检索结果-南通市图书馆

国际医学放射学杂志 2020年第6期 745-746页

作者：梁演婷 h.Wang r.Wei G.h.rao J.Zhu B.Song Department of radiology Minhang Hospital Fudan University

摘要目的旨在探讨能鉴别新型冠状病毒肺炎(COVID-19)与流行性感冒的特征性CT表现。方法回顾性分析2020年1月16日—2020年2月25日确诊的13例

关键词：

Interleukin-6: a villain in the drama of pancreatic cancer development and progression

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

hepatobiliary & Pancreatic Diseases International 2014年第4期13卷 371-380页

作者： reinhild holmer freya A Goumas Georg h Waetzig Stefan rose-John holger Kalthoff Division of Molecular Oncology Institute for Experimental Cancer Research CCC-NorthUniversity Hospital Schleswig-Holstein Kiel Germany Clinic for General Surgery Visceral Thoracic Transplantation Pediatric Surgery University Hospital Schleswig-Holstein Kiel Germany CONArIS research Institute AG Kiel Germany Institute of Biochemistry Christian-Albrechts-University KielGermany Division of Molecular Oncology Institute for Experimental Cancer Research CCC-North University Hospital Schleswig-Holstein Kiel Germany

BACKGrOUND： Pancreatic ductal adenocarcinoma（PDAC）is a devastating malignancy with a poor prognosis and little treatment options. The development and progression of the disease is fostered by inflammatory cells and cytokines. One of these cytokines is interleukin-6（IL-6）, which plays an important role in a wide range of biologic *** SOUrCES： A systematic search of PubMed was performed to identify relevant studies using key words such as interleukin-6,inflammatory cytokines, inflammation and pancreatic cancer or PDAC. Articles related to IL-6 and pancreatic cancer were systematically ***： IL-6 is elevated in the serum of pancreatic cancer patients and correlates with cachexia, advanced tumor stage and poor survival. Its expression is enhanced by hypoxia and proteins involved in pancreatic cancer development like Kras,mesothelin or ZIP4. IL-6 in turn contributes to the generation of a pro-tumorigenic microenvironment and is probably involved in angiogenesis and metastasis. In experimental mouse models of PDAC, IL-6 was important for the development and progression of precursor ***： IL-6 emerges as a key player in pancreatic cancer development and progression, and hence should be considered as a new therapeutic target.

关键词： IL-6 signaling IL-6 trans-signaling targeted therapy tumor microenvironment tumor stroma pancreatic ductal adenocarcinoma sgp130fc

维普期刊数据库

highly efficient GaAs solar cells by limiting light emission angle

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2013年第1期2卷 236-241页

作者： Emily D Kosten Jackson h Atwater James Parsons Albert Polman harry A Atwater Thomas J.Watson Laboratories of Applied Physics California Institute of TechnologyPasadenaCA 91125 USA Center for Nanophotonics FOM-Institute AMOLFScience Park 1041098XG AmsterdamThe Netherlands

In a conventional flat plate solar cell under direct sunlight,light is received from the solar disk,but is re-emitted *** isotropic emission corresponds to a significant entropy increase in the solar cell,with a corresponding drop in ***,using a detailed balance model,we show that limiting the emission angle of a high-quality GaAs solar cell is a feasible route to achieving power conversion efficiencies above 38%with a single *** highest efficiencies are predicted for a thin,light trapping cell with an ideal back reflector,though the scheme is robust to a non-ideal back *** with a conventional planar cell geometry illustrates that limiting emission angle in a light trapping geometry not only allows for much thinner cells,but also for significantly higher overall efficiencies with an excellent rear ***,we present ray-tracing and detailed balance analysis of two angular coupler designs,show that significant efficiency improvements are possible with these couplers,and demonstrate initial fabrication of one coupler design.

关键词： detailed balance GaAs solar cell light trapping photovoltaics two photon lithography

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

悬浮于石墨烯空位/孔洞中的独立纳米结构

Science China Materials 2023年第1期66卷 35-50页

作者：刘玉 huy Q Ta 杨晓琴张月周军华施启涛曾梦琪 Thomas Gemming Barbara Trzebicka 付磊 Mark h.rümmeli Soochow Institute for Energy and Materials Innovations College of PhysicsOptoelectronics and EnergyCollaborative Innovation Center of Suzhou Nano Science and TechnologyKey Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu ProvinceSoochow UniversitySuzhou 215006China IfW Dresden P.O.Box D-01171 DresdenGermany Gusu Laboratory of Materials Suzhou 215123China Leibniz Institute for Solid State and Materials research Dresden P.O.Box 270116D-01171 DresdenGermany Centre of Polymer and Carbon Materials Polish Academy of SciencesM.Curie-Sklodowskiej 34Zabrze 41-819Poland Institute of Environmental Technology VSB-Technical University of Ostrava17.Listopadu 15Ostrava70833Czech Republic College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072China

在电子束辐照下,石墨烯较易形成空位、孔洞等缺陷,从而捕获外来原子,形成新的结构.由于这些结构具有一些令人兴奋的性质,它们和石墨烯之间的相互作用引起了科研工作者相当大的研究兴趣.本文总结了利用透射电子显微镜在制备和表征悬浮在... 详细信息

在电子束辐照下,石墨烯较易形成空位、孔洞等缺陷,从而捕获外来原子,形成新的结构.由于这些结构具有一些令人兴奋的性质,它们和石墨烯之间的相互作用引起了科研工作者相当大的研究兴趣.本文总结了利用透射电子显微镜在制备和表征悬浮在石墨烯中的独立纳米结构的方法,以及原子分辨率下观察到的此类材料中原子/结构的动态行为过程,讨论了新型金属/非金属掺杂剂对具有不同键结构的石墨烯空位的影响,以及位于石墨烯边缘的单原子/团簇的催化活性.此外,还讨论了独立单原子厚二维团簇/金属/金属烯和二维团簇/金属/金属烯氧化物的动态形成过程.并指出这些纳米结构的形成、稳定性和宏观效应对于新的原子/分子尺度纳米技术的实际应用至关重要.以上数据证实了新型纳米结构的数量不断增加,并预示着相关研究的不断深入.

关键词：纳米结构透射电子显微镜纳米技术键结构石墨烯单原子电子束辐照分子尺度

维普期刊数据库

The impact of Pinus halepensis afforestation on Mediterranean spontaneous vegetation:do soil treatment and canopy cover matter?

在线全文

学校读者我要写书评

暂无评论

Journal of forestry research 2012年第4期23卷 517-528页

作者： Pasta Salvatore Tommaso La Mantia Juliane rühl Dipartimento DEMETrA Università di PalermoViale delle ScienzeEd.4Ingr H90128 PalermoItaly.

We investigated central Mediterranean Pinus halepensis plantations under semi-arid climate in order to evaluate the combined effect of soil treatment and afforestation practices on spontaneous plant species composition, richness and evenness, and on the trend and speed of vegetation dynamics. Phytosociological releves of three different plot typologies, i.e. （1） soil-treatment and plantation, （2） only soil-treatment, （3） no soil-treatment and no plantation, were compared by （a） multivari- ate analysis and （b） with reference to species richness and evenness. Moreover, in order to compare vegetation dynamics within the planta- tions with those ones ongoing in semi-natural garrigue communities, we compared life form and syntaxonomic spectra between phytosociological relev6s taken at 8 years of distance. DCA showed that floristic species composition and similarity are influenced by the canopy cover of Pine trees as well as by soil-treatment practices. Although species richness and evenness are not clearly related to neither soil treatment nor Pine afforestation, canopy cover clearly plays a major role： in fact, the highest Ph cover rates correspond to the lowest values of understory species richness. This is true also if only species of biogeographical/conservation interest are considered. regarding vegetation dynamics, sites with dense Pine canopy cover evolve much slower than the adjacent garrigue communities. The same factors invoqued to explain the patterns of floristic composition and similarity （i.e. allelopathy and competition for light, water and nutrients） may also explain the lowering of diversity of therophytes and the strong decline of the cover perfomed by both therophytes and hemicryptophytes underneath the canopy of dense Ph plantations. Thus, in sites where Ph cover exceeds about 80%, thinning is recommended not only in order to accelerate succession, but also to give a natural ＇shape＇ to afforestations.

关键词： plant diversity understory vegetation dynamics plantation

维普期刊数据库

在线全文

学校读者我要写书评

暂无评论

在人体肠胃内采用内窥镜激光凝结治疗

中国医疗器械杂志 1976年第5期 105-106页

作者： f.Bodem h—D.reidenbach h.Brand

我们用氩激光内窥镜凝结系统在肠胃区域内进行了无数次急性和慢性动物实验,在长期仔细地观察组织反应以及其组织学的价值后,在人的肠胃区域成功地采用激光凝结治疗血管瘤和止住胃出血。近几年,纤维光学内窥镜的发展,对人体肠胃区域的诊... 详细信息

我们用氩激光内窥镜凝结系统在肠胃区域内进行了无数次急性和慢性动物实验,在长期仔细地观察组织反应以及其组织学的价值后,在人的肠胃区域成功地采用激光凝结治疗血管瘤和止住胃出血。近几年,纤维光学内窥镜的发展,对人体肠胃区域的诊断得到了更进一步的便利条件,并由此而发展了许多内窥镜的和手术诊断与治疗方法。

关键词：塑料纤维导光纤维光导纤维激光内窥镜肠胃

体外重建皮肤模型（老化模型）中特定的晚期糖化终末产物诱导的生物学效应

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中华皮肤科杂志 2017年第9期50卷 698-699页

作者： hervé Pageon hélène Zucchi Zhenyu Dai David r Sell Christopher M Strauch Vincent M Monnier Daniel Asselineau L'Oréal Research & Innovation Aulnay-sous-bois France . Department of Pathology Case Western Reserve University Cleveland Ohio. Department of Pathology Case Western Reserve University Cleveland Ohio. Department of Biochemistry Case Western Reserve University Cleveland Ohio.

人皮肤老化的特征包括弹性纤维减少、不溶性胶原蛋白蓄积以及创伤修复能力受损等。而对于皮肤曝光部位，促炎性改变还能导致富含胶原蛋白基质的重构，进一步加重上述变化。该基质重构过程可通过两种方式实现。第一种涉及晚期糖化终末产... 详细信息

人皮肤老化的特征包括弹性纤维减少、不溶性胶原蛋白蓄积以及创伤修复能力受损等。而对于皮肤曝光部位，促炎性改变还能导致富含胶原蛋白基质的重构，进一步加重上述变化。该基质重构过程可通过两种方式实现。第一种涉及晚期糖化终末产物（AGE）的产生（由葡萄糖和羰基醛经过化学反应生成），可导致细胞外基质发生蛋白质交联、固化及失去弹性等损害。第二种涉及富含AGE的真皮基质与真皮细胞之间的相互作用，通过AGE受体（rAGE）和其他受体途径引起细胞活化，导致生长因子和细胞因子的释放，从而使细胞外基质发生深度重构。

关键词：晚期糖化终末产物皮肤模型生物学效应老化模型体外重建细胞外基质 AGE受体弹性纤维

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

福桑氏有机化学农医学院适用

福桑氏有机化学农医学院适用

Themis regulates metabolic signaling and effector functions in CD4^(+) T cells by controlling NfAT nuclear translocation

1952年

作者： r.C.fuson r.Connor C.C.Price h.r.Snyder 徐墨耕任云峰薛选仙译

福桑氏有机化学（农医学院适用）

ISBN: (数字)353775

ISBN: (纸本)353775

福桑氏有机化学（农医学院适用）

关键词：数理科学和化学化学有机化学

来源：汇雅图书（南通市图书馆... 评论

在线全文

汇雅图书（南通市图书馆）

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第9期18卷 2249-2261页

作者： Mukul Prasad Joanna Brzostek Namrata Gautam renu Balyan Vasily rybakin Nicholas r.J.Gascoigne Translational Immunology Programme Yong Loo Lin School of MedicineNational University of Singapore5 Science Drive 2Singapore 117545Singapore Department of Microbiology and Immunology Yong Loo Lin School of MedicineNational University of Singapore5 Science Drive 2Singapore 117545Singapore h.Lee Moffitt Cancer Center and research Institute TampaFLUSA Torque Therapeutics CambridgeMAUSA

Themis is a T cell lineage-specific molecule that is involved in TCr signal *** effects of germline Themis deletion on peripheral CD4^(+)T cell function have not been described *** this study,we found that Themis-deficient CD4^(+)T cells had poor proliferative responses,reduced cytokine production in vitro and weaker inflammatory potential,as measured by their ability to cause colitis in *** T cells are quiescent,whereas activated T cells have high metabolic *** of these metabolic demands depends upon nutrient availability and upregulation of nutrient intake channels after efficient TCr signal transduction,which leads to metabolic reprogramming in T *** tested whether defects in effector functions were caused by impaired metabolic shifts in Themis-deficient CD4^(+)T cells due to inefficient TCr signal transduction,in turn caused by the lack of *** found that upon TCr stimulation,Themis-deficient CD4^(+)T cells were unable to upregulate the expression of insulin receptor(Ir),glucose transporter(GLUT1),the neutral amino acid transporter CD98 and the mTOr pathway,as measured by c-Myc and pS6 *** analysis of activated Themis-deficient CD4^(+)T cells showed more oxidative phosphorylation(OXPhOS)than aerobic glycolysis,indicating defective metabolic ***,we found reduced NfAT translocation in Themis-deficient CD4^(+)T cells upon TCr *** previously reported ChIP-seq and rnA-seq data,we found that NfAT nuclear translocation controls Ir gene ***,our results describe an internal circuit between TCr signal transduction,NfAT nuclear translocation,and metabolic signaling in CD4^(+)T cells.

关键词： Immunometabolism NfAT nuclear translocation Insulin receptor mTOr Mitochondria

Dielectric spectroscopy and structural characterization of nano-filler-loaded epoxy resin

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Advanced Dielectrics 2021年第2期11卷 15-26页

作者： S.G.Thakor V.A.rana h.P.Vankar T.r.Pandit Department of Physics School of SciencesGujarat University Ahmedabad 380009GujaratIndia

This work outlines the characterization of epoxy resin[Bisphenol A-(epichlorhydrin):epoxy]and hardener[N(3-dimethylaminopropyl)-1,3-propylenediamine]with various inorganic *** characterizations of epoxy,hardener,neat epoxy(epoxy+hardener)and nano-epoxy(nano-filler+neat epoxy)composites loaded with 1 wt.%of inorganic nano-fillers(SiO_(2),Al_(2)O_(3),TiO_(2)and ZnO)were carried out using precision LCr meter,over the frequency range of 1 khz-2 Mhz at a constant temperature of 300.15 *** structural information of nano-fillers,neat epoxy and nano-epoxy composites was understood by fourier transform infrared spectroscopy and by ***,hardness and shear strength(shear punch)were also determined in order to gain additional information about the mechanical properties of epoxy *** of inorganic nano-fillers on the dielectric properties,structural chemistry and mechanical properties of neat epoxy composite is discussed thoroughly in this study.

关键词： Epoxy resin nano-fillers dielectric relaxation spectroscopy fTIr mechanical properties XrD