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In vitro Cyto and Blood Compatibility of Titanium Containing Diamond-Like Carbon Prepared by Hybrid Sputtering Method

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Plasma Science and Technology 2012年第9期14卷 829-836页

作者： Krishnasamy NAVANEETHA PANDIYARAJ Jan HEEG Andreas LAMPKA fabian JUNGE Torsten BARFELS Marion WIENECKE Young Ha RHEE Hyoung Woo KIM Department of Physics Sri Shakthi Institute of Engineering and Technology Institute of Surface and Thin Film Technology Hochschule WismarGermany Department of Microbiology College of Bioscience&BiotechnologyChungnam National University

In recent years, diamond-like carbon films （DLC） have been given more attention in research in the biomedical industry due to their potential application as surface coating on biomedical materials such as metals and polymer substrates. There are many ways to prepare metal containing DLC films deposited on polymeric film substrates, such as coatings from car- bonaceous precursors and some means that incorporate other elements. In this study, we in- vestigated both the surface and biocompatible properties of titanium containing DLC （Ti-DLC） films. The Ti-DLC films were prepared on the surface of poly （ethylene terephthalate）（PET） film as a function of the deposition power level using reactive sputtering technique. The films＇ hydrophilicity was studied by contact angle and surface energy tests. Their surface morphology was studied by scanning electron microscopy （SEM） and atomic force microscopy （AFM）. Their elemental chemical composition was analyzed using energy dispersive X-spectra （EDX） and X-ray photoelectron spectroscopy （XPS）. Their blood and cell compatibility was studied by in vitro tests, including tests on platelet adhesion, thrombus formation, whole blood clotting time and osteoblast cell compatibility. Significant changes in the morphological and chemical composition of the Ti-DLC films were observed and found to be a function of the deposition level. These morphological and chemical changes reduced the interfacial tension between Ti-DLC and blood proteins as well as resisted the adhesion and activation of platelets on the surface of the Ti-DLC films. The cell compatibility results exhibited significant growth of osteoblast cells on the surface of Ti incorporated DLC film compared with that of DLC film surface.

关键词： Ti-DLC hybrid reactive sputtering technique surface analysis cyto and blood compatibility

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A New Statistical Tool： Scalar Score Function

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Computer Technology and Application 2011年第2期2卷 109-116页

作者： Zdenek fabian Institute of Computer Science Academy of Sciences CR Pod Vod6renskou vY2i 2 Prague 182 00 Czech Republic

The basic inference function of mathematical statistics, the score function, is a vector function. The author has introduced the scalar score, a scalar inference function, which reflects main features of a continuous probability distribution and which is simple. Its simplicity makes it possible to introduce new relevant numerical characteristics of continuous distributions. The t-mean and score variance are descriptions of distributions without the drawbacks of the mean and variance, which may not exist even in cases of regular distributions. Their sample counterparts appear to be alternative descriptions of the observed data. The scalar score itself appears to be a new mathematical tool, which could be used in solving traditional statistical problems for models far from the normal one, skewed and heavy-tailed.

关键词： Statistics inference function data characteristics point estimates heavy tails.

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Variation-aware fault modeling

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Science China(Information Sciences) 2011年第9期54卷 1813-1826页

作者： HOPSCH fabian BECKER Bernd HELLEBRAND Sybille POLIAN Ilia STRAUBE Bernd VERMEIREN Wolfgang WUNDERLICH Hans-Joachim Fraunhofer IIS/EAS University of Freiburg University of Paderborn University of Passau University of Stuttgart

To achieve a high product quality for nano-scale systems,both realistic defect mechanisms and process variations must be taken into *** existing approaches for variation-aware digital testing either restrict themselves to special classes of defects or assume given probability distributions to model variabilities,the proposed approach combines defect-oriented testing with statistical library *** uses Monte Carlo simulations at electrical level to extract delay distributions of cells in the presence of defects and for the defect-free *** allows distinguishing the effects of process variations on the cell delay from defect-induced cell delays under process *** provide a suitable interface for test algorithms at higher levels of abstraction,the distributions are represented as histograms and stored in a histogram data base (HDB).Thus,the computationally expensive defect analysis needs to be performed only once as a preprocessing step for library characterization,and statistical test algorithms do not require any low level information beyond the *** generation of the HDB is demonstrated for primitive cells in 45 nm technology.

关键词： process variations test methods statistical test histogram data base

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Open wedge re-correction high tibial osteotomy in an elderly patient with a varus angulated non-united dome-shaped high tibial osteotomy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第11期14卷 1054-1058页

作者： Steffen SCHROTER Lukas KONSTANTINIDIS Tobias M. KRAUS fabian STUBY Ulrich STOCKLE Thomas FREUDE Department of Traumatology and Reconstructive Surgery BG Trauma Center Department of Orthopaedics and Trauma Surgery University Medical Centre Freiburg

The high tibial osteotomy(HTO)is a wellestablished and commonly used treatment for younger and active patients with a medial unicompartmental osteoarthritis of the knee and varus *** aim of this technique is to shift the load to a functional lateral compartment in order to delay total knee *** dome-shaped HTO was introduced by Blaimont et al.(1975)and later popularized by Maquet(1980).Out of 118 cases,96 cases of overcorrection,13 cases of undercorrection,and 9 cases

关键词： HTO MPTA high

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In vitro Evaluation with 5SBF of Alloy ASTM F75 Thermally Treated with Wollastonite

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Journal of Wuhan University of Technology(Materials Science) 2016年第3期31卷 487-490页

作者： MUNIZ Rodrigo ORTIZ Juan LUNA Jesus MARTINEZ Jesus RODRIGEZ Nelly HERNANDEZ Marco OROZCO Pilar EQUIHUA fabian Faculty of Engineering Autonomous University of CoahuilaCUSaltilloMexico Department of Metal Mechanics Technological Institute of SaltilloMexico Faculty of Engineering Mechanical and Electrical Autonomous University of Nuevo LeonMexico Faculty of Engineering Autonomous University of Zacatecas Faculty of Mechanical and Electrical Engineering Autonomous University of Coahuila North UnitMonclovaMexico

Samples of a cobalt-based alloy that underwent a surface treatment were evaluated. The samples, which were obtained by casting alloy ASTM F 75, were ground and polished on one side until a mirror finish was obtained. The samples were encapsulated in wollastonite （W） using uniaxial pressure, treated at 1 220 ~C for 1 h and subsequently tempered in water. The characterisation of the sample indicated that part of the ceramic encapsulating material was mechanically incorporated on the metallic surface by growth of the oxide layer of the alloy. After thermal treatment, a series of specimens were submerged in a solution with 5-fold simulated body fluid （5SBF） for 3, 5 and 21 days. Characterisation by scanning electron microscopy （SEM）, energy dispersive spectroscopy （EDS） and X-ray diffraction （XRD） indicated nucleation and growth of a homogenous layer of apatite, beginning on the third day when the sample was submerged.

关键词： cobalt-based alloy wollastonite 5SBF apatite.

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Evaluation of Ultrasound-based Surveillance for Hepatocellular Carcinoma in Patients at Risk:Results From a German Multicenter Retrospective Cohort Study

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Journal of Clinical and Translational Hepatology 2023年第3期11卷 626-637页

作者： Johannes Gillessen Philipp Reuken Peter-Marton Hunyady Matthias Christian Reichert Lucian Lothschütz fabian Finkelmeier Matthias Nowka Gabriel Allo fabian Kütting Martin Bürger Dirk Nierhoff Hans-Michael Steffen Christoph Schramm University Hospital Cologne Department of Gastroenterology and HepatologyCologneGermany University Hospital Jena Department of Internal Medicine IV-GastroenterologyHepatologyInfectious DiseaseJenaGermany University Hospital Frankfurt Department of Internal Medicine 1-Gastroenterology und HepatologyPulmonology und AllergologyEndocrinologyFrankfurtGermany Department of Medicine II Saarland University Medical CenterHomburgGermany Department of Gastroenterology and Hepatology University Hospital of EssenEssenGermany

Background and Aims:Hepatocellular carcinoma(HCC)surveillance in patients at risk is strongly recommended and usually performed by ultrasound(US)semiannually with or without alfa-fetoprotein(AFP)*** pa-rameters except for surveillance intervals have not been strictly *** aimed to evaluate surveillance success and risk factors for surveillance ***:Patients with≥1 US prior to HCC diagnosis performed at four tertiary referral hospitals in Germany between 2008 and 2019 were retrospectively *** success was defined as HCC detection within Milan ***:Only 47%of 156 patients,median age 63(interquartile range:57-70)years,56%male,and 96%with cirrhosis,received recom-mended surveillance modality and *** fail-ure occurred in 29%and was significantly associated with lower median model for end-stage liver disease(MELD)score odds ratio(OR)1.154,95%confidence interval(CI):1.027-1.297,p=0.025)and HCC localization within right liver lobe(OR:6.083,95%CI:1.303-28.407,p=0.022),but not with AFP≥200μg/*** with surveillance failure had sig-nificantly more intermediate/advanced tumor stages(93%vs.6%,p<0.001),fewer curative treatment options(15%vs.75%,p<0.001)and lower survival at 1 year(54%vs.75%,p=0.041),2 years(32%vs.57%,p=0.019)and 5 years(0%vs.16%,p=0.009).Alcoholic and non-alcoholic fatty liver disease(OR:6.1,95%CI:1.7-21.3,p=0.005)and ascites(OR:3.9,95%CI:1.2-12.6,p=0.021)were in-dependently associated with severe visual limitations on ***:US-based HCC surveillance in patients at risk frequently fails and its failure is associated with unfavorable patient-related *** MELD score and HCC lo-calization within right liver lobe were significantly associated with surveillance failure.

关键词： Hepatocellular carcinoma Surveillance success Screening Ultra-sound.

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赋能柔性加工助力智能制造

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现代制造 2024年第1期 60-60页

作者：薄方彬 HAINBUCH中国

2023年疫情结束后,市场也在逐步复苏。随着市场需求的深层变局,面对新的机遇与挑战,HAINBUCH作为工装夹具的领头羊,坚持为客户提供高精度、高效率、快速更换以及个性化夹具的初心,不断进行技术革新和升级,致力于在柔性自动化加工领域大... 详细信息

2023年疫情结束后,市场也在逐步复苏。随着市场需求的深层变局,面对新的机遇与挑战,HAINBUCH作为工装夹具的领头羊,坚持为客户提供高精度、高效率、快速更换以及个性化夹具的初心,不断进行技术革新和升级,致力于在柔性自动化加工领域大放异彩。工装夹具行业是制造业的基础。

关键词：工装夹具柔性自动化智能制造柔性加工快速更换技术革新制造业高效率

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Preparation and application of highly porous aerogel-based bioactive materials in dentistry

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Frontiers of Materials Science 2014年第1期8卷 46-52页

作者： Andrea KUTTOR Melinda SZALOKI TLinde RENTE Farkas KERENYI Jozsef BAKO Istvan fabian Istvan LAZAR Attila JENEI Csaba HEGEDUES Department of Prosthetic Dentistry and Biomaterials Faculty of Dentistry University of Debrecen 4012 Debrecen Hungary Aerogel Research Group Department of Inorganic and Analytical Chemistry Faculty of Science University of Debrecen 4010 Debrecen Hungary Department of Dental Biochemistry Faculty of Dentistry University of Debrecen 4012 Debrecen Hungary Department of Biophysics and Cell Biology Faculty of Medicine University of Debrecen 4012 Debrecen Hungary

In this study, the possibility of preparation and application of highly porous silica aerogel-based bioactive materials are presented. The aerogel was combined with hydroxyapatite and *** phosphate as bioactive and osteoinductive agents. The porosity of aerogels was in themesoporous region with a maximum pore diameter of 7,4 and 12.7 nm for the composite materials. The newly developed bioactive materials were characterized by scant electron microscopy. The in vitro biological effect of these modified surfaces was also tested on SAOS-2 osteogenic sarcoma cells by confocal laser scanning microscopy.

关键词： aerogel sol-gel technique bioactive matedal SAOS-2 cell

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Does endurance training improve red blood cell aging and hemorheology in moderate-trained healthy individuals?

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Journal of Sport and Health Science 2020年第6期9卷 595-603页

作者： Daniel A.Bizjak fabian Tomschi Gunnar Bales Elie Nader Marc Romana Philippe Connes Wilhelm Bloch Marijke Grau Department of Molecular and Cellular Sports Medicine German Sport University CologneCologne 50933Germany Laboratoire LIBM EA7424-Equipe“Biologie Vasculaire et du Globule Rouge” UniversitéClaude Bernard Lyon 1Villeurbanne 69100France Laboratoire d’Excellence du Globule Rouge GR-Ex Paris 75015France Universitédes Antilles InsermUnitéBiologie Intégrée du Globule RougeCHU de PointeàPitrePointe_a PitreGuadeloupe 97157France Institut Universitaire de France Paris 75231France The German Research Centre of Elite Sport German Sport University CologneCologne 50933Germany

Objective:To examine the impact of a 6-week endurance training on red blood cell(RBC)aging and deformability of healthy participants to detect possible improved hemorheological and performance-related ***:A total of 31 participants(17 females and 14 males)performed a 6-week moderate training protocol(three 1-h running sessions per week at 70%of maximal heart rate).Blood was sampled before and after the *** from each participant were fractioned according to density and age into 4 RBC *** were examined for changes of RBC properties,including aging distribution,RBC deformability,RBC microparticles,and phosphatidylserine *** and plasma nitrite levels were measured as indicators of nitric oxide ***:Aerobic performance,peak oxygen consumption,ventilatory thresholds,velocity at the aerobic-anaerobic threshold,and lactate at exhaustion improved after *** relative amount of both young RBCs and old RBCs increased,and the amount of the main RBC fraction *** externalization and RBC-derived microparticles *** deformability expressed as shear stress required to achieve half-maximum deformation to theoretical maximal elongation index at infinite shear stress improved in unfractioned RBCs(p<0.001).Nitrite decreased in total(p=0.001),young(p<0.001),main(p<0.001),and old(p=0.020)aged RBCs and in plasma(p=0.002),but not in very old ***:These results indicate that non-endurance-trained healthy participants benefit from a regular moderate running training program because performance-related parameters improve and a younger RBC population with improved RBC properties is induced,which might support oxygen supply in the microcirculation.

关键词： Cellular adaptation Hemorheology Nitric oxide Performance RBC physiology and aging

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基于建筑废物的人工湿地除磷滤料的制备及其性能

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环境工程技术学报 2024年第5期14卷 1572-1579页

作者：张震宇王泉龙发编沈琳珠周俊于会娟黎发明线二摆李雨欣大理大学工程学院大理大学农学与生物科学学院云南兆泓环境工程有限公司

高效、高容量的吸附滤料是提高人工湿地除磷效率的重要手段。以建筑废物(废混凝土和废泡沫砖)为主要原料制备多孔除磷滤料,采用X射线衍射和扫描电子显微镜对滤料主要化学组分和形貌特征进行表征,利用吸附动力学和吸附等温线试验、静态... 详细信息

高效、高容量的吸附滤料是提高人工湿地除磷效率的重要手段。以建筑废物(废混凝土和废泡沫砖)为主要原料制备多孔除磷滤料,采用X射线衍射和扫描电子显微镜对滤料主要化学组分和形貌特征进行表征,利用吸附动力学和吸附等温线试验、静态对比试验和动态试验评估了滤料对水中磷的吸附性能。结果表明:该滤料比表面积大、孔隙发达,内部微观结构为片层孔隙结构,比表面积为22.7 m^(2)/g;其吸附过程满足拟二级吸附动力学模型和Langmuir吸附等温模型,吸附机理以单分子层物理和化学复合吸附为主,最大吸附容量达到693.21 mg/g。在总磷浓度为0.4 mg/L的静态吸附试验中,多孔滤料在4 h内对磷的平均去除率为65.38%,分别是废混凝土、废泡沫砖、陶粒、硅藻土和活性炭的4.10、1.98、3.52、2.29和1.59倍。在模拟水平流潜流湿地动态试验中,在进水总磷浓度为0.40 mg/L,水力负荷为0.48、0.96、1.20、2.40 m^(3)/(m^(2)·d)的条件下,多孔滤料对总磷的平均去除率分别为95.74%、93.56%、80.42%、55.34%;在水力负荷为0.96 m^(3)/(m^(2)·d)、进水平均总磷浓度为0.52 mg/L、连续进水45 d条件下,多孔滤料对总磷的平均去除率为92.65%。该滤料制备方法简单,除磷性能优异,还实现了对建筑废物的有效利用,作为人工湿地填料具有应用潜力。

关键词：建筑废物人工湿地除磷多孔滤料

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