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A novel fused bi-macrocyclic host for sensitive detection of Cr_(2)O_(7)^(2-)based on enrichment effect

Chinese Chemical Letters 2024年第7期35卷 291-295页

作者： Ting-Ting Huang Jin-fa.Chen Juan Liu Tai-Bao Wei hong Yao Bingbing Shi Qi Lin Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education Key Laboratory of Eco-environmental Polymer Materials of Gansu ProvinceCollege of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou 730070China Key Laboratory of Environment-Friendly Composite Materials of the State Ethnic Affa.rs Commission Gansu Provincial Biomass Function Composites Engineering Research CenterCollege of Chemical EngineeringNorthwest Minzu University(Northwest University for Nationalities)Lanzhou 730000China

Improving the highly selective and sensitive binding of chemosensor to target guest is always very *** order to solve this issue,herein,the enrichment effect was introduced into the design of chemosensor molecule.A novel bi-fused-macrocyclic host molecule BPN1 was synthesized by bridging a pillar[5]arene and a naphthalene diimide(NDI)group through hydrogen-bond-rich *** the BPN1,the naphthalimide side ring is outside the cavity of the pillar[5]*** addition,Cr(VI)greatly threat human health and the environment due to its severe toxicity,and it is very important to develop effective chemosensor for sensitive and selective detection of Cr_(2)O_(7)^(2-)or its ion *** this paper,the novel bi-fused-macrocyclic host molecule BPN1 can recognize Cr_(2)O_(7)^(2-)with high selectivity and *** mechanism of BPN1 recognition of Cr_(2)O_(7)^(2-)was studied through experiments and density functional theory(DFT),the results show that BPN1 could supply enrichment effect to bind Cr_(2)O_(7)^(2-)through multiple weak interactions such as hydrogen bonds and anion-π,and achieve highly sensitive and selective detection of Cr_(2)O_(7)^(2-).It is a significant and feasible strategy for improve high selectivity and sensitivity of host to specific objects by using the enrichment effect of fused bi-macrocyclic.

关键词： Pillararene Bi-macrocyclic Detection of Cr_(2)O_(7)^(2−) DFT The enrichment effect

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Overexpression of wild-type HRAS drives non-alcoholic steatohepatitis to hepatocellular carcinoma in mice

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Zoological Research 2024年第3期45卷 551-566页

作者： Chen Ling Su-Su Liu Yu-Ya Wang Gui-Tao Huo Yan-Wei Yang Nan Xu hong Wang Yong Wu Yu-fa.Miao Rui Fu Yu-Wei Zhao Chang-fa.fa. College of Life Sciences Northwest UniversityProvincial Key Laboratory of Biotechnology of Shaanxi ProvinceXi’anShaanxi 710069China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China National Center for Safety Evaluation of Drugs National Institutes for Food and Drug Control(NIFDC)Beijing 100176China Division of HIV/AIDS and Sexually Transmitted Virus Vaccines Institute for Biological Products ControlNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China Division of Laboratory Animal Monitoring Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China

Hepatocellular carcinoma(HCC),a prevalent solid carcinoma of significant concern,is an aggressive and often fa.al disease with increasing global incidence rates and poor therapeutic *** etiology and pathological progression of non-alcoholic steatohepatitis(NASH)-related HCC is multifa.torial and ***,no single animal model can accurately mimic the full NASH-related HCC pathological progression,posing considerable challenges to transition and mechanistic ***,a novel conditional inducible wild-type human HRAS overexpressed mouse model(HRAS-HCC)was established,demonstrating 100%morbidity and mortality within approximately one month under normal dietary and lifestyle *** symptoms of HCC such as ascites,thrombus,internal hemorrhage,jaundice,and lung metastasis were successfully replicated in ***-depth pathological features of NASH-related HCC were demonstrated by pathological staining,biochemical analyses,and typical marker gene *** murine anti-PD-1 and sorafenib treatment effectively prolonged mouse survival,further confirming the accuracy and reliability of the *** on protein-protein interaction(PPI)network and RNA sequencing analyses,we speculated that overexpression of HRAS may initiate the THBS1-COL4A3 axis to induce NASH with severe fibrosis,with subsequent progression to ***,our study successfully duplicated natural sequential progression in a single murine model over a very short period,providing an accurate and reliable preclinical tool for therapeutic evaluations targeting the NASH to HCC continuum.

关键词： HRAS THBS1 HCC driver fa.tor NASH Fibrosis Cirrhosis HCC Treatment evaluation

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Evaluation of microRNA expression profiles in human sperm frozen using permeable cryoprotectant-free droplet vitrification and conventional methods

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Asian Journal of Andrology 2024年第4期26卷 366-376页

作者： Li-Xin Zhang Jing Mao Yan-Dong Zhou Guang-Yao Mao Run-fa.Guo hong-Shan Ge Xia Chen Department of Histology and Embryology Medical SchoolNantong UniversityNantong 226001China Department of Reproductive Medicine The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityTaizhou School of Clinical MedicineNanjing Medical UniversityTaizhou 225300China.

For sperm cryopreservation,the conventional method,which requires glycerol,has been used for a long *** addition,the permeable cryoprotectant-free vitrification method has been continuously *** the differences of cryopreservation effects between the two methods have being studied,differences in microRNA(miRNA)profiles between them remain *** this study,we investigated the differences in miRNA expression profiles among conventional freezing sperm,droplet vitrification freezing sperm and fresh human *** also analyzed the differences between these methods in terms of differentially expressed miRNAs(DEmiRs)related to early embryonic development and paternal *** results showed no significant differences between the cryopreservation methods in terms of sperm motility ratio,plasma membrane integrity,DNA integrity,mitochondrial membrane potential,acrosome integrity,and ultrastructural ***,sperm miRNA-sequencing showed differences between the two methods in terms of the numbers of DEmiRs(28 and 19 with vitrification using a nonpermeable cryoprotectant and the conventional method,respectively)in postthaw and fresh sperm *** related to early embryonic development and paternal epigenetics mainly included common DEmiRs between the *** results showed that the differences between conventional freezing and droplet vitrification were minimal in terms of miRNA expression related to embryonic development and *** in sperm miRNA expression due to freezing are not always detrimental to embryonic *** study compared differences in miRNA expression profiles before and after cryopreservation between cryopreservation by conventional and vitrification *** offers a new perspective to evaluate various methods of sperm cryopreservation.

关键词： cryopreservation cryoprotectant-free vitrification early embryonic development paternal epigenetic inheritance sperm miRNAs sucrose

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Perioperative outcomes of transvaginal specimen extraction laparoscopic total gastrectomy and conventional laparoscopicassisted total gastrectomy

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1527-1536页

作者： Zhi-Cao Zhang Wen-Sheng Wang Jiang-hong Chen Yuan-Hang Ma Qi-fa.Luo Yun-Bo Li Yang Yang Dan Ma Department of General Surgery Xinqiao Hospital of Army Medical UniversityChongqing 400037China

BACKGROUND Natural orifice specimen extraction surgery(NOSES)has emerged as a promising alternative compared to conventional laparoscopic-assisted total gastrectomy(LATG)for treating gastric cancer(GC).However,evidence regarding the efficacy and safety of NOSES for GC surgery is *** study aimed to compare the safety and feasibility,in addition to postoperative complications of NOSES and *** Dual circular staplers were used in Roux-en-Y digestive tract reconstruction for transvaginal specimen extraction LATG,and its outcomes were compared with LATG in a cohort of 51 GC patients with tumor size≤5 *** study was conducted from May 2018 to September 2020,and patients were categorized into the NOSES group(n=22)and LATG group(n=29).Perioperative parameters were compared and analyzed,including patient and tumor characteristics,postoperative outcomes,and anastomosis-related complications,postoperative hospital stay,the length of abdominal incision,difference in tumor type,postoperative complications,and postoperative *** Postoperative exhaust time,operation duration,mean postoperative hospital stay,length of abdominal incision,number of specific staplers used,and Brief Illness Perception Questionnaire score were significant in both groups(Pfa.ter postoperative recovery,and achieved abdominal minimally invasive incision that met aesthetic *** were no significant differences in gender,age,tumor type,postoperative complications,and postoperative survival between the two *** The application of dual circular staplers in Roux-en-Y digestive tract reconstruction combined with NOSES gastrectomy is safe and *** approach offers better short-term outcomes compared to LATG,while long-term survival

关键词： Gastric cancer Circular stapler Natural orifice specimen extraction surgery Laparoscopic-assisted total gastrectomy

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Characteristics and origin of low-organicmatter carbonate source rocks in the Middle-Upper Ordovician, Tarim Basin, northwestern China

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Journal of Palaeogeography 2024年第3期13卷 594-619页

作者： Jun-Qing Chen Fu-Jie Jiang Xiong-Qi Pang Hai-Jun Yang Kan-Yuan Shi Bo Pang hong Pang Jian-fa.Chen Zhuo-Heng Chen Xin-Gang Zhang Song Wu State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing 102249China Basic Research Center for Energy Interdisciplinary College of ScienceChina University of Petroleum(Beijing)Beijing 102249China Beijing Key Laboratory of Optical Detection Technology for Oil and Gas China University of Petroleum(Beijing)Beijing 102249China College of Geosciences China University of Petroleum(Beijing)Beijing 102249China Research Institute of Petroleum Exploration and Development PetroChina Tarim Oilfield CompanyKorla 841000Xinjiang Uygur Autonomous RegionChina Geological Survey of Canada Natural Resources CanadaCalgary T2L 2A7Canada

The continually-discovered large volumes of marine hydrocarbons indicate a huge exploration potential within the carbonate rocks of Ordovician in the Tarim Basin,northwestern *** Middle-Upper Ordovician(O2+3)carbonate source rocks are at a highly mature *** rocks presently contain a low amount of total organic carbon(TOC_(pd)≤0.5%)(TOC_(pd) means the present-day TOC).A mass balance approach is used to identify the source rocks that have expelled *** characteristics and origin of hydrocarbon expulsion from low-TOC_(pd) source rocks are studied,which are significant for oil exploration in the *** results showed that a low-TOC_(pd) O2+3 source rock having expelled hydrocarbons was type I and had a very narrow oil *** a high rock maturity and a high original TOC(TOCo)value exceeding 1%,nearly 80%of the generated hydrocarbons were *** content of gammacerane and C28 steranes in the oil and source rock extracts were relatively lean,with a V-shaped distribution of regular steranes,suggesting a possible genetic relation between the low-TOC_(pd) source rocks and the marine oil in the Tabei *** planktonic algae or acritarchs were the main hydrocarbon parent materials,distributed in the subsiding platform-slope *** matter was preserved under reducing conditions,and source rocks were formed with a fa.orable kerogen type and a moderate hydrocarbon generation *** study illustrates the hydrocarbon expulsion of low TOC_(pd) source rocks in northern Tarim Basin,which is greatly significant for analyzing the genesis of marine crude oil in Tarim Basin,and evaluating the distribution of marine source *** research method is theoretically significant for oil and gas exploration in the same type of highlymature carbonate paleobasins.

关键词： Carbonate source rock Mass balance approach Present-day TOC Genesis mechanism Tarim Basin

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Application of prostate resectoscope in the treatment of massive rectal bleeding after transrectal prostate puncture

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World Journal of Clinical Cases 2024年第18期12卷 3438-3443页

作者： hong-Mei Li fa.Ying Yang Song Tu Peng Yan Jun Qian Jia-Xi Yao Department of Urology Hexi University Affiliated Zhangye People’s HospitalHexi UniversityZhangye 734000Gansu ProvinceChina Department of General Surgery II Hexi UniversityZhangye 734000Gansu ProvinceChina

BACKGROUND Ultrasound-guided prostate biopsy is a reliable diagnostic procedure for prostate cancer diagnosis with minimal procedure-related ***,complications,such as massive rectal bleeding may occur after the *** hypothesized that using a transrectal resectoscope could help treat massive rectal bleeding after transrectal prostate *** To identify a simple and effective treatment for massive rectal bleeding after transrectal prostate *** Patients requiring treatment for massive rectal bleeding after transrectal prostate punctures were included.A SIMAI resectoscope was inserted through the *** electrocoagulation was performed for superficial bleeding *** of the rectal mucosa or surfa.e muscle layer was removed to expose deep bleeding points,followed by *** electric cutting ring was used to compress and stop the bleeding for jet-like points before *** fluid color in the drainage tube was monitored postoperatively for continuous *** Eight patients were included from 2012 to *** of the patients with massive rectal bleeding after the transrectal prostate punctures improved with conventional conservative and blood transfusion *** patients had an inferior artery embolism,and digital subtraction angiography was *** patients received emergency transanal prostate resection,which immediately stopped the *** days after the procedure,the patients had recovered and were *** Using a transanal prostate resection instrument is a simple,safe,and effective method for treating massive rectal bleeding after transrectal prostate punctures.

关键词： Electrocoagulation Hemostasis Transanal prostate resection instrumentation Prostate puncture

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Interlayer Magnetic Interaction in the CrI_(3)/CrSe_(2) Heterostructure

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Chinese Physics Letters 2024年第5期41卷 85-89页

作者：王秋皓倪美燕李淑静郑法伟路洪艳张平 School of Physics and Physical Engineering Qufu Normal UniversityQufu 273165China Center for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and MeasurementSchool of PhysicsBeijing Institute of TechnologyBeijing 100081China Beijing Key Lab of Nanophotonics and Ultrafine Optoelectronic Systems School of PhysicsBeijing Institute of TechnologyBeijing 100081China College of Mathematics and Physics Beijing University of Chemical TechnologyBeijing 100029China Institute of Applied Physics and Computational Mathematics Beijing 100088China

Based on first-principles calculations, we systematically study the stacking energy and interlayer magnetic interaction of the heterobilayer composed of CrI_(3) and CrSe_(2) monolayers. It is found that the stacking order plays a crucial role in the interlayer magnetic coupling. Among all possible stacking structures, the AA-stacking is the most stable heterostructure, exhibiting interlayer antiferromagnetic interactions. Interestingly, the interlayer magnetic interaction can be effectively tuned by biaxial strain. A 4.3% compressive strain would result in a ferromagnetic interlayer interaction in all stacking orders. These results reveal the magnetic properties of CrI_(3)/CrSe_(2) heterostructure, which is expected to be applied to spintronic devices.

关键词： strain stacking interlayer

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梅兰芳访美演出剧目考辨与溯因

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文化遗产 2024年第1期 66-82页

作者：董存发洪朝辉复旦大学亚太区域合作与治理研究中心上海200433 美国纽约福坦莫大学(Fordham University)

梅兰芳1930年访美成功的原因离不开梅剧团精心取舍剧目、合理组合剧目、适时适地变换剧目组合。梅剧团在154天访美期间,在美国六大城市、九大剧院成功演出96场京剧大戏,共推出35部传统剧目、改良剧目和舞蹈节目。为了顺应和适应美国观... 详细信息

梅兰芳1930年访美成功的原因离不开梅剧团精心取舍剧目、合理组合剧目、适时适地变换剧目组合。梅剧团在154天访美期间,在美国六大城市、九大剧院成功演出96场京剧大戏,共推出35部传统剧目、改良剧目和舞蹈节目。为了顺应和适应美国观众的喜好,梅剧团取舍剧目的优先是形体动作表演为主,并符合中美两国的共享文化价值,包括尊重女性、公平正义、英雄情节、忠贞爱情。梅剧团运用“三剧一舞”的基本组合,作为每一场演出的基本准则,而且因时因地不断变换组合、调整剧目。利用美国地方报纸信息和运用溯因研究方法,考辩上演剧目的中英文名称、地点、时间、顺序、组合和内容,溯因梅兰芳访美成功的剧目因素,能够为梅兰芳访美演出这一历史性事件,提供新的观察视角、开发新的研究方法、发现新的参考史料。

关键词：梅兰芳访美表演剧目跨文化共享文化价值溯因法

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运动目标的多维度微运动特征提取研究

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物理学报 2024年第7期73卷 186-198页

作者：陈思张海洋靳发宏汪林赵长明北京理工大学光电学院北京100081

微多普勒特征提取作为一种常用的时频分析工具,对微动目标特征的提取重构具有重要意义.为了更好地研究多运动的微多普勒效应,提出了一种运动姿态分类方法.按照目标频移是否随时间变化可以将运动姿态分为频移时变运动和频移时不变运动.... 详细信息

微多普勒特征提取作为一种常用的时频分析工具,对微动目标特征的提取重构具有重要意义.为了更好地研究多运动的微多普勒效应,提出了一种运动姿态分类方法.按照目标频移是否随时间变化可以将运动姿态分为频移时变运动和频移时不变运动.频移时变运动包括平移、翻滚和振动.针对这种运动应分析对比不同时间对应的瞬态频移,频移时不变运动主要为旋转运动.本文通过微多普勒效应理论结合电磁波频域模型,实现3D运动目标微动特性提取的仿真建立目标,分析不同环境条件例如晴天阴天、有无湍流对探测的影响,为后续实验研究奠定理论基础.开展基于收发同置系统的多特征运动目标的微多普勒频移探测实验,实验结果表明,不同目标位置上频移的幅度、正负性和谱线宽度旨在反演目标形状、运动姿态、运动方向和速度.利用FFTshift函数对一维数据进行解调分析,实现三维时间-频率-强度关系的研究.本研究实现了对目标宏观形状特性的测量以及微观运动信息的提取,为雷达探测和识别奠定基础.

关键词：微多普勒效应多特征运动目标识别时间-频率-强度关系

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农俗文化景观符号化运作下的传统村落旅游地方营造——以江西婺源县篁岭村为例

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自然资源学报 2024年第8期39卷 1974-1992页

作者：黄成昆张行发徐虹南开大学旅游与服务学院天津300350

城镇化的快速发展,让传统村落文化景观面临凋敝危机。旅游引发的景观符号生产与消费,为新时期传统村落文化景观的保护与活化利用提供了新思路。基于行动者网络理论,以江西婺源县篁岭村为例,探究“晒秋”农俗文化景观符号化运作下的旅游... 详细信息

城镇化的快速发展,让传统村落文化景观面临凋敝危机。旅游引发的景观符号生产与消费,为新时期传统村落文化景观的保护与活化利用提供了新思路。基于行动者网络理论,以江西婺源县篁岭村为例,探究“晒秋”农俗文化景观符号化运作下的旅游地方营造过程与机制。结果表明:(1)在篁岭村旅游地方营造中,篁岭文旅公司始终扮演着关键行动者的角色,围绕“晒秋”景观的符号化运作,通过利益赋予、征召与动员推动着更多异质行动者加入行动者网络。(2)篁岭村的旅游地方营造经历了“晒秋”核心景观符号塑造与“晒秋”泛化景观符号融入两个阶段。在阶段演化过程中,行动者网络的强制通行点(OPP)由“发展乡村旅游,振兴篁岭”转变为“提升旅游项目品质,打造乡村旅游综合体”。(3)关键行动者的能动性发挥、非人类行动者的属性挖掘与重要异质行动者的介入是在农俗文化景观符号化运作下,驱动篁岭村旅游地方营造的内在机制。研究结果从景观符号化运作的视角拓展了地方营造的理论内涵,为新时期传统村落文化景观的保护与更新提供了实践启示。

关键词：传统村落文化景观符号化运作旅游地方营造行动者网络篁岭村

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