检索结果-南通市图书馆

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

抗菌素生成基因的克隆和表达

遗传工程 1984年第4期 91-93页

作者： Juan f.martin Jose’ A.Gil 齐小兰

最近在抗菌素生物合成的分子遗传学方面的进展为改进抗菌素生产开辟了新的前景。看来编码抗菌素生物合成有关的酶的基因是簇集在产生抗菌素生物的DNA上。已开发了一些低和高拷贝的质粒和噬菌体载体以便在产生抗菌素的链霉属(strcptomyc... 详细信息

最近在抗菌素生物合成的分子遗传学方面的进展为改进抗菌素生产开辟了新的前景。看来编码抗菌素生物合成有关的酶的基因是簇集在产生抗菌素生物的DNA上。已开发了一些低和高拷贝的质粒和噬菌体载体以便在产生抗菌素的链霉属(strcptomyces)中进行克隆。借助于聚乙烯乙二醇的转化或转染链霉属原生质体的方法可将DNA引入。一些对抗菌素生物合成特异的基因已被克隆。为抗菌素生物合成编码的基因已在链霉属

关键词：生物合成聚乙烯乙二醇霉属转染紫霉素次级代谢物 DNA 杆菌属分子遗传学抗性决定子

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

蓄热室热工性能的计算软件

玻璃 2003年第5期30卷 51-54页

作者： f.Pomar Y.BoussantRoux A.Pinard f.martin 陈恭源不详 SEPR.B.P.25 84131LePontetcedex BSNEMBALLAGE.B.P.1228 69611Villeurbanneeedex BSNVidrioEspania Apartadodecorreos194PiadelaBrugueras／n08211CastelarDelVallesEspagne

1前言西普公司自1973年发明十字形格子砖以来,从未停止过改善蓄热室热工效率方面的研究和开发工作.考虑到玻璃熔窑的运行成本和比以往任何时代更注重的环境保护,研究出了一套可靠性好和效率高的蓄热室格子体方案.

关键词：玻璃熔窑蓄热室热工性能计算软件格子体

Photoinduced Radical-Ionic Transfer of Various Chlorofluorocarbons to Alkenes from Oxime-Based Surrogates

在线全文

学校读者我要写书评

暂无评论

CCS Chemistry 2024年第5期6卷 1222-1230页

作者： Jinghui Zhang Muliang Zhang martin Oestreich Institut für Chemie Technische Universität Berlin10623 Berlin Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry University of Science and Technology of ChinaHefei 230026

functional-group-transfer strategies that avoid the use of unsustainable chemicals are attractive for the development of green ***(CfCs)not only contribute to the depletion of the stratospheric ozone layer,but their gaseous nature also poses a serious threat in scientific ***,the design of effective and sustainable alternatives to CfCs is highly ***,a practical CfC transfer platform for the addition of both a fluoroalkyl group and a chlorine substituent across alkenes by a photomediated redox-neutral manifold using bench-stable and easy-to-handle oxime-based surrogates is *** distinct reactivity of these tunable reagents allows for their single-electron reduction to trigger fragmentation driven by benzonitrile formation and loss of carbon *** other fragments released in that step,namely an electrophilic fluoroalkyl radical and a nucleophilic chloride anion,are subsequently transferred onto alkenes by a radical-ionic mechanism to deliver the desired chlorofluorocarbon products.

关键词： alkenes chlorofluorocarbons functionalgroup transfer radical-ionic crossover photoredox catalysis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

外科在急性胰腺炎治疗中的作用

临床消化病杂志 1989年第2期1卷 84-85页

作者： G.P.MARZOLI P.L.CATALANO S.CEMIN f.martin 白植军

关于急性胰腺炎的治疗方法在欧洲与美国已有所改变,目前的看法仍然是倾向于在良好设备的重症监护机构中以保守治疗为基础。另一方面,关键还在于胃肠病学专家和外科医生与重症监护专家的尽力协作。急性脂腺炎不仅是胰腺的疾病,而且是全... 详细信息

关于急性胰腺炎的治疗方法在欧洲与美国已有所改变,目前的看法仍然是倾向于在良好设备的重症监护机构中以保守治疗为基础。另一方面,关键还在于胃肠病学专家和外科医生与重症监护专家的尽力协作。急性脂腺炎不仅是胰腺的疾病,而且是全身的复杂反应。该病的最初损害取决于心脏循环、肺及肾脏系统的受累程度。有学者研究分析心脏循环系统受累及的程度,证实了重症监护的重要性。应用氧耗指数（O2CI）。

关键词：重症监护胰腺炎治疗外科医生受累程度氧耗复杂反应心功能外科处理胰腺手术早期死亡率

Wear dependent virtual flow rate sensor for progressing cavity pumps with deformable stator

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2024年第2期21卷 1346-1353页

作者： Jens Müller Sebastian Leonow Johannes Schulz Christian Hansen martin Monnigmann Ruhr-Universitat Bochum Universit atsstraûe 150Bochum44801Germany SEEPEX GmbH Scharnh olzstraûe 344Bottrop46240Germany

This contribution presents a novel wear dependent virtual flow rate sensor for single stage single lobe progressing cavity pumps. We study the wear-induced material loss of the pump components and the impact of this material loss on the volumetric efficiency. The results are combined with an established backflow model to implement a backflow calculation procedure that is adaptive to wear. We use a laboratory test setup with a highly abrasive fluid and operate a pump from new to worn condition to validate our approach. The obtained measurement data show that the presented virtual sensor is capable of calculating the flow rate of a pump being subject to wear during its regular operation.

关键词： Backflow Progressing cavity pump Virtual sensor Wear

Porphyrinic Acceptors forfullerene-free MolecularPhotovoltaics

在线全文

学校读者我要写书评

暂无评论

CCS Chemistry 2024年第2期6卷 276-296页

作者： Jorge Labella Juan Laforga-martin Tomás Torres Department of Organic Chemistry Universidad Aut´onoma de Madrid28049 Madrid Institute for Advanced Research in Chemical Sciences Universidad Aut´onoma de MadridMadrid IMDEA—Nanociencia 28049 Madrid

Over the past few years,the development of nonfullerene acceptors(NfAs)has become a prominent focus in both organic and perovskite solar cell(OSCs and PSCs,respectively)research *** this context,porphyrinoids,compounds structurally related to porphyrins,have emerged as promising solar cell *** contrast to the widely used fullerene acceptors,porphyrinoids exhibit strong,broad absorption properties across the UV–vis/NIR spectrum,which can be easily tuned through chemical ***,they can be prepared and derivatized using cost-effective and straightforward methodologies,allowing for convenient adjustments in thin-film morphology,processability,supramolecular organization,and energy ***,these compounds offer higher thermal and photochemical stability,resulting in longer device lifetimes compared to their fullerene-based *** this review,we outline the utilization of porphyrinoids as NfAs in OSCs and PSCs,discussing essential aspects such as design guidelines,molecular properties,and device *** goal is to inspire and further promote the development of n-type porphyrinoids,which have not yet fully unleashed their potential.

关键词： fullerene-free molecular photovoltaics nonfullerene acceptors porphyrinic acceptors n-type porphyrinoids organic and perovskite solar cells

A novel saliva-based miRNA profile to diagnose and predict oral cancer

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Oral Science 2024年第1期16卷 97-109页

作者： Jaikrishna Balakittnen Chameera Ekanayake Weeramange Daniel f.Wallace Pascal H.G.Duijf Alexandre S.Cristino Gunter Hartel Roberto A.Barrero Touraj Taheri Liz Kenny Sarju Vasani martin Batstone Omar Breik Chamindie Punyadeera Saliva&Liquid Biopsy Translational Laboratory Griffith Institute for Drug DiscoveryGriffith UniversityNathanQLDAustralia Department of Medical Laboratory Sciences Faculty of Allied Health SciencesUniversity of JaffnaJaffnaSri Lanka Menzies Health Institute Griffith UniversityGold CoastQLDAustralia School of Biomedical Sciences Faculty of HealthQueensland University of TechnologyBrisbaneQLDAustralia Centre for Cancer Biology Clinical and Health SciencesUniversity of South Australia&SA PathologyAdelaideSAAustralia Institute of Clinical Medicine Faculty of MedicineUniversity of OsloOsloNorway Department of Medical Genetics Oslo University HospitalOsloNorway Griffith Institute for Drug Discovery Griffith UniversityNathanQLDAustralia QIMR Berghofer Medical Research Institute Statistics UnitBrisbaneQLDAustralia School of Public Health The University of QueenslandBrisbaneQLDAustralia School of Nursing Queensland University of TechnologyBrisbaneQLDAustralia eResearch Research InfrastructureAcademic DivisionQueensland University of TechnologyBrisbaneQLDAustralia Department of Anatomical Pathology Royal Brisbane and Women’s HospitalHerstonQLDAustralia faculty of Medicine The University of QueenslandBrisbaneQLDAustralia Royal Brisbane and Women’s Hospital Cancer Care ServicesHerstonQLDAustralia Department of Otolaryngology Royal Brisbane and Women’s HospitalHerstonQLDAustralia Department of Oral and Maxillofacial Surgery Royal Brisbane and Women’s HospitalHerstonQLDAustralia

Oral cancer (OC) is the most common form of head and neck cancer. Despite the high incidence and unfavourable patient outcomes, currently, there are no biomarkers for the early detection of OC. This study aims to discover, develop, and validate a novel saliva-based microRNA signature for early diagnosis and prediction of OC risk in oral potentially malignant disorders (OPMD).The Cancer Genome Atlas (TCGA) miRNA sequencing data and small RNA sequencing data of saliva samples were used to discover differentially expressed miRNAs. Identified miRNAs were validated in saliva samples of OC (n=50), OPMD (n=52), and controls(n=60) using quantitative real-time PCR. Eight differentially expressed miRNAs (miR-7-5p, miR-10b-5p, miR-182-5p, miR-215-5p,miR-431-5p, miR-486-3p, miR-3614-5p, and miR-4707-3p) were identified in the discovery phase and were validated. The efficiency of our eight-miRNA signature to discriminate OC and controls was:area under curve (AUC):0.954, sensitivity:86%, specificity:90%,positive predictive value (PPV):87.8%and negative predictive value (NPV):88.5%whereas between OC and OPMD was:AUC:0.911,sensitivity:90%, specificity:82.7%, PPV:74.2%and NPV:89.6%. We have developed a risk probability score to predict the presence or risk of OC in OPMD patients. We established a salivary miRNA signature that can aid in diagnosing and predicting OC,revolutionising the management of patients with OPMD. Together, our results shed new light on the management of OC by salivary miRNAs to the clinical utility of using miRNAs derived from saliva samples.

关键词： specificity salivary diagnosis

CO_(2)capture costs of chemical looping combustion of biomass:A comparison of natural and synthetic oxygen carrier

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第5期92卷 296-310页

作者： Benjamin fleiß Juraj Priscak martin Hammerschmid Josef fuchs Stefan Müller Hermann Hofbauer Institute of Chemical Environmental and Bioscience EngineeringTU WienVienna1060 ViennaAustria BEST–Bioenergy and Sustainable Technologies GmbH Graz8010 StyriaAustria

Chemical looping combustion has the potential to be an efficient and low-cost technology capable of contributing to the reduction of the atmospheric concentration of CO_(2) in order to reach the 1.5/2°C goal and mitigate climate *** this process,a metal oxide is used as oxygen carrier in a dual fluidized bed to generate clean CO_(2) via combustion of *** commonly,natural ores or synthetic materials are used as oxygen carrier whereas both must meet special requirements for the conversion of solid *** oxygen carriers are characterized by higher reactivity at the expense of higher costs versus the lower-cost natural *** determine the viability of both possibilities,a techno-economic comparison of a synthetic material based on manganese,iron,and copper to the natural ore ilmenite was *** synthetic oxygen carrier was characterized and tested in a pilot plant,where high combustion efficiencies up to 98.4%and carbon capture rates up to 98.5%were *** techno-economic assessment resulted in CO_(2) capture costs of 75 and 40€/tCO_(2) for the synthetic and natural ore route respectively,whereas a sensitivity analysis showed the high impact of production costs and attrition rates of the synthetic *** synthetic oxygen carrier could break even with the natural ore in case of lower production costs and attrition rates,which could be reached by adapting the production process and recycling *** comparison to state-of-the-art technologies,it is demonstrated that both routes are viable and the capture cost of CO_(2) could be reduced by implementing the chemical looping combustion technology.

关键词： Chemical looping combustion BECCS Techno-economic assessment CO_(2)capture costs Oxygen carrier development Synthetic materials Ilmenite

RANKL inhibition reduces lesional cellularity and Gαs variant expression and enables osteogenic maturation in fibrous dysplasia

在线全文

学校读者我要写书评

暂无评论

Bone Research 2024年第1期12卷 165-179页

作者： Luis f.de Castro Jarred M.Whitlock Zachary Michel Kristen Pan Jocelyn Taylor Vivian Szymczuk Brendan Boyce Daniel martin Vardit Kram Rebeca Galisteo Kamran Melikov Leonid V.Chernomordik Michael T.Collins Alison M.Boyce Skeletal Disorders and Mineral Homeostasis Section National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Section on Membrane Biology Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaMDUSA Metabolic Bone Disorders Unit National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Department of Plastic and Reconstructive Surgery The Johns Hopkins Medical InstitutionsBaltimoreMDUSA Department of Pathology and Laboratory Medicine University of Rochester Medical CenterRochesterNYUSA NIDCR Genomics and Computational Biology Core National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA

fibrous dysplasia(fD)is a rare,disabling skeletal disease for which there are no established *** evidence supports inhibiting the osteoclastogenic factor receptor activator of nuclear kappa-B ligand(RANKL)as a potential treatment *** this study,we investigated the mechanisms underlying RANKL inhibition in fD tissue and its likely indirect effects on osteoprogenitors by evaluating human fD tissue pre-and post-treatment in a phase 2 clinical trial of denosumab(NCT03571191)and in murine in vivo and ex vivo preclinical *** analysis of human and mouse tissue demonstrated increased osteogenic maturation,reduced cellularity,and reduced expression of the pathogenic Gαs variant in fD lesions after RANKL *** sequencing of human and mouse tissue supported these *** interaction between osteoclasts and mutant osteoprogenitors was further assessed in an ex vivo lesion model,which indicated that the proliferation of abnormal fD osteoprogenitors was dependent on *** results from this study demonstrated that,in addition to its expected antiosteoclastic effect,denosumab reduces fD lesion activity by decreasing fD cell proliferation and increasing osteogenic maturation,leading to increased bone formation within *** findings highlight the unappreciated role of cellular crosstalk between osteoclasts and preosteoblasts/osteoblasts as a driver of fD pathology and demonstrate a novel mechanism of action of denosumab in the treatment of bone disease.

关键词： dysplasia treatment finding