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Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults

Journal of Sport and Health Science 2024年第3期13卷 409-418页

作者： Jérémy raffin Yves rolland Annelise Genoux Guillaume Combes Mikael Croyal Bertrand Perret Sophie Guyonnet Bruno Vellas Laurent O.Martinez Philipe de Souto Barreto f.r the mapt/dsa group Institut du Vieillissement Gérontopôle de ToulouseCentre Hospitalo-Universitaire de ToulouseToulouse 31000France Centre d'Epidémiologie et de recherche en Santédes Populations UnitéMixte de Recherche 1295Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse-III-Paul-SabatierToulouse 31000France LimitAging Team Institut des Maladies Métaboliques et CardiovasculairesUnitéMixte de Recherche 1297Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse III-Paul SabatierToulouse 31432France Service de Biochimie Pôle de biologieHôpital de PurpanCentre Hospitalo-Universitaire de ToulouseToulouse 31300France L'Institut du Thorax Institut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France BioCore US16Structure Fédérative de Recherche BonamyInstitut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France Plate-f.rme de spectrométrie de masse Centre de Recherche en Nutrition HumaineOuestNantes 44000France 不详

Background:Adenosine triphosphatase inhibitory factor 1(If1)is a key protein involved in energy ***1 has been linked to various agerelated diseases,although its relationship with physical activity(PA)remains ***,the apolipoprotein A-I(apoA-I),a PA-modulated lipoprotein,could play a role in this relationship because it shares a binding site with If1 on the cell-surface ATP *** examined here the associations between chronic PA and plasma If1 concentrations among older adults,and we investigated whether apoA-I mediated these ***:In the present work,1096 healthy adults(63.8%females)aged 70 years and over who were involved in the Multidomain Alzheimer Prevention Trial study were ***1 plasma concentrations(square root of ng/mL)were measured at the 1-year visit of the Multidomain Alzheimer Prevention Trial,while PA levels(square root of metabolic equivalent task min/week)were assessed using questionnaires administered each year from baseline to the 3-year *** linear regressions were perf.rmed to investigate the associations between the f.rst-year mean PA levels and If1 *** analyses were conducted to examine whether apoA-I mediated these *** linear regressions were carried out to investigate whether the 1-year visit If1 concentrations predicted subsequent changes in ***:Multiple linear regressions indicated that f.rst-year mean PA levels were positively associated with If1 concentrations(B=0.021;SE=0.010;p=0.043).Mediation analyses revealed that about 37.7%of this relationship was mediated by apoA-I(B_(ab)=0.008;SE=0.004;p=0.023).Longitudinal investigations demonstrated that higher concentrations of If1 at the 1-year visit predicted a faster decline in PA levels over the subsequent 2 years(time×If1:B=0.148;SE=0.066;p=0.025).Conclusion:This study demonstrates that regular PA is associated with plasma If1 concentrations,and it suggests that apoA-I partly med

关键词： Aging Apolipoprotein Bioenergetics Exerkine Mitochondria

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Time to treat the climate and nature crisis as one indivisible global health emergency

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Stroke & Vascular Neurology 2024年第4期9卷 325-327页

作者： Chris Zielinski on behalf of the authorship group listed below Centre f.r Global Health University of WinchesterWinchesterUK 不详

Over 200 health journals call on the United Nations(UN),political leaders and health professionals to recognise that climate change and biodiversity loss are one indivisible crisis and must be tackled together to pres... 详细信息

关键词： preserve global divisible

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Cross-sectional associations between cortical thiclmess and physical activity in older adults with spontaneous memory complaints:The mapt Study

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Journal of Sport and Health Science 2023年第3期12卷 324-332页

作者： Jérémy raffin Yves rolland Clara fischer Jean-francois Mangin Audrey Gabelle Bruno Vellas Philipe de Souto Barreto the mapt/dsa group Gérontopôle de Toulouse Institut du VieillissementCentre Hospitalo-Universitaire de ToulouseToulouse 31000France UniversitéPaul-Sabatier/Institut National de la Santéet de la recherche Médicale UnitéMixte de recherche 1027 Facultéde médecineUniversity of Toulouse ⅢToulouse 31000France Centre pour l'Acquisition et le Traitement des Images Multicenter Neuroimaging Platf.rm NeurospinUniversitéParis-SaclayGif sur Yvette 91191France Memory resources and research Center Montpellier University HospitalMontpellier 34295France Institut National de la Santéet de la recherche Médicale Unité1061 i-site Montpellier Universitéd'Excellence University of MontpellierMontpellier 34090France 不详

Background:Age-related changes in brain structure may constitute the starting point f.r cerebral function *** activity(PA)demonstrated favorable associations with total brain volume,but its relationship with cortical thickness(CT)remains *** investigated the cross-sectional associations between PA level and CT in community-dwelling people aged 70 years and ***:A total of 403 older adults aged 74.8±4.0 years(mean±SD)who underwent a baseline magnetic resonance imaging examination and who had data on PA and confounders were *** was assessed with a *** were categorized according to PA *** linear regressions were used to compare the brain CT(mm)of the inactive group(no PA at all)with 6 active groups(growing PA levels)in 34 regions of ***:Compared with inactive persons,people who achieved PA at a level of 1500-1999 metabolic equivalent task-min/week(i.e.,about6-7 h of brisk walking f.r exercise) and those who achieved it at 2000-2999 metabolic equivalent task-min/week(i.e.,8-11 h of brisk walking f.r exercise)had higher CT in the fusif.rm gyrus and the temporal ***,dose-response associations between PA and CT were found in the fusif.rm gyrus(B=0.011,SE=0.004,adj.p=0.035),the temporal pole(B=0.026,SE=0.009,adj.p=0.048),and the caudal middle frontal gyrus,the entorhinal,medial orbitofrontal,lateral occipital,and insular ***:This study demonstrates a positive association between PA level and CT in temporal areas such as the fusif.rm gyrus,a brain region often associated to Alzheimer’s disease in people aged 70 years and *** investigations focusing on PA type may help to fulfil remaining knowledge gaps in this field.

关键词： Alzheimer's disease Brain aging Cortical thickness Physical activity

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Application of novel constrained friction processing method to produce fine grained biomedical Mg-Zn-Ca alloy

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Journal of Magnesium and Alloys 2024年第2期12卷 516-529页

作者： Ting Chen Banglong fu Junjun Shen Uceu f.H.r.Suhuddin Björn Wiese Yuanding Huang Min Wang Jorge f.dos Santos Jean Pierre Bergmann Benjamin Klusemann Solid State Materials Processing Institute of Material MechanicsHelmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht 21502Germany functional Magnesium Materials Institute of Metallic BiomaterialsHelmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht 21502Germany Shanghai Key Laboratory of Materials Laser Processing and Modification Shanghai Jiao Tong UniversityDongchuan Road 800Shanghai 200240China Applied Materials and Manufacturing Energy and Environment DivisionPacific Northwest National LaboratoryPO Box 999RichlandWA 99352USA Production Technology group Technisiche Universität IlmenauGustav-Kirchhoff-Platz 2Ilmenau 98693Germany Institute f.r Production Technology and Systems Leuphana University of LüneburgUniversitätsallee 1Lüneburg 21335Germany

In order to obtain Mg alloys with fine microstructures and high mechanical perf.rmances,a novel friction-based processing method,name as“constrained friction processing(CfP)”,was *** CfP,defect-free Mg-Zn-Ca rods with greatly refined grains and high mechanical properties were *** to the previous as-cast microstructure,the grain size was reduced from more than 1 mm to around 4μm within 3 s by a single process *** compressive yield strength was increased by 350%while the ultimate compressive strength by 53%.According to the established material flow behaviors by“tracer material”,the plastic material was transported by shear *** the base material to the rod,the material experienced three stages,*** by the tool,upward flow with additional tilt,followed by upward *** microstructural evolution was revealed by“stop-action”*** microstructural development at regions adjacent to the rod is mainly controlled by twinning,dynamic recrystallization(DrX)as well as particle stimulated nucleation,while that within the rod is related to DrX combined with grain growth.

关键词： Constrained friction processing Magnesium alloys Microstructure Mechanical properties Grain refinement Plastic def.rmation

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revolutionize fashion with waterless technology f.r wood-based cellulosic fibers

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China Textile 2024年第3期 50-51页

作者： Lenzing group Lenzing group

from producing fibers made from wood to becoming a global technology leader:take an inspiring journey in time through 80 years of innovation *** journey began in 1890,when Emil Hamburger,a paper industrialist from Lower Austria,acquired the"Starlingermühle"in Lenzing(Austria).Today,the Lenzing group is an internationally established company with nine production sites and nine sales and planning offices in more than 10 countries.

关键词： fibers becoming technology

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Lenzing introduces new Black Towel Collection with long-lasting softness

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China Textile 2024年第4期 32-33页

作者： Lenzing group Lenzing group

The Lenzing group,a prominent global producer of woodbased specialty fibers,has announced the introduction of its latest Black Towel Collection,crafted with LENZING^(TM) ECOVErO^(TM) branded black viscose fibers and TENCEL~(TM) branded black modal *** collection comprises six essential everyday washable and reusable face and body care items,including makeup removal pads,makeup removal towels,gym towels,bath towels,hand towels,hair bonnets,and beachtowels.

关键词： Lenzing fibers everyday

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Machine learning approach to assess the association between anthropometric,metabolic,and nutritional status and semen parameters

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Asian Journal of Andrology 2024年第4期26卷 349-355页

作者： Guillaume Bachelot Antonin Lamaziere Sebastien Czernichow Celine faure Chrystelle racine rachel Levy Charlotte Dupont Nutrition and f.rtility(ALIf.rT)group Author Inf.rmation Sorbonne University School of Medicine Saint-Antoine Research CenterINSERM UMR 93827 rue ChalignyParis 75012France reproductive Biology Department-CECOS Tenon HospitalAP-HP.Sorbonne UniversityParis 75020France Clinical Metabolomics Department Saint-Antoine HospitalAP-HP27 rue ChalignyParis 75012France Nutrition Department Obesity Specialist CentreGeorges Pompidou European HospitalAP-HPParis 75015France 不详

Many lifestyle factors,such as nutritional imbalance leading to obesity,metabolic disorders,and nutritional deficiency,have been identified as potential risk factors f.r male *** aim of this study was to evaluate the relationship between semen parameters and anthropometric,metabolic and nutritional *** was f.rst assessed individually,then after the application of a previously constructed and validated machine learning score that allows their ***,metabolic,antioxidant,micronutrient,and sperm parameters from 75 men suff.ring from idiopathic inf.rtility from four inf.rtility centers in france(Jean-Verdier ArT Center Hospital,Bondy;North Hospital ArT Center,Saint-Étienne;Navarre Polyclinic ArT Center,Pau;and Cochin Hospital ArT Center,Paris)between September 2009 and December 2013 were *** assessing standard correlation analysis,a previously built machine learning model,providing a score ranging from 0(the poorest)to 1(the most favorable),was calculated f.r each man in the study *** machine learning model,which separates inf.rtile/f.rtile men with unexplained inf.rtility on the basis of their bioclinical signature,provides a more holistic evaluation of the influence of the considered markers(anthropometric,metabolic,and oxidative status).We observed a significant correlation of some anthropometric,metabolic,and nutritional disorders with some sperm ***,an unfavorable machine learning score was associated with a high level of sperm DNA *** anthropometric,metabolic,and oxidative patterns,which may reflect an appropriate lifestyle,appear to positively impact overall health,in particular reproductive *** study,consistent with previous publications,suggests that beyond semen quality parameters,in an essential assessment of male f.rtility,other key factors should be taken into *** this regard,the application of emerging artificial intelligence t

关键词： lifestyle machine learning metabolism nutrition sperm DNA fragmentation

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real-World Treatment Adherence to Smoking Cessation Medications and Association with Treatment Outcome—27 Centers,China,2017–2022

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China CDC weekly 2024年第22期6卷 522-529,I0001-I0003页

作者： Anqi Cheng Zhao Liu Xinmei Zhou Zheng Su Dan Xiao Chen Wang the China National Tobacco Cessation Cohort Study(CNTCCS)Study group Department of Tobacco Control and Prevention of.respiratory Disease Center of Respiratory MedicineChina-Japan Friendship Hospital/WHO Collaborating Center for Tobacco Cessation and Respiratory Diseases Prevention/National Center for Respiratory Medicine/National Clinical Research Center for Respiratory Diseases/Institute of Respiratory MedicineChinese Academy of Medical SciencesBeijingChina Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship Hospital/WHO Collaborating Center for Tobacco Cessation and Respiratory Diseases Prevention/China National Center for Respiratory Medicine/China National Clinical Research Center for Respiratory DiseasesBeijingChina Chinese Academy of Medical Sciences and Peking Union Medical College BeijingChina 不详

What is already known about this topic?Medication non-adherence significantly impedes smoking cessation *** effective smoking cessation medications are accessible in China,realworld adherence and its correlation with treatment outcomes remain largely *** is added by this report?from December 2017 to January 2022,1,120 participants were recruited from 27 centers in all seven geographical regions of *** revealed that only 38.2%of smokers adhered to the prescribed 12-week smoking cessation treatment and those with a higher education level were more likely to be *** addition,smokers with good adherence were more likely to successfully quit *** are the implications f.r public health practice?The data obtained could enhance our understanding of smoking cessation practices in *** adherence is a crucial strategy to enhance the effectiveness of smoking cessation treatments and management provided to smokers.

关键词： China smoke likely

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Antimicrobial,antibiofilm,angiogenesis,anti-inflammatory,and wound healing activities of zinc nanoparticles green synthesized using f.rula macrecolea extract

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Asian Pacific Journal of Tropical Biomedicine 2024年第6期14卷 259-268页

作者： Sultan f.Alnomasy Department of Medical Laboratories Sciences College of Applied Medical SciencesShaqra UniversityAl-Quwayiyah 19257Saudi Arabia

Objective:To assess the antimicrobial,antibiofilm,anti-inflammatory,angiogenic,and wound healing activities of zinc nanoparticles(ZNPs)green synthesized using f.rula macrecolea ***:The green synthesis was conducted using the precipitation ***,the minimum inhibitory concentration(MIC),minimum bactericidal concentration(MBC),and minimum biofilm inhibition concentration 50%(MBIC50)of ZNPs against Staphylococcus aureus(***)and Pseudomonas aeruginosa(***)were *** effects of ZNPs on the gene expressions of Staphylococcus spp.[intracellular adhesion A(icaA)and D(icaD)]and ***(rhlI and rhlr)were investigated using quantitative real-time *** addition,the effects of ZNPs on wound healing,angiogenesis,and anti-inflammatory markers were ***:The green-synthesized ZNPs demonstrated significant antimicrobial efficacy against *** and *** biofilm f.rmation in *** and *** was also inhibited by ZNPs with MBIC50 values of 3.30μg/mL and 2.08μg/mL,***,ZNPs downregulated the expression of biofilm-related genes icaA,icaD,rhlI,and rhlr in the tested *** also demonstrated promising in vitro wound healing effects by promoting fibroblast cell prolif.ration and wound closure in a dose-dependent manner.A significant increase in the expression of HLA-G5 and VEGf-A genes as well as a marked decrease in the expression of Nf-κB,IL-1β,and TNf-αgenes were observed in cells treated with ZNPs compared to the control group(Promising antibacterial effects against *** and *** and wound-healing effects by inhibiting biofilm f.rmation,inducing angiogenesis,and reducing ***,f.rther studies must be conducted to specify the accurate mechanisms of action and toxicity of ZNPs.

关键词： Wound healing Antibacterial Angiogenesis Nanomedicine f.rula macrecolea Inflammation

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川剧文化保护传承弘扬专题调研报告

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四川戏剧 2024年第9期 14-18页

作者： Planning Editing Work group 《规划》编制工作组

新时代川剧发展危机与机遇并存，通过数据分析、实地调研、学者研讨和数据汇总，发现川剧保护传承面临着市场萎缩、观众流失、演出团体生存艰难、从业人员老化、人才培养断层、大众接受多样化等现实问题。基于此，报告建议在优化区域统... 详细信息

新时代川剧发展危机与机遇并存，通过数据分析、实地调研、学者研讨和数据汇总，发现川剧保护传承面临着市场萎缩、观众流失、演出团体生存艰难、从业人员老化、人才培养断层、大众接受多样化等现实问题。基于此，报告建议在优化区域统筹、加大资金政策支持力度的基础上，以院团改革、人才储备、繁荣创作、普及引导和文旅融合等措施来推进川剧文化保护传承发展目标的实现。

关键词：川剧文化保护传承弘扬调研报告

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