManausBrazil Soil Science Federal Institute of RondoniaCampus Colorado do OesteColorado do OesteBrazil Soil Laboratory Federal Institute of RondoniaCampus Colorado do OesteColorado do OesteBrazil

Sandy soils have limitations for growing plants. In general, they have low fertility, high toxic aluminum content and low organic matter. The organic matter is responsible for most of the cation exchange capacity of these soils. Added to this, the low clay content and the structure of these soils with large volumes of macropores, determine their low water retention. An alternative is the incorporation of organic waste combined with the practice of liming. Thus, the aim of this study was to evaluate the contribution of the incorporation of poultry litter and limestone in the fertility of sandy soils in the Brazilian Amazon. The experiment was conducted in Colorado do Oeste, RO, on a Quartzipsamment in a completely randomized block design in a 4 × 4 × 2 factorial scheme, corresponding to four doses of poultry litter (0, 5, 10 and 15 mg·ha-1), its incorporation for four times (0, 75, 110 and 145 days) in the presence and absence of 2 mg·ha-1 of limestone, with six replications. The incorporation of 15 mg·ha-1 of poultry litter combined with 2 mg·ha-1 of limestone for 75 days after the merger raises several components of Quartzipsamment fertility, mainly being the availability of phosphorus.

关键词： Quartzipsamments Organic Waste Liming

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基于GIS方法与综合城市规划计算城市林地损失--以巴西Jo§io Pessoa为例

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Journal of Geographical Sciences 2021年第10期31卷 1529-1552页

作者： leandro Ismael de Azevedo LACERda JoséAugusto Ribeiro da SILVEIRA Celso Augusto Guimarães SANTOS Richarde Marques da silva Alexandro Medeiros silva Thiago Victor Medeiros do NASCIMENTO Edson Leite RIBEIRO Paulo Vitor Nascimento de FREITAS Federal University of Paraíba Laboratory of Urban and Built Environment-LAURBE58051-900 João PessoaParaíbaBrazil Federal University of Paraíba Department of Architecture and Urbanism58051-900 João PessoaPBBrazil Federal University of Paraíba Department of Civil and Environmental Engineering58051-900 João PessoaPBBrazil Federal University of Paraíba Department of Geosciences58051-900 João PessoaPBBrazil Ministry of Cities Setor de Autarquias SulQuadra 01Lote 01/06Bloco HEd.Telemundi II70070-010 BrasíliaDFBrazil

Urban forests play an important role in the thermal comfort and overall life of local populations in large-and medium-sized *** study analyzes urban forest loss and maps land use and land cover(LULC)changes between 1991 and 2018 by evaluating the use of urban planning instruments for the mitigation of urban forest loss in Jo?o Pessoa,*** this purpose,satellite-derived LULC images from 1991,2006,2010 and 2018 and data on urban forest loss areas obtained using the Google Earth Engine were *** addition,this paper also discusses the instruments used for integrated urban planning,which are(a)the legal sector,responsibility and nature;(b)the urban expansion process;and(c)the elements of urban *** results show a clear shift in land use in the study *** major changes in LULC classes occurred in urban areas and herbaceous vegetation,while the greatest loss was in arboreal/shrub ***,an increase in the pressure to occupy zones intended for environmental preservation could be *** results showed similar accuracies with other studies and more spatial *** characteristics of the patterns,traces,and hotspots of urban expansion and forest cover loss were *** highlighted the potential use of this proposed framework to be applied and validated in other parts of the world to help better understand and quantify various aspects of urban-related problems such as urban forest loss mapping using instruments for integrated urban planning and low-cost approaches.

关键词： integrated planning mapping thematic synthesis urban afforestation urban planning

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Retro-Analysis of Rehabilitation of Existing Bridge over the River Cubiculo on Federal Highway BR-101, Brazil

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Journal of Mechanics Engineering and Automation 2016年第8期6卷 434-441页

作者： Iviane Cunha e Santos fabio Pessoa da silva Nunes Thyala Anarelli Cunha e Santos Road Directory National Department of Transportation Infrastructure Brasilia 70.040-902 Brazil Post-Graduate Program in Structures and Civil Construction University of Brasilia Brasilia 70.910-900 Brazil

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A re-evaluation of the Chaetothyriales using criteria of comparative biology

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Fungal Diversity 2020年第4期103卷 47-85页

作者： Yu Quan Lucia Muggia leandro F.Moreno Meizhu Wang Abdullah M.S.Al-Hatmi Nickolas da silva Menezes Dongmei Shi Shuwen Deng Sarah Ahmed Kevin D.Hyde Vania A.Vicente Yingqian Kang JBenjamin Stielow Sybren de Hoog Centre of Expertise in Mycology of Radboud University Medical Centre/Canisius Wilhelmina Hospital NijmegenThe Netherlands Key Laboratory of Environmental Pollution Monitoring and Disease Control Ministry of Education of Guizhou&Key Laboratory of Medical Microbiology and ParasitologySchool of Basic Medical SciencesGuizhou Medical UniversityGuiyangChina College of Food and Pharmaceutical Engineering Guizhou Institute of TechnologyGuiyangChina Department of Life Sciences University of TriesteTriesteItaly Amsterdam Medical Center AmsterdamThe Netherlands Foundation Atlas of Clinical Fungi HilversumThe Netherlands Ministry of Health Directorate General of Health ServicesIbriOman Postgraduate Program in Microbiology Parasitology and PathologyBiological SciencesDepartment of Basic PathologyFederal University of ParanaCuritibaBrazil Department of Dermatology&Laboratory of Medical Mycology Jining No.1 People’s HospitalJiningShandongChina Department of Medical Microbiology People’s Hospital of Suzhou National New&Hi-Tech Industrial Development ZoneSuzhouChina Center of Excellence in Fungal Diversity Mae Fah Luang UniversityChiang RaiThailand Thermo Fisher Diagnostics Specialty Diagnostics GroupLandsmeerThe Netherlands Guizhou Academy of Tobacco Science GuiyangChina Engineering Bioprocess and Biotechnology Post-graduation Program Department of Bioprocess Engineering and BiotechnologyFederal University of ParanaCuritibaBrazil

Chaetothyriales is an ascomycetous order within *** order is particularly known through the black yeasts and filamentous relatives that cause opportunistic infections in *** species in the order are consistently *** and habitats of species are highly diverse,and often rather extreme in terms of exposition and *** are defined on the basis of evolutionary history,which is reconstructed by time of divergence and concepts of comparative biology using stochastical character mapping and a multi-rate Brownian motion model to reconstruct ecological ancestral character *** is hypothesized to be with a rock-inhabiting life *** disparity increased significantly in late Jurassic,probably due to expansion of cytochromes followed by colonization of vacant *** diversification took place subsequently,but at a low level of innovation resulting in strong niche conservatism for extant *** are ecologically different in degrees of *** of the clades has adapted ant domatia,which are rich in *** derived families,similar processes have enabled survival in domesticated environments rich in creosote and toxic hydrocarbons,and this ability might also explain the pronounced infectious ability of vertebrate hosts observed in these *** systems of morphological classification poorly correspond with recent phylogenetic *** are hypothesized to have low competitive ability against neighboring microbes,which interferes with their laboratory isolation on routine *** dataset is unbalanced in that a large part of the extant biodiversity has not been analyzed by molecular methods,novel taxonomic entities being introduced at a regular *** study comprises all available species sequenced to date for LSU and ITS,and a nomenclatural overview is provided.A limited number of species could not be assigned to any extant family.

关键词： Black yeasts Phylogeny Ecology Ancestral reconstruction Evolution Nomenclature

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Proximal sensor-enhanced soil mapping in complex soil-landscape areas of Brazil

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Pedosphere 2021年第4期31卷 615-626页

作者： Sérgio H.G.silva david C.WEINDORF Wilson M.FARIA leandro C.PINTO Michele D.MENEZES Luiz R.G.GUILHERME Nilton CURI Department of Soil Science Federal University of LavrasLavras 37200-000(Brazil) Department of Earth and Atmospheric Sciences Central Michigan UniversityMount Pleasant 48858(USA)

Portable X-ray fluorescence(pXRF) spectrometry and magnetic susceptibility(MS) via magnetometer have been increasingly used with terrain variables for digital soil mapping. However, this methodology is still emerging in many countries with tropical soils. The objective of this study was to use proximal soil sensor data associated with terrain variables at varying spatial resolutions to predict soil classes using the Random Forest(RF) algorithm. The study was conducted on a 316-ha area featuring highly variable soil classes and complex soil-landscape relationships in Minas Gerais State, Brazil. The overall accuracy and Kappa index were evaluated using soils that were classified at 118 sites, with 90 being used for modeling and 28 for validation. Digital elevation models(DEMs) were created at 5-, 10-, 20-, and 30-m resolutions using contour lines from two sources. The resulting DEMs were processed to generate 12 terrain variables. Total Fe, Ti, and SiO_(2) contents were obtained using pXRF, with MS determined via a magnetometer. Soil class prediction was performed using the RF algorithm. The quality of the soil maps improved when using only the five most important covariates and combining proximal sensor data with terrain variables at different spatial resolutions. The finest spatial resolution did not always provide the most accurate maps. The high soil complexity in the area prevented highly accurate predictions. The most important variables influencing the soil mapping were MS, Fe, and Ti. Proximal sensor data associated with terrain information were successfully used to map Brazilian soils at variable spatial resolutions.

关键词： magnetic susceptibility magnetometer portable X-ray fluorescence spectrometer soil class soil spatial analysis spatial resolution terrain variables

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Automatic System for Failure Detection in Hydro-Power Generators

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Journal of Power and Energy Engineering 2014年第4期2卷 36-46页

作者： Luis Carlos Ribeiro Levy Ely de Lacerda de Oliveira Erik leandro Bonaldi Luiz Eduardo Borges da silva Camila Paes Salomon Jonas G. Borges da silva Germano Lambert-Torres Itapebi-Neoenergia Power Plant Co. Salvador Brazil Institute Gnarus Itajuba Brazil Itajuba Federal University Itajuba Brazil

This paper presents an automatic system for failure detection in hydro-power generators. The main idea of this system is to detect failure using current and voltage signals acquired without any type of internal interference in the generator operation. The detected failures could be mechanical or electrical origins, such as: problems in bearings, unwanted vibrations, partial discharges, misalignment, unbalancing, among others. It is possible because the generator acts as a transducer for mechanical problems, and they appear in current and voltage signals. This automatic system based on electric signature analysis has been installed in Itapebi Power Plant generators since 2012. Some results are presented in this paper.

关键词： Automatic System On-Line Measurements Digital Signal Processing Predictive Maintenance Failure Detection

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Emphysematous Complications Following Third Molars Removal: Incidence among 10779 Surgeries and Report of Two Cases

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Open Journal of Stomatology 2014年第7期4卷 352-357页

作者： leandro E. Klüppel Fernando Antonini Alessandro Costa da silva Márcio de Moraes Saulo Ellery Santos Oral and Maxillofacial Surgery Department School of Dentistry Universidade Estadual de Campinas Piracicaba Brazil

Subcutaneous emphysema is a condition that results from introduction of air into soft tissues. In head and neck, it is commonly observed following fractures of paranasal sinuses. Less frequently, it may occur during surgical procedures for tooth removal, when air from dental hand-pieces is forced into surgical site. Depending on its extension, it may involve vital spaces such as mediastinum. This specific finding may induce life-threatening situations. The aim of this article is to establish the incidence of subcutaneous emphysema among 10,779 impacted third molar surgical procedures and report the cases in which such complications had occurred. In this retrospective study, data collected from 10,779 third molar extraction procedures performed at Piracicaba School of Dentistry were evaluated for the occurrence of subcutaneous emphysema. Two cases of subcutaneous emphysema (0.018%) occurred following extraction of impacted third molars. Both were associated with mandibular tooth and related to the use of dental air hand-piece. One of the cases involved submandibular and buccal spaces while the other involved buccal and canine spaces. Regression of emphysema occurred spontaneously and postoperative recovery was uneventful. Subcutaneous emphysema following impacted third molar extractions is rare and strongly associated with the use of air turbines. Follow-up and preservation are the treatments of choice, but clinicians should be aware about the possibility of microbial spreading through facial spaces.

关键词： Subcutaneous Emphysema Impacted Tooth Air Hand-Piece

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Updates in the Diagnosis of Gestational Trophoblast Disease

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Health 2023年第1期15卷 48-58页

作者： Maira de Lima Oliveira Mota Marcela Curvêllo Beltrão Elizabeth Bacha Eduardo Fonseca Mascarenhas Filho Maísa Mendonça de Jesus Nelson Henriky Felix Mascarenhas Tallys leandro Barbosa da silva Maria Fernanda Telles Pires de Souza Victoria de Oliveira Carmo Borges Séfora Maria Fragoso Braga Centro Universitário Tiradentes (UNIT) Maceió Brasil Estácio de Juazeiro do Norte (FMJ) Ceará Brasil Universidade Federal de Alagoas (UFAL) Maceió Brasil Sã o Leopoldo Mandic Campinas Brasil Hospital Regional de Arapiraca Arapiraca Brasil

GTD (Gestational Trophoblastic Disease) is a pathology that encompasses benign and malignant clinical forms, affects women of childbearing age, has a variable incidence and is more frequent in developing or underdeveloped countries, colliding with the economic barrier. The frequent absence of clear protocols and guidelines for the correct diagnosis of the pathology results in inadequate classification, imprecise treatment and failed post-therapeutic observation, increasing the risk of relapses, morbidity and mortality. The present study aims to point out updated national and international practice protocols of diagnosis of GTD, through an integrative review. Seven articles were selected and it was observed that the main international reference centers are agreed with the management suggested by the IFGO (International Federation of Gynecology and Obstetrics), being the conduct in the Hydatidiform Mole (HM): evacuation by suction and curettage under ultrasound guidance, followed by hCG monitoring every 1 - 2 weeks until normalized (usually one month for Partial Hydatidiform Mole six months for Complete Hydatidiform Mole and one year for Gestational Trophoblastic Neoplasia). Unfortunately, regarding the diagnosis of MH, the guidelines of some countries show the absence or difficulty of access to the karyotype test and ploid p57 or pelvic ultrasound accompanying the uterine curettage, contrary to what is proposed by the IFGO guideline. Establishing and complying with consistent guidelines can improve patient care, with early diagnosis of the pathology and its complications, reducing the rate of recurrence, morbidity and mortality, especially in less developed countries.

关键词： Diagnosis Gestational Trophoblastic Disease Updates

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CDX2 Overexpression in Barrett’s Esophagus and Esophageal Adenocarcinoma

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Journal of Cancer Therapy 2014年第7期5卷 657-663页

作者： leandro Almeida Streher Vinicius Campos Guilherme da silva Mazzini Marcelo Binato Luise Meurer Maria Isabel Edelweiss Richard Ricachenevsky Gurski Gastrointestinal Surgery Department Hospital de Clínicas de Porto Alegre Porto Alegre Brazil School of Medicine Universidade Federal do Rio Grande do Sul Porto Alegre Brazil

Background: Patients with Barrett’s esophagus have an increased risk of developing esophageal adenocarcinoma. Our purpose was to determine CDX2 expression in esophageal mucosa and establish a correlation between this marker and the progression of disease. Methods: We analyzed biopsies and surgical specimens from 150 patients who were divided into five groups according to histopathological diagnosis: G1, normal mucosa (n = 29);G2, esophagitis (n = 19);G3, columnar epithelium without intestinal metaplasia (n = 26);G4, Barrett’s esophagus (n = 32), and G5, adenocarcinoma (n = 44). Immuno-histochemical determination of CDX2 expression was considered positive in the presence of nuclear staining. Results: No CDX2 expression was detected in the G1 or G3 groups;5% of G2, 62.5% of G4 and 70.5% of G5 patients were CDX2 positive. There was a statistically significant difference between the G4 and G5 groups compared to the G1, G2 and G3 (p < 0.05). Conclusions: CDX2 expression was observed among patients with Barrett’s esophagus and adenocarcinoma compared to other groups. CDX2 was not expressed in the phases preceding Barrett’s esophagus, but there was no linear correlation between CDX2 expression and metaplasia-adenocarcinoma progression.

关键词： CDX2 Barrett’s Esophagus Intestinal Metaplasia Esophageal Adenocarcinoma Immunohistochemistry

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