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基于视觉指标的雾天高速公路限速值

公路交通科技 2024年第7期41卷 194-206页

作者：何富勇杨雅钧张驰王世法肖锋四川成绵苍巴高速公路有限责任公司成都分公司四川成都610000 四川省交通勘察设计研究院有限公司四川成都610047 长安大学公路学院陕西西安710064 四川雅康高速公路有限责任公司四川雅安625000 四川藏区高速公路有限责任公司四川成都610047

为解决雾天高速公路能见度降低和驾驶人视距受限的交通安全问题,提出了一种基于驾驶人视觉指标的限速控制方法。首先,对雾天高速公路行驶速度与驾驶人视觉的变化进行了分析,并确定了能综合表征路况信息和能见度水平的视觉指标;其次,通过... 详细信息

为解决雾天高速公路能见度降低和驾驶人视距受限的交通安全问题,提出了一种基于驾驶人视觉指标的限速控制方法。首先,对雾天高速公路行驶速度与驾驶人视觉的变化进行了分析,并确定了能综合表征路况信息和能见度水平的视觉指标;其次,通过UC-win/Road模拟了不同能见度下的驾驶环境,并收集了视觉指标和运行速度数据,进一步分析了雾天视觉指标的影响因素;然后,使用SPSS构建了运行速度和视觉指标间的数学模型,根据能见度与视觉指标间的线性关系提出了不同能见度下的视觉指标参考值;最后,基于能见度、交通流量、视觉指标3个因素,提出了一种考虑视觉指标的多条件限速控制标准。结果表明:在能见度低于200 m的环境下,视觉指标明显低于无雾环境下的视觉指标,降低范围在0.578%~1.407%之间;视觉指标与运行速度两变量间的相关系数达到0.863,这说明雾天能见度降低和视觉指标下降对行驶速度有显著影响;预测运行速度与实测速度的相对误差平均值为2.43%,满足预测精度要求。综上所述,本研究提出的限速控制方法同时考虑了能见度、交通流量和驾驶人视觉,对于保障雾天高速公路的安全行驶具有重要的实用价值。

关键词：交通工程车速限制驾驶仿真雾天行车驾驶人视觉

Serum bile acid and unsaturated fa.ty acid profiles of non-alcoholic fa.ty liver disease in type 2 diabetic patients

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World Journal of Diabetes 2024年第5期15卷 898-913页

作者： Su-Su Feng Si-Jing Wang Lin Guo Pan-Pan Ma Xiao-Long Ye Ming-Lin Pan Bo Hang Jian-Hua Mao Antoine M Snijders Yi-Bing Lu Da-fa.Ding Department of Endocrinology The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Biological Systems and Engineering Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720United States

BACKGROUND The understanding of bile acid(BA)and unsaturated fa.ty acid(Ufa.profiles,as well as their dysregulation,remains elusive in individuals with type 2 diabetes mellitus(T2DM)coexisting with non-alcoholic fa.ty liver disease(NAFLD).Investigating these metabolites could offer valuable insights into the pathophy-siology of NAFLD in *** To identify potential metabolite biomarkers capable of distinguishing between NAFLD and *** A training model was developed involving 399 participants,comprising 113 healthy controls(HCs),134 individuals with T2DM without NAFLD,and 152 individuals with T2DM and *** validation encompassed 172 *** patients were divided based on liver fibrosis *** analytical approach employed univariate testing,orthogonal partial least squares-discriminant analysis,logistic regression,receiver operating characteristic curve analysis,and decision curve analysis to pinpoint and assess the diagnostic value of serum *** Compared to HCs,both T2DM and NAFLD groups exhibited diminished levels of specific *** Ufa.,particular acids exhibited a positive correlation with NAFLD risk in T2DM,while theω-6:ω-3 Ufa.ratio demonstrated a negative *** ofα-linolenic acid andγ-linolenic acid were linked to significant liver fibrosis in *** validation cohort substantiated the predictive efficacy of these biomarkers for assessing NAFLD risk in T2DM *** This study underscores the connection between altered BA and Ufa.profiles and the presence of NAFLD in individuals with T2DM,proposing their potential as biomarkers in the pathogenesis of NAFLD.

关键词： Bile acid Non-alcoholic fa.ty liver disease Type 2 diabetes mellitus Unsaturated fa.ty acid

Utilizing sediment grain size characteristics to assess the effectiveness of clay–sand barriers in reducing aeolian erosion in Minqin desert area,China

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Journal of Arid Land 2024年第5期16卷 668-684页

作者： SONG Dacheng ZHAO Wenzhi LI Guangyu WEI Lemin WANG Lide yang Jingyi WU Hao MA Quanlin College of Forestry Gansu Agricultural UniversityLanzhou 730070China Gansu Hexi Corridor Forest Ecosystem National Research Station Gansu Desert Control Research InstituteLanzhou 730070China Linze Inland River Basin Research Station Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China

The clay–sand barriers in Minqin desert area,China,represent a pioneering windbreak and sand fixation project with a venerable history of 60 ***,studies on evaluating the long-term effectiveness of clay–sand barriers against aeolian erosion,particularly from the perspective of surfa.e sediment grain size,are limited and thus insufficient to ascertain the protective impact of these barriers on regional aeolian *** study focused on the surfa.e sediments(topsoil of 0–3 cm depth)of clay–sand barriers in Minqin desert area to explain their erosion resistance from the perspective of surfa.e sediment grain *** March 2023,six clay–sand barrier sampling plots with clay–sand barriers of different deployment durations(1,5,10,20,40,and 60 a)were selected as experimental plots,and one control sampling plot was set in an adjacent mobile sandy area without sand *** sediment samples were collected from the topsoil of each sampling plot in the study area in April 2023 and sediment grain size characteristics were *** indicated a predominance of fine and medium sands in the surfa.e sediments of the study *** deployment of clay–sand barriers cultivated a fine quality in grain size composition of the regional surfa.e sediments,increasing the average contents of very fine sand,silt,and clay by 30.82%,417.38%,and 381.52%,*** trend became markedly pronounced a decade after the deployment of clay–sand *** effectiveness of clay–sand barriers in erosion resistance was manifested through reduced wind velocity,the interception of sand flow,and the promotion of fine surfa.e sediment *** particles such as medium,coarse,and very coarse sands predominantly accumulated on the external side of the barriers,while finer particles such as fine and very fine sands concentrated in the upwind(northwest)region of the *** contrast,the contents of finest particles such as silt and clay were higher in the downwind

关键词： clay-sand barriers sediment grain size grain size distribution aeolian erosion windbreak and sand fixation Minqin desert area

Interindividual Age-Independent Differences in Human CX43 Impact Ventricular Arrhythmic Risk

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Research 2024年第3期6卷 417-432页

作者： Laura García-Mendívil María Pérez-Zabalza Antoni Oliver-Gelabert JoséMaría Vallejo-Gil Javier fa.anás-Mastral Manuel Vázquez-Sancho Javier AndréBellido-Morales Alexánder Sebastián Vaca-Núñez Carlos Ballester-Cuenca Emiliano Diez Laura Ordovás Esther Pueyo Biomedical Signal Interpretation and Computational Simulation group(BSICoS) Aragón Institute of Engineering ResearchUniversity of ZaragozaZaragoza 50018Spain BSICoS Instituto de Investigación Sanitaria Aragón(IISA)Zaragoza 50018Spain Centro Universitario de la Defensa(CUD) Zaragoza 50090Spain. Department of Cardiovascular Surgery University Hospital Miguel ServetZaragoza 50009Spain. Institute of Experimental Medicine and Biology of Cuyo(IMBECU) CONICETMendoza 5500Argentina. Fundación Agencia Aragonesa para la Investigación y el Desarrollo(ARAID) Zaragoza 50018Spain. Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)Zaragoza 50018Spain.

Connexin 43 (CX43) is one of the major components of gap junctions, the structures responsible for the intercellular communication and transmission of the electrical impulse in the left ventricle. There is limited information on the histological changes of CX43 with age and their effect on electrophysiology, especially in humans. Here, we analyzed left ventricular biopsies from living donors starting at midlife to characterize age-related CX43 remodeling. We assessed its quantity, degree of lateralization, and spatial heterogeneity together with fibrotic deposition. We observed no significant age-related remodeling of CX43. Only spatial heterogeneity increased slightly with age, and this increase was better explained by biological age than by chronological age. Importantly, we found that CX43 features varied considerably among individuals in our population with no relevant relationship to age or fibrosis content, in contrast to animal species. We used our experimental results to feed computational models of human ventricular electrophysiology and to assess the effects of interindividual differences in specific features of CX43 and fibrosis on conduction velocity, action potential duration, and arrhythmogenicity. We found that larger amounts of fibrosis were associated with the highest arrhythmic risk, with this risk being increased when fibrosis deposition was combined with a reduction in CX43 amount and/or with an increase in CX43 spatial heterogeneity. These mechanisms underlying high arrhythmic risk in some individuals were not associated with age in our study population. In conclusion, our data rule out CX43 remodeling as an age-related arrhythmic substrate in the population beyond midlife, but highlight its potential as a proarrhythmic fa.tor at the individual level, especially when combined with increased fibrosis.

关键词： CX43 rhythm Independent

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土体本构模型参数的不确定性评估研究

岩土力学 2024年第9期45卷 2797-2807页

作者：薛阳苗发盛吴益平温韬王艳昆长江大学地球科学学院湖北武汉430100 湖北长大科技开发有限公司加查县分公司西藏山南856499 中国地质大学(武汉)工程学院湖北武汉430074

模型参数评估是本构模型发展的重要研究内容。为了考虑本构模型参数评估过程中存在的误差,采用基于结构可靠度、子集模拟和自适应条件抽样方法的贝叶斯框架,提出一种基于试验数据反演的本构模型参数不确定性评估方法。分别以表征岩土体... 详细信息

模型参数评估是本构模型发展的重要研究内容。为了考虑本构模型参数评估过程中存在的误差,采用基于结构可靠度、子集模拟和自适应条件抽样方法的贝叶斯框架,提出一种基于试验数据反演的本构模型参数不确定性评估方法。分别以表征岩土体剪应力−剪应变的节理剪切本构模型和描述土体非线性应变增量−应力增量的亚塑性黏土本构模型为例,研究了本构模型参数、土体偏应力−应变和孔隙比−压力曲线的不确定性表征结果,并分析了模型参数对试验结果的敏感性。结果表明该方法可以评估验数据驱动下本构模型参数的拟合不确定性。对于应力−应变曲线的表征,节理模型参数■和η的贡献相对较大,而亚塑性模型的多数参数贡献度差异较小。研究结果有助于加深对这两种本构模型的理解以及提高本构模型预测的可靠性。

关键词：节理本构模型亚塑性模型贝叶斯理论不确定性量化

网红博主与网红场景对出游意愿和口碑推荐的影响

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人文地理 2024年第1期39卷 184-192页

作者：肖宁杨金华徐元诏雷发宇衡阳师范学院地理与旅游学院衡阳421002 南京大学地理与海洋科学学院南京210023

旅游地短视频的网红宣传对消费者的出游有重要影响,该现象受到了学术界的广泛关注,但短视频如何影响受众的出游意愿和口碑推荐仍是有待深入研究的问题。因此,文章基于SOR理论和意见领袖理论,通过收集问卷调查数据,采用结构方程模型进行... 详细信息

旅游地短视频的网红宣传对消费者的出游有重要影响,该现象受到了学术界的广泛关注,但短视频如何影响受众的出游意愿和口碑推荐仍是有待深入研究的问题。因此,文章基于SOR理论和意见领袖理论,通过收集问卷调查数据,采用结构方程模型进行实证研究,探究网红博主和网红场景对出游意愿和口碑推荐的影响。研究发现:(1)短视频中网红博主的特质和网红场景对消费者的认知反应和情感反应具有显著的正向影响;(2)认知反应和情感反应对消费者出游意愿和口碑推荐亦具有显著的正向影响;(3)消费者的认知反应、情感反应、出游意愿在网红博主、网红场景与口碑推荐之间发挥链式中介效应。本研究可为旅游地提升以短视频为代表的新媒体营销效果提供理论与实践启示。

关键词：网红短视频网红博主 SOR理论出游意愿

Enhancing Geological Understanding and Identifying Gold Anomalies in the Ailaoshan Orogen

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 441-453页

作者： ZHAO Shiyu yang Lin SONG Yiwei DONG Yuntao FENG Lihao LI Huajian WU Junyu WANG Qingfei State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesBeijing 100083China Xi’an Center of Mineral Resources Survey China Geological SurveyXi’an 710010China Yunnan Gold Mining Industry Group Kunming 650299China Jiangxi Provincial Key Laboratory of Genesis and Prospect for Strategic Minerals East China University of TechnologyNanchang 330013China Frontiers Science Center for Deep-time Digital Earth China University of Geosciences(Beijing)Beijing 100083China

The Ailaoshan Orogen in the southeastern Tibet Plateau,situated between the yangtze and Simao blocks,underwent a complex structural,magmatic,and metamorphic evolution resulting in different tectonic subzones with varying structural lineaments and elemental *** elements can conceal or reduce anomalies due to the mutual effect between different anomaly *** the whole zone into subzones based on tectonic settings,ore cluster areas,or sample catchment basins(Scb),geochemical and structural anomalies associated with gold(Au)mineralization have been identified utilizing mean plus twice standard deviations(Mean+2STD),fa.tor analysis(fa.,concentration-area(CA)modeling of stream sediment geochemical data,and lineament density in both the Ailaoshan Orogen and the individual *** fa.in the divided 98 Scbs with 6 Scbs containing Au deposits can roughly ascertain unknown rock types,identify specific element associations of known rocks and discern the porphyry or skarn-type Au *** with methods of Mean+2STD and C-A model of data in the whole orogen,which mistake the anomalies as background or act the background as anomalies,the combined methods of fa.and C-A in the separate subzones or Scbs works well in regional metallogenic potential *** of lineament densities with a 10-km circle diameter is not suitable to locate Au deposits because of the delineated large areas of medium-high lineament *** contrast,the use of circle diameters of 1.3 km or 1.7 km in the ore cluster scale delineates areas with a higher concentration of lineament density,consistent with the locations of known Au *** analyzing the map of fa.lts and Au anomalies,two potential prospecting targets,Scbs 1 and 63 with a sandstone as a potential host rock for Au,have been identified in the Ailaoshan *** use of combined methods in the divided subzones proved to be more effective in improving geological understanding and identifying

关键词： minerology geochemistry gold stream sediment sample catchment basin concentration-area model lineament density Ailaoshan Orogen

A Mendelian randomisation,propensity score matching study to investigate causal association between serum homocysteine and intracranial aneurysm

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Stroke & Vascular Neurology 2024年第3期9卷 202-211,I0104-I0109页

作者： Zhuohua Wen Xin Feng Xin Tong Chao Peng Anqi Xu Haiyan fa. Yiming Bi Wenchao Liu Zhenjun Li Shenquan Guo fa.Jin Ran Li Yanchao Liu Shixing Su Xin Zhang Xifeng Li Xuying He Aihua Liu Chuanzhi Duan Neurosurgery Center Department of Cerebrovascular SurgeryEngineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular DiseaseZhujiang HospitalSouthern Medical UniversityGuangzhouChina Beijing Neurosurgical Institute Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina

Background and purpose Recent observational studies have reported that serum total homocysteine(tHcy)is associated with intracranial aneurysms(IAs).However,the causal effect of tHcy on IAs is *** leveraged large-scale genetic association and real-world data to investigate the causal effect of tHcy on IA *** We performed a two-sample Mendelian randomisation(MR)using publicly available genome-wide association studies summary statistics to investigate the causal relationship between tHcy and IAs,following the recommendations of the Strengthening the Reporting of Observational Studies in Epidemiology-MR ***,a propensity score matching(PSM)analysis was conducted to evaluate the detailed effects of tHcy on risk of IA formation by utilizing real-world multicentre data,including 9902 patients with and without IAs(1:1 matched).Further interaction and subgroup analyses were performed to elucidate how tHcy affects risk of IA *** MR analyses indicated that genetically determined tHcy was causally associated with IA risk(OR,1.38,95%CI 1.07 to 1.79;p=0.018).This is consistent with the more conservative weighted median analysis(OR,1.41,95%CI 1.03 to 1.93;p=0.039).Further sensitivity analyses showed no evidence of horizontal pleiotropy or heterogeneity of single nucleotide polymorphisms in causal *** to the PSM study,we found that,compared with low tHcy(≤15μmol/L),moderate tHcy(>15-30μmol/L)(OR 2.13,95%CI 1.93 to 2.36)and high tHcy(>30μmol/L)(OR 3.66,95%CI 2.71 to 4.95)were associated with a higher IA risk(p trend<0.001).Subgroup analyses demonstrated significant ORs of tHcy in each subgroup when stratified by traditional cardiovascular risk ***,there was also a synergistic effect of tHcy and hypertension on IA risk(p interaction<0.001;the relative excess risk due to interaction=1.65,95%CI 1.29 to 2.01).Conclusion Both large-scale genetic evidence and multicentre real-world data support a causal as

关键词： matching random centre

Emergency Care for Children and Adolescents after Sexual Violence, in Brazil’s Capital, Brasilia

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Open Journal of Epidemiology 2024年第2期14卷 397-403页

作者： Evaldo Lima Da Costa Karla Simônia de Pádua Aníbal fa.ndes Rui Nunes Bioethics at the School of Medicine University of Porto/Federal Council of Medicine Porto Portugal Center for Research in Women’ s Reproductive Health (CEMICAMP) Center for Integral Attention to Women (CAISM) State University of Campinas Campinas Brazil Center for Research in Women’ s Reproductive Health (CEMICAMP) State University of Campinas (UNICAMP) Campinas Brazil. The Centre of Bioethics Faculty of Medicine University of Porto Porto Portugal

Objective: Sexual violence affects women of all ages but, more commonly, children and adolescents. This study aimed to identify the extent to which services are being provided at the hospitals responsible for the emergency care of children and adolescents who have suffered sexual violence and to determine whether there is any difference in the provision of such services as a function of the victim’s age. Method: This cross-sectional study investigated differences in the care received by female children and adolescents who are victims of sexual violence in a capital city, comparing the treatment given to girls under 15 with that given to adolescents of 15 to 19 years of age. The data were extracted from the State Department of Health database between 01/01/2012 and 31/12/2016. Results: Children under 15 were much less likely to receive prophylaxis against HIV, sexually transmitted infections and hepatitis B, with the number of adolescent girls treated adequately corresponding to between twice and almost three times the number of children treated prophylactically. Only 10% of girls under 15 received emergency contraception. Conclusion: The lack of standard care established by the Ministry of Health highlights the need for urgent debates both locally and probably throughout the country, as the situation may be similar in other regions of the country.

关键词： Aggressors Children Sexual Violence Teenagers