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Upregulation of the APE1 and H2AX genes and miRNAs involved in DNA damage response and repair in gastric cancer

Genes & Diseases 2019年第2期6卷 176-184页

作者： f.rnanda s.manoel-caetano Ana flávia T.Rossi Gabriela Calvet de Morais fábio Eduardo severino Ana Elizabete silva Department of Biology UNESPSāo Paulo State UniversityCampus of Sāo Josédo Rio PretoRua Cristòvāo Colombo226515.054-000Sāo Josédo Rio PretoSāo PauloBrazil Department of surgery and Orthopedics Faculty of MedicineUNESPSāo Paulo State UniversityCampus of BotucatuAv.Prof.Mário Rubens Guimarāes Montenegros/n18.618-687BotucatuSāo PauloBrazil

Gastric cancer remains one of the leading causes of cancer-related death worldwide,and most of the cases are associated with Helicobacter pylori *** bacterium promotes the production of reactive oxygen species(ROs),which cause DNA damage in gastric epithelial *** this study,we evaluated the expression of important genes involved in the recognition of DNA damage(ATM,ATR,and H2AX)and ROs-induced damage repair(APE1)and the expression of some miRNAs(miR-15a,miR-21,miR-24,miR-421 and miR-605)that target genes involved in the DNA damage response(DDR)in 31 fresh tissues of gastric *** v3.1.1 was used to construct the postulated miRNA:mRNA interaction *** performed by real-time quantitative PCR exhibited significantly increased levels of the APE1(RQ=2.55,ps beyond the miR-421 and miR-605 in the gastric cancer *** addition,significantly elevated levels of miR-21,miR-24 and miR-421 were observed in diffuse-type gastric *** analysis reinforced some of the gene:gene(ATM/ATR/H2AX)and miRNA:mRNA relationships obtained also with the interaction ***,our findings show that tumor cells from gastric cancer presents deregulation of genes and miRNAs that participate in the recognition and repair of DNA damage,which could confer an advantage to cell survival and proliferation in the tumor microenvironment.

关键词： DNA damage response DNA repair Gastric cancer Gene expression microRNA

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Merging bound states in the continuum in an open acoustic resonator

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science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem s.Pilipchuk sibo Huang Chen shen Almas f.sadreev Yong Li Andrey E.Miroshnichenko school of Physics and Electronic sciences East China Normal University Institute of Acoustics Tongji University L.V.Kirensky Institute of Physics Department of Mechanical Engineering Rowan University school of Engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

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A large epeiric methanogenic Bambuí sea in the core of Gondwana supercontinent?

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Geoscience frontiers 2021年第1期12卷 203-218页

作者： sergio caetano-filho Pierre sansjofre Magali Ader Gustavo M.Paula-santos Cristian Guacaneme Marly Babinski Carolina Bedoya-Rueda Matheus Kuchenbecker Humberto L.s.Reis Ricardo I.f.Trindade Universidade de sao Paulo Instituto de GeocienciasRua do Lago562-Sao Paulo05508-080Brazil MNHN Sorbonne UniversiteCNRS UMR 7590Institut de Mineralogiede Physique des Materiaux et de Cosmochimie75005ParisFrance Universite de Paris Institut de Physique du Globe de ParisCNRSF-75005ParisFrance Universidade Estadual de Campinas Instituto de GeocienciasRua Carlos Gomes250-Campinas13083-855Brazil Universidade federal dos Vales do Jequitinhonha e Mucuri Instituto de Ciencia e TecnologiaLaboratorio de Estudos TectonicosRodovia MGT 367Km 583-Diamantina39100-000Brazil Universidade federal de Ouro Preto Departamento de Geologia-Escola de MinasLaboratiorio de Modelagem TectonicaCampus Morro do Cruzeiro-Ouro Preto35400-000Brazil Universidade de sao Paulo Instituto de AstronomiaGeofísica e Ciencias AtmosfericasRua do Matao1226-Sao Paulo05508-090Brazil

Carbon isotope compositions of both sedimentary carbonate and organic matter can be used as key proxies of the global carbon cycle and of its evolution through time,as long as they are acquired from waters where the dissolved inorganic carbon(DIC)is in isotope equilibrium with the atmospheric ***,in shallow water platforms and epeiric settings,the influence of local to regional parameters on carbon cycling may lead to DIG isotope variations unrelated to the global carbon *** may be especially true for the terminal Neoproterozoic,when Gondwana assembly isolated waters masses from the global ocean,and extreme positive and negative carbon isotope excursions are recorded,potentially decoupled from global *** improve our understanding on the type of information recorded by these excursions,we investigate the pairedδ^13Ccarb andδ^13Corg evolution for an increasingly restricted late Ediacaran-Cambrian foreland system in the West Gondwana interior:the basal Bambui *** succession represents a 1~(st)-order sedimentary sequence and records two majorδ^13Ccarb excursions in its two lowermost lower-rank *** basal cap carbonate interval at the base of the first sequence,deposited when the basin was connected to the ocean,hosts antithetical negative and positive excursions forδ^13Ccarb andδ^13Corg,respectively,resulting inΔ^13C values lower than 25‰.from the top of the basal sequence upwards,an extremely positiveδ^13Ccarb excursion is coupled toδ^13Corg,reaching values of+14‰and-14‰,*** positive excursion represents a remarkable basin-wide carbon isotope feature of the Bambui Group that occurs with only minor changes inΔ^13C values,suggesting change in the DIC isotope *** argue that this regional isotopic excursion is related to a disconnection between the intrabasinal and the global carbon *** extreme carbon isotope excursion may have been a product of a disequilibria between the basin DIC and atmospheric CO2

关键词： Methanogenesis Ediacaran Cambrian Carbon isotopes sao francisco Basin Bambui Group

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Pain inhibition through transplantation of fetal neuronal progenitors into the injured spinal cord in rats

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Neural Regeneration Research 2019年第11期14卷 2011-2019页

作者： Chary M. Batista Eric D. Mariano Camila s. Dale Alexandre f. Cristante Luiz R. Britto Jose P. Otoch manoel J. Teixeira Matthias Morgalla Guilherme Lepski Department of Neurology School of MedicineUniversity of Sao PauloSao PauloBrazil Department of Anatomy Institute of Biomedical ScienceUniversity of Sao PauloSao PauloBrazil Department of Orthopedic and Traumatology School of MedicineUniversity of Sao PauloSao PauloBrazil Department of Physiology and Biophysics Institute of Biomedical ScienceUniversity of Sao PauloSao PauloBrazil Department of surgery School of MedicineUniversity of Sao PauloSao PauloBrazil Department of Neurosurgery Eberhard-Karls UniversityTuebingenGermany Department of Psychiatry School of MedicineUniversity of Sao PauloSao PauloBrazil

Neuropathic pain after spinal cord injury(sCI) is a complex condition that responds poorly to usual treatments. Cell transplantation represents a promising therapy;nevertheless, the ideal cell type in terms of neurogenic potential and effectiveness against pain remains largely controversial. Here, we evaluated the ability of fetal neural stem cells(fNsC) to relieve chronic pain and, secondarily, their effects on motor recovery. Adult Wistar rats with traumatic sCI were treated, 10 days after injury, with intra-spinal injections of culture medium(sham) or fNsCs extracted from telencephalic vesicles(TV group) or the ventral medulla(VM group) of E/14 embryos. sensory(von frey filaments and hot plate) and motor(the Basso, Beattie,Bresnahan locomotor rating scale and inclined plane test) assessments were performed during 8 weeks. Thereafter, spinal cords were processed for immunofluorescence and transplanted cells were quantified by stereology. The results showed improvement of thermal hyperalgesia in the TV and VM groups at 4 and 5 weeks after transplantation, respectively. Moreover, mechanical allodynia improved in both the TV and VM groups at 8 weeks. No significant motor recovery was observed in the TV or VM groups compared with sham. stereological analyses showed that ~70% of TV and VM cells differentiated into NeuN+ neurons,with a high proportion of enkephalinergic and GABAergic cells in the TV group and enkephalinergic and serotoninergic cells in the VM group. Our study suggests that neuronal precursors from TV and VM, once implanted into the injured spinal cord, maturate into different neuronal subtypes, mainly GABAergic, serotoninergic, and enkephalinergic, and all subtypes alleviate pain, despite no significant motor recovery. The study was approved by the Animal Ethics Committee of the Medical school of the University of s?o Paulo(protocol number 033/14) on March 4, 2016.

关键词： spinal cord injuries chronic pain neural stem cells cell transplantation neuronal differentiation GABAergic neuron serotoninergic neuron enkephalinergic neuron

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Elastic, thermodynamic, electronic, and optical properties of recently discovered superconducting transition metal boride NbRuB:An ab-initio investigation

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Chinese Physics B 2017年第10期26卷 339-347页

作者： f Parvin s H Naqib Department of Physics University of Rajshahi

The elastic, thermodynamic, electronic, and optical properties of recently discovered and potentially technologically important transition metal boride NbRuB, are investigated using the density functional formalism. Both generalized gradient approximation （GGA） and local density approximation （LDA） are used for optimizing the geometry and for estimating various elastic moduli and constants. The optical properties of NbRuB are studied for the first time with different photon polarizations. The frequency （energy） dependence of various optical constants complement quite well the essential features of the electronic band structure calculations. Debye temperature of NbRuB is estimated from the thermodynamical study. All these theoretical estimates are compared with published results, where available, and discussed in detail. Both electronic band structure and optical conductivity reveal robust metallic characteristics. The NbRuB possesses significant elastic anisotropy. Electronic features, on the other hand, are almost isotropic in nature. The effects of electronic band structure and Debye temperature on the emergence of superconductivity are also analyzed.

关键词： hard materials ternary borides DfT calculations electronic band structure optical properties superconductivity

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Nonlinear continuous bi-inductance electrical line with dissipative elements:Dynamics of the low frequency modulated waves

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Chinese Physics B 2020年第4期29卷 179-189页

作者： s M Ngounou f B Pelap Unite de Recherche de Mecanique et de Modelisation des systèmes Physiques(UR-2 MsP) Faculte des SciencesUniversite de DschangBP 69 DschangCameroun Unite de Recherche de Matiere Condensee d'Electronique et de Traitement du signal(UR-MACETs) Faculte des SciencesUniversite de DschangBP 67 DschangCameroun

The dynamics of modulated waves in a nonlinear bi-inductance transmission line with dissipative elements are *** show the existence of two frequency modes and carry out intensive investigations on the low frequency *** to the multiple scales method,the behavior of these waves is investigated and the dissipative effects are *** appears that the dissipation coefficient increases with the carrier wave *** the continuous approximation,we derive that the propagation of these waves is governed by the complex Ginzburg-Landau equation instead of the Korteweg-de-Vries equation as previously *** studies of the dynamics of plane waves in the line reveal the existence of three additional regions in the dispersion curve where the modulational phenomenon is *** the low frequency mode,we demonstrate that the network allows the propagation of dark and bright *** findings are in perfect agreement with the analytical predictions.

关键词： dissipative bi-inductance network low frequency mode continuous approximation complex Ginzburg-Landau equation

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Dynamics of high-frequency modulated waves in a nonlinear dissipative continuous bi-inductance network

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Chinese Physics B 2021年第6期30卷 193-205页

作者： s M Ngounou f B Pelap Unitéde Recherche de Mécanique et de Modélisation des systèmes Physiques(UR-2 MsP) Facultédes SciencesUniversitéde DschangBP 69 DschangCameroun Unitéde Recherche de Matière Condensée d'Electronique et de Traitement du signal(UR-MACETs) Facultédes SciencesUniversitéde DschangBP 67 DschangCameroun

This paper presents intensive investigation of dynamics of high frequency nonlinear modulated excitations in a damped bimodal lattice. The effects of the dissipation are considered through a linear dissipation coefficient whose evolution in terms of the carrier wave frequency is checked. There appears that the dissipation coefficient increases with the carrier wave frequency. In the linear limit and for high frequency waves, study of the asymptotic behavior of plane waves reveals the existence of two additional regions in the dispersion curve where the modulational phenomenon is observed compared to the lossless line. Based on the multiple scales method exploited in the continuum approximation using an appropriate decoupling ansatz for the voltage of the two different cells, it appears that the motion of modulated waves is described by a dissipative complex Ginzburg–Landau equation instead of a Korteweg–de Vries equation. We also show that this amplitude wave equation admits envelope and hole solitons in the high frequency mode. from basic sources, we design a programmable electronic generator of complex signals with desired characteristics, which delivers signals exploited as input waves for all our numerical simulations. These simulations are performed in the LTspice software that uses realistic components and give the results that corroborate perfectly our analytical predictions.

关键词： dissipative bi-inductance network high-frequency mode continuous approximation dissipative complex Ginzburg–Landau equation programmable electronic generator LT-Pspice observations

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Tensile and spring-Back Behavior of DP600 Advanced High strength steel at Warm Temperatures

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Journal of Iron and steel Research International 2009年第6期16卷 41-46页

作者： f Ozturk s Toros s Kilic Department of Mechanical Engineering Nigde University

In recent years, the use of advanced high strength steels in automotive industry has been increased remarkably. Among advanced high strength steels, dual phase （DP） steels have gained a great attention owing to a combination of high strength and good formability. However, high strength usually increases the spring-back behavior of the material, which creates problems for the parts during the assembly. Thus, the uniaxial tensile deformation and spring-back behaviors of DP600 advanced high strength steel were investigated in rolling （0°）, diagonal （45°） , and transverse （90°） directions in the temperature range from room temperature （RT） to 300 ℃. All tests were performed at a deformation speed of 25 mm/min. A V-shaped die （60°） was used for the spring-back measurements. The results indicated that the formability and spring-back of the material were decreased with increasing the temperatures. The material showed complex behaviors in different directions and at different temperatures.

关键词： advanced high strength steel DP600 warm forming spring-back

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fORGING AsIA′s GLOBAL TRANsPARK IN THE PEARL RIVER DELTA AT ZHUHAI

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Chinese Geographical science 2003年第4期13卷 300-309页

作者： Victor f s sIT .

The main purpose of the paper is to introduce the concept of the Global TransPark (GTP). It is a critical time to develop air logistics infrastructure in the New Economy. The paper also presents a brief review of the air cargo industry in the Asian-Pacific region and China,in particular China’s development in the industry as its economy has grown rapidly and globalized in the past two decades. The paper argues that China needs to develop a GTP to support its future growth,and explains why the Pearl River Delta-Hong Kong-Macao city-region or Extended Metropolitan Region (EMR) is the best location. finally,it proposes that Zhuhai Airport,one of the five airports in the EMR,is the best site for the GTP. New policies from Chinese government as well as close cooperation between local governments of Guangdong and the two special Administrative Regions of Hong Kong and Macao will be needed to make the establishment of the GTP possible.

关键词： Global TransPark airport air cargo transport Hong Kong Extended Metropolitan Region the Pearl River Delta New Economy

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