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Mitochondria. DNa.methyla.ion a.d mitochondria.rela.ed epigenetics in neurodegenera.ion

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Neura. Regenera.ion Resea.ch 2024年第2期19卷 405-406页

作者： fabio Coppedè Depa.tment of Tra.sla.iona. Resea.ch a.d of New Surgica. a.d Medica. Technologies Laboratory of Medical GeneticsUniversity of PisaPisaItaly、Interdepartmental Research Center of Biology and Pathology of AgingUniversity of PisaPisaItaly

Mitochondria.a.e cytopla.mic orga.elles referred to a. the powerhouse of the cell beca.se they a.e prima.ily involved in oxida.ive phosphoryla.ion a.d energy *** a.e pa.ticula.ly a.unda.t in tissues with high energy dema.ds,including muscle,liver,a.d bra.n,a.d mitochondria. dysfunction,oxida.ive mitochondria. DNa.mtDNa.da.a.e,a.d impa.red mitochondria. dyna.ics ha.e often been a.socia.ed with neurodegenera.ion.

关键词： impa.red neurodegenera.ion oxida.ive

Knowledge-Enha.ced Conversa.iona. a.ents

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Journa. of Computer Science & Technology 2024年第3期39卷 585-609页

作者： fabio Ca.fa.o Giuseppe Rizzo LINKS Founda.ion 10138 TurinItaly

Huma.ity ha. fa.ta.ized a.out a.tificia. intelligence tools a.le to discuss with huma. beings fluently for *** efforts ha.e been proposed ra.ging from ELIZa.to the modern voca. *** the la.ge interest in this resea.ch a.d innova.ion field,there is a.la.k of common understa.ding on the concept of conversa.iona. a.ents a.d genera. over expecta.ions tha. hide the current limita.ions of existing *** work proposes a.litera.ure review on the subject with a.focus on the most promising type of conversa.iona. a.ents tha. a.e powered on top of knowledge ba.es a.d tha. ca. offer the ground knowledge to hold conversa.ion a.tonomously on different *** describe a.conceptua. a.chitecture to define the knowledge-enha.ced conversa.iona. a.ents a.d investiga.e different doma.ns of *** conclude this work by listing some promising resea.ch pa.hwa.s for future work.

关键词： conversa.iona. a.ent dia.ogue system knowledge enha.cing a.tificia. a.ent intelligent conversa.ion

a.qua.tita.ive a.a.ysis of the US ma.eria.s flow methodology a.d compa.ison to the EU methodology for MSW sta.istics

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Wa.te Disposa. a.d Susta.na.le Energy 2024年第1期6卷 85-94页

作者： Demetra.Tsia.is fabio Poretti Stefa.o Consonni Ma.co J.Ca.ta.di Ea.th Engineering Center Department of Chemical EngineeringThe City College of New YorkNew YorkNYUSA Dipa.timento Di Energetica Politecnico Di MilanoPiazza Leonardo da Vinci 3220133MilanItaly

The Europea. Union(EU)a.d the United Sta.es(US)determine municipa. solid wa.te(MSW)sta.istics *** EU a.plies a.site-specific methodology tha. directly mea.ures wa.te wherea. the US employs a.ma.eria.s flow methodology tha. estima.es MSW sta.istics indirectly ba.ed on production a.d recovery da.a.from *** study dissects the ma.eria.s flow methodology a.d presents qua.tita.ive ma.eria.s flow Sa.key dia.ra.s for the prima.y MSW ma.eria.s to highlight da.a.ga.s tha. ca. be a.dressed to improve the methodology’s *** industry pla.tics da.a.were a.plied to the ma.eria.s flow methodology,a.d the results were within 10%of the pla.tics sta.istics reported by the US Environmenta. Protection a.ency(US EPa..Dra.ba.ks to the methodologies include EU mea.urement ina.cura.ies due to double-counting a.d not a.counting for residua. wa.te in the *** la.ter ma. pa.tia.ly expla.n why la.dfilling tonna.es reported by the US EPa.were a.proxima.ely 60%less tha. the tonna.es reported by the Wa.te to Energy Resea.ch a.d Technology Council(WTERT)in its na.iona. MSW survey tha. a.plied the EU methodology in the *** the EU,there is no US na.iona. policy tha. requires sta.es to mea.ure a.d report sta.e-level wa.te da.a.to the US *** improvements in US MSW sta.istics rely hea.ily on the implementa.ion of na.iona. policies to homogenize the mea.urement a.d collection of wa.te da.a.from sta.es.

关键词： Ma.eria.s flow methodology Site-specific methodology United Sta.es Europea. Union Municipa. solid wa.te Discrepa.cy

In situ Simula.ion of Therma. Rea.ity

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Resea.ch 2024年第2期2023卷 685-690页

作者： Peng Jin Jinrong Liu Fuba. Ya.g fabio Ma.chesoni Jia.-Hua.Jia.g Jiping Hua.g Depa.tment of Physics State Key Laboratory of Surface Physicsand Key Laboratory of Micro and Nano Photonic Structures(MOE)Fudan UniversityShanghai 200438China Center for Phononics a.d Therma. Energy Science Shanghai Key Laboratory of Special Artificial Microstructure Materials and TechnologySchool of Physics Science and EngineeringTongji UniversityShanghai 200092China Depa.tment of Physics University of CamerinoCamerino 62032Italy Suzhou Institute for a.va.ced Resea.ch University of Science and Technology of ChinaSuzhou 215123China

Simula.ed rea.ity encompa.ses virtua.,a.gmented,a.d mixed rea.ities梕a.h cha.a.terized by different degrees of truthfulness in the visua. perception:"a.l fa.se","coexistence of true a.d fa.se,"a.d"difficult distinction between true a.d fa.se,"*** a.l these technologies,however,the tempera.ure rendering of virtua. objects is still a. unsolved ***,the la.k of therma. ta.tile functions substa.tia.ly reduces the qua.ity of the user's rea.-experience *** a.dress this cha.lenge,we propose theoretica.ly a.d rea.ize experimenta.ly a.technologica. pla.form for the in situ simula.ion of therma. *** this purpose,we design a.therma. meta.evice consisting of a.reconfigura.le a.ra. of ra.ia.ing units,ca.a.le of genera.ing the therma. ima.e of a.y virtua. object,a.d thus rendering it in situ together with its therma. *** is a.substa.tia. technologica. a.va.ce,which opens up new possibilities for simula.ed rea.ity a.d its a.plica.ions to huma. a.tivities.

关键词： fa.se rendering signa.ure

Predicting ca.diova.cula. events in out-of-hospita. pa.ients presenting with a.ypica. chest pa.n a.d complete left bundle bra.ch block: role of CTa.a.d echoca.diogra.hic Global Longitudina. Stra.n

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Journa. of Geria.ric Ca.diology 2024年第7期21卷 760-767页

作者： Guido Pa.torini fabio a.a.ta.io a.na.Botto Va.entina.Ta.divo Ma.ro Feola Ca.diology Division Regina Montis Regalis HospitalASLCN1Mondovi’Italy Intensive Ca.e Regina Montis Re-galis HospitalASLCN1 Mondovi’Italy School of Geria.ry University of MedicineTurinItaly

Ba.kground Out-of-hospita. pa.ients presenting with a.ypica. chest pa.n a.d complete left bundle bra.ch block(LBBB)ha.e to be stra.ified for the presence of corona.y a.tery disea.e a.d the risk of developing hea.t fa.lure(HF).We investiga.ed the pro-gnostic role of corona.y CT-a.giogra.hy(CTa.a.d echoca.diogra.hic global longitudina. stra.n(GLS)in those pa.ients in a.mid-term *** Out-of-hospita. pa.ients with LBBB underwent echoca.diogra.hy a.d a.64-slice CT a.giogra.hy were eva.ua.ed *** of HF or a.ca.diova.cula. dea.h were the events *** Seventy-eight pa.ients(32 fema.e;mea. a.e:66.0±10.4 yea.s were *** a.follow-up of 33 months(IQR:17-77),one pa.ient(1.5%)experienced a.ca.diova.cula. dea.h,14 pa.ients(17.9%)required urgent outpa.ient visits due to a.ute de-compensa.ed HF(12 hospita.iza.ions).Echoca.diogra.hy showed a.slightly reduced left ventricula. ejection fra.tion(LVEF)(50.0%±9.8%)a.d GLS within the norma. ra.ge(-16.2%±4.1%).CTa.a.a.ysis showed corona.y stenosis>50%in 28 pa.ients(35.9%).a.high a.a.ston score(>100)wa. observed in 29.5%.Nota.ly,25 pa.ients(32.1%)were dia.nosed with left ma.n coron-a.y a.tery disea.e a.d 15 pa.ients(16.7%)underwent reva.cula.iza.ion during the follow *** a.socia.ions were ob-served between events a.d LVEF(P=0.001),dia.tolic dysfunction gra.e≥2(P=0.02),GLS(Pa.y stenos-is(P=0.04)a.d a.a.ston score(P=0.05).Multiva.ia.e a.a.ysis confirmed the rela.ionships with LVEF(R^(2)=0.89,Pa.stolic dysfunction(R^(2)=3.30,P=0.04),GLS(R^(2)=1.43,Pa.d a.a.ston score(R^(2)=1.01,P=0.05).Conclusions In pa.ients with complete LBBB,CTa.a.d GLS identified those a. a.high risk of development HF.

关键词： pa.ients echoca.diogra.hic bra.ch

Physica. exercise a.d syna.tic protection in huma. a.d pre-clinica. models of multiple sclerosis

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Neura. Regenera.ion Resea.ch 2024年第8期19卷 1768-1771页

作者： Federica.a.zolini Ettore Dolcetti a.tonio Bruno Va.entina.Rovella.Diego Centonze fabio Butta.i Unit of Neurology IRCCS NeuromedPozzilliItaly Depa.tment of System Medicine University of Tor VergataRomeItaly Syna.tic Immunopa.hology La. Department of Systems MedicineTor Vergata UniversityRomeItaly

In multiple sclerosis,only immunomodula.o ry a.d immunosuppressive drugs a.e recognized a. disea.e-modifying *** r,in recent yea.s,severa. da.a.from pre-clinica. a.d clinica. studies suggested a.possible role of physica. exe rcise a. disea.e-modifying thera.y in multiple *** evidence is spa.se a.d often conflicting,a.d the mecha.isms underlying the neuroprotective a.d a.tinfla.ma.ory role of exercise in multiple sclerosis ha.e not been fully ***,ma.nly derived from pre-clinica. studies,suggest tha. exe rcise could enha.ce longterm potentia.ion a.d thus neuropla.ticity,could reduce neuroinfla.ma.ion a.d syna.topa.hy,a.d da.pen a.trogliosis a.d *** huma.s,most tria.s focused on direct clinica. a.d MRI outcomes,a. investiga.ing syna.tic,neuroinfla.ma.o ry,a.d pa.hologica. cha.ges is not stra.ghtfo rwa.d compa.ed to a.ima. *** present review a.a.yzed current evidence a.d limita.ions in resea.ch concerning the potentia. disea.e-modifying thera.y effects of exercise in multiple sclerosis in a.ima. models a.d huma. studies.

关键词： disea.e-modifying beha.iour endoca.na.inoid system long-term potentia.ion multiple sclerosis neuropla.ticity neuroprotection physica. exercise syna.topa.hy

Pola.iza.ion Study of Swift J151857.0–572147 with IXPE Observa.ion

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Resea.ch in a.tronomy a.d a.trophysics 2024年第9期24卷 60-65页

作者： Yu-Sha. Ling Fei Xie Ming-Yu Ge fabio La.Mona.a Gua.gxi Key La.ora.ory for Rela.ivistic a.trophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Key La.ora.ory of Pa.ticle a.trophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China INa. Istituto di a.trofisica.e Pla.etologia.Spa.ia.i Via del Fosso del Cavaliere 10000133 RomaItaly Dipa.timento di Fisica Universitàdegli Studi di Roma“Tor Vergata”Via della Ricerca Scientifica 100133 RomaItaly Dipa.timento di Fisica Universitàdegli Studi di Roma“La Sapienza”Piazzale Aldo Moro 500185 RomaItaly

We present a. a.a.ysis of the Ima.ing X-ra. Pola.imetry Explorer observa.ion from a.newly discovered tra.sient source:Swift *** obta.ned pola.iza.ion degree(PD)a.d a.gle a.e 0.3%±0.3% a.d -24°±26°respectively in 2-8 keV within 68%confidence level errors,a.d pola.iza.ion results a.e below MDP99in a.l energy bins,with the upper limit on PD of 0.8% in the 2-8 keV energy *** qua.i-periodic oscilla.ions(QPOs)a.e detected in this *** pola.iza.ion a.d QPO a.a.yses support the hypothesis tha. the source wa. in the high soft sta.e,a.d the results a.e consistent with predictions for a.thin a.cretion disk model.

关键词： sta.s:bla.k holes pola.iza.ion X-ra.s:bursts

Time-Series Embeddings from La.gua.e Models:a.Tool for Wind Direction Nowca.ting

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Journa. of Meteorologica. Resea.ch 2024年第3期38卷 558-569页

作者： Decio a.VES fabio MENDONCa.Sheikh Sha.a.a. MOSTa.a.Ferna.do MORGa.O-DIa. University of Ma.eira Campus Universitário da Penteada9020-105FunchalPortugal Intera.tive Technologies Institute/La.ora.ory for Robotics a.d Engineering Systems a.d a.ência.Regiona. pa.a.o Desenvolvimento da.Investiga.ão Tecnologia e InovaçãoEdif.Madeira TecnopoloCaminho da Penteada piso-29020-105FunchalPortugal

Wind direction nowca.ting is crucia. in va.ious sectors,pa.ticula.ly for ensuring a.ia.ion opera.ions a.d *** this context,the TELMo(Time-series Embeddings from La.gua.e Models)model,a.sophistica.ed deep lea.ning a.chitecture,ha. been introduced in this work for enha.ced wind-direction *** by using three yea.s of da.a.from multiple sta.ions in the complex terra.n of a. interna.iona. a.rport,TELMo incorpora.es the horizonta. u(ea.t-west)a.d v(north-south)wind components to significa.tly reduce foreca.ting *** a.da. with high wind direction va.ia.ility,TELMo a.hieved mea. a.solute error va.ues of 5.66 for 2-min,10.59 for 10-min,a.d 14.79 for 20-min foreca.ts,processed within a.swift 9-ms/step *** degree-ba.ed a.a.ysis,in compa.ison,yielded lower performa.ce,empha.izing the effectiveness of the u a.d v *** contra.t,a.Va.illa.neura. network,representing a.sha.low-lea.ning a.proa.h,underperformed in a.l a.a.yses,highlighting the superiority of deep lea.ning methodologies in wind direction *** is a. efficient model,ca.a.le of a.cura.ely foreca.ting wind direction for a.r tra.fic opera.ions,with a. error less tha. 20°in 97.49%of the predictions,a.igning with recommended interna.iona. *** model design ena.les its a.plica.ility a.ross va.ious geogra.hica. loca.ions,ma.ing it a.versa.ile tool in global a.ia.ion meteorology.

关键词： wind nowca.ting wind components wind direction time series prediction deep lea.ning

Diplopoda.in the world fossil record

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Zoologica. Systema.ics 2024年第3期49卷 185-245页

作者： Michelle Álva.ez-Rodríguez Fra.cisco Riquelme Miguel Hernández-Pa.ricio fabio Cupul-Ma.a.a La.ora.orio de Sistemática.Molecula. Escuela de Estudios Superiores del JicareroUniversidad Autónoma del Estado de MorelosC.P.62909JojutlaMorelosMexico MMRN Centro de Investigaciones BiológicasUniversidad Autónoma del Estado de MorelosC.P.62209CuernavacaMorelosMexico Una.ília.e Centro Universita.io de la.Costa Universidad de GuadalajaraC.P.48280Puerto VallartaJaliscoMexico

We present a.comprehensive ca.a.og with a. upda.ed da.a.a.e of the fossil record of Diplopoda.in the *** da.a.wa. collected from descriptions a.d reports published from 1854 to the *** a.so include new records from Mexica. a.ber(Upper Oligocene-Lower Miocene),counting 83 unknown fossil inclusions,with the first records of the orders Polyxenida.Pla.ydesmida.a.d Julida.a. well a. the fa.ilies Spha.riodesmida. a.d Trichopolydesmida. within *** to our results,Diplopoda.counts 413 records fea.uring 299 distinct ta.a.ra.ging from the Middle Siluria. to the Upper Pleistocene,representing three subcla.ses,two subtercla.ses,six superorders,25 orders,15 superfa.ilies,55 fa.ilies,93 genera.a.d 161 fossil *** da.e,no fossils of the order Siphonocryptida.ha.e been *** fossil record extends over three geologica. era.:the Pa.eozoic,with 161 ta.a.including 97 species;the Mesozoic,with 53 ta.a.a.d 22 species;a.d the Cenozoic,with 85 ta.a.a.d 42 *** referred ma.eria. shows different forms of fossil *** comprises 123 impressions,99 compressions,26 ichnites,predomina.tly from Pa.eozoic a.d Mesozoic sediments,a.d 165 a.ber inclusions from la.e Mesozoic a.d Cenozoic ***,this ca.a.og a.lows us to estima.e the size a.d ta.onomic composition of Diplopoda.in the fossil record worldwide.

关键词： Millipedes Pa.eozoic Mesozoic Cenozoic new records ca.a.og